JP2008526835A5 - - Google Patents
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- Publication number
- JP2008526835A5 JP2008526835A5 JP2007550300A JP2007550300A JP2008526835A5 JP 2008526835 A5 JP2008526835 A5 JP 2008526835A5 JP 2007550300 A JP2007550300 A JP 2007550300A JP 2007550300 A JP2007550300 A JP 2007550300A JP 2008526835 A5 JP2008526835 A5 JP 2008526835A5
- Authority
- JP
- Japan
- Prior art keywords
- sibutramine
- sulfonate
- values
- ray diffraction
- sulfonic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 claims 14
- 229960004425 sibutramine Drugs 0.000 claims 14
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 6
- 238000002441 X-ray diffraction Methods 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 3
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 3
- 208000008589 Obesity Diseases 0.000 claims 2
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 150000008054 sulfonate salts Chemical class 0.000 claims 2
- MIOPJNTWMNEORI-GMSGAONNSA-N (S)-camphorsulfonic acid Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C MIOPJNTWMNEORI-GMSGAONNSA-N 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 claims 1
- 229940077388 benzenesulfonate Drugs 0.000 claims 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 claims 1
- 229940092714 benzenesulfonic acid Drugs 0.000 claims 1
- MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical group C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- AFAXGSQYZLGZPG-UHFFFAOYSA-L ethane-1,2-disulfonate Chemical compound [O-]S(=O)(=O)CCS([O-])(=O)=O AFAXGSQYZLGZPG-UHFFFAOYSA-L 0.000 claims 1
- AFAXGSQYZLGZPG-UHFFFAOYSA-N ethanedisulfonic acid Chemical compound OS(=O)(=O)CCS(O)(=O)=O AFAXGSQYZLGZPG-UHFFFAOYSA-N 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020050001404A KR20060080818A (ko) | 2005-01-06 | 2005-01-06 | 시부트라민의 술폰산염 |
| PCT/KR2006/000072 WO2006073291A1 (en) | 2005-01-06 | 2006-01-06 | A sulphonic acid salt of sibutramine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008526835A JP2008526835A (ja) | 2008-07-24 |
| JP2008526835A5 true JP2008526835A5 (https=) | 2008-11-27 |
Family
ID=36647750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007550300A Withdrawn JP2008526835A (ja) | 2005-01-06 | 2006-01-06 | シブトラミンのスルホン酸塩 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7429679B2 (https=) |
| EP (1) | EP1846360A4 (https=) |
| JP (1) | JP2008526835A (https=) |
| KR (1) | KR20060080818A (https=) |
| CN (1) | CN101098849A (https=) |
| WO (1) | WO2006073291A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008526836A (ja) * | 2005-01-06 | 2008-07-24 | シージェー チェイルジェダン コーポレーション | シブトラミンの無機酸塩 |
| KR20060080817A (ko) * | 2005-01-06 | 2006-07-11 | 씨제이 주식회사 | 시부트라민의 디카복실산염 |
| KR100800561B1 (ko) * | 2006-03-29 | 2008-02-04 | 주식회사 삼오제약 | 시부트라민 술포닐염의 제조방법 및 이를 포함하는비만관련 질환 예방 및 치료용 약학조성물 |
| CN101555214B (zh) * | 2008-04-08 | 2012-07-11 | 北京嘉事联博医药科技有限公司 | 苯基环丁基酰胺衍生物及其光学异构体、制备方法和用途 |
| KR101007927B1 (ko) * | 2008-12-24 | 2011-01-14 | 주식회사 셀트리온제약 | 시부트라민-ｌ-카르니틴 다이술폰산염, 이의 제조방법 및 이를 포함하는 약제학적 조성물 |
| CN102786444A (zh) * | 2012-07-24 | 2012-11-21 | 上海瑞博化学有限公司 | 一种西布曲明类似物的磺酸盐的制备方法 |
| KR101374939B1 (ko) * | 2013-10-18 | 2014-03-14 | 제일약품주식회사 | 이토프라이드 염산염 제조에 사용되는 신규 중간체염, 이의 제조방법 및 이를 이용한 이토프라이드 염산염의 제조방법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9402641D0 (en) | 1994-02-11 | 1994-04-06 | Boots Co Plc | Therapeutic agents |
| GB9619961D0 (en) * | 1996-09-25 | 1996-11-13 | Knoll Ag | Medical treatment |
| US6331571B1 (en) | 1998-08-24 | 2001-12-18 | Sepracor, Inc. | Methods of treating and preventing attention deficit disorders |
| IL145241A0 (en) | 1999-03-19 | 2002-06-30 | Knoll Gmbh | Method of controlling weight gain associated with therapeutic drugs |
| US6376551B1 (en) | 1999-03-19 | 2002-04-23 | Knoll Pharmaceutical Company | Treatment of chronic fatigue syndrome |
| NZ538966A (en) * | 2002-10-05 | 2006-11-30 | Hanmi Pharm | Pharmaceutical composition comprising crystalline sibutramine methanesulfonate hemihydrate |
| JP2008526836A (ja) | 2005-01-06 | 2008-07-24 | シージェー チェイルジェダン コーポレーション | シブトラミンの無機酸塩 |
| KR20060080817A (ko) | 2005-01-06 | 2006-07-11 | 씨제이 주식회사 | 시부트라민의 디카복실산염 |
-
2005
- 2005-01-06 KR KR1020050001404A patent/KR20060080818A/ko not_active Abandoned
-
2006
- 2006-01-06 EP EP06700097A patent/EP1846360A4/en not_active Withdrawn
- 2006-01-06 CN CNA2006800018244A patent/CN101098849A/zh active Pending
- 2006-01-06 JP JP2007550300A patent/JP2008526835A/ja not_active Withdrawn
- 2006-01-06 US US10/580,135 patent/US7429679B2/en not_active Expired - Fee Related
- 2006-01-06 WO PCT/KR2006/000072 patent/WO2006073291A1/en not_active Ceased
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