JP2008526699A5 - - Google Patents
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- Publication number
- JP2008526699A5 JP2008526699A5 JP2007548733A JP2007548733A JP2008526699A5 JP 2008526699 A5 JP2008526699 A5 JP 2008526699A5 JP 2007548733 A JP2007548733 A JP 2007548733A JP 2007548733 A JP2007548733 A JP 2007548733A JP 2008526699 A5 JP2008526699 A5 JP 2008526699A5
- Authority
- JP
- Japan
- Prior art keywords
- sup
- peptide
- array
- providing
- loading factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 5
- 235000001014 amino acid Nutrition 0.000 claims 4
- 239000011347 resin Substances 0.000 claims 4
- 229920005989 resin Polymers 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- OBSIQMZKFXFYLV-QMMMGPOBSA-N L-phenylalanine amide Chemical compound NC(=O)[C@@H](N)CC1=CC=CC=C1 OBSIQMZKFXFYLV-QMMMGPOBSA-N 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 239000012071 phase Substances 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 238000010532 solid phase synthesis reaction Methods 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- -1 chloro-trityl group Chemical group 0.000 claims 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64071604P | 2004-12-30 | 2004-12-30 | |
| US60/640,716 | 2004-12-30 | ||
| PCT/EP2005/013854 WO2006069729A1 (en) | 2004-12-30 | 2005-12-22 | Synthesis of peptide t-1249 using peptide intermediate fragments |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008526699A JP2008526699A (ja) | 2008-07-24 |
| JP2008526699A5 true JP2008526699A5 (cg-RX-API-DMAC10.html) | 2009-01-08 |
| JP4886703B2 JP4886703B2 (ja) | 2012-02-29 |
Family
ID=36001047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548733A Expired - Fee Related JP4886703B2 (ja) | 2004-12-30 | 2005-12-22 | ペプチド中間体断片を使用するペプチドｔ−１２４９の合成 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7544665B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1856142B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP4886703B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN101133076B (cg-RX-API-DMAC10.html) |
| AT (1) | ATE439371T1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2593866C (cg-RX-API-DMAC10.html) |
| DE (1) | DE602005016024D1 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2329270T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2006069729A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4886702B2 (ja) * | 2004-12-30 | 2012-02-29 | エフ．ホフマン−ラ ロシュ アーゲー | ペプチド中間体断片を使用するペプチドｔ−２０の合成 |
| JP5473925B2 (ja) * | 2007-10-27 | 2014-04-16 | コーデン ファーマ コロラド インコーポレイテッド | 固相および溶液相の組み合わせ技法を使用するインスリン分泌性ペプチドの合成 |
| CA2707132A1 (en) * | 2007-12-11 | 2009-06-18 | F. Hoffmann-La Roche Ag | Insulinotropic peptide synthesis using solid and solution phase combination techniques |
| DE102008017645A1 (de) | 2008-04-04 | 2009-10-08 | Carl Zeiss Smt Ag | Vorrichtung zur mikrolithographischen Projektionsbelichtung sowie Vorrichtung zur Inspektion einer Oberfläche eines Substrats |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100358209B1 (ko) * | 1992-07-20 | 2003-01-24 | 듀크 유니버시티 | Hiv복제를저해하는조성물 |
| US6281335B1 (en) * | 1993-10-08 | 2001-08-28 | Coulter Corporation | Hybridoma and anti-KC-4 humanized monoclonal antibody |
| US6479055B1 (en) * | 1993-06-07 | 2002-11-12 | Trimeris, Inc. | Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission |
| US5464933A (en) * | 1993-06-07 | 1995-11-07 | Duke University | Synthetic peptide inhibitors of HIV transmission |
| US6281331B1 (en) * | 1998-03-23 | 2001-08-28 | Trimeris, Inc. | Methods and compositions for peptide synthesis |
| US6469136B1 (en) * | 1999-07-07 | 2002-10-22 | Trimeris, Inc. | Methods and composition for peptide synthesis |
| US20040209999A1 (en) * | 2002-08-16 | 2004-10-21 | Bohling James Charles | Method of manufacturing polypeptides, including T-20 and T-1249, at commercial scale, and polypeptide compositions related thereto |
| AU2004200485A1 (en) * | 2003-02-25 | 2004-09-09 | Rohm And Haas Company | Method of manufacturing T-20 and T-1249 peptides at commercial scale, and T-20 and T-1249 compositions related thereto |
| JP4886702B2 (ja) * | 2004-12-30 | 2012-02-29 | エフ．ホフマン−ラ ロシュ アーゲー | ペプチド中間体断片を使用するペプチドｔ−２０の合成 |
-
2005
- 2005-12-22 ES ES05821840T patent/ES2329270T3/es not_active Expired - Lifetime
- 2005-12-22 CN CN2005800488419A patent/CN101133076B/zh not_active Expired - Fee Related
- 2005-12-22 EP EP05821840A patent/EP1856142B1/en not_active Expired - Lifetime
- 2005-12-22 CA CA2593866A patent/CA2593866C/en not_active Expired - Fee Related
- 2005-12-22 WO PCT/EP2005/013854 patent/WO2006069729A1/en not_active Ceased
- 2005-12-22 AT AT05821840T patent/ATE439371T1/de not_active IP Right Cessation
- 2005-12-22 DE DE602005016024T patent/DE602005016024D1/de not_active Expired - Lifetime
- 2005-12-22 JP JP2007548733A patent/JP4886703B2/ja not_active Expired - Fee Related
- 2005-12-30 US US11/322,394 patent/US7544665B2/en not_active Expired - Fee Related
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