JP2008526818A5 - - Google Patents

Download PDF

Info

Publication number
JP2008526818A5
JP2008526818A5 JP2007549915A JP2007549915A JP2008526818A5 JP 2008526818 A5 JP2008526818 A5 JP 2008526818A5 JP 2007549915 A JP2007549915 A JP 2007549915A JP 2007549915 A JP2007549915 A JP 2007549915A JP 2008526818 A5 JP2008526818 A5 JP 2008526818A5
Authority
JP
Japan
Prior art keywords
alkyl
alkoxy
hydrogen
substituted
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2007549915A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008526818A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2006/050167 external-priority patent/WO2006089815A1/en
Publication of JP2008526818A publication Critical patent/JP2008526818A/ja
Publication of JP2008526818A5 publication Critical patent/JP2008526818A5/ja
Withdrawn legal-status Critical Current

Links

JP2007549915A 2005-01-12 2006-01-11 Ｐｄｅ１０インヒビターとしての新規のピロロジヒドロイソキノリン Withdrawn JP2008526818A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05100154 2005-01-12
PCT/EP2006/050167 WO2006089815A1 (en) 2005-01-12 2006-01-11 Novel pyrrolodihydroisoquinolines as pde10 inhibitors

Publications (2)

Publication Number Publication Date
JP2008526818A JP2008526818A (ja) 2008-07-24
JP2008526818A5 true JP2008526818A5 (enExample) 2009-03-05

Family

ID=36097003

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007549915A Withdrawn JP2008526818A (ja) 2005-01-12 2006-01-11 Ｐｄｅ１０インヒビターとしての新規のピロロジヒドロイソキノリン

Country Status (9)

Country Link
US (1) US20080161338A1 (enExample)
EP (1) EP1838707B1 (enExample)
JP (1) JP2008526818A (enExample)
AT (1) ATE430148T1 (enExample)
AU (1) AU2006218054A1 (enExample)
CA (1) CA2593750A1 (enExample)
DE (1) DE602006006544D1 (enExample)
ES (1) ES2326337T3 (enExample)
WO (1) WO2006089815A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05013553A (es) * 2003-06-30 2006-03-09 Altana Pharma Ag Pirrolodihidroisoquinolinas como inhibidores de pde10.
AU2006205797A1 (en) * 2005-01-12 2006-07-20 4Sc Ag Pyrrolodihydroisoquinolines as antiproliferative agents
EP2225248A1 (en) * 2007-11-30 2010-09-08 Wyeth LLC Aryl and heteroaryl fused imidazo[1,5-a]pyrazines as inhibitors of phosphodiesterase 10
US20090143361A1 (en) * 2007-11-30 2009-06-04 Elbion Gmbh Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10
TW200944523A (en) 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines
WO2012112946A1 (en) 2011-02-18 2012-08-23 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a)
GB201117453D0 (en) * 2011-10-10 2011-11-23 Univ Dundee Improved sperm function/activity
WO2014071044A1 (en) 2012-11-01 2014-05-08 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)
US9200016B2 (en) 2013-12-05 2015-12-01 Allergan, Inc. Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
CN119367368B (zh) * 2024-11-28 2025-12-05 中山大学 氮杂四元环连接的吡唑并吡啶类化合物在制备治疗肺动脉高压的药物中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2761358B1 (fr) * 1997-03-27 1999-05-07 Adir Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6930114B2 (en) * 2000-12-13 2005-08-16 Bayer Pharmaceuticals Corporation Pyrrolo (2.1a)dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors
US20030018047A1 (en) * 2001-04-20 2003-01-23 Pfizer Inc. Therapeutic use of selective PDE10 inhibitors
IL149106A0 (en) * 2001-04-20 2002-11-10 Pfizer Prod Inc Therapeutic use of selective pde10 inhibitors
US20030032579A1 (en) * 2001-04-20 2003-02-13 Pfizer Inc. Therapeutic use of selective PDE10 inhibitors
WO2003014115A1 (en) * 2001-08-06 2003-02-20 Bayer Aktiengesellschaft 3-substituted pyrrolo (2.1-a) isoquinoline derivatives
AU2002366362A1 (en) * 2001-12-18 2003-06-30 Bayer Aktiengesellschaft 2-substituted pyrrolo(2.1-a)isoquinolines against cancer
MXPA05013553A (es) * 2003-06-30 2006-03-09 Altana Pharma Ag Pirrolodihidroisoquinolinas como inhibidores de pde10.

Similar Documents

Publication Publication Date Title
TWI694076B (zh) 三唑并嘧啶化合物及其用途
KR102279999B1 (ko) 선택적 에스트로겐 수용체 분해제로서의 벤조티오펜 유도체 및 그의 조성물
ES2823477T3 (es) Aril éteres y usos de los mismos
ES2625959T3 (es) 5-Aril-triazolo-azepinas inhibidoras de la proteína BET
US8906902B2 (en) Antibacterial compounds
JP2022501431A5 (enExample)
KR20200011965A (ko) Map4k1의 신규한 억제제
WO2015092634A1 (en) 1,2,3,4-tetrahydroisoquinoline compounds and compositions as selective estrogen receptor antagonists and degraders
RU2012134306A (ru) Азотосодержащие производные гетероарилов
WO2021092336A1 (en) Heterocyclic rip1 inhibitory compounds
JP2017527586A (ja) 癌の治療に有用な縮合二環式（ヘテロ）芳香族化合物
KR20130048293A (ko) 단백질 키나제 억제제로서의 헤테로아릴 화합물 및 조성물
JP7482324B2 (ja) 新規なジアシルグリセリドｏ－アシルトランスフェラーゼ２阻害剤としてのオキシインドール誘導体の製造
CA2953004C (en) Aromatic heterocyclic derivatives and pharmaceutical applications thereof
RU2016121854A (ru) Производные гетероарила
JP2008545670A (ja) 疾患を処置するためのジアリールウレア類を含む組合せ治療
JP2017530154A5 (enExample)
TW202045516A (zh) 雙環磺醯胺
US9650377B2 (en) Diazepinone derivatives
Asif Antitubercular drugs: advances in nitrogen containing heterocyclic compounds and some other derivatives
WO2025235389A1 (en) P53 modulators
WO2026035752A1 (en) P53 modulators
WO2025217389A1 (en) P53 modulators
CN116970029A (zh) 桥环类化合物、其制备方法及其在医药上的应用
CA3149900A1 (en) Rip1 inhibitory compounds and methods for making and using the same