CN101076340B - Gaba-类固醇拮抗剂及其治疗cns障碍的用途 - Google Patents

Gaba-类固醇拮抗剂及其治疗cns障碍的用途 Download PDF

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Publication number
CN101076340B
CN101076340B CN2005800394888A CN200580039488A CN101076340B CN 101076340 B CN101076340 B CN 101076340B CN 2005800394888 A CN2005800394888 A CN 2005800394888A CN 200580039488 A CN200580039488 A CN 200580039488A CN 101076340 B CN101076340 B CN 101076340B
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CN
China
Prior art keywords
gaba
pregnane
steroids
hydroxy
steroid
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Expired - Fee Related
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CN2005800394888A
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English (en)
Chinese (zh)
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CN101076340A (zh
Inventor
T·巴克斯特龙
P·隆德格伦
王明德
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Umecrine AB
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Umecrine AB
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2005800394888A 2004-11-18 2005-11-07 Gaba-类固醇拮抗剂及其治疗cns障碍的用途 Expired - Fee Related CN101076340B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62951104P 2004-11-18 2004-11-18
US60/629,511 2004-11-18
PCT/SE2005/001671 WO2006054938A1 (en) 2004-11-18 2005-11-07 Gaba-steroid antagonists and their use for the treatment of cns disorders

Publications (2)

Publication Number Publication Date
CN101076340A CN101076340A (zh) 2007-11-21
CN101076340B true CN101076340B (zh) 2011-01-12

Family

ID=36407411

Family Applications (1)

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CN2005800394888A Expired - Fee Related CN101076340B (zh) 2004-11-18 2005-11-07 Gaba-类固醇拮抗剂及其治疗cns障碍的用途

Country Status (11)

Country Link
US (2) US8114860B2 (cg-RX-API-DMAC7.html)
EP (1) EP1812009B1 (cg-RX-API-DMAC7.html)
JP (1) JP4914368B2 (cg-RX-API-DMAC7.html)
CN (1) CN101076340B (cg-RX-API-DMAC7.html)
AU (1) AU2005307151B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0518359A2 (cg-RX-API-DMAC7.html)
CA (1) CA2585359C (cg-RX-API-DMAC7.html)
DK (1) DK1812009T3 (cg-RX-API-DMAC7.html)
ES (1) ES2423493T3 (cg-RX-API-DMAC7.html)
MX (1) MX2007006032A (cg-RX-API-DMAC7.html)
WO (1) WO2006054938A1 (cg-RX-API-DMAC7.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2585359C (en) 2004-11-18 2013-01-08 Umecrine Ab Gaba-steroid antagonists and their use for the treatment of cns disorders
HUE033037T2 (hu) 2006-11-21 2017-11-28 Umecrine Cognition Ab Pregnán és androsztán szteroidok alkalmazása központi idegrendszerbeli rendellenességek kezelésére szolgáló gyógyszerészeti készítmények elõállítására
CN101585862B (zh) * 2008-05-20 2014-12-17 梅克芳股份公司 甾族化合物
US20110086828A1 (en) * 2009-10-07 2011-04-14 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Treatment of alcohol abuse and alcoholism using modulators of neurosteroid binding sites on gabaa receptors
CA2786330C (en) 2010-01-14 2013-11-19 Umecrine Mood Ab A pharmaceutical composition comprising 3-beta-hydroxy-5-alpha-pregnan-20-one with improved storage and solubility properties

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003059357A1 (en) * 2001-12-27 2003-07-24 Umecrine Ab Pregnane steroids for use in the treatment of cns disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4614499A (en) * 1985-04-29 1986-09-30 Universite Laval Simulator for use as a neurosurgical aid in determining potential paths for the implantation of probes through the human body
AU756001B2 (en) 1998-03-11 2003-01-02 Umecrine Mood Ab Epiallopregnanolone in the treatment of CNS disorders
US20030125311A1 (en) * 2000-03-17 2003-07-03 Etienne-Emile Baulieu Compounds capable of binding with the cytoskeleton
FR2806303B1 (fr) * 2000-03-17 2002-09-27 Inst Nat Sante Rech Med Composes capables de se lier a des proteines constituantes ou associees aux elements du cytosquelette et leurs applications pour la fabrication de medicaments
CA2585359C (en) * 2004-11-18 2013-01-08 Umecrine Ab Gaba-steroid antagonists and their use for the treatment of cns disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003059357A1 (en) * 2001-12-27 2003-07-24 Umecrine Ab Pregnane steroids for use in the treatment of cns disorders

Also Published As

Publication number Publication date
DK1812009T3 (da) 2013-08-05
CA2585359A1 (en) 2006-05-26
ES2423493T3 (es) 2013-09-20
EP1812009B1 (en) 2013-05-15
US8372824B2 (en) 2013-02-12
US8114860B2 (en) 2012-02-14
JP4914368B2 (ja) 2012-04-11
MX2007006032A (es) 2007-10-17
EP1812009A4 (en) 2010-08-11
WO2006054938A1 (en) 2006-05-26
JP2008525317A (ja) 2008-07-17
AU2005307151B2 (en) 2011-10-20
CA2585359C (en) 2013-01-08
EP1812009A1 (en) 2007-08-01
BRPI0518359A2 (pt) 2008-11-18
AU2005307151A1 (en) 2006-05-26
CN101076340A (zh) 2007-11-21
US20120142657A1 (en) 2012-06-07
US20080070876A1 (en) 2008-03-20

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Termination date: 20201107

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