JP2008529989A - 癌のような増殖性の疾病の治療用のテトラヒドロピリドチオフェン - Google Patents

癌のような増殖性の疾病の治療用のテトラヒドロピリドチオフェン Download PDF

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Publication number
JP2008529989A
JP2008529989A JP2007553625A JP2007553625A JP2008529989A JP 2008529989 A JP2008529989 A JP 2008529989A JP 2007553625 A JP2007553625 A JP 2007553625A JP 2007553625 A JP2007553625 A JP 2007553625A JP 2008529989 A JP2008529989 A JP 2008529989A
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JP
Japan
Prior art keywords
cyano
pyridine
dihydro
thieno
carboxylic acid
Prior art date
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Pending
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JP2007553625A
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English (en)
Japanese (ja)
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JP2008529989A5 (https=
Inventor
ペカリ クラウス
シュミット マティアス
ベーア トーマス
ベッカース トーマス
バルテルス ビェルン
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Takeda GmbH
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Nycomed GmbH
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Application filed by Nycomed GmbH filed Critical Nycomed GmbH
Publication of JP2008529989A publication Critical patent/JP2008529989A/ja
Publication of JP2008529989A5 publication Critical patent/JP2008529989A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007553625A 2005-02-09 2006-02-08 癌のような増殖性の疾病の治療用のテトラヒドロピリドチオフェン Pending JP2008529989A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05100895 2005-02-09
EP05104488 2005-05-25
EP05112158 2005-12-14
PCT/EP2006/050782 WO2006084869A1 (en) 2005-02-09 2006-02-08 Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer

Publications (2)

Publication Number Publication Date
JP2008529989A true JP2008529989A (ja) 2008-08-07
JP2008529989A5 JP2008529989A5 (https=) 2009-04-02

Family

ID=36146917

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007553625A Pending JP2008529989A (ja) 2005-02-09 2006-02-08 癌のような増殖性の疾病の治療用のテトラヒドロピリドチオフェン

Country Status (6)

Country Link
US (3) US7714135B2 (https=)
EP (1) EP1851229A1 (https=)
JP (1) JP2008529989A (https=)
AU (1) AU2006212224A1 (https=)
CA (1) CA2596202A1 (https=)
WO (1) WO2006084869A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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ES2309765T3 (es) 2004-05-28 2008-12-16 4Sc Ag Tetrahidropiridotiofenos.
US7714134B2 (en) 2004-06-11 2010-05-11 4Sc Ag Compounds and use of tetrahydropyridothiophenes
EP1851229A1 (en) 2005-02-09 2007-11-07 Nycomed GmbH Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer
AU2006212179A1 (en) 2005-02-11 2006-08-17 4Sc Ag Tetrahydropyridothiophenes as antripoliferative agents for the treatment of cancer
US7714136B2 (en) 2005-05-25 2010-05-11 4Sc Ag Tetrahydropyridothiophenes
US7763728B2 (en) 2005-05-25 2010-07-27 4Sc Ag Tetrahydropyridothiophenes
WO2008066854A2 (en) * 2006-11-28 2008-06-05 Novartis Ag Methods and compositions for inducing apoptosis in cancer cells
BR112020025696A2 (pt) 2018-06-19 2021-03-16 Novartis Ag Derivados de tetra-hidrotienopiridina n-substituída e usos dos mesmos
CN111763217B (zh) * 2019-03-30 2022-06-28 上海凌达生物医药有限公司 一类噻吩并氮杂环类化合物、制备方法和用途
CN111909167B (zh) * 2019-05-07 2021-11-19 华东师范大学 一种哌啶并噻吩衍生物及其在制备治疗银屑病的药物中的应用

Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2002506072A (ja) * 1998-03-12 2002-02-26 ノボ ノルディスク アクティーゼルスカブ プロテインチロシンホスファターゼ（ＰＴＰａｓｅ）のモジュレーター
WO2002092076A1 (en) * 2001-05-16 2002-11-21 Cytovia, Inc. Substituted coumarins and quinolines as caspases activators
WO2005033102A2 (en) * 2003-10-03 2005-04-14 Amphora Discovery Corporation Thiophene-based compounds exhibiting atp-utilizing enzyme inhibitory activity, and compositions, and uses thereof

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JPS5498337A (en) 1978-01-06 1979-08-03 Dai Ichi Seiyaku Co Ltd Anticarcinogenic and/or antimetastatic agent
DD272078A1 (de) 1986-04-15 1989-09-27 Dresden Arzneimittel Verfahren zur herstellung von 6-substituierten 2-acylamio-4,5,6,7-tetrahydro-thieno[2,3-c]-pyridin-3-carbonsaeure-derivaten
DE4039734A1 (de) 1990-12-13 1992-06-17 Basf Ag Substituierte 2-aminothiophene enthaltende herbizide mittel
GB9310700D0 (en) 1993-05-24 1993-07-07 Zeneca Ltd Novel composition
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US7714134B2 (en) 2004-06-11 2010-05-11 4Sc Ag Compounds and use of tetrahydropyridothiophenes
SE0401970D0 (sv) 2004-08-02 2004-08-02 Astrazeneca Ab Novel compounds
EP1851229A1 (en) 2005-02-09 2007-11-07 Nycomed GmbH Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer
AU2006212179A1 (en) 2005-02-11 2006-08-17 4Sc Ag Tetrahydropyridothiophenes as antripoliferative agents for the treatment of cancer
US7714136B2 (en) 2005-05-25 2010-05-11 4Sc Ag Tetrahydropyridothiophenes
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Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002506072A (ja) * 1998-03-12 2002-02-26 ノボ ノルディスク アクティーゼルスカブ プロテインチロシンホスファターゼ（ＰＴＰａｓｅ）のモジュレーター
WO2002092076A1 (en) * 2001-05-16 2002-11-21 Cytovia, Inc. Substituted coumarins and quinolines as caspases activators
WO2005033102A2 (en) * 2003-10-03 2005-04-14 Amphora Discovery Corporation Thiophene-based compounds exhibiting atp-utilizing enzyme inhibitory activity, and compositions, and uses thereof

Also Published As

Publication number Publication date
US20080096914A1 (en) 2008-04-24
AU2006212224A1 (en) 2006-08-17
US20100324038A1 (en) 2010-12-23
US7714135B2 (en) 2010-05-11
US20090227577A1 (en) 2009-09-10
EP1851229A1 (en) 2007-11-07
CA2596202A1 (en) 2006-08-17
WO2006084869A1 (en) 2006-08-17

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