JP2008529500A5 - - Google Patents
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- Publication number
- JP2008529500A5 JP2008529500A5 JP2007554332A JP2007554332A JP2008529500A5 JP 2008529500 A5 JP2008529500 A5 JP 2008529500A5 JP 2007554332 A JP2007554332 A JP 2007554332A JP 2007554332 A JP2007554332 A JP 2007554332A JP 2008529500 A5 JP2008529500 A5 JP 2008529500A5
- Authority
- JP
- Japan
- Prior art keywords
- scrfr2
- composition
- urocortin
- releasing factor
- corticotropin releasing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100038018 Corticotropin-releasing factor receptor 1 Human genes 0.000 claims 8
- 108060003951 Immunoglobulin Proteins 0.000 claims 6
- 102000005630 Urocortins Human genes 0.000 claims 6
- 108010059705 Urocortins Proteins 0.000 claims 6
- 102000018358 immunoglobulin Human genes 0.000 claims 6
- 239000000777 urocortin Substances 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 5
- 102100021752 Corticoliberin Human genes 0.000 claims 4
- 108010022152 Corticotropin-Releasing Hormone Proteins 0.000 claims 4
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 claims 4
- 108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 claims 4
- 101100061417 Homo sapiens CRHR1 gene Proteins 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 150000001413 amino acids Chemical group 0.000 claims 3
- 102000001711 Copine Human genes 0.000 claims 2
- 108010054424 Copine Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- FCENQCVTLJEGOT-KIHVXQRMSA-N stresscopin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)C1=CN=CN1 FCENQCVTLJEGOT-KIHVXQRMSA-N 0.000 claims 2
- ZEBBPGHOLWPSGI-KPLDDXDLSA-N urocortin ii Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CS)C(N)=O)CC1=CN=CN1 ZEBBPGHOLWPSGI-KPLDDXDLSA-N 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65086605P | 2005-02-08 | 2005-02-08 | |
| US60/650,866 | 2005-02-08 | ||
| PCT/US2006/004321 WO2006086402A2 (en) | 2005-02-08 | 2006-02-08 | Compositions and methods related to soluble g-protein coupled receptors(sgpcrs) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008529500A JP2008529500A (ja) | 2008-08-07 |
| JP2008529500A5 true JP2008529500A5 (https=) | 2009-03-12 |
| JP4859248B2 JP4859248B2 (ja) | 2012-01-25 |
Family
ID=36793648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007554332A Expired - Fee Related JP4859248B2 (ja) | 2005-02-08 | 2006-02-08 | 可溶性Ｇタンパク質共役型レセプター（ｓＧＰＣＲ）に関する組成物および方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7507794B2 (https=) |
| EP (1) | EP1885746B1 (https=) |
| JP (1) | JP4859248B2 (https=) |
| KR (1) | KR20070112155A (https=) |
| CN (1) | CN101137668B (https=) |
| AT (1) | ATE540970T1 (https=) |
| AU (1) | AU2006212813B2 (https=) |
| CA (1) | CA2597065C (https=) |
| DK (1) | DK1885746T3 (https=) |
| RU (1) | RU2423378C2 (https=) |
| WO (1) | WO2006086402A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7815905B2 (en) * | 2006-01-27 | 2010-10-19 | Research Development Foundation | Methods of increasing insulin sensitivity or decreasing insulin secretion by administering corticotropin releasing factor receptor-2 inhibitors |
| EP2190533A2 (en) * | 2007-09-11 | 2010-06-02 | Mondobiotech Laboratories AG | Use of a peptide as a therapeutic agent |
| US20100204113A1 (en) * | 2007-09-11 | 2010-08-12 | Dorian Bevec | Use of stresscopin-related peptide as a therapeutic agent |
| KR20100056507A (ko) * | 2007-09-11 | 2010-05-27 | 몬도바이오테크 래보래토리즈 아게 | 치료제로서의 펩티드 ｐｒｏ－ｇｌｙ－ｔｈｒ－ｃｙｓ－ｇｌｕ－ｉｌｅ－ｃｙｓ－ａｌａ－ｔｙｒ－ａｌａ－ａｌａ－ｃｙｓ－ｔｈｒ－ｇｌｙ－ｃｙｓ의 용도 |
| WO2009046874A1 (en) * | 2007-09-11 | 2009-04-16 | Mondobiotech Laboratories Ag | Therapeutic combination of trh-potentiating peptide and stresscopin |
| WO2011025905A1 (en) | 2009-08-28 | 2011-03-03 | Research Development Foundation | Urocortin 2 analogs and uses thereof |
| WO2011062935A1 (en) * | 2009-11-17 | 2011-05-26 | The Regents Of The University Of California | Compositions and assay systems for intracellular processes |
| AR081066A1 (es) | 2010-04-02 | 2012-06-06 | Hanmi Holdings Co Ltd | Conjugado de insulina donde se usa un fragmento de inmunoglobulina |
| US9981017B2 (en) | 2010-04-02 | 2018-05-29 | Hanmi Science Co., Ltd. | Insulin conjugate using an immunoglobulin fragment |
| SG10201701547VA (en) * | 2011-02-23 | 2017-03-30 | Massachusetts Inst Technology | Water soluble membrane proteins and methods for the preparation and use thereof |
| CN108310396B (zh) | 2012-02-14 | 2022-07-15 | 加利福尼亚大学董事会 | 用于心血管疾病和其它病况的旁分泌基因的全身性递送和受调节的表达 |
| JOP20170153A1 (ar) | 2016-07-15 | 2019-01-30 | Lilly Co Eli | نظائر urocortin-2 جديدة معدلة بحمض دهني لعلاج داء السكري وأمراض الكلى المزمنة |
| WO2018132768A1 (en) * | 2017-01-13 | 2018-07-19 | Sanna Pietro P | Methods and compositions for treating hpa hyperactivity |
| US10995361B2 (en) | 2017-01-23 | 2021-05-04 | Massachusetts Institute Of Technology | Multiplexed signal amplified FISH via splinted ligation amplification and sequencing |
| WO2018157074A1 (en) | 2017-02-24 | 2018-08-30 | Massachusetts Institute Of Technology | Methods for diagnosing neoplastic lesions |
| WO2018157048A1 (en) | 2017-02-24 | 2018-08-30 | Massachusetts Institute Of Technology | Methods for examining podocyte foot processes in human renal samples using conventional optical microscopy |
| US11180804B2 (en) | 2017-07-25 | 2021-11-23 | Massachusetts Institute Of Technology | In situ ATAC sequencing |
| WO2019046699A1 (en) * | 2017-09-01 | 2019-03-07 | Massachustetts Institute Of Technology | NON-DETERGENT GPCR BIOELECTRONIC INTERFACES COUPLED TO THE 2D S-PROTEIN NETWORK, DEVICES AND METHODS OF USE THEREOF |
| US11173992B2 (en) | 2017-12-28 | 2021-11-16 | Legionarus, Llc | Buoyancy garment |
| US11873374B2 (en) | 2018-02-06 | 2024-01-16 | Massachusetts Institute Of Technology | Swellable and structurally homogenous hydrogels and methods of use thereof |
| WO2020013833A1 (en) | 2018-07-13 | 2020-01-16 | Massachusetts Institute Of Technology | Dimethylacrylamide (dmaa) hydrogel for expansion microscopy (exm) |
| US11471112B2 (en) | 2018-11-21 | 2022-10-18 | Legionarius, Llc | Mobile application for wearable device |
| USD905935S1 (en) | 2019-02-20 | 2020-12-29 | Legionarius, Llc | Shirt with back pocket |
| US12478324B2 (en) | 2019-02-20 | 2025-11-25 | Legionarius, Llc | Sensors for wearable devices |
| US12405193B2 (en) | 2019-02-22 | 2025-09-02 | Massachusetts Institute Of Technology | Iterative direct expansion microscopy |
| US12265004B2 (en) | 2019-11-05 | 2025-04-01 | Massachusetts Institute Of Technology | Membrane probes for expansion microscopy |
| WO2021113505A1 (en) | 2019-12-05 | 2021-06-10 | Massachusetts Institute Of Technology | Method for preparing a specimen for expansion microscopy |
| WO2026021448A1 (zh) * | 2024-07-22 | 2026-01-29 | 健达九州(北京)生物科技有限公司 | 一种M4Di变体以及其治疗癫痫的应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4196265A (en) | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
| US4215051A (en) | 1979-08-29 | 1980-07-29 | Standard Oil Company (Indiana) | Formation, purification and recovery of phthalic anhydride |
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US4883750A (en) | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| US5549910A (en) | 1989-03-31 | 1996-08-27 | The Regents Of The University Of California | Preparation of liposome and lipid complex compositions |
| US5063245A (en) * | 1990-03-28 | 1991-11-05 | Nova Pharmaceutical Corporation | Corticotropin-releasing factor antagonism compounds |
| JP3218637B2 (ja) | 1990-07-26 | 2001-10-15 | 大正製薬株式会社 | 安定なリポソーム水懸濁液 |
| JP2958076B2 (ja) | 1990-08-27 | 1999-10-06 | 株式会社ビタミン研究所 | 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法 |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5792451A (en) | 1994-03-02 | 1998-08-11 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
| US5786203A (en) * | 1994-06-14 | 1998-07-28 | Neurocrine Biosciences, Inc. | Isolated nucleic acid encoding corticotropin-releasing factor2 receptors |
| US5741516A (en) | 1994-06-20 | 1998-04-21 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| US5580579A (en) | 1995-02-15 | 1996-12-03 | Nano Systems L.L.C. | Site-specific adhesion within the GI tract using nanoparticles stabilized by high molecular weight, linear poly (ethylene oxide) polymers |
| IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
| US5738868A (en) | 1995-07-18 | 1998-04-14 | Lipogenics Ltd. | Liposome compositions and kits therefor |
| US6353152B1 (en) * | 1999-07-15 | 2002-03-05 | Research Development Foundation | Corticotropin releasing factor receptor 2 deficient mice and uses thereof |
| US6831158B2 (en) | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
| CA2576435A1 (en) | 2004-08-09 | 2006-03-23 | Research Development Foundation | Determination of the 3d-structure of an extracellular domain of a b1 g-protein coupled receptor by nmr analysis |
-
2006
- 2006-02-08 KR KR1020077020593A patent/KR20070112155A/ko not_active Ceased
- 2006-02-08 US US11/350,411 patent/US7507794B2/en not_active Expired - Fee Related
- 2006-02-08 WO PCT/US2006/004321 patent/WO2006086402A2/en not_active Ceased
- 2006-02-08 EP EP06734527A patent/EP1885746B1/en not_active Expired - Lifetime
- 2006-02-08 CN CN2006800078724A patent/CN101137668B/zh not_active Expired - Fee Related
- 2006-02-08 CA CA2597065A patent/CA2597065C/en not_active Expired - Fee Related
- 2006-02-08 JP JP2007554332A patent/JP4859248B2/ja not_active Expired - Fee Related
- 2006-02-08 DK DK06734527.2T patent/DK1885746T3/da active
- 2006-02-08 AT AT06734527T patent/ATE540970T1/de active
- 2006-02-08 RU RU2007133648/10A patent/RU2423378C2/ru not_active IP Right Cessation
- 2006-02-08 AU AU2006212813A patent/AU2006212813B2/en not_active Ceased
-
2008
- 2008-09-24 US US12/236,806 patent/US8258279B2/en not_active Expired - Fee Related