JP2008528505A5 - - Google Patents

Info

Publication number

JP2008528505A5

JP2008528505A5 JP2007552311A JP2007552311A JP2008528505A5 JP 2008528505 A5 JP2008528505 A5 JP 2008528505A5 JP 2007552311 A JP2007552311 A JP 2007552311A JP 2007552311 A JP2007552311 A JP 2007552311A JP 2008528505 A5 JP2008528505 A5 JP 2008528505A5

Authority

JP

Japan

Prior art keywords

alkyl

sulfhydryl

hydroxyl

amino

formula

Prior art date

2006-01-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 125000000217 alkyl group Chemical group 0.000 claims 45
• 239000003814 drug Substances 0.000 claims 41
• 229940124597 therapeutic agent Drugs 0.000 claims 41
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 29
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 29
• 125000003396 thiol group Chemical group [H]S* 0.000 claims 29
• 125000003118 aryl group Chemical group 0.000 claims 18
• 125000000753 cycloalkyl group Chemical group 0.000 claims 17
• 125000003545 alkoxy group Chemical group 0.000 claims 16
• 125000002252 acyl group Chemical group 0.000 claims 15
• 125000004104 aryloxy group Chemical group 0.000 claims 15
• 229910052736 halogen Inorganic materials 0.000 claims 15
• 150000002367 halogens Chemical class 0.000 claims 15
• 125000001072 heteroaryl group Chemical group 0.000 claims 15
• -1 nitro, sulfo Chemical group 0.000 claims 15
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 14
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 14
• 150000001875 compounds Chemical class 0.000 claims 14
• 229910052739 hydrogen Inorganic materials 0.000 claims 14
• 239000001257 hydrogen Substances 0.000 claims 14
• 239000000651 prodrug Substances 0.000 claims 14
• 229940002612 prodrug Drugs 0.000 claims 14
• 150000003839 salts Chemical class 0.000 claims 14
• 230000002401 inhibitory effect Effects 0.000 claims 11
• 201000010099 disease Diseases 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 210000001744 T-lymphocyte Anatomy 0.000 claims 4
• 208000027866 inflammatory disease Diseases 0.000 claims 4
• 230000001404 mediated effect Effects 0.000 claims 4
• 208000023275 Autoimmune disease Diseases 0.000 claims 3
• 208000012902 Nervous system disease Diseases 0.000 claims 2
• 208000025966 Neurological disease Diseases 0.000 claims 2
• 210000004698 lymphocyte Anatomy 0.000 claims 2
• 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 102000008070 Interferon-gamma Human genes 0.000 claims 1
• 108010074328 Interferon-gamma Proteins 0.000 claims 1
• 102000003816 Interleukin-13 Human genes 0.000 claims 1
• 108090000176 Interleukin-13 Proteins 0.000 claims 1
• 102000004890 Interleukin-8 Human genes 0.000 claims 1
• 108090001007 Interleukin-8 Proteins 0.000 claims 1
• 208000019693 Lung disease Diseases 0.000 claims 1
• 230000006044 T cell activation Effects 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
• 230000004913 activation Effects 0.000 claims 1
• 208000026935 allergic disease Diseases 0.000 claims 1
• 230000007815 allergy Effects 0.000 claims 1
• 239000002269 analeptic agent Substances 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
• 239000000221 dopamine uptake inhibitor Substances 0.000 claims 1
• 230000028993 immune response Effects 0.000 claims 1
• 208000026278 immune system disease Diseases 0.000 claims 1
• 230000002757 inflammatory effect Effects 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 229960003130 interferon gamma Drugs 0.000 claims 1
• 229940096397 interleukin-8 Drugs 0.000 claims 1
• XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 1
• 210000001616 monocyte Anatomy 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 230000000770 proinflammatory effect Effects 0.000 claims 1
• 230000035755 proliferation Effects 0.000 claims 1
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
• 0 *OC(C(C1NCCCC1)C1=CC=*=CC=C1)=O Chemical compound *OC(C(C1NCCCC1)C1=CC=*=CC=C1)=O 0.000 description 1