JP2008528701A - 腫瘍性疾患の治療又は予防に用いるためのニトロキシド類 - Google Patents
腫瘍性疾患の治療又は予防に用いるためのニトロキシド類 Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64923005P | 2005-02-02 | 2005-02-02 | |
| PCT/US2006/003972 WO2006084197A2 (en) | 2005-02-02 | 2006-02-02 | Nitroxides for use in treating or preventing neoplastic disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008528701A true JP2008528701A (ja) | 2008-07-31 |
| JP2008528701A5 JP2008528701A5 (https=) | 2008-11-06 |
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ID=36777996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007554268A Pending JP2008528701A (ja) | 2005-02-02 | 2006-02-02 | 腫瘍性疾患の治療又は予防に用いるためのニトロキシド類 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20120046314A1 (https=) |
| JP (1) | JP2008528701A (https=) |
| WO (1) | WO2006084197A2 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019509352A (ja) * | 2016-03-23 | 2019-04-04 | ルイス ハバシュ， | ヒトの被験物質をニトロキシドで処理することによってａｐｏｐｔｏｓｉｓ関連遺伝子の発現レベルを増加させる |
| US11819500B2 (en) | 2016-03-23 | 2023-11-21 | Louis Habash | T-cell regulation in t-cell mediated diseases by reducing pathogenic function of TH17 in a human subject through treatment with a nitroxide |
| US11839606B2 (en) | 2016-03-23 | 2023-12-12 | Louis Habash | Increasing expression level of apoptosis-related genes by treating a human subject with a nitroxide |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2325908C1 (ru) * | 2006-09-20 | 2008-06-10 | Государственное учреждение научно-исследовательский институт онкологии Томского Научного центра Сибирского отделения Российской академии медицинских наук (ГУ НИИ онкологии ТНЦ СО РАМН) | Способ профилактики осложнений при комбинированном лечении больных раком легкого и желудка |
| EP2030624A1 (en) | 2007-08-28 | 2009-03-04 | Johannes Gutenberg Universität | Antioxidant and paramagnetic heparin-nitroxide derivatives |
| US8460862B2 (en) * | 2009-03-11 | 2013-06-11 | Marker Gene Technologies | Enzyme substrates for visualizing acidic organelles |
| US8853277B2 (en) | 2009-11-30 | 2014-10-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nitroxide therapy for the treatment of von Hippel—Lindau disease (VHL) and renal clear cell carcinoma (RCC) |
| US10159665B2 (en) | 2016-03-23 | 2018-12-25 | Louis Habash | Preventing amyloid plaque formation by treating a human subject with a nitroxide |
| US9545398B1 (en) * | 2016-03-23 | 2017-01-17 | Louis Habash | Increasing expression level of apoptosis-related genes by treating a human subject with a nitroxide |
| US10441578B2 (en) | 2018-01-19 | 2019-10-15 | Louis Habash | Altering expression level of glutathione S-transferase genes by treating a human subject with a nitroxide |
| US10828291B2 (en) | 2018-01-22 | 2020-11-10 | Louis Habash | Decreasing expression level of proteasome subunit genes by treating a human subject with a nitroxide |
| US20220378771A1 (en) * | 2021-05-25 | 2022-12-01 | Louis Habash | Modifying the expression level of a gene encoding an cyclooxygenase enzyme by treating a human subject with a nitroxide |
| US20220378767A1 (en) * | 2021-05-25 | 2022-12-01 | Louis Habash | Modulating expression level of a gene encoding an uncoupling protein by treating a human subject with a nitroxide |
| US11510913B1 (en) | 2021-05-25 | 2022-11-29 | Louis Habash | Modulating expression level of a gene encoding an apurinic/apyrimidinic endodeoxyribonuclease protein by treating a human subject with a nitroxide |
| US12208089B2 (en) * | 2021-05-25 | 2025-01-28 | Louis Habash | Adjusting expression level of a gene encoding a Sirtuin protein by treating a human subject with a nitroxide |
| US11324737B1 (en) * | 2021-05-25 | 2022-05-10 | Louis Habash | Modulating expression level of a gene encoding a heat shock protein by treating a human subject with a nitroxide |
| CN118649240A (zh) * | 2024-07-09 | 2024-09-17 | 哈尔滨医科大学附属肿瘤医院(哈尔滨医科大学附属第三医院、哈尔滨医科大学第三临床医学院、黑龙江省肿瘤医院) | 低氧抑制剂联合sting激动剂在制备用于治疗肿瘤药物中的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998053835A1 (en) * | 1997-05-27 | 1998-12-03 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | The use of a nitroxide or a prodrug thereof in the prophylactic and therapeutic treatment of cancer |
| WO2000000157A2 (en) * | 1998-06-26 | 2000-01-06 | Georgetown University Medical Center | Use of tempo and tempo derivatives for inducing cell death |
-
2006
- 2006-02-02 WO PCT/US2006/003972 patent/WO2006084197A2/en not_active Ceased
- 2006-02-02 JP JP2007554268A patent/JP2008528701A/ja active Pending
- 2006-02-02 US US11/815,444 patent/US20120046314A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998053835A1 (en) * | 1997-05-27 | 1998-12-03 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | The use of a nitroxide or a prodrug thereof in the prophylactic and therapeutic treatment of cancer |
| WO2000000157A2 (en) * | 1998-06-26 | 2000-01-06 | Georgetown University Medical Center | Use of tempo and tempo derivatives for inducing cell death |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019509352A (ja) * | 2016-03-23 | 2019-04-04 | ルイス ハバシュ， | ヒトの被験物質をニトロキシドで処理することによってａｐｏｐｔｏｓｉｓ関連遺伝子の発現レベルを増加させる |
| JP2021138777A (ja) * | 2016-03-23 | 2021-09-16 | ルイス ハバシュ， | ヒト被験体をニトロキシドで処置することによる、アポトーシス関連遺伝子の発現レベルの増大 |
| US11819500B2 (en) | 2016-03-23 | 2023-11-21 | Louis Habash | T-cell regulation in t-cell mediated diseases by reducing pathogenic function of TH17 in a human subject through treatment with a nitroxide |
| US11839606B2 (en) | 2016-03-23 | 2023-12-12 | Louis Habash | Increasing expression level of apoptosis-related genes by treating a human subject with a nitroxide |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006084197A2 (en) | 2006-08-10 |
| US20120046314A1 (en) | 2012-02-23 |
| WO2006084197A3 (en) | 2007-04-05 |
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