JP2002215241A - 流量の制御方法及びそれに用いるマイクロバルブ - Google Patents
流量の制御方法及びそれに用いるマイクロバルブInfo
- Publication number
- JP2002215241A JP2002215241A JP2001013056A JP2001013056A JP2002215241A JP 2002215241 A JP2002215241 A JP 2002215241A JP 2001013056 A JP2001013056 A JP 2001013056A JP 2001013056 A JP2001013056 A JP 2001013056A JP 2002215241 A JP2002215241 A JP 2002215241A
- Authority
- JP
- Japan
- Prior art keywords
- fluid
- flow rate
- solid
- phase transition
- flow path
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
- F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
- F15C5/00—Manufacture of fluid circuit elements; Manufacture of assemblages of such elements integrated circuits
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0036—Operating means specially adapted for microvalves operated by temperature variations
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0073—Fabrication methods specifically adapted for microvalves
- F16K2099/0076—Fabrication methods specifically adapted for microvalves using electrical discharge machining [EDM], milling or drilling
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0073—Fabrication methods specifically adapted for microvalves
- F16K2099/008—Multi-layer fabrications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
- Y10T137/218—Means to regulate or vary operation of device
- Y10T137/2191—By non-fluid energy field affecting input [e.g., transducer]
- Y10T137/2196—Acoustical or thermal energy
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
- Y10T137/2224—Structure of body of device
Landscapes
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Theoretical Computer Science (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Computer Hardware Design (AREA)
- Temperature-Responsive Valves (AREA)
- Micromachines (AREA)
- Fluid-Pressure Circuits (AREA)
- Flow Control (AREA)
Abstract
流路中を通る流体自体の物性を利用して微小流路の流量
を制御しうる新規な方法を提供する。 【解決手段】 断熱性固体基板に穿設した微小流路に、
熱により可逆的に固液相転移しうる流体を流しながら、
相転移点以下に冷却して生成した固体をもって流路を閉
塞し、また相転移点以上に加熱して流路を開放すること
により微小流路内の流体の流量を調節する。またそれに
用いるマイクロバルブとして、断熱性固体基板に穿設さ
れた微小流路、その流路内に充填された熱により可逆的
に固液相転移しうる流体及びその微小流路の適所に配置
された流体を加熱及び冷却しうる温度制御手段から構成
されたものとする。
Description
流体の流量を何ら機械的な開閉機構を用いずに任意に調
節しうる流量の制御方法及びそれに用いるマイクロバル
ブに関するものである。
通寸法の装置に用いられているバルブ機構を単に小型化
したものや、膜状の弁を利用した開閉機構を用いて行わ
れている。しかしながら、これらの方法は、いずれも機
械的な動作要素を必要とするため、長期間にわたって使
用すると部品の摩耗や腐食により精度が低下するのを免
れない上に、摩耗や腐食が著しくなると流体の漏れを生
じるおそれがある。しかも、動作部分にはアクチュエー
タが用いられるため、機構自体が複雑化し、また所望の
流量が得られるようにバルブの開閉状態を調整するに
は、特殊な制御機構を用いなければならないため、連続
的流量制御には構造が著しく複雑化するという欠点があ
る。
的に切り替え、反応系の動的改変を行うために、形状記
憶合金を利用したマイクロ切り替えバルブチップも提案
されているが、この方法も形状記憶合金という特殊な材
料を用いる必要がある上に、光硬化性樹脂をもって特定
形状の弁を成形しなければならないという煩雑さを伴
い、実用に供するにはいくつかの解決しなければならな
い問題がある。
流路の流量制御方法における欠点を克服し、機械的素子
や特殊な材料を用いることなく、流路中を通る流体自体
の物性を利用して微小流路の流量を制御しうる新規な方
法を提供することを目的としてなされたものである。
の流量を制御する方法について種々研究を重ねた結果、
可逆的に固相−液相変化しうる流体を流路に通し、流路
中の適所にこの流体を冷却及び加熱する機構を設けて、
流体自体の固相化状態を任意に形成させ、その固相をも
って流路を遮断し、流れを阻止すれば、流体の流量を連
続的に変えうることを見出し、この知見に基づいて本発
明をなすに至った。
設した微小流路に、熱により可逆的に固液相転移しうる
流体を流しながら、相転移点以下に冷却して生成した固
体をもって流路を閉塞し、また相転移点以上に加熱して
流路を開放することにより微小流路内の流体の流量を調
節することを特徴とする流量の制御方法、及び断熱性固
体基板に穿設された微小流路、その流路内に充填された
熱により可逆的に固液相転移しうる流体及びその微小流
路の適所に配置された流体を加熱及び冷却しうる温度制
御手段から構成されたマイクロバルブを提供するもので
ある。
法をさらに詳細に説明する。図1は、本発明方法の基本
理論を説明するための斜視図であって、断熱性材料で構
成した基体1に微小流路2が穿設され、その微小流路2
の両側面に温度制御機構4,4′が配置されている。そ
して、この微小流路2に可逆的に固液相転移可能な流体
3を転移点以上の温度を維持して流すと、この微小流路
2には流体3が液相を保ち、自由に流通するが、温度制
御機構4,4′を作動し、流体3を転移点よりも低く冷
却すると、この位置で固相に変化し、流れが阻止され、
閉止状態となる。次に、温度制御機構4,4′を作動さ
せて、流体3を転移点以上に加熱すると、固相は液相に
変化し、流体3は自由に流れるようになり、開放状態と
なる。
る材料としては、断熱性材料、例えばセラミックス、プ
ラスチック、黒鉛、木材などが好ましいが、断熱加工し
た金属も用いることができる。次に、この断熱性材料に
穿設される微小流路としては、表面を掘削した条溝や内
部を貫通した管路を挙げることができ、これらの寸法と
して径0.1〜1mmの範囲が選ばれる。また、流体と
しては、可逆的固液転移性感熱樹脂、例えばポリ(ジイ
ソプロピルアクリルアミド)、高級炭化水素油、例えば
パラフィン、低融点合金などが用いられるが、特に感温
性の作用流体が好適である。
制御機構4,4′としては、冷却・加熱の両方が可能な
ペルチェ素子が好適である。この際、熱容量を大きくす
るために大型素子を用いる必要があって、微小流路2の
近傍に配置できない場合には、基板1より熱伝導率の高
い材料で該素子から流路2まで熱伝導チャンネルを形成
させるのがよい。
るため、流体の熱容量は小さく、熱伝導も短時間で行わ
れやすいので、温度制御機構4,4′の熱容量を十分に
大きくすれば、凍結、融解を短時間で起させることがで
き、流路の閉止、開放を容易に実現することができる。
この際、流体として転移点以下に冷却できないもの、例
えば気体を用いる場合には、温度制御機構4,4′で囲
まれた個所にだけ、側流としてバルブ作動用液体を流す
ことによって閉止状態を実現することができる。
化させることもできる。図2は、この方法を説明するた
めの流量の変化を示すグラフである。すなわち、微細流
路2の一方の側面に配置された温度制御機構4を流体の
転移点以下に、他方の側面に配置された温度制御機構
4′を転移点以上に調整すると、図2の実線で示される
ような温度勾配が生じる。そして、転移点以上の範囲で
は流体は円滑に流れるが、転移点以下の範囲では、流体
が凍結し、流れを妨げるので流量は減少する。したがっ
て、このような機構を用い、温度差によって流体の固相
部分の割合を調整すると流量を連続的に変えることがで
きる。
ることなく、単に微小流路内を流れる流体の固液相変化
を利用するだけで、微小流路内の流量制御を行うことが
できる。
るための流量変化グラフ。
5)
化させることもできる。図2は、この方法を説明するた
めの温度制御機構の断面図及び流路の流れ方向に垂直な
断面内における温度分布を示すグラフである。すなわ
ち、微小流路2の一方の側面に配置された温度制御機構
4を流体の転移点以下に、他方の側面に配置された温度
制御機構4′を転移点以上に調整すると、図2の実線で
示されるような温度勾配が生じる。そして、転移点以上
の範囲では流体は円滑に流れるが、転移点以下の範囲で
は、流体が凍結し、流れを妨げるので流量は減少する。
したがって、このような機構を用い、温度差によって流
体の固相部分の割合を調整すると流量を連続的に変える
ことができる。
るための温度制御機構の断面図及び流路の流れ方向に垂
直な断面内における温度分布を示すグラフ。
Claims (3)
- 【請求項1】 断熱性固体基板に穿設した微小流路に、
熱により可逆的に固液相転移しうる流体を流しながら、
相転移点以下に冷却して生成した固体をもって流路を閉
塞し、また相転移点以上に加熱して流路を開放すること
により微小流路内の流体の流量を調節することを特徴と
する流量の制御方法。 - 【請求項2】 冷却又は加熱を徐々に行って、流路断面
積を連続的に変化させる請求項1記載の流量の制御方
法。 - 【請求項3】 断熱性固体基板に穿設された微小流路、
その流路内に充填された熱により可逆的に固液相転移し
うる流体及びその微小流路の適所に配置された流体を加
熱及び冷却しうる温度制御手段から構成されたマイクロ
バルブ。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001013056A JP3548858B2 (ja) | 2001-01-22 | 2001-01-22 | 流量の制御方法及びそれに用いるマイクロバルブ |
US10/046,406 US6536476B2 (en) | 2001-01-22 | 2002-01-16 | Flow rate-controlling method and microvalve therefor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001013056A JP3548858B2 (ja) | 2001-01-22 | 2001-01-22 | 流量の制御方法及びそれに用いるマイクロバルブ |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002215241A true JP2002215241A (ja) | 2002-07-31 |
JP3548858B2 JP3548858B2 (ja) | 2004-07-28 |
Family
ID=18879977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2001013056A Expired - Lifetime JP3548858B2 (ja) | 2001-01-22 | 2001-01-22 | 流量の制御方法及びそれに用いるマイクロバルブ |
Country Status (2)
Country | Link |
---|---|
US (1) | US6536476B2 (ja) |
JP (1) | JP3548858B2 (ja) |
Cited By (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004537695A (ja) * | 2001-07-26 | 2004-12-16 | ハンディラブ・インコーポレーテッド | マイクロフルイディック・デバイスにおける流体制御方法及びシステム |
KR100468854B1 (ko) * | 2002-10-10 | 2005-01-29 | 삼성전자주식회사 | 미소 유량의 제어가 가능한 마이크로 구조체 |
JP2007303674A (ja) * | 2006-05-10 | 2007-11-22 | Samsung Electronics Co Ltd | 相転移物質からなる弁及びその製造方法 |
JP2007533936A (ja) * | 2004-04-21 | 2007-11-22 | ウオーターズ・インベストメンツ・リミテツド | 高圧毛細管マイクロ流体バルブ装置およびその製造方法 |
JP2008045745A (ja) * | 2006-08-16 | 2008-02-28 | Samsung Electronics Co Ltd | バルブユニット、これを備えた反応装置、及びチャンネルにバルブを形成する方法 |
JP2008528886A (ja) * | 2005-01-21 | 2008-07-31 | ウオーターズ・インベストメンツ・リミテツド | 温度制御された可変流体抵抗装置 |
US7998433B2 (en) | 2006-04-04 | 2011-08-16 | Samsung Electronics Co., Ltd. | Valve unit and apparatus having the same |
JP2012528995A (ja) * | 2009-06-03 | 2012-11-15 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 変更可能な透過性の程度をもつ材料によるバルブ |
US8415103B2 (en) | 2007-07-13 | 2013-04-09 | Handylab, Inc. | Microfluidic cartridge |
US8420015B2 (en) | 2001-03-28 | 2013-04-16 | Handylab, Inc. | Systems and methods for thermal actuation of microfluidic devices |
KR101258434B1 (ko) | 2007-05-03 | 2013-05-02 | 삼성전자주식회사 | 미세유동 시스템 및,이의 제조방법 |
US8440149B2 (en) | 2001-02-14 | 2013-05-14 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
US8470586B2 (en) | 2004-05-03 | 2013-06-25 | Handylab, Inc. | Processing polynucleotide-containing samples |
US8499793B2 (en) | 2006-04-04 | 2013-08-06 | Samsung Electronics Co., Ltd. | Valve unit and reaction apparatus having the same |
KR101335726B1 (ko) | 2007-06-04 | 2013-12-04 | 삼성전자주식회사 | 면역혈청 검사 및 생화학 검사를 동시에 수행하는 디스크형미세유동장치 |
US8617905B2 (en) | 1995-09-15 | 2013-12-31 | The Regents Of The University Of Michigan | Thermal microvalves |
US8679831B2 (en) | 2003-07-31 | 2014-03-25 | Handylab, Inc. | Processing particle-containing samples |
US8685341B2 (en) | 2001-09-12 | 2014-04-01 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
US8703069B2 (en) | 2001-03-28 | 2014-04-22 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
US8710211B2 (en) | 2007-07-13 | 2014-04-29 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
US8709787B2 (en) | 2006-11-14 | 2014-04-29 | Handylab, Inc. | Microfluidic cartridge and method of using same |
CN103807502A (zh) * | 2013-12-16 | 2014-05-21 | 浙江大学 | 热控可变流阻 |
US8768517B2 (en) | 2001-03-28 | 2014-07-01 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
US9040288B2 (en) | 2006-03-24 | 2015-05-26 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
US9080207B2 (en) | 2006-03-24 | 2015-07-14 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
USD742027S1 (en) | 2011-09-30 | 2015-10-27 | Becton, Dickinson And Company | Single piece reagent holder |
US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US9222954B2 (en) | 2011-09-30 | 2015-12-29 | Becton, Dickinson And Company | Unitized reagent strip |
US9259734B2 (en) | 2007-07-13 | 2016-02-16 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US9347586B2 (en) | 2007-07-13 | 2016-05-24 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
US9765389B2 (en) | 2011-04-15 | 2017-09-19 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
US10179910B2 (en) | 2007-07-13 | 2019-01-15 | Handylab, Inc. | Rack for sample tubes and reagent holders |
US10822644B2 (en) | 2012-02-03 | 2020-11-03 | Becton, Dickinson And Company | External files for distribution of molecular diagnostic tests and determination of compatibility between tests |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US11453906B2 (en) | 2011-11-04 | 2022-09-27 | Handylab, Inc. | Multiplexed diagnostic detection apparatus and methods |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6679279B1 (en) * | 2002-07-10 | 2004-01-20 | Motorola, Inc. | Fluidic valve having a bi-phase valve element |
NZ538196A (en) * | 2002-08-12 | 2007-05-31 | Osteotech Inc | Synthesis of a bone-polymer composite material for forming osteoimplants |
GB0304082D0 (en) * | 2003-02-22 | 2003-03-26 | Synthese O Grande Vitesse Ltd | Improvements in and relating to circuits |
US7315109B1 (en) * | 2003-08-15 | 2008-01-01 | Medrad, Inc. | Actuators and fluid delivery systems using such actuators |
US7694694B2 (en) * | 2004-05-10 | 2010-04-13 | The Aerospace Corporation | Phase-change valve apparatuses |
US8642353B2 (en) | 2004-05-10 | 2014-02-04 | The Aerospace Corporation | Microfluidic device for inducing separations by freezing and associated method |
US7650910B2 (en) * | 2004-06-24 | 2010-01-26 | The Aerospace Corporation | Electro-hydraulic valve apparatuses |
US7721762B2 (en) * | 2004-06-24 | 2010-05-25 | The Aerospace Corporation | Fast acting valve apparatuses |
US7686040B2 (en) | 2004-06-24 | 2010-03-30 | The Aerospace Corporation | Electro-hydraulic devices |
US20070092409A1 (en) * | 2005-10-21 | 2007-04-26 | Beatty Christopher C | Reconfigurable valve using optically active material |
KR100763922B1 (ko) | 2006-04-04 | 2007-10-05 | 삼성전자주식회사 | 밸브 유닛 및 이를 구비한 장치 |
DE102006020716B4 (de) * | 2006-05-04 | 2012-03-01 | Technische Universität Dresden | Mikrofluidik-Prozessor |
KR100763924B1 (ko) | 2006-08-16 | 2007-10-05 | 삼성전자주식회사 | 밸브 유닛, 이를 구비한 반응 장치 및, 채널에 밸브를형성하는 방법 |
KR100851980B1 (ko) | 2006-09-05 | 2008-08-12 | 삼성전자주식회사 | 열 활성 유닛을 구비한 원심력 기반의 미세유동 장치, 이를포함하는 미세유동 시스템 및 상기 미세유동 시스템의구동방법 |
DE102006051535A1 (de) * | 2006-10-27 | 2008-12-18 | Andreas Dr. Richter | Automatischer Mikrofluidik-Prozessor |
KR101578149B1 (ko) * | 2009-01-29 | 2015-12-17 | 삼성전자주식회사 | 미세유체 제어용 밸브 유닛, 및 이의 제조방법 |
DE102009018365A1 (de) | 2009-04-23 | 2010-11-04 | Albert-Ludwigs-Universität Freiburg | Thermopneumatischer Aktor und Verfahren zum Herstellen eines solchen |
US8714193B2 (en) | 2011-07-14 | 2014-05-06 | National Oilwell Varco, L.P. | Poppet valve with integrated dampener |
DE102012206042B4 (de) | 2012-04-13 | 2013-11-07 | Technische Universität Dresden | Verfahren und Vorrichtung zur gezielten Prozessführung in einem Mikrofluidik-Prozessor mit integrierten aktiven Elementen |
EP2986809B1 (en) | 2013-04-18 | 2019-12-18 | National Oilwell Varco, L.P. | Poppet valve with variable dampener and elastically supported guide |
WO2021207686A1 (en) * | 2020-04-10 | 2021-10-14 | The Regents Of The University Of California | Microfluidic phase-change membrane microvalves |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0814337B2 (ja) * | 1988-11-11 | 1996-02-14 | 株式会社日立製作所 | 流体自体の相変化を利用した流路の開閉制御弁及び開閉制御方法 |
JP3028826B2 (ja) * | 1990-03-09 | 2000-04-04 | 株式会社日立製作所 | 流体流路の開閉装置及びその開閉制御方法及び閉止確認方法 |
FR2730545B1 (fr) * | 1995-02-13 | 1997-03-28 | Bio Merieux | Vanne statique a congelation, et enceinte de traitement controlee par au moins une vanne |
-
2001
- 2001-01-22 JP JP2001013056A patent/JP3548858B2/ja not_active Expired - Lifetime
-
2002
- 2002-01-16 US US10/046,406 patent/US6536476B2/en not_active Expired - Fee Related
Cited By (107)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8617905B2 (en) | 1995-09-15 | 2013-12-31 | The Regents Of The University Of Michigan | Thermal microvalves |
US8734733B2 (en) | 2001-02-14 | 2014-05-27 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
US8440149B2 (en) | 2001-02-14 | 2013-05-14 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
US9051604B2 (en) | 2001-02-14 | 2015-06-09 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
US8768517B2 (en) | 2001-03-28 | 2014-07-01 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
US9677121B2 (en) | 2001-03-28 | 2017-06-13 | Handylab, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US10351901B2 (en) | 2001-03-28 | 2019-07-16 | Handylab, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US10571935B2 (en) | 2001-03-28 | 2020-02-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
US8703069B2 (en) | 2001-03-28 | 2014-04-22 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
US8420015B2 (en) | 2001-03-28 | 2013-04-16 | Handylab, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US10619191B2 (en) | 2001-03-28 | 2020-04-14 | Handylab, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US8894947B2 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US9259735B2 (en) | 2001-03-28 | 2016-02-16 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
JP2004537695A (ja) * | 2001-07-26 | 2004-12-16 | ハンディラブ・インコーポレーテッド | マイクロフルイディック・デバイスにおける流体制御方法及びシステム |
JP2010181031A (ja) * | 2001-07-26 | 2010-08-19 | Handylab Inc | マイクロフルイディック・デバイスにおける流体制御方法及びシステム |
US8685341B2 (en) | 2001-09-12 | 2014-04-01 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
US9028773B2 (en) | 2001-09-12 | 2015-05-12 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
KR100468854B1 (ko) * | 2002-10-10 | 2005-01-29 | 삼성전자주식회사 | 미소 유량의 제어가 가능한 마이크로 구조체 |
US10865437B2 (en) | 2003-07-31 | 2020-12-15 | Handylab, Inc. | Processing particle-containing samples |
US8679831B2 (en) | 2003-07-31 | 2014-03-25 | Handylab, Inc. | Processing particle-containing samples |
US10731201B2 (en) | 2003-07-31 | 2020-08-04 | Handylab, Inc. | Processing particle-containing samples |
US9670528B2 (en) | 2003-07-31 | 2017-06-06 | Handylab, Inc. | Processing particle-containing samples |
US11078523B2 (en) | 2003-07-31 | 2021-08-03 | Handylab, Inc. | Processing particle-containing samples |
JP2007533936A (ja) * | 2004-04-21 | 2007-11-22 | ウオーターズ・インベストメンツ・リミテツド | 高圧毛細管マイクロ流体バルブ装置およびその製造方法 |
US8470586B2 (en) | 2004-05-03 | 2013-06-25 | Handylab, Inc. | Processing polynucleotide-containing samples |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US10364456B2 (en) | 2004-05-03 | 2019-07-30 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US10443088B1 (en) | 2004-05-03 | 2019-10-15 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US11441171B2 (en) | 2004-05-03 | 2022-09-13 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US10604788B2 (en) | 2004-05-03 | 2020-03-31 | Handylab, Inc. | System for processing polynucleotide-containing samples |
US10494663B1 (en) | 2004-05-03 | 2019-12-03 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
JP2008528886A (ja) * | 2005-01-21 | 2008-07-31 | ウオーターズ・インベストメンツ・リミテツド | 温度制御された可変流体抵抗装置 |
US10821436B2 (en) | 2006-03-24 | 2020-11-03 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
US10857535B2 (en) | 2006-03-24 | 2020-12-08 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same |
US9080207B2 (en) | 2006-03-24 | 2015-07-14 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US11959126B2 (en) | 2006-03-24 | 2024-04-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US11666903B2 (en) | 2006-03-24 | 2023-06-06 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same |
US10821446B1 (en) | 2006-03-24 | 2020-11-03 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US11142785B2 (en) | 2006-03-24 | 2021-10-12 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US11141734B2 (en) | 2006-03-24 | 2021-10-12 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US9040288B2 (en) | 2006-03-24 | 2015-05-26 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
US11085069B2 (en) | 2006-03-24 | 2021-08-10 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US10695764B2 (en) | 2006-03-24 | 2020-06-30 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US10913061B2 (en) | 2006-03-24 | 2021-02-09 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US9802199B2 (en) | 2006-03-24 | 2017-10-31 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US10799862B2 (en) | 2006-03-24 | 2020-10-13 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same |
US10843188B2 (en) | 2006-03-24 | 2020-11-24 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
US7998433B2 (en) | 2006-04-04 | 2011-08-16 | Samsung Electronics Co., Ltd. | Valve unit and apparatus having the same |
US8920753B2 (en) | 2006-04-04 | 2014-12-30 | Samsung Electronics Co., Ltd. | Valve unit and apparatus having the same |
US8499793B2 (en) | 2006-04-04 | 2013-08-06 | Samsung Electronics Co., Ltd. | Valve unit and reaction apparatus having the same |
JP2007303674A (ja) * | 2006-05-10 | 2007-11-22 | Samsung Electronics Co Ltd | 相転移物質からなる弁及びその製造方法 |
JP2008045745A (ja) * | 2006-08-16 | 2008-02-28 | Samsung Electronics Co Ltd | バルブユニット、これを備えた反応装置、及びチャンネルにバルブを形成する方法 |
US8464760B2 (en) | 2006-08-16 | 2013-06-18 | Samsung Electronic Co., Ltd. | Valve unit, reaction apparatus with the same, and method of forming valve in channel |
US9815057B2 (en) | 2006-11-14 | 2017-11-14 | Handylab, Inc. | Microfluidic cartridge and method of making same |
US12030050B2 (en) | 2006-11-14 | 2024-07-09 | Handylab, Inc. | Microfluidic cartridge and method of making same |
US8765076B2 (en) | 2006-11-14 | 2014-07-01 | Handylab, Inc. | Microfluidic valve and method of making same |
US10710069B2 (en) | 2006-11-14 | 2020-07-14 | Handylab, Inc. | Microfluidic valve and method of making same |
US8709787B2 (en) | 2006-11-14 | 2014-04-29 | Handylab, Inc. | Microfluidic cartridge and method of using same |
KR101258434B1 (ko) | 2007-05-03 | 2013-05-02 | 삼성전자주식회사 | 미세유동 시스템 및,이의 제조방법 |
KR101335726B1 (ko) | 2007-06-04 | 2013-12-04 | 삼성전자주식회사 | 면역혈청 검사 및 생화학 검사를 동시에 수행하는 디스크형미세유동장치 |
US10844368B2 (en) | 2007-07-13 | 2020-11-24 | Handylab, Inc. | Diagnostic apparatus to extract nucleic acids including a magnetic assembly and a heater assembly |
US10234474B2 (en) | 2007-07-13 | 2019-03-19 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US10590410B2 (en) | 2007-07-13 | 2020-03-17 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
US10100302B2 (en) | 2007-07-13 | 2018-10-16 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
US8710211B2 (en) | 2007-07-13 | 2014-04-29 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
US10625261B2 (en) | 2007-07-13 | 2020-04-21 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10625262B2 (en) | 2007-07-13 | 2020-04-21 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10632466B1 (en) | 2007-07-13 | 2020-04-28 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10179910B2 (en) | 2007-07-13 | 2019-01-15 | Handylab, Inc. | Rack for sample tubes and reagent holders |
US11845081B2 (en) | 2007-07-13 | 2023-12-19 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10717085B2 (en) | 2007-07-13 | 2020-07-21 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US8415103B2 (en) | 2007-07-13 | 2013-04-09 | Handylab, Inc. | Microfluidic cartridge |
US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10071376B2 (en) | 2007-07-13 | 2018-09-11 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US9217143B2 (en) | 2007-07-13 | 2015-12-22 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
US10065185B2 (en) | 2007-07-13 | 2018-09-04 | Handylab, Inc. | Microfluidic cartridge |
US11549959B2 (en) | 2007-07-13 | 2023-01-10 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US11466263B2 (en) | 2007-07-13 | 2022-10-11 | Handylab, Inc. | Diagnostic apparatus to extract nucleic acids including a magnetic assembly and a heater assembly |
US10139012B2 (en) | 2007-07-13 | 2018-11-27 | Handylab, Inc. | Integrated heater and magnetic separator |
US9701957B2 (en) | 2007-07-13 | 2017-07-11 | Handylab, Inc. | Reagent holder, and kits containing same |
US11266987B2 (en) | 2007-07-13 | 2022-03-08 | Handylab, Inc. | Microfluidic cartridge |
US11254927B2 (en) | 2007-07-13 | 2022-02-22 | Handylab, Inc. | Polynucleotide capture materials, and systems using same |
US10875022B2 (en) | 2007-07-13 | 2020-12-29 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US9238223B2 (en) | 2007-07-13 | 2016-01-19 | Handylab, Inc. | Microfluidic cartridge |
US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
US11060082B2 (en) | 2007-07-13 | 2021-07-13 | Handy Lab, Inc. | Polynucleotide capture materials, and systems using same |
US9259734B2 (en) | 2007-07-13 | 2016-02-16 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US9347586B2 (en) | 2007-07-13 | 2016-05-24 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
JP2012528995A (ja) * | 2009-06-03 | 2012-11-15 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 変更可能な透過性の程度をもつ材料によるバルブ |
US11788127B2 (en) | 2011-04-15 | 2023-10-17 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
US9765389B2 (en) | 2011-04-15 | 2017-09-19 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
US10781482B2 (en) | 2011-04-15 | 2020-09-22 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
USD905269S1 (en) | 2011-09-30 | 2020-12-15 | Becton, Dickinson And Company | Single piece reagent holder |
US9222954B2 (en) | 2011-09-30 | 2015-12-29 | Becton, Dickinson And Company | Unitized reagent strip |
USD831843S1 (en) | 2011-09-30 | 2018-10-23 | Becton, Dickinson And Company | Single piece reagent holder |
US9480983B2 (en) | 2011-09-30 | 2016-11-01 | Becton, Dickinson And Company | Unitized reagent strip |
USD742027S1 (en) | 2011-09-30 | 2015-10-27 | Becton, Dickinson And Company | Single piece reagent holder |
USD1029291S1 (en) | 2011-09-30 | 2024-05-28 | Becton, Dickinson And Company | Single piece reagent holder |
US10076754B2 (en) | 2011-09-30 | 2018-09-18 | Becton, Dickinson And Company | Unitized reagent strip |
US11453906B2 (en) | 2011-11-04 | 2022-09-27 | Handylab, Inc. | Multiplexed diagnostic detection apparatus and methods |
US10822644B2 (en) | 2012-02-03 | 2020-11-03 | Becton, Dickinson And Company | External files for distribution of molecular diagnostic tests and determination of compatibility between tests |
CN103807502A (zh) * | 2013-12-16 | 2014-05-21 | 浙江大学 | 热控可变流阻 |
Also Published As
Publication number | Publication date |
---|---|
US6536476B2 (en) | 2003-03-25 |
US20020096222A1 (en) | 2002-07-25 |
JP3548858B2 (ja) | 2004-07-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2002215241A (ja) | 流量の制御方法及びそれに用いるマイクロバルブ | |
US7686040B2 (en) | Electro-hydraulic devices | |
US7874305B2 (en) | Microvalve having magnetic wax plug and flux control method using magnetic wax | |
US7650910B2 (en) | Electro-hydraulic valve apparatuses | |
US20100252124A1 (en) | Valve for a microfluidic system | |
Gui et al. | Ice valve for a mini/micro flow channel | |
JP2008528886A (ja) | 温度制御された可変流体抵抗装置 | |
EP1797385B1 (en) | Heat exchanger with temperature-controlled valve | |
US9267616B2 (en) | Method for controlling valves during the thermocyclization of a substance for the purpose of polymer chain reaction (PCR) and associated arrangement | |
ATE339619T1 (de) | Mikrofluidventil mit elektrischer öffnungssteuerung | |
Gui et al. | Microfluidic phase change valve with a two-level cooling/heating system | |
JPH03259726A (ja) | 流体流路の開閉装置及びその開閉制御方法及び閉止確認方法 | |
US7559485B2 (en) | Variable orifice valve | |
JP4053042B2 (ja) | 寒剤の使用を制限する凍結融解バルブ | |
JPS6363795B2 (ja) | ||
CN210344518U (zh) | 相变微阀装置 | |
US7090003B2 (en) | Method and apparatus for temperature control of a microfluidic device | |
CN100363669C (zh) | 用于启、闭微/纳米流体通道的冰阀 | |
TWI307714B (en) | Self-sealing high-temperature biochemical reaction apparatus and method for the same | |
DE102004017021A1 (de) | Latentwärmespeicher | |
WO2001001053A1 (en) | Electro-thermal expansion valve system | |
JP2002182749A (ja) | 半導体微小流体制御素子及びそれを用いた半導体微小流体制御回路 | |
Strijker | Decreasing cool-down time of a Joule-Thomson microcooler by introducing multiple closable restriction channels | |
KR100884764B1 (ko) | 마이크로 밸브 | |
Bogdanov et al. | Active new microvalve based on phase change effect |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20040130 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20040325 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 Ref document number: 3548858 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
S533 | Written request for registration of change of name |
Free format text: JAPANESE INTERMEDIATE CODE: R313533 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
EXPY | Cancellation because of completion of term |