JP2008529537A - プリオン特異的なペプチド試薬 - Google Patents

プリオン特異的なペプチド試薬 Download PDF

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Publication number
JP2008529537A
JP2008529537A JP2007555399A JP2007555399A JP2008529537A JP 2008529537 A JP2008529537 A JP 2008529537A JP 2007555399 A JP2007555399 A JP 2007555399A JP 2007555399 A JP2007555399 A JP 2007555399A JP 2008529537 A JP2008529537 A JP 2008529537A
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Prior art keywords
pathogenic
prion
sample
peptide
peptide reagent
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JP2007555399A
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Japanese (ja)
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JP2008529537A5 (enExample
Inventor
メリッサ ミシェリッチ，
セリーヌ ユアン−ウェイ フー，
マイケル ディー． コノリー，
ロナルド ズッカーマン，
Original Assignee
ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド
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Application filed by ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド filed Critical ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド
Publication of JP2008529537A publication Critical patent/JP2008529537A/ja
Publication of JP2008529537A5 publication Critical patent/JP2008529537A5/ja
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
JP2007555399A 2005-02-11 2006-02-07 プリオン特異的なペプチド試薬 Pending JP2008529537A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/056,950 US20060035242A1 (en) 2004-08-13 2005-02-11 Prion-specific peptide reagents
PCT/US2006/007001 WO2006086799A2 (en) 2005-02-11 2006-02-07 Prion-specific peptide reagents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011289829A Division JP2012080899A (ja) 2005-02-11 2011-12-28 プリオン特異的なペプチド試薬

Publications (2)

Publication Number Publication Date
JP2008529537A true JP2008529537A (ja) 2008-08-07
JP2008529537A5 JP2008529537A5 (enExample) 2009-04-02

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2007555399A Pending JP2008529537A (ja) 2005-02-11 2006-02-07 プリオン特異的なペプチド試薬
JP2011289829A Pending JP2012080899A (ja) 2005-02-11 2011-12-28 プリオン特異的なペプチド試薬

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011289829A Pending JP2012080899A (ja) 2005-02-11 2011-12-28 プリオン特異的なペプチド試薬

Country Status (4)

Country Link
US (2) US20060035242A1 (enExample)
EP (1) EP1858537A4 (enExample)
JP (2) JP2008529537A (enExample)
WO (1) WO2006086799A2 (enExample)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP2012108035A (ja) * 2010-11-18 2012-06-07 Sumika Chemical Analysis Service Ltd 免疫反応測定用担体及びその製造方法ならびにこれを用いた免疫反応測定用装置、免疫反応測定用キット及び免疫反応測定方法

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US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
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WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
US20090130774A1 (en) * 2005-01-13 2009-05-21 David Peretz Elisa assays using prion-specific peptide reagents
EP1853915B1 (en) * 2005-02-15 2011-10-12 Adlyfe, Inc. Method for detecting misfolded proteins and prions
WO2007030804A1 (en) * 2005-09-09 2007-03-15 Novartis Ag Prion-specific peptoid reagents
JP5097206B2 (ja) * 2006-07-28 2012-12-12 エイディーライフ インコーポレイティッド 診断および治療のためのペプチドプローブ
JP2010523977A (ja) * 2007-04-04 2010-07-15 ノバルティス アーゲー プリオンアッセイ
EP2140272A1 (en) * 2007-04-04 2010-01-06 Novartis Ag Prion elisa
JP2011520108A (ja) * 2008-04-30 2011-07-14 ノバルティス アーゲー 病原性配座異性体についてのアッセイ
CN102725639A (zh) * 2009-11-04 2012-10-10 诺华有限公司 蛋白质聚集物与单体分离中作为结合试剂的带正电物质
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WO2020157381A1 (en) * 2019-01-29 2020-08-06 Teknologian Tutkimuskeskus Vtt Oy Methods for screening polypeptides capable of binding specific target molecules and tools related thereto

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