JP2008529500A5 - - Google Patents
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- Publication number
- JP2008529500A5 JP2008529500A5 JP2007554332A JP2007554332A JP2008529500A5 JP 2008529500 A5 JP2008529500 A5 JP 2008529500A5 JP 2007554332 A JP2007554332 A JP 2007554332A JP 2007554332 A JP2007554332 A JP 2007554332A JP 2008529500 A5 JP2008529500 A5 JP 2008529500A5
- Authority
- JP
- Japan
- Prior art keywords
- scrfr2
- composition
- urocortin
- releasing factor
- corticotropin releasing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100038018 Corticotropin-releasing factor receptor 1 Human genes 0.000 claims 8
- 108060003951 Immunoglobulin Proteins 0.000 claims 6
- 102000005630 Urocortins Human genes 0.000 claims 6
- 108010059705 Urocortins Proteins 0.000 claims 6
- 102000018358 immunoglobulin Human genes 0.000 claims 6
- 239000000777 urocortin Substances 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 5
- 102100021752 Corticoliberin Human genes 0.000 claims 4
- 108010022152 Corticotropin-Releasing Hormone Proteins 0.000 claims 4
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 claims 4
- 108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 claims 4
- 101100061417 Homo sapiens CRHR1 gene Proteins 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 150000001413 amino acids Chemical group 0.000 claims 3
- 102000001711 Copine Human genes 0.000 claims 2
- 108010054424 Copine Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- FCENQCVTLJEGOT-KIHVXQRMSA-N stresscopin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)C1=CN=CN1 FCENQCVTLJEGOT-KIHVXQRMSA-N 0.000 claims 2
- ZEBBPGHOLWPSGI-KPLDDXDLSA-N urocortin ii Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CS)C(N)=O)CC1=CN=CN1 ZEBBPGHOLWPSGI-KPLDDXDLSA-N 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65086605P | 2005-02-08 | 2005-02-08 | |
| US60/650,866 | 2005-02-08 | ||
| PCT/US2006/004321 WO2006086402A2 (en) | 2005-02-08 | 2006-02-08 | Compositions and methods related to soluble g-protein coupled receptors(sgpcrs) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008529500A JP2008529500A (ja) | 2008-08-07 |
| JP2008529500A5 true JP2008529500A5 (https=) | 2009-03-12 |
| JP4859248B2 JP4859248B2 (ja) | 2012-01-25 |
Family
ID=36793648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007554332A Expired - Fee Related JP4859248B2 (ja) | 2005-02-08 | 2006-02-08 | 可溶性Ｇタンパク質共役型レセプター（ｓＧＰＣＲ）に関する組成物および方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7507794B2 (https=) |
| EP (1) | EP1885746B1 (https=) |
| JP (1) | JP4859248B2 (https=) |
| KR (1) | KR20070112155A (https=) |
| CN (1) | CN101137668B (https=) |
| AT (1) | ATE540970T1 (https=) |
| AU (1) | AU2006212813B2 (https=) |
| CA (1) | CA2597065C (https=) |
| DK (1) | DK1885746T3 (https=) |
| RU (1) | RU2423378C2 (https=) |
| WO (1) | WO2006086402A2 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007090087A2 (en) * | 2006-01-27 | 2007-08-09 | Research Development Foundation | Use of corticotropin releasing factor receptor-2 inhibitors for treating insulin-related diseases |
| KR20100056507A (ko) * | 2007-09-11 | 2010-05-27 | 몬도바이오테크 래보래토리즈 아게 | 치료제로서의 펩티드 ｐｒｏ－ｇｌｙ－ｔｈｒ－ｃｙｓ－ｇｌｕ－ｉｌｅ－ｃｙｓ－ａｌａ－ｔｙｒ－ａｌａ－ａｌａ－ｃｙｓ－ｔｈｒ－ｇｌｙ－ｃｙｓ의 용도 |
| AU2008303922A1 (en) * | 2007-09-11 | 2009-04-02 | Mondobiotech Laboratories Ag | Use of the peptide His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe alone or in combination with the peptide Gly-Ard-Gly-Asp-Asn-Pro-OH as a therapeutic agent |
| EP2190533A2 (en) * | 2007-09-11 | 2010-06-02 | Mondobiotech Laboratories AG | Use of a peptide as a therapeutic agent |
| WO2009046874A1 (en) * | 2007-09-11 | 2009-04-16 | Mondobiotech Laboratories Ag | Therapeutic combination of trh-potentiating peptide and stresscopin |
| US20120238509A1 (en) | 2009-08-28 | 2012-09-20 | Research Development Foundation | Urocortin 2 analogs and uses thereof |
| WO2011062935A1 (en) * | 2009-11-17 | 2011-05-26 | The Regents Of The University Of California | Compositions and assay systems for intracellular processes |
| AR081066A1 (es) | 2010-04-02 | 2012-06-06 | Hanmi Holdings Co Ltd | Conjugado de insulina donde se usa un fragmento de inmunoglobulina |
| US9981017B2 (en) | 2010-04-02 | 2018-05-29 | Hanmi Science Co., Ltd. | Insulin conjugate using an immunoglobulin fragment |
| AU2012220558A1 (en) * | 2011-02-23 | 2013-08-22 | Massachusetts Institute Of Technology | Water soluble membrane proteins and methods for the preparation and use thereof |
| CA2864100A1 (en) | 2012-02-14 | 2013-08-22 | The Regents Of The University Of California | Systemic delivery and regulated expression of paracrine genes for cardiovascular diseases and other conditions |
| JOP20170153A1 (ar) | 2016-07-15 | 2019-01-30 | Lilly Co Eli | نظائر urocortin-2 جديدة معدلة بحمض دهني لعلاج داء السكري وأمراض الكلى المزمنة |
| WO2018132768A1 (en) * | 2017-01-13 | 2018-07-19 | Sanna Pietro P | Methods and compositions for treating hpa hyperactivity |
| WO2018136856A1 (en) | 2017-01-23 | 2018-07-26 | Massachusetts Institute Of Technology | Multiplexed signal amplified fish via splinted ligation amplification and sequencing |
| WO2018157048A1 (en) | 2017-02-24 | 2018-08-30 | Massachusetts Institute Of Technology | Methods for examining podocyte foot processes in human renal samples using conventional optical microscopy |
| WO2018157074A1 (en) | 2017-02-24 | 2018-08-30 | Massachusetts Institute Of Technology | Methods for diagnosing neoplastic lesions |
| US11180804B2 (en) | 2017-07-25 | 2021-11-23 | Massachusetts Institute Of Technology | In situ ATAC sequencing |
| US11293923B2 (en) | 2017-09-01 | 2022-04-05 | Massachusetts Institute Of Technology | S-layer protein 2D lattice coupled detergent-free GPCR bioelectronic interfaces, devices, and methods for the use thereof |
| US11173992B2 (en) | 2017-12-28 | 2021-11-16 | Legionarus, Llc | Buoyancy garment |
| WO2019156957A1 (en) | 2018-02-06 | 2019-08-15 | Massachusetts Institute Of Technology | Swellable and structurally homogenous hydrogels and methods of use thereof |
| WO2020013833A1 (en) | 2018-07-13 | 2020-01-16 | Massachusetts Institute Of Technology | Dimethylacrylamide (dmaa) hydrogel for expansion microscopy (exm) |
| US11471112B2 (en) | 2018-11-21 | 2022-10-18 | Legionarius, Llc | Mobile application for wearable device |
| USD905935S1 (en) | 2019-02-20 | 2020-12-29 | Legionarius, Llc | Shirt with back pocket |
| US12478324B2 (en) | 2019-02-20 | 2025-11-25 | Legionarius, Llc | Sensors for wearable devices |
| CA3130889A1 (en) | 2019-02-22 | 2020-08-27 | Massachusetts Institute Of Technology | Iterative direct expansion microscopy |
| US12265004B2 (en) | 2019-11-05 | 2025-04-01 | Massachusetts Institute Of Technology | Membrane probes for expansion microscopy |
| US11802822B2 (en) | 2019-12-05 | 2023-10-31 | Massachusetts Institute Of Technology | Multiplexed expansion (MultiExM) pathology |
| WO2026021448A1 (zh) * | 2024-07-22 | 2026-01-29 | 健达九州(北京)生物科技有限公司 | 一种M4Di变体以及其治疗癫痫的应用 |
| CN121177454A (zh) * | 2025-09-05 | 2025-12-23 | 南通大学 | Gip受体激动剂在促进毛发再生中的应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4196265A (en) | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
| US4215051A (en) | 1979-08-29 | 1980-07-29 | Standard Oil Company (Indiana) | Formation, purification and recovery of phthalic anhydride |
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US4883750A (en) | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| US5549910A (en) | 1989-03-31 | 1996-08-27 | The Regents Of The University Of California | Preparation of liposome and lipid complex compositions |
| US5063245A (en) | 1990-03-28 | 1991-11-05 | Nova Pharmaceutical Corporation | Corticotropin-releasing factor antagonism compounds |
| JP3218637B2 (ja) | 1990-07-26 | 2001-10-15 | 大正製薬株式会社 | 安定なリポソーム水懸濁液 |
| JP2958076B2 (ja) | 1990-08-27 | 1999-10-06 | 株式会社ビタミン研究所 | 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法 |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5792451A (en) | 1994-03-02 | 1998-08-11 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
| US5786203A (en) * | 1994-06-14 | 1998-07-28 | Neurocrine Biosciences, Inc. | Isolated nucleic acid encoding corticotropin-releasing factor2 receptors |
| US5741516A (en) | 1994-06-20 | 1998-04-21 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| US5580579A (en) | 1995-02-15 | 1996-12-03 | Nano Systems L.L.C. | Site-specific adhesion within the GI tract using nanoparticles stabilized by high molecular weight, linear poly (ethylene oxide) polymers |
| IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
| US5738868A (en) | 1995-07-18 | 1998-04-14 | Lipogenics Ltd. | Liposome compositions and kits therefor |
| IL147657A0 (en) * | 1999-07-15 | 2002-08-14 | Res Dev Foundation | Corticotropin releasing factor receptor 2 deficient mice and uses thereof |
| US6831158B2 (en) | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
| CA2576435A1 (en) * | 2004-08-09 | 2006-03-23 | Research Development Foundation | Determination of the 3d-structure of an extracellular domain of a b1 g-protein coupled receptor by nmr analysis |
-
2006
- 2006-02-08 AT AT06734527T patent/ATE540970T1/de active
- 2006-02-08 CN CN2006800078724A patent/CN101137668B/zh not_active Expired - Fee Related
- 2006-02-08 RU RU2007133648/10A patent/RU2423378C2/ru not_active IP Right Cessation
- 2006-02-08 WO PCT/US2006/004321 patent/WO2006086402A2/en not_active Ceased
- 2006-02-08 AU AU2006212813A patent/AU2006212813B2/en not_active Ceased
- 2006-02-08 US US11/350,411 patent/US7507794B2/en not_active Expired - Fee Related
- 2006-02-08 EP EP06734527A patent/EP1885746B1/en not_active Expired - Lifetime
- 2006-02-08 KR KR1020077020593A patent/KR20070112155A/ko not_active Ceased
- 2006-02-08 DK DK06734527.2T patent/DK1885746T3/da active
- 2006-02-08 CA CA2597065A patent/CA2597065C/en not_active Expired - Fee Related
- 2006-02-08 JP JP2007554332A patent/JP4859248B2/ja not_active Expired - Fee Related
-
2008
- 2008-09-24 US US12/236,806 patent/US8258279B2/en not_active Expired - Fee Related
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