JP2008528212A5 - - Google Patents
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- JP2008528212A5 JP2008528212A5 JP2007553364A JP2007553364A JP2008528212A5 JP 2008528212 A5 JP2008528212 A5 JP 2008528212A5 JP 2007553364 A JP2007553364 A JP 2007553364A JP 2007553364 A JP2007553364 A JP 2007553364A JP 2008528212 A5 JP2008528212 A5 JP 2008528212A5
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- Prior art keywords
- polymer
- medical device
- block
- implantable
- monomers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920000642 polymer Polymers 0.000 claims 26
- 229920001577 copolymer Polymers 0.000 claims 14
- 229920001519 homopolymer Polymers 0.000 claims 12
- 239000004621 biodegradable polymer Substances 0.000 claims 11
- 229920002988 biodegradable polymer Polymers 0.000 claims 11
- 125000002947 alkylene group Chemical group 0.000 claims 5
- 229920001400 block copolymer Polymers 0.000 claims 5
- 150000001336 alkenes Chemical class 0.000 claims 4
- 238000006065 biodegradation reaction Methods 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000000178 monomer Substances 0.000 claims 4
- NIXOWILDQLNWCW-UHFFFAOYSA-M acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 3
- 229920000229 biodegradable polyester Polymers 0.000 claims 3
- 239000004622 biodegradable polyester Substances 0.000 claims 3
- CERQOIWHTDAKMF-UHFFFAOYSA-M methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000005375 organosiloxane group Chemical group 0.000 claims 3
- QYKIQEUNHZKYBP-UHFFFAOYSA-N vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 claims 3
- 230000002792 vascular Effects 0.000 claims 2
- 206010002329 Aneurysm Diseases 0.000 claims 1
- 210000003709 Heart Valves Anatomy 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 235000019994 cava Nutrition 0.000 claims 1
- 230000002490 cerebral Effects 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000002107 myocardial Effects 0.000 claims 1
- 229920000747 poly(lactic acid) polymer Polymers 0.000 claims 1
- 229920001281 polyalkylene Polymers 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 239000004632 polycaprolactone Substances 0.000 claims 1
- 230000001172 regenerating Effects 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
Claims (22)
- 相分離高分子領域を含む移植可能なまたは挿入可能な医療機器であって、該相分離高分子領域が(a)生体安定性高分子相と、(b)該相分離高分子領域がin vivoでナノ多孔質高分子領域となるようにin vivoで生体崩壊を受ける、ナノスケール規模の、生体崩壊性高分子相とを含む、移植可能なまたは挿入可能な医療機器。
- 前記生体崩壊性高分子相と前記生体安定性高分子相が前記高分子領域の少なくとも一部において共連続的である、請求項１記載の移植可能なまたは挿入可能な医療機器。
- 前記生体崩壊性高分子相が前記高分子領域の少なくとも一部において前記高分子領域の厚さ全体にわたっている、請求項１記載の移植可能なまたは挿入可能な医療機器。
- ガイドワイヤー、バルーン、大静脈フィルター、ステント、ステントグラフト、血管グラフト、脳動脈瘤フィラーコイル、心筋プラグ、心臓弁、血管弁、および再生医療用スキャフォールドから選択される、請求項１記載の移植可能なまたは挿入可能な医療機器。
- 前記高分子領域が(a)生体安定性ホモポリマーまたはコポリマーと、(b)生体崩壊性ホモポリマーまたはコポリマーとを含む、請求項１記載の移植可能なまたは挿入可能な医療機器。
- 前記生体安定性ホモポリマーまたはコポリマーが、アクリレートモノマー、メタクリレートモノマー、アルキレンモノマー、ハロゲン化アルキレンモノマー、ビニルエーテルモノマー、ビニル芳香族モノマー、およびオルガノシロキサンモノマーから選択される1種以上のモノマーを含む、請求項５記載の移植可能なまたは挿入可能な医療機器。
- 前記生体安定性コポリマーが、ビニル芳香族モノマーおよびアルキレンモノマーを含む、請求項６記載の移植可能なまたは挿入可能な医療機器。
- 前記生体分解性ホモポリマーまたはコポリマーが生体分解性ポリエステルホモポリマーまたはコポリマーである、請求項５記載の移植可能なまたは挿入可能な医療機器。
- 前記高分子領域が(a)生体安定性ホモポリマーまたはコポリマーと、(b)生体溶解性ホモポリマーまたはコポリマーとを含む、請求項５記載の移植可能なまたは挿入可能な医療機器。
- 前記生体溶解性ホモポリマーまたはコポリマーがアルキレンオキシドモノマーまたはアルキレンオキシドモノマーの組合せを含む、請求項９記載の移植可能なまたは挿入可能な医療機器。
- 前記高分子領域が、生体安定性ポリマーブロックと、生体分解性ポリマーブロックとを含むブロックコポリマーを含む、請求項１記載の移植可能なまたは挿入可能な医療機器。
- 前記生体安定性ポリマーブロックが、アクリレートモノマー、メタクリレートモノマー、ビニル芳香族モノマー、ビニルエーテルモノマー、アルケンモノマー、ハロゲン化アルケンモノマー、オルガノシロキサンモノマー、およびそれらの組合せから選択されるモノマーを含むホモポリマーまたはコポリマーブロックであり、かつ前記生体分解性ポリマーブロックが生体分解性ポリエステルホモポリマーまたはコポリマーブロックである、請求項１１記載の移植可能なまたは挿入可能な医療機器。
- 前記ブロックコポリマーが、生体安定性ポリ（ビニル芳香族）ブロックと、生体安定性ポリアルキレンブロックと、ポリカプロラクトンブロック、ポリ（グリコール酸）ブロック、ポリ（乳酸）ブロック、およびポリ（乳酸−コ−グリコール酸）ブロックから選択される生体分解性ブロックとを含む、請求項１１記載の移植可能なまたは挿入可能な医療機器。
- 前記コポリマーが(i)生体安定性低Tgブロックと、(ii)生体分解性ポリマーブロックを含む、請求項１１記載の移植可能なまたは挿入可能な医療機器。
- 前記生体安定性低Tgブロックが、アクリレートモノマー、メタクリレートモノマー、ビニルエーテルモノマー、アルケンモノマー、ハロゲン化アルケンモノマー、オルガノシロキサンモノマー、およびそれらの組合せから選択されるモノマーを含むホモポリマーまたはコポリマーブロックであり、かつ前記生体分解性ポリマーブロックが生体分解性ポリエステルホモポリマーまたはコポリマーブロックである、請求項１４記載の移植可能なまたは挿入可能な医療機器。
- 前記ブロックコポリマーがポリイオスブチレン中間ブロック(polyiosbutylene midblock)と、複数の生体分解性ポリマー末端ブロックとを含む、請求項１１記載の移植可能なまたは挿入可能な医療機器。
- 前記ブロックコポリマーが生体安定性ポリマー主鎖と、複数の生体分解性ポリマー側鎖とを、または生体安定性ポリマー中間ブロックと、複数の生体分解性ポリマー末端ブロックとを含む、請求項１１記載の移植可能なまたは挿入可能な医療機器。
- 前記高分子領域が医療機器基材に対する被膜である、請求項１に記載の移植可能なまたは挿入可能な医療機器。
- 前記高分子領域の真下にまたは内部に配置された治療薬をさらに含む、請求項１記載の移植可能なまたは挿入可能な医療機器。
- 前記高分子領域が高分子層形態であり、かつ、該高分子層が前記治療薬を含む領域上に配置されているか、あるいは該高分子層が治療薬を含む、請求項１記載の移植可能なまたは挿入可能な医療機器。
- 移植可能なまたは挿入可能な医療機器であって、(a)生体安定性ポリマーブロックと、in vivoで生体崩壊を受ける生体分解性ポリマーブロックとを含むブロックコポリマーを含む相分離高分子領域と、(b)該相分離高分子領域内部に配置され、in vivoで放出される治療薬とを含む、移植可能なまたは挿入可能な医療機器。
- ナノ多孔質高分子領域を含む移植可能なまたは挿入可能な医療機器の製造方法であって、(a)安定性高分子相と、ナノスケール規模の崩壊性高分子相とを含む相分離高分子領域を準備すること、(b)該崩壊性高分子相を選択的に除去し、それにより該ナノ多孔質高分子領域を作り出すことを含む、前記製造方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/048,616 | 2005-02-01 | ||
| US11/048,616 US8535702B2 (en) | 2005-02-01 | 2005-02-01 | Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility |
| PCT/US2006/003455 WO2006083904A2 (en) | 2005-02-01 | 2006-02-01 | Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008528212A JP2008528212A (ja) | 2008-07-31 |
| JP2008528212A5 true JP2008528212A5 (ja) | 2009-03-19 |
| JP5475950B2 JP5475950B2 (ja) | 2014-04-16 |
Family
ID=36754845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007553364A Expired - Fee Related JP5475950B2 (ja) | 2005-02-01 | 2006-02-01 | 制御された薬物送達および調節された生体適合性のための多孔質高分子領域を有する医療機器 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8535702B2 (ja) |
| EP (1) | EP1846056B1 (ja) |
| JP (1) | JP5475950B2 (ja) |
| CA (1) | CA2611454A1 (ja) |
| WO (1) | WO2006083904A2 (ja) |
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- 2006-02-01 EP EP06720017.0A patent/EP1846056B1/en not_active Not-in-force
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