JP2008528886A - 温度制御された可変流体抵抗装置 - Google Patents

温度制御された可変流体抵抗装置 Download PDF

Info

Publication number
JP2008528886A
JP2008528886A JP2007552210A JP2007552210A JP2008528886A JP 2008528886 A JP2008528886 A JP 2008528886A JP 2007552210 A JP2007552210 A JP 2007552210A JP 2007552210 A JP2007552210 A JP 2007552210A JP 2008528886 A JP2008528886 A JP 2008528886A
Authority
JP
Japan
Prior art keywords
fluid
cooling
heating
flow
fluid path
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007552210A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008528886A5 (https=
Inventor
ゲルハルト，ジエフ・シー
チヤールトン，クリストフアー・シー
Original Assignee
ウオーターズ・インベストメンツ・リミテツド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ウオーターズ・インベストメンツ・リミテツド filed Critical ウオーターズ・インベストメンツ・リミテツド
Publication of JP2008528886A publication Critical patent/JP2008528886A/ja
Publication of JP2008528886A5 publication Critical patent/JP2008528886A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C1/00—Circuit elements having no moving parts
    • F15C1/02—Details, e.g. special constructional devices for circuits with fluid elements, such as resistances, capacitive circuit elements; devices preventing reaction coupling in composite elements ; Switch boards; Program devices
    • F15C1/04—Means for controlling fluid streams to fluid devices, e.g. by electric signals or other signals, no mixing taking place between the signal and the flow to be controlled
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K13/00—Other constructional types of cut-off apparatus; Arrangements for cutting-off
    • F16K13/08—Arrangements for cutting-off not used
    • F16K13/10—Arrangements for cutting-off not used by means of liquid or granular medium
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0021—No-moving-parts valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0032—Constructional types of microvalves; Details of the cutting-off member using phase transition or influencing viscosity
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0036—Operating means specially adapted for microvalves operated by temperature variations
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/30—Control of physical parameters of the fluid carrier of temperature
    • G01N2030/3038—Control of physical parameters of the fluid carrier of temperature temperature control of column exit, e.g. of restrictors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/0318—Processes
    • Y10T137/0391—Affecting flow by the addition of material or energy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/6416—With heating or cooling of the system

Landscapes

  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Flow Control (AREA)
  • Fluid-Pressure Circuits (AREA)
  • Control Of Temperature (AREA)
JP2007552210A 2005-01-21 2006-01-18 温度制御された可変流体抵抗装置 Pending JP2008528886A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64580405P 2005-01-21 2005-01-21
PCT/US2006/001564 WO2006078634A2 (en) 2005-01-21 2006-01-18 Temperature-controlled variable fluidic resistance device

Publications (2)

Publication Number Publication Date
JP2008528886A true JP2008528886A (ja) 2008-07-31
JP2008528886A5 JP2008528886A5 (https=) 2012-10-04

Family

ID=36692781

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007552210A Pending JP2008528886A (ja) 2005-01-21 2006-01-18 温度制御された可変流体抵抗装置

Country Status (4)

Country Link
US (1) US20080302423A1 (https=)
EP (1) EP1838967B1 (https=)
JP (1) JP2008528886A (https=)
WO (1) WO2006078634A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101573573B1 (ko) * 2013-06-07 2015-12-07 성균관대학교산학협력단 유압액추에이터의 제어장치

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008032098A1 (de) * 2008-07-08 2010-02-25 Hte Ag The High Throughput Experimentation Company Teststand mit steuerbaren oder regelbaren Restriktoren
EP2349569A1 (de) * 2008-07-08 2011-08-03 HTE Aktiengesellschaft The High Throughput Experimentation Company Teststand mit steuerbaren oder regelbaren restriktoren
DE102008032097A1 (de) * 2008-07-08 2010-01-14 Hte Ag The High Throughput Experimentation Company Teststand mit Gruppen von Restriktoren
CN102341761A (zh) * 2009-03-20 2012-02-01 阿凡田控股有限公司 用于微流体应用的流量控制器组件以及用于并行地执行多个实验的系统
WO2013028450A1 (en) 2011-08-19 2013-02-28 Waters Technologies Corporation Column manager with a multi-zone thermal system for use in liquid chromatography
CN103149949B (zh) * 2013-01-09 2016-08-03 上海空间推进研究所 一种基于帕尔贴效应的气体微流量控制器
WO2014158340A1 (en) * 2013-03-12 2014-10-02 Waters Technologies Corporation Matching thermally modulated variable restrictors to chromatography separation columns
WO2014143419A1 (en) * 2013-03-12 2014-09-18 Waters Technologies Corporation Thermally modulated variable restrictor
EP2999961A4 (en) * 2013-05-22 2016-12-28 Waters Technologies Corp THERMALLY MODULATED VARIABLE THROTTLE FOR NORMALIZING DYNAMIC DIVISION RATIOS
CN103807502A (zh) * 2013-12-16 2014-05-21 浙江大学 热控可变流阻
WO2015183290A1 (en) 2014-05-29 2015-12-03 Agilent Technologies, Inc. Apparatus and method for introducing a sample into a separation unit of a chromatography system
US9764323B2 (en) 2014-09-18 2017-09-19 Waters Technologies Corporation Device and methods using porous media in fluidic devices
EP3429717B1 (fr) * 2015-03-18 2020-05-06 François Parmentier Procédé de séparation chromatographique énergetiquement économe
CN105954448B (zh) * 2016-06-22 2020-06-26 山东省计量科学研究院 一种恒温电导检测装置及检测方法
US10935149B2 (en) * 2018-03-15 2021-03-02 University Of Washington Temperature-actuated valve, fluidic device, and related methods of use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02134480A (ja) * 1988-11-11 1990-05-23 Hitachi Ltd 流体自体の相変化を利用した流路の開閉制御弁及び開閉制御方法
JP2002215241A (ja) * 2001-01-22 2002-07-31 National Institute Of Advanced Industrial & Technology 流量の制御方法及びそれに用いるマイクロバルブ
JP2003240757A (ja) * 2002-02-19 2003-08-27 Ngk Insulators Ltd マイクロ化学チップ

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5316262A (en) * 1992-01-31 1994-05-31 Suprex Corporation Fluid restrictor apparatus and method for making the same
US5975856A (en) * 1997-10-06 1999-11-02 The Aerospace Corporation Method of pumping a fluid through a micromechanical valve having N-type and P-type thermoelectric elements for heating and cooling a fluid between an inlet and an outlet
DE19847952C2 (de) * 1998-09-01 2000-10-05 Inst Physikalische Hochtech Ev Fluidstromschalter
US6672076B2 (en) * 2001-02-09 2004-01-06 Bsst Llc Efficiency thermoelectrics utilizing convective heat flow
US6557575B1 (en) * 2001-11-19 2003-05-06 Waters Investments Limited Fluid flow control freeze/thaw valve for narrow bore capillaries or microfluidic devices
US6622746B2 (en) * 2001-12-12 2003-09-23 Eastman Kodak Company Microfluidic system for controlled fluid mixing and delivery
WO2004053370A1 (en) * 2002-12-09 2004-06-24 Waters Investments Limited Peltier based freeze-thaw valves and method of use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02134480A (ja) * 1988-11-11 1990-05-23 Hitachi Ltd 流体自体の相変化を利用した流路の開閉制御弁及び開閉制御方法
JP2002215241A (ja) * 2001-01-22 2002-07-31 National Institute Of Advanced Industrial & Technology 流量の制御方法及びそれに用いるマイクロバルブ
JP2003240757A (ja) * 2002-02-19 2003-08-27 Ngk Insulators Ltd マイクロ化学チップ

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101573573B1 (ko) * 2013-06-07 2015-12-07 성균관대학교산학협력단 유압액추에이터의 제어장치

Also Published As

Publication number Publication date
WO2006078634A3 (en) 2007-08-30
EP1838967B1 (en) 2017-12-13
WO2006078634A2 (en) 2006-07-27
US20080302423A1 (en) 2008-12-11
EP1838967A4 (en) 2011-11-02
EP1838967A2 (en) 2007-10-03

Similar Documents

Publication Publication Date Title
JP2008528886A (ja) 温度制御された可変流体抵抗装置
CN108393101B (zh) 具有多个温度区的微流体器件
CN101641596B (zh) 微流体气相色谱系统体系结构
JP2002215241A (ja) 流量の制御方法及びそれに用いるマイクロバルブ
KR100996197B1 (ko) 개선된 열 제어 경계면
Ranjit et al. Entropy generation on electromagnetohydrodynamic flow through a porous asymmetric micro-channel
US20090175736A1 (en) System and method for providing a thermal transpiration gag pump using a nanoporous ceramic material
Schepperle et al. Noninvasive platinum thin-film microheater/temperature sensor array for predicting and controlling flow boiling in microchannels
WO2013140917A1 (ja) 液体クロマトグラフ分析装置及びその温度制御方法
US20110220332A1 (en) Micro channel device temperature control
JP2009033192A (ja) 基板熱管理の方法
JP2007523351A (ja) オンチップ温度制御型液体クロマトグラフィー方法およびデバイス
US6472643B1 (en) Substrate thermal management system
CA2611700A1 (en) Temperature controller for small fluid samples having different heat capacities
US8381798B2 (en) Micro fluid device having piping to control fluid temperature
Gui et al. Microfluidic phase change valve with a two-level cooling/heating system
US10401332B2 (en) System and method for reducing chromatographic band broadening in separation devices
Wang et al. Development and examination of precise heating in microfluidic devices with liquid metal
JP2007247404A (ja) マイクロポンプ
US6536471B2 (en) Low-cost stream switching system
JP2007533936A (ja) 高圧毛細管マイクロ流体バルブ装置およびその製造方法
US5626166A (en) Temperature control valve without moving parts
US7559485B2 (en) Variable orifice valve
Chen et al. Continuous-flow DNA amplification device employing microheaters
US7139070B2 (en) Ultra-fast temperature switch for microscopic samples

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090116

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A712

Effective date: 20090723

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20110628

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110705

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20111004

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20111012

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111226

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120214

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120511

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120518

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120807

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20120807

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20121205

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20130201

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130212