JP2008526818A5 - - Google Patents

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Publication number
JP2008526818A5
JP2008526818A5 JP2007549915A JP2007549915A JP2008526818A5 JP 2008526818 A5 JP2008526818 A5 JP 2008526818A5 JP 2007549915 A JP2007549915 A JP 2007549915A JP 2007549915 A JP2007549915 A JP 2007549915A JP 2008526818 A5 JP2008526818 A5 JP 2008526818A5
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JP
Japan
Prior art keywords
alkyl
alkoxy
hydrogen
substituted
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2007549915A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008526818A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2006/050167 external-priority patent/WO2006089815A1/en
Publication of JP2008526818A publication Critical patent/JP2008526818A/ja
Publication of JP2008526818A5 publication Critical patent/JP2008526818A5/ja
Withdrawn legal-status Critical Current

Links

JP2007549915A 2005-01-12 2006-01-11 Ｐｄｅ１０インヒビターとしての新規のピロロジヒドロイソキノリン Withdrawn JP2008526818A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05100154 2005-01-12
PCT/EP2006/050167 WO2006089815A1 (en) 2005-01-12 2006-01-11 Novel pyrrolodihydroisoquinolines as pde10 inhibitors

Publications (2)

Publication Number Publication Date
JP2008526818A JP2008526818A (ja) 2008-07-24
JP2008526818A5 true JP2008526818A5 (enExample) 2009-03-05

Family

ID=36097003

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007549915A Withdrawn JP2008526818A (ja) 2005-01-12 2006-01-11 Ｐｄｅ１０インヒビターとしての新規のピロロジヒドロイソキノリン

Country Status (9)

Country Link
US (1) US20080161338A1 (enExample)
EP (1) EP1838707B1 (enExample)
JP (1) JP2008526818A (enExample)
AT (1) ATE430148T1 (enExample)
AU (1) AU2006218054A1 (enExample)
CA (1) CA2593750A1 (enExample)
DE (1) DE602006006544D1 (enExample)
ES (1) ES2326337T3 (enExample)
WO (1) WO2006089815A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060030483A (ko) * 2003-06-30 2006-04-10 알타나 파마 아게 Ｐｄｅ10 억제제로서 피롤로디히드로이소퀴놀린
EP1838708A2 (en) * 2005-01-12 2007-10-03 Nycomed GmbH Pyrrolodihydroisoquinolines as antiproliferative agents
WO2009070584A1 (en) 2007-11-30 2009-06-04 Wyeth Aryl and heteroaryl fused imidazo[1,5-a]pyrazines as inhibitors of phosphodiesterase 10
US20090143361A1 (en) * 2007-11-30 2009-06-04 Elbion Gmbh Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10
TW200944523A (en) 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines
MX2013009575A (es) 2011-02-18 2014-10-14 Exonhit Therapeutics Sa Derivados de 6, 7-dialcoxi-3-isoquinolinol sustituidos como inhibidores de fosfodiesterasa 10 (pdei0a).
GB201117453D0 (en) * 2011-10-10 2011-11-23 Univ Dundee Improved sperm function/activity
WO2014071044A1 (en) 2012-11-01 2014-05-08 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)
US9200016B2 (en) 2013-12-05 2015-12-01 Allergan, Inc. Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
CN119367368B (zh) * 2024-11-28 2025-12-05 中山大学 氮杂四元环连接的吡唑并吡啶类化合物在制备治疗肺动脉高压的药物中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2761358B1 (fr) * 1997-03-27 1999-05-07 Adir Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2004517843A (ja) * 2000-12-13 2004-06-17 バイエル アクチェンゲゼルシャフト ピロロ［２．１−ａ］ジヒドロイソキノリンおよびホスホジエステラーゼ１０ａ阻害薬としてのその使用
IL149106A0 (en) * 2001-04-20 2002-11-10 Pfizer Prod Inc Therapeutic use of selective pde10 inhibitors
US20030018047A1 (en) * 2001-04-20 2003-01-23 Pfizer Inc. Therapeutic use of selective PDE10 inhibitors
US20030032579A1 (en) * 2001-04-20 2003-02-13 Pfizer Inc. Therapeutic use of selective PDE10 inhibitors
WO2003014115A1 (en) * 2001-08-06 2003-02-20 Bayer Aktiengesellschaft 3-substituted pyrrolo (2.1-a) isoquinoline derivatives
WO2003051877A1 (en) * 2001-12-18 2003-06-26 Bayer Corporation 2-substituted pyrrolo[2.1-a]isoquinolines against cancer
KR20060030483A (ko) * 2003-06-30 2006-04-10 알타나 파마 아게 Ｐｄｅ10 억제제로서 피롤로디히드로이소퀴놀린

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