JP2008526835A5 - - Google Patents
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- Publication number
- JP2008526835A5 JP2008526835A5 JP2007550300A JP2007550300A JP2008526835A5 JP 2008526835 A5 JP2008526835 A5 JP 2008526835A5 JP 2007550300 A JP2007550300 A JP 2007550300A JP 2007550300 A JP2007550300 A JP 2007550300A JP 2008526835 A5 JP2008526835 A5 JP 2008526835A5
- Authority
- JP
- Japan
- Prior art keywords
- sibutramine
- sulfonate
- values
- ray diffraction
- sulfonic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 claims 14
- 229960004425 sibutramine Drugs 0.000 claims 14
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 6
- 238000002441 X-ray diffraction Methods 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 3
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 3
- 208000008589 Obesity Diseases 0.000 claims 2
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 150000008054 sulfonate salts Chemical class 0.000 claims 2
- MIOPJNTWMNEORI-GMSGAONNSA-N (S)-camphorsulfonic acid Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C MIOPJNTWMNEORI-GMSGAONNSA-N 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 claims 1
- 229940077388 benzenesulfonate Drugs 0.000 claims 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 claims 1
- 229940092714 benzenesulfonic acid Drugs 0.000 claims 1
- MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical group C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- AFAXGSQYZLGZPG-UHFFFAOYSA-L ethane-1,2-disulfonate Chemical compound [O-]S(=O)(=O)CCS([O-])(=O)=O AFAXGSQYZLGZPG-UHFFFAOYSA-L 0.000 claims 1
- AFAXGSQYZLGZPG-UHFFFAOYSA-N ethanedisulfonic acid Chemical compound OS(=O)(=O)CCS(O)(=O)=O AFAXGSQYZLGZPG-UHFFFAOYSA-N 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020050001404A KR20060080818A (ko) | 2005-01-06 | 2005-01-06 | 시부트라민의 술폰산염 |
| PCT/KR2006/000072 WO2006073291A1 (en) | 2005-01-06 | 2006-01-06 | A sulphonic acid salt of sibutramine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008526835A JP2008526835A (ja) | 2008-07-24 |
| JP2008526835A5 true JP2008526835A5 (https=) | 2008-11-27 |
Family
ID=36647750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007550300A Withdrawn JP2008526835A (ja) | 2005-01-06 | 2006-01-06 | シブトラミンのスルホン酸塩 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7429679B2 (https=) |
| EP (1) | EP1846360A4 (https=) |
| JP (1) | JP2008526835A (https=) |
| KR (1) | KR20060080818A (https=) |
| CN (1) | CN101098849A (https=) |
| WO (1) | WO2006073291A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006073292A1 (en) * | 2005-01-06 | 2006-07-13 | Cj Corporation | Inorganic acid salts of sibutramine |
| KR20060080817A (ko) * | 2005-01-06 | 2006-07-11 | 씨제이 주식회사 | 시부트라민의 디카복실산염 |
| KR100800561B1 (ko) * | 2006-03-29 | 2008-02-04 | 주식회사 삼오제약 | 시부트라민 술포닐염의 제조방법 및 이를 포함하는비만관련 질환 예방 및 치료용 약학조성물 |
| CN101555214B (zh) * | 2008-04-08 | 2012-07-11 | 北京嘉事联博医药科技有限公司 | 苯基环丁基酰胺衍生物及其光学异构体、制备方法和用途 |
| KR101007927B1 (ko) * | 2008-12-24 | 2011-01-14 | 주식회사 셀트리온제약 | 시부트라민-ｌ-카르니틴 다이술폰산염, 이의 제조방법 및 이를 포함하는 약제학적 조성물 |
| CN102786444A (zh) * | 2012-07-24 | 2012-11-21 | 上海瑞博化学有限公司 | 一种西布曲明类似物的磺酸盐的制备方法 |
| KR101374939B1 (ko) * | 2013-10-18 | 2014-03-14 | 제일약품주식회사 | 이토프라이드 염산염 제조에 사용되는 신규 중간체염, 이의 제조방법 및 이를 이용한 이토프라이드 염산염의 제조방법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9402641D0 (en) | 1994-02-11 | 1994-04-06 | Boots Co Plc | Therapeutic agents |
| GB9619961D0 (en) | 1996-09-25 | 1996-11-13 | Knoll Ag | Medical treatment |
| US6331571B1 (en) * | 1998-08-24 | 2001-12-18 | Sepracor, Inc. | Methods of treating and preventing attention deficit disorders |
| WO2000056310A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Treatment of chronic fatigue syndrome |
| AU3757800A (en) | 1999-03-19 | 2000-10-09 | Abbott Gmbh & Co. Kg | Method of controlling weight gain associated with therapeutic drugs |
| JP4278652B2 (ja) * | 2002-10-05 | 2009-06-17 | ハンミ ファーム． シーオー．， エルティーディー． | 結晶性シブトラミンメタンスルホン酸塩半水和物を含む医薬組成物 |
| WO2006073292A1 (en) | 2005-01-06 | 2006-07-13 | Cj Corporation | Inorganic acid salts of sibutramine |
| KR20060080817A (ko) | 2005-01-06 | 2006-07-11 | 씨제이 주식회사 | 시부트라민의 디카복실산염 |
-
2005
- 2005-01-06 KR KR1020050001404A patent/KR20060080818A/ko not_active Abandoned
-
2006
- 2006-01-06 WO PCT/KR2006/000072 patent/WO2006073291A1/en not_active Ceased
- 2006-01-06 EP EP06700097A patent/EP1846360A4/en not_active Withdrawn
- 2006-01-06 CN CNA2006800018244A patent/CN101098849A/zh active Pending
- 2006-01-06 US US10/580,135 patent/US7429679B2/en not_active Expired - Fee Related
- 2006-01-06 JP JP2007550300A patent/JP2008526835A/ja not_active Withdrawn