JP2008525317A5 - - Google Patents

Info

Publication number

JP2008525317A5

JP2008525317A5 JP2007542970A JP2007542970A JP2008525317A5 JP 2008525317 A5 JP2008525317 A5 JP 2008525317A5 JP 2007542970 A JP2007542970 A JP 2007542970A JP 2007542970 A JP2007542970 A JP 2007542970A JP 2008525317 A5 JP2008525317 A5 JP 2008525317A5

Authority

JP

Japan

Prior art keywords

pregnane

diol

3beta

beta

5beta

Prior art date

2005-11-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• YWYQTGBBEZQBGO-UHFFFAOYSA-N UC1011 Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(O)C)C1(C)CC2 YWYQTGBBEZQBGO-UHFFFAOYSA-N 0.000 claims 21
• YWYQTGBBEZQBGO-HUTKLZKUSA-N 5beta-pregnane-3beta,20alpha-diol Chemical compound C([C@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](O)C)[C@@]2(C)CC1 YWYQTGBBEZQBGO-HUTKLZKUSA-N 0.000 claims 18
• 239000008194 pharmaceutical composition Substances 0.000 claims 13
• 239000000126 substance Substances 0.000 claims 13
• YWYQTGBBEZQBGO-XFHAOOBSSA-N (3s,5s,8r,9s,10s,13s,14s,17s)-17-[(1r)-1-hydroxyethyl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](O)C)[C@@]2(C)CC1 YWYQTGBBEZQBGO-XFHAOOBSSA-N 0.000 claims 8
• YWYQTGBBEZQBGO-ZVPCKFNKSA-N (3s,5s,8r,9s,10s,13s,14s,17s)-17-[(1s)-1-hydroxyethyl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical group C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](O)C)[C@@]2(C)CC1 YWYQTGBBEZQBGO-ZVPCKFNKSA-N 0.000 claims 7
• 102000004300 GABA-A Receptors Human genes 0.000 claims 6
• 108090000839 GABA-A Receptors Proteins 0.000 claims 6
• 208000015114 central nervous system disease Diseases 0.000 claims 5
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 4
• 230000003042 antagnostic effect Effects 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 3
• AURFZBICLPNKBZ-FZCSVUEKSA-N 3beta-hydroxy-5alpha-pregnan-20-one Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1 AURFZBICLPNKBZ-FZCSVUEKSA-N 0.000 claims 2
• JWMFYGXQPXQEEM-NUNROCCHSA-N 5β-pregnane Chemical compound C([C@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](CC)[C@@]2(C)CC1 JWMFYGXQPXQEEM-NUNROCCHSA-N 0.000 claims 2
• AURFZBICLPNKBZ-UHFFFAOYSA-N Pregnanolone Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(=O)C)C1(C)CC2 AURFZBICLPNKBZ-UHFFFAOYSA-N 0.000 claims 2
• 229960003692 gamma aminobutyric acid Drugs 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 102000005962 receptors Human genes 0.000 claims 2
• 108020003175 receptors Proteins 0.000 claims 2
• OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims 1
• YWYQTGBBEZQBGO-BERLURQNSA-N Pregnanediol Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](O)C)[C@@]2(C)CC1 YWYQTGBBEZQBGO-BERLURQNSA-N 0.000 claims 1
• UESYMIFUVPHBHL-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O.CC(O)=O.CC(O)=O UESYMIFUVPHBHL-UHFFFAOYSA-N 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 239000000463 material Substances 0.000 claims 1