JP2008525033A - Ｂ群連鎖球菌 - Google Patents
Ｂ群連鎖球菌 Download PDFInfo
- Publication number
- JP2008525033A JP2008525033A JP2007548453A JP2007548453A JP2008525033A JP 2008525033 A JP2008525033 A JP 2008525033A JP 2007548453 A JP2007548453 A JP 2007548453A JP 2007548453 A JP2007548453 A JP 2007548453A JP 2008525033 A JP2008525033 A JP 2008525033A
- Authority
- JP
- Japan
- Prior art keywords
- protein
- family
- proteins
- conserved virtual
- virtual
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000193990 Streptococcus sp. 'group B' Species 0.000 title description 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 124
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 120
- 229920001184 polypeptide Polymers 0.000 claims abstract description 116
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 95
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 90
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 90
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 8
- 239000000203 mixture Substances 0.000 claims description 87
- 150000001413 amino acids Chemical class 0.000 claims description 76
- 238000000034 method Methods 0.000 claims description 45
- 239000002773 nucleotide Substances 0.000 claims description 34
- 125000003729 nucleotide group Chemical group 0.000 claims description 34
- 239000012634 fragment Substances 0.000 claims description 31
- 238000004519 manufacturing process Methods 0.000 claims description 14
- 208000015181 infectious disease Diseases 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 4
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 3
- 239000012646 vaccine adjuvant Substances 0.000 claims description 2
- 229940124931 vaccine adjuvant Drugs 0.000 claims description 2
- 229960005486 vaccine Drugs 0.000 abstract description 15
- 230000003115 biocidal effect Effects 0.000 abstract description 7
- 241000193985 Streptococcus agalactiae Species 0.000 abstract description 3
- 238000011161 development Methods 0.000 abstract description 3
- 102000004169 proteins and genes Human genes 0.000 description 686
- 235000018102 proteins Nutrition 0.000 description 681
- 108090000623 proteins and genes Proteins 0.000 description 382
- 108010006533 ATP-Binding Cassette Transporters Proteins 0.000 description 113
- 102000043966 ABC-type transporter activity proteins Human genes 0.000 description 110
- 102000021527 ATP binding proteins Human genes 0.000 description 67
- 108091011108 ATP binding proteins Proteins 0.000 description 67
- 235000001014 amino acid Nutrition 0.000 description 67
- 229940024606 amino acid Drugs 0.000 description 65
- 239000000427 antigen Substances 0.000 description 51
- 108010052285 Membrane Proteins Proteins 0.000 description 50
- 108091007433 antigens Proteins 0.000 description 50
- 102000036639 antigens Human genes 0.000 description 50
- 102000018697 Membrane Proteins Human genes 0.000 description 49
- 230000002103 transcriptional effect Effects 0.000 description 48
- 102000003939 Membrane transport proteins Human genes 0.000 description 38
- 239000002671 adjuvant Substances 0.000 description 38
- 108090000301 Membrane transport proteins Proteins 0.000 description 37
- 230000006870 function Effects 0.000 description 37
- 101100138542 Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) phbH gene Proteins 0.000 description 36
- 101150045242 ptsH gene Proteins 0.000 description 36
- 108050001144 ABC transporter, permeases Proteins 0.000 description 34
- 102000014914 Carrier Proteins Human genes 0.000 description 34
- 108010078791 Carrier Proteins Proteins 0.000 description 30
- 108010020764 Transposases Proteins 0.000 description 28
- 102000008579 Transposases Human genes 0.000 description 28
- 102000004316 Oxidoreductases Human genes 0.000 description 27
- 108090000854 Oxidoreductases Proteins 0.000 description 27
- 230000000295 complement effect Effects 0.000 description 27
- -1 aromatic amino acids Chemical class 0.000 description 26
- 102000005421 acetyltransferase Human genes 0.000 description 25
- 108020002494 acetyltransferase Proteins 0.000 description 25
- 239000013615 primer Substances 0.000 description 25
- 102000035195 Peptidases Human genes 0.000 description 24
- 108091005804 Peptidases Proteins 0.000 description 24
- 230000027455 binding Effects 0.000 description 24
- 108091008324 binding proteins Proteins 0.000 description 23
- 230000001419 dependent effect Effects 0.000 description 23
- 102000004157 Hydrolases Human genes 0.000 description 22
- 108090000604 Hydrolases Proteins 0.000 description 22
- 150000001875 compounds Chemical class 0.000 description 22
- 108020004414 DNA Proteins 0.000 description 20
- 108091061015 GNAT family Proteins 0.000 description 20
- 102000041143 GNAT family Human genes 0.000 description 20
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 20
- 108700023372 Glycosyltransferases Proteins 0.000 description 18
- 108090001030 Lipoproteins Proteins 0.000 description 17
- 102000004895 Lipoproteins Human genes 0.000 description 17
- 229910019142 PO4 Inorganic materials 0.000 description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 16
- 108010072039 Histidine kinase Proteins 0.000 description 16
- 239000010452 phosphate Substances 0.000 description 16
- 230000008569 process Effects 0.000 description 16
- 229930182490 saponin Natural products 0.000 description 16
- 235000017709 saponins Nutrition 0.000 description 16
- 150000007949 saponins Chemical class 0.000 description 16
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 15
- 235000014469 Bacillus subtilis Nutrition 0.000 description 15
- 102000003960 Ligases Human genes 0.000 description 15
- 108090000364 Ligases Proteins 0.000 description 15
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 15
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 15
- 210000004027 cell Anatomy 0.000 description 15
- 238000009472 formulation Methods 0.000 description 14
- 235000021317 phosphate Nutrition 0.000 description 14
- 239000002243 precursor Substances 0.000 description 14
- 235000019833 protease Nutrition 0.000 description 14
- 235000000346 sugar Nutrition 0.000 description 14
- 108010018763 Biotin carboxylase Proteins 0.000 description 13
- 102000051366 Glycosyltransferases Human genes 0.000 description 13
- 108060004795 Methyltransferase Proteins 0.000 description 13
- 108091034117 Oligonucleotide Proteins 0.000 description 13
- 102000002278 Ribosomal Proteins Human genes 0.000 description 13
- 108010000605 Ribosomal Proteins Proteins 0.000 description 13
- 238000009396 hybridization Methods 0.000 description 13
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 13
- 230000004044 response Effects 0.000 description 13
- 230000032258 transport Effects 0.000 description 13
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 12
- 102100034343 Integrase Human genes 0.000 description 12
- 108010061833 Integrases Proteins 0.000 description 12
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 12
- 102000003697 P-type ATPases Human genes 0.000 description 12
- 108090000069 P-type ATPases Proteins 0.000 description 12
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 12
- 210000002421 cell wall Anatomy 0.000 description 12
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 11
- DRHZYJAUECRAJM-DWSYSWFDSA-N (2s,3s,4s,5r,6r)-6-[[(3s,4s,4ar,6ar,6bs,8r,8ar,12as,14ar,14br)-8a-[(2s,3r,4s,5r,6r)-3-[(2s,3r,4s,5r,6s)-5-[(2s,3r,4s,5r)-4-[(2s,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-3,5-dihydroxyoxan-2-yl]oxy-3,4-dihydroxy-6-methyloxan-2-yl]oxy-5-[(3s,5s, Chemical compound O([C@H]1[C@H](O)[C@H](O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O1)O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@H]5CC(C)(C)CC[C@@]5([C@@H](C[C@@]4(C)[C@]3(C)CC[C@H]2[C@@]1(C=O)C)O)C(=O)O[C@@H]1O[C@H](C)[C@@H]([C@@H]([C@H]1O[C@H]1[C@@H]([C@H](O)[C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@](O)(CO)CO3)O)[C@H](O)CO2)O)[C@H](C)O1)O)O)OC(=O)C[C@@H](O)C[C@H](OC(=O)C[C@@H](O)C[C@@H]([C@@H](C)CC)O[C@H]1[C@@H]([C@@H](O)[C@H](CO)O1)O)[C@@H](C)CC)C(O)=O)[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O DRHZYJAUECRAJM-DWSYSWFDSA-N 0.000 description 10
- 108091006112 ATPases Proteins 0.000 description 10
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 description 10
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 description 10
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 10
- 102000004190 Enzymes Human genes 0.000 description 10
- 108090000790 Enzymes Proteins 0.000 description 10
- 102000016397 Methyltransferase Human genes 0.000 description 10
- 102100027330 Phosphoribosylaminoimidazole carboxylase Human genes 0.000 description 10
- 239000004365 Protease Substances 0.000 description 10
- 239000000839 emulsion Substances 0.000 description 10
- 229940088598 enzyme Drugs 0.000 description 10
- 150000004804 polysaccharides Chemical class 0.000 description 10
- 239000000523 sample Substances 0.000 description 10
- 238000003786 synthesis reaction Methods 0.000 description 10
- 101710146995 Acyl carrier protein Proteins 0.000 description 9
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 9
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 9
- 108010081687 Glutamate-cysteine ligase Proteins 0.000 description 9
- 108010052919 Hydroxyethylthiazole kinase Proteins 0.000 description 9
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 9
- 108091028043 Nucleic acid sequence Proteins 0.000 description 9
- 108090000637 alpha-Amylases Proteins 0.000 description 9
- 239000002158 endotoxin Substances 0.000 description 9
- 229920006008 lipopolysaccharide Polymers 0.000 description 9
- 229940035032 monophosphoryl lipid a Drugs 0.000 description 9
- 239000002245 particle Substances 0.000 description 9
- 229920001282 polysaccharide Polymers 0.000 description 9
- 239000005017 polysaccharide Substances 0.000 description 9
- 235000019419 proteases Nutrition 0.000 description 9
- 239000000758 substrate Substances 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 239000013598 vector Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 101710191958 Amino-acid acetyltransferase Proteins 0.000 description 8
- 102100023167 Argininosuccinate lyase Human genes 0.000 description 8
- 108060002716 Exonuclease Proteins 0.000 description 8
- 108091023040 Transcription factor Proteins 0.000 description 8
- 102000040945 Transcription factor Human genes 0.000 description 8
- 239000002775 capsule Substances 0.000 description 8
- 102000013165 exonuclease Human genes 0.000 description 8
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 8
- 230000002163 immunogen Effects 0.000 description 8
- 238000002347 injection Methods 0.000 description 8
- 239000007924 injection Substances 0.000 description 8
- 108010035774 phosphoribosylaminoimidazole carboxylase Proteins 0.000 description 8
- 239000011734 sodium Substances 0.000 description 8
- 239000011701 zinc Substances 0.000 description 8
- 108020004705 Codon Proteins 0.000 description 7
- 108010071146 DNA Polymerase III Proteins 0.000 description 7
- 102000007528 DNA Polymerase III Human genes 0.000 description 7
- 108090000133 DNA helicases Proteins 0.000 description 7
- 102000003844 DNA helicases Human genes 0.000 description 7
- 102000030782 GTP binding Human genes 0.000 description 7
- 108091000058 GTP-Binding Proteins 0.000 description 7
- 108091070975 Group 2 family Proteins 0.000 description 7
- 102000002798 Phenylalanine-tRNA Ligase Human genes 0.000 description 7
- 108010004478 Phenylalanine-tRNA Ligase Proteins 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 241000194017 Streptococcus Species 0.000 description 7
- 102000014701 Transketolase Human genes 0.000 description 7
- 108010043652 Transketolase Proteins 0.000 description 7
- 150000005693 branched-chain amino acids Chemical class 0.000 description 7
- 230000032823 cell division Effects 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- 239000003153 chemical reaction reagent Substances 0.000 description 7
- 101150089678 glnQ gene Proteins 0.000 description 7
- 239000003112 inhibitor Substances 0.000 description 7
- 150000002506 iron compounds Chemical class 0.000 description 7
- 239000012528 membrane Substances 0.000 description 7
- 230000004048 modification Effects 0.000 description 7
- 238000012986 modification Methods 0.000 description 7
- 231100000252 nontoxic Toxicity 0.000 description 7
- 230000003000 nontoxic effect Effects 0.000 description 7
- 150000003839 salts Chemical class 0.000 description 7
- 238000006467 substitution reaction Methods 0.000 description 7
- 230000014616 translation Effects 0.000 description 7
- 102000045406 ABC-type peptide transporter activity proteins Human genes 0.000 description 6
- 108700014215 ABC-type peptide transporter activity proteins Proteins 0.000 description 6
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 6
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 6
- 102100039239 Amidophosphoribosyltransferase Human genes 0.000 description 6
- 108010039224 Amidophosphoribosyltransferase Proteins 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 6
- 102000007132 Carboxyl and Carbamoyl Transferases Human genes 0.000 description 6
- 108010072957 Carboxyl and Carbamoyl Transferases Proteins 0.000 description 6
- 108010054814 DNA Gyrase Proteins 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 102100039696 Glutamate-cysteine ligase catalytic subunit Human genes 0.000 description 6
- 102000000179 Glycosyl transferase, family 8 Human genes 0.000 description 6
- 108050008543 Glycosyl transferase, family 8 Proteins 0.000 description 6
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 description 6
- 108010027436 Hydroxymethylpyrimidine kinase Proteins 0.000 description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 6
- 201000005702 Pertussis Diseases 0.000 description 6
- 108010064209 Phosphoribosylglycinamide formyltransferase Proteins 0.000 description 6
- 102100039654 Phosphoribosylglycinamide formyltransferase Human genes 0.000 description 6
- 102000055027 Protein Methyltransferases Human genes 0.000 description 6
- 108700040121 Protein Methyltransferases Proteins 0.000 description 6
- 101000796819 Pseudomonas putida Glycerol metabolism activator Proteins 0.000 description 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 6
- 108020000772 Ribose-Phosphate Pyrophosphokinase Proteins 0.000 description 6
- 102000000439 Ribose-phosphate pyrophosphokinase Human genes 0.000 description 6
- 108091068521 Sortase family Proteins 0.000 description 6
- 108010085193 UDP-N-acetylglucosamine 1-carboxyvinyltransferase Proteins 0.000 description 6
- 101150008263 accD gene Proteins 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 6
- 239000012472 biological sample Substances 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 6
- 230000003308 immunostimulating effect Effects 0.000 description 6
- 230000036961 partial effect Effects 0.000 description 6
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 6
- 229920000053 polysorbate 80 Polymers 0.000 description 6
- 238000012216 screening Methods 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000004094 surface-active agent Substances 0.000 description 6
- 239000003053 toxin Substances 0.000 description 6
- 231100000765 toxin Toxicity 0.000 description 6
- 108700012359 toxins Proteins 0.000 description 6
- 238000013519 translation Methods 0.000 description 6
- 108091000036 uracil phosphoribosyltransferase Proteins 0.000 description 6
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 5
- 108010002945 Acetoin dehydrogenase Proteins 0.000 description 5
- 101710201712 Amino acid binding protein Proteins 0.000 description 5
- 108050005273 Amino acid transporters Proteins 0.000 description 5
- 101100131847 Bacillus subtilis (strain 168) murAB gene Proteins 0.000 description 5
- 108010029692 Bisphosphoglycerate mutase Proteins 0.000 description 5
- 101710185074 DNA-directed RNA polymerase subunit beta' Proteins 0.000 description 5
- 102100020743 Dipeptidase 1 Human genes 0.000 description 5
- 108010059378 Endopeptidases Proteins 0.000 description 5
- 102000005593 Endopeptidases Human genes 0.000 description 5
- 101001076781 Fructilactobacillus sanfranciscensis (strain ATCC 27651 / DSM 20451 / JCM 5668 / CCUG 30143 / KCTC 3205 / NCIMB 702811 / NRRL B-3934 / L-12) Ribose-5-phosphate isomerase A Proteins 0.000 description 5
- 239000005715 Fructose Substances 0.000 description 5
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 description 5
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 5
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 5
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 5
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 5
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 5
- 108091000080 Phosphotransferase Proteins 0.000 description 5
- 239000005700 Putrescine Substances 0.000 description 5
- 102000046755 Ribokinases Human genes 0.000 description 5
- 108091081024 Start codon Proteins 0.000 description 5
- 101100038645 Streptomyces griseus rppA gene Proteins 0.000 description 5
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 5
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 5
- 101150070497 accC gene Proteins 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 229960003767 alanine Drugs 0.000 description 5
- 150000001720 carbohydrates Chemical class 0.000 description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 5
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 5
- 108010021469 exodeoxyribonuclease VII Proteins 0.000 description 5
- 102000045442 glycosyltransferase activity proteins Human genes 0.000 description 5
- 108700014210 glycosyltransferase activity proteins Proteins 0.000 description 5
- 102000020235 metallo-beta-lactamase Human genes 0.000 description 5
- 108060004734 metallo-beta-lactamase Proteins 0.000 description 5
- 101150025333 murA gene Proteins 0.000 description 5
- 101150089003 murA2 gene Proteins 0.000 description 5
- 210000001322 periplasm Anatomy 0.000 description 5
- 102000020233 phosphotransferase Human genes 0.000 description 5
- 239000013612 plasmid Substances 0.000 description 5
- 108010049718 pseudouridine synthases Proteins 0.000 description 5
- 229940031439 squalene Drugs 0.000 description 5
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 230000035897 transcription Effects 0.000 description 5
- 238000013518 transcription Methods 0.000 description 5
- 108091005703 transmembrane proteins Proteins 0.000 description 5
- 102000035160 transmembrane proteins Human genes 0.000 description 5
- 230000007723 transport mechanism Effects 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 101710187319 33 kDa chaperonin Proteins 0.000 description 4
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 4
- 101710157736 ATP-dependent 6-phosphofructokinase Proteins 0.000 description 4
- 101710200244 ATP-dependent 6-phosphofructokinase isozyme 2 Proteins 0.000 description 4
- 102000034263 Amino acid transporters Human genes 0.000 description 4
- 108010014885 Arginine-tRNA ligase Proteins 0.000 description 4
- 108010077805 Bacterial Proteins Proteins 0.000 description 4
- 102000047411 CBS domains Human genes 0.000 description 4
- 108700037257 CBS domains Proteins 0.000 description 4
- 108010040467 CRISPR-Associated Proteins Proteins 0.000 description 4
- 101710132601 Capsid protein Proteins 0.000 description 4
- 101710113083 Carbamoyl-phosphate synthase Proteins 0.000 description 4
- 108091075974 Cof family Proteins 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 4
- 108090000695 Cytokines Proteins 0.000 description 4
- 108020003338 D-alanine-D-alanine ligase Proteins 0.000 description 4
- 108010041052 DNA Topoisomerase IV Proteins 0.000 description 4
- 230000004568 DNA-binding Effects 0.000 description 4
- 108090000204 Dipeptidase 1 Proteins 0.000 description 4
- 108090000860 Endopeptidase Clp Proteins 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 4
- 108010015895 Glycerone kinase Proteins 0.000 description 4
- 101001037191 Homo sapiens Hyaluronan synthase 1 Proteins 0.000 description 4
- 102100040203 Hyaluronan synthase 1 Human genes 0.000 description 4
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 4
- 108030003782 L-xylulokinases Proteins 0.000 description 4
- 108010090665 Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase Proteins 0.000 description 4
- 201000009906 Meningitis Diseases 0.000 description 4
- 108010063372 N-Glycosyl Hydrolases Proteins 0.000 description 4
- 102000010722 N-Glycosyl Hydrolases Human genes 0.000 description 4
- 102100030397 N-acetylmuramoyl-L-alanine amidase Human genes 0.000 description 4
- 108010081778 N-acylneuraminate cytidylyltransferase Proteins 0.000 description 4
- 101710083586 Oligopeptide transport ATP-binding protein OppF Proteins 0.000 description 4
- 102100036629 Phosphoglucomutase-2 Human genes 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- 101150071963 RBSK gene Proteins 0.000 description 4
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 4
- 108010038105 Ribonucleoside-diphosphate reductase Proteins 0.000 description 4
- 102000028649 Ribonucleoside-diphosphate reductase Human genes 0.000 description 4
- 108010048287 Short Chain Dehydrogenase-Reductases Proteins 0.000 description 4
- 102000009105 Short Chain Dehydrogenase-Reductases Human genes 0.000 description 4
- 108010052160 Site-specific recombinase Proteins 0.000 description 4
- 206010043376 Tetanus Diseases 0.000 description 4
- 108010022394 Threonine synthase Proteins 0.000 description 4
- 102000003929 Transaminases Human genes 0.000 description 4
- 108090000340 Transaminases Proteins 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 4
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 4
- 102000021052 amino acid binding proteins Human genes 0.000 description 4
- 230000003321 amplification Effects 0.000 description 4
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 101150038923 atpF gene Proteins 0.000 description 4
- 101150105110 atpF2 gene Proteins 0.000 description 4
- 101150018639 atpFH gene Proteins 0.000 description 4
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 230000003197 catalytic effect Effects 0.000 description 4
- 230000021615 conjugation Effects 0.000 description 4
- 230000009260 cross reactivity Effects 0.000 description 4
- 108091000099 cysteine desulfurase Proteins 0.000 description 4
- 206010013023 diphtheria Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000007850 fluorescent dye Substances 0.000 description 4
- 101150053745 fruK gene Proteins 0.000 description 4
- 102000034356 gene-regulatory proteins Human genes 0.000 description 4
- 108091006104 gene-regulatory proteins Proteins 0.000 description 4
- 101150032876 glnP gene Proteins 0.000 description 4
- 108010022717 glucosamine-6-phosphate isomerase Proteins 0.000 description 4
- 230000028993 immune response Effects 0.000 description 4
- 230000005847 immunogenicity Effects 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical class O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 4
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- 101150023205 murA1 gene Proteins 0.000 description 4
- 101150019488 nrdI gene Proteins 0.000 description 4
- 238000003199 nucleic acid amplification method Methods 0.000 description 4
- 108010086507 peptide-chain-release factor 3 Proteins 0.000 description 4
- 150000003904 phospholipids Chemical class 0.000 description 4
- 108010001722 phosphopentomutase Proteins 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 108010045801 polysaccharide deacetylase Proteins 0.000 description 4
- 239000002987 primer (paints) Substances 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 101150034471 rbsC gene Proteins 0.000 description 4
- 230000010076 replication Effects 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 4
- 239000000277 virosome Substances 0.000 description 4
- 229910052725 zinc Inorganic materials 0.000 description 4
- 101710142619 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ Proteins 0.000 description 3
- 241000023308 Acca Species 0.000 description 3
- 102000057234 Acyl transferases Human genes 0.000 description 3
- 108700016155 Acyl transferases Proteins 0.000 description 3
- 108020000543 Adenylate kinase Proteins 0.000 description 3
- 102000002281 Adenylate kinase Human genes 0.000 description 3
- 108700023418 Amidases Proteins 0.000 description 3
- 102000002249 Arginine-tRNA Ligase Human genes 0.000 description 3
- KDZOASGQNOPSCU-WDSKDSINSA-N Argininosuccinic acid Chemical compound OC(=O)[C@@H](N)CCC\N=C(/N)N[C@H](C(O)=O)CC(O)=O KDZOASGQNOPSCU-WDSKDSINSA-N 0.000 description 3
- 108010003415 Aspartate Aminotransferases Proteins 0.000 description 3
- 102000004625 Aspartate Aminotransferases Human genes 0.000 description 3
- 101100378010 Bacillus subtilis (strain 168) accC1 gene Proteins 0.000 description 3
- 101100322122 Bacillus subtilis (strain 168) accC2 gene Proteins 0.000 description 3
- 101100424428 Bacillus subtilis (strain 168) tagU gene Proteins 0.000 description 3
- 208000031729 Bacteremia Diseases 0.000 description 3
- 102100021277 Beta-secretase 2 Human genes 0.000 description 3
- 101710150190 Beta-secretase 2 Proteins 0.000 description 3
- 102100039866 CTP synthase 1 Human genes 0.000 description 3
- 108010018956 CTP synthetase Proteins 0.000 description 3
- 108010039939 Cell Wall Skeleton Proteins 0.000 description 3
- 102000011045 Chloride Channels Human genes 0.000 description 3
- 108010062745 Chloride Channels Proteins 0.000 description 3
- 108091026890 Coding region Proteins 0.000 description 3
- 241000689227 Cora <basidiomycete fungus> Species 0.000 description 3
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 description 3
- 102000004403 Cysteine-tRNA ligases Human genes 0.000 description 3
- 108090000918 Cysteine-tRNA ligases Proteins 0.000 description 3
- 108010022613 Cytochrome d Group Proteins 0.000 description 3
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 description 3
- 101150035424 DAK2 gene Proteins 0.000 description 3
- 102000053602 DNA Human genes 0.000 description 3
- 108010092681 DNA Primase Proteins 0.000 description 3
- 102000016559 DNA Primase Human genes 0.000 description 3
- 101710200672 DNA repair protein RadA Proteins 0.000 description 3
- 102000052510 DNA-Binding Proteins Human genes 0.000 description 3
- 101710096438 DNA-binding protein Proteins 0.000 description 3
- 101710088194 Dehydrogenase Proteins 0.000 description 3
- 102000011107 Diacylglycerol Kinase Human genes 0.000 description 3
- 108010062677 Diacylglycerol Kinase Proteins 0.000 description 3
- 102100032823 Dihydroorotate dehydrogenase (quinone), mitochondrial Human genes 0.000 description 3
- 101100019554 Drosophila melanogaster Adk2 gene Proteins 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 3
- 229930091371 Fructose Natural products 0.000 description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 3
- 102100041034 Glucosamine-6-phosphate isomerase 1 Human genes 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 102000004263 Glutamate-Cysteine Ligase Human genes 0.000 description 3
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 3
- 101150037156 HAM1 gene Proteins 0.000 description 3
- 102000010437 HD domains Human genes 0.000 description 3
- 108050001906 HD domains Proteins 0.000 description 3
- 102000018932 HSP70 Heat-Shock Proteins Human genes 0.000 description 3
- 108010027992 HSP70 Heat-Shock Proteins Proteins 0.000 description 3
- 101001052021 Haemophilus phage HP1 (strain HP1c1) Probable tail fiber protein Proteins 0.000 description 3
- 101001017254 Homo sapiens Myb-binding protein 1A Proteins 0.000 description 3
- 101000582992 Homo sapiens Phospholipid phosphatase-related protein type 5 Proteins 0.000 description 3
- 108010072462 Hydroxymethyl and Formyl Transferases Proteins 0.000 description 3
- 102000006933 Hydroxymethyl and Formyl Transferases Human genes 0.000 description 3
- 102000029793 Isoleucine-tRNA ligase Human genes 0.000 description 3
- 101710176147 Isoleucine-tRNA ligase, cytoplasmic Proteins 0.000 description 3
- 102000004195 Isomerases Human genes 0.000 description 3
- 108090000769 Isomerases Proteins 0.000 description 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 3
- 101710159527 Maturation protein A Proteins 0.000 description 3
- 101710091157 Maturation protein A2 Proteins 0.000 description 3
- 101100045395 Mus musculus Tap1 gene Proteins 0.000 description 3
- 102100034005 Myb-binding protein 1A Human genes 0.000 description 3
- 101710163270 Nuclease Proteins 0.000 description 3
- 108010038807 Oligopeptides Proteins 0.000 description 3
- 102000015636 Oligopeptides Human genes 0.000 description 3
- 102000011025 Phosphoglycerate Mutase Human genes 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- 101710149031 Probable isoleucine-tRNA ligase, cytoplasmic Proteins 0.000 description 3
- 102100026126 Proline-tRNA ligase Human genes 0.000 description 3
- 102000001253 Protein Kinase Human genes 0.000 description 3
- 108010076504 Protein Sorting Signals Proteins 0.000 description 3
- 101000802260 Pseudomonas phage D3112 Anti-CRISPR protein 31 Proteins 0.000 description 3
- 101710135670 Putative Xaa-Pro dipeptidyl-peptidase Proteins 0.000 description 3
- 101710127274 Putative tail protein Proteins 0.000 description 3
- 101710181816 Pyruvate-formate-lyase deactivase Proteins 0.000 description 3
- 108010003817 RNA polymerase omega subunit Proteins 0.000 description 3
- 101710176131 Ribosomal protein L11 methyltransferase Proteins 0.000 description 3
- 102000030899 Serine-Type D-Ala-D-Ala Carboxypeptidase Human genes 0.000 description 3
- 108010004832 Serine-Type D-Ala-D-Ala Carboxypeptidase Proteins 0.000 description 3
- 108010030161 Serine-tRNA ligase Proteins 0.000 description 3
- 102100040516 Serine-tRNA ligase, cytoplasmic Human genes 0.000 description 3
- 108020004682 Single-Stranded DNA Proteins 0.000 description 3
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 3
- 229930182558 Sterol Natural products 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 102000003673 Symporters Human genes 0.000 description 3
- 108090000088 Symporters Proteins 0.000 description 3
- 101150024271 TKT gene Proteins 0.000 description 3
- 101710151026 Transcriptional repressor CopY Proteins 0.000 description 3
- 108020004566 Transfer RNA Proteins 0.000 description 3
- 102000004357 Transferases Human genes 0.000 description 3
- 108090000992 Transferases Proteins 0.000 description 3
- VQQVWGVXDIPORV-UHFFFAOYSA-N Tryptanthrine Natural products C1=CC=C2C(=O)N3C4=CC=CC=C4C(=O)C3=NC2=C1 VQQVWGVXDIPORV-UHFFFAOYSA-N 0.000 description 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 3
- 108010074827 UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Proteins 0.000 description 3
- 101710159648 Uncharacterized protein Proteins 0.000 description 3
- 101710143531 Xaa-Pro dipeptidyl-peptidase Proteins 0.000 description 3
- JBGSPJNXVJCLOQ-HJZCUYRDSA-N [(2-amino-2-oxoethyl)-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonyl]amino]phosphonic acid Chemical compound NC(=O)CN(P(O)(O)=O)C(=O)C1O[C@H](CO)[C@@H](O)[C@H]1O JBGSPJNXVJCLOQ-HJZCUYRDSA-N 0.000 description 3
- 235000004279 alanine Nutrition 0.000 description 3
- 150000001323 aldoses Chemical class 0.000 description 3
- 102000004139 alpha-Amylases Human genes 0.000 description 3
- 229940024171 alpha-amylase Drugs 0.000 description 3
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 3
- 102000005922 amidase Human genes 0.000 description 3
- 101150099875 atpE gene Proteins 0.000 description 3
- 210000004899 c-terminal region Anatomy 0.000 description 3
- 238000004113 cell culture Methods 0.000 description 3
- 210000004520 cell wall skeleton Anatomy 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 238000010367 cloning Methods 0.000 description 3
- 239000002299 complementary DNA Substances 0.000 description 3
- 238000012217 deletion Methods 0.000 description 3
- 230000037430 deletion Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 101150084167 fabZ gene Proteins 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 235000013922 glutamic acid Nutrition 0.000 description 3
- 239000004220 glutamic acid Substances 0.000 description 3
- 108010015320 glutamyl-tRNA(Gln) amidotransferase Proteins 0.000 description 3
- 230000013595 glycosylation Effects 0.000 description 3
- 238000006206 glycosylation reaction Methods 0.000 description 3
- 229940029575 guanosine Drugs 0.000 description 3
- 230000003053 immunization Effects 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 230000002458 infectious effect Effects 0.000 description 3
- 206010022000 influenza Diseases 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 229910052742 iron Inorganic materials 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 239000002502 liposome Substances 0.000 description 3
- 101150038424 lytR gene Proteins 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229930182817 methionine Natural products 0.000 description 3
- 238000002493 microarray Methods 0.000 description 3
- JMUHBNWAORSSBD-WKYWBUFDSA-N mifamurtide Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCC)COP(O)(=O)OCCNC(=O)[C@H](C)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O JMUHBNWAORSSBD-WKYWBUFDSA-N 0.000 description 3
- 229960005225 mifamurtide Drugs 0.000 description 3
- 125000001446 muramyl group Chemical group N[C@@H](C=O)[C@@H](O[C@@H](C(=O)*)C)[C@H](O)[C@H](O)CO 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 108010071189 phosphoenolpyruvate-glucose phosphotransferase Proteins 0.000 description 3
- 108010004621 phosphoketolase Proteins 0.000 description 3
- 108010006451 phosphomethylpyrimidine kinase Proteins 0.000 description 3
- 229920000056 polyoxyethylene ether Polymers 0.000 description 3
- 229920000136 polysorbate Polymers 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000000069 prophylactic effect Effects 0.000 description 3
- 101150112050 pstB gene Proteins 0.000 description 3
- 101150013628 pstB1 gene Proteins 0.000 description 3
- 101150070239 pstB2 gene Proteins 0.000 description 3
- 210000004270 pstb Anatomy 0.000 description 3
- 101150056177 purM gene Proteins 0.000 description 3
- 101150112726 purN gene Proteins 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 3
- 235000003702 sterols Nutrition 0.000 description 3
- 230000004936 stimulating effect Effects 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 101150074714 thiD gene Proteins 0.000 description 3
- 108060008226 thioredoxin Proteins 0.000 description 3
- 101150014795 tktA gene Proteins 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 108091008023 transcriptional regulators Proteins 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 108010087967 type I signal peptidase Proteins 0.000 description 3
- 229940045145 uridine Drugs 0.000 description 3
- 101150018396 ychF gene Proteins 0.000 description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- 108010023317 1-phosphofructokinase Proteins 0.000 description 2
- 108020004465 16S ribosomal RNA Proteins 0.000 description 2
- MXHRCPNRJAMMIM-SHYZEUOFSA-N 2'-deoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-SHYZEUOFSA-N 0.000 description 2
- 108010065780 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Proteins 0.000 description 2
- 108010024807 2-keto-3-deoxygluconokinase Proteins 0.000 description 2
- 108010038550 3-dehydroquinate dehydratase Proteins 0.000 description 2
- 101710168866 3-oxoacyl-[acyl-carrier-protein] synthase 3 Proteins 0.000 description 2
- 108050001922 30S ribosomal protein S17 Proteins 0.000 description 2
- 102100033051 40S ribosomal protein S19 Human genes 0.000 description 2
- 102100033409 40S ribosomal protein S3 Human genes 0.000 description 2
- 102100037663 40S ribosomal protein S8 Human genes 0.000 description 2
- 102100024406 60S ribosomal protein L15 Human genes 0.000 description 2
- 102100023990 60S ribosomal protein L17 Human genes 0.000 description 2
- 102100037685 60S ribosomal protein L22 Human genes 0.000 description 2
- 101710187788 60S ribosomal protein L22 Proteins 0.000 description 2
- 102100021308 60S ribosomal protein L23 Human genes 0.000 description 2
- 102100035322 60S ribosomal protein L24 Human genes 0.000 description 2
- 102100021671 60S ribosomal protein L29 Human genes 0.000 description 2
- 102100038237 60S ribosomal protein L30 Human genes 0.000 description 2
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- 102000048456 Acyl carrier protein (ACP) Human genes 0.000 description 2
- 108700037654 Acyl carrier protein (ACP) Proteins 0.000 description 2
- 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 description 2
- 102000055161 Adenylosuccinate lyases Human genes 0.000 description 2
- 102000005602 Aldo-Keto Reductases Human genes 0.000 description 2
- 108010084469 Aldo-Keto Reductases Proteins 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 2
- 102100020999 Argininosuccinate synthase Human genes 0.000 description 2
- 101710114114 Argininosuccinate synthase, chloroplastic Proteins 0.000 description 2
- 108010055400 Aspartate kinase Proteins 0.000 description 2
- 101001006364 Bacillus cereus Hemolysin-3 Proteins 0.000 description 2
- 101100381860 Bacillus subtilis (strain 168) bmr gene Proteins 0.000 description 2
- 101100417074 Bacillus subtilis (strain 168) rocE gene Proteins 0.000 description 2
- 101100362510 Bacillus subtilis (strain 168) rpsN1 gene Proteins 0.000 description 2
- 101100368724 Bacillus subtilis (strain 168) tagE gene Proteins 0.000 description 2
- 101100376289 Bacillus subtilis (strain 168) yhfF gene Proteins 0.000 description 2
- 101100267522 Bacillus subtilis (strain 168) ylmH gene Proteins 0.000 description 2
- 101100096227 Bacteroides fragilis (strain 638R) argF' gene Proteins 0.000 description 2
- 108091067161 BioY family Proteins 0.000 description 2
- 102000016084 Biotin-acetyl-CoA-carboxylase ligases Human genes 0.000 description 2
- 108050004505 Biotin-acetyl-CoA-carboxylase ligases Proteins 0.000 description 2
- 241000588832 Bordetella pertussis Species 0.000 description 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 description 2
- 108010059574 C5a peptidase Proteins 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 108020004827 Carbamate kinase Proteins 0.000 description 2
- 102000003846 Carbonic anhydrases Human genes 0.000 description 2
- 108090000209 Carbonic anhydrases Proteins 0.000 description 2
- 108090000994 Catalytic RNA Proteins 0.000 description 2
- 102000053642 Catalytic RNA Human genes 0.000 description 2
- 101710163595 Chaperone protein DnaK Proteins 0.000 description 2
- 101000709520 Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B) Atypical response regulator protein ChxR Proteins 0.000 description 2
- 101710104108 CinA-like protein Proteins 0.000 description 2
- 241000193401 Clostridium acetobutylicum Species 0.000 description 2
- 101100423897 Clostridium perfringens (strain 13 / Type A) glnS gene Proteins 0.000 description 2
- 101100039285 Clostridium perfringens (strain 13 / Type A) rpsM gene Proteins 0.000 description 2
- 101100538459 Clostridium perfringens (strain 13 / Type A) truA1 gene Proteins 0.000 description 2
- 101100100749 Clostridium perfringens (strain 13 / Type A) truA2 gene Proteins 0.000 description 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 2
- 101710116957 D-alanyl-D-alanine carboxypeptidase Proteins 0.000 description 2
- 101710105693 D-alanyl-D-alanine carboxypeptidase DacA Proteins 0.000 description 2
- 101710105699 D-alanyl-D-alanine carboxypeptidase DacB Proteins 0.000 description 2
- 101710105661 D-alanyl-D-alanine carboxypeptidase DacC Proteins 0.000 description 2
- 101710105697 D-alanyl-D-alanine carboxypeptidase DacD Proteins 0.000 description 2
- 101710201881 D-alanyl-D-alanine-carboxypeptidase/endopeptidase AmpH Proteins 0.000 description 2
- 150000008574 D-amino acids Chemical class 0.000 description 2
- 102000038880 D-isomer specific 2-hydroxyacid dehydrogenase family Human genes 0.000 description 2
- 108091065033 D-isomer specific 2-hydroxyacid dehydrogenase family Proteins 0.000 description 2
- 108010001539 D-lactate dehydrogenase Proteins 0.000 description 2
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 2
- 101710127865 DNA translocase FtsK Proteins 0.000 description 2
- 101710161637 DNA-entry nuclease Proteins 0.000 description 2
- 101100410642 Dictyostelium discoideum purC/E gene Proteins 0.000 description 2
- 102100023319 Dihydrolipoyl dehydrogenase, mitochondrial Human genes 0.000 description 2
- 108010073112 Dihydrolipoyllysine-residue acetyltransferase Proteins 0.000 description 2
- 102000009093 Dihydrolipoyllysine-residue acetyltransferase Human genes 0.000 description 2
- 108091000126 Dihydroorotase Proteins 0.000 description 2
- 101710099431 Dimethyladenosine transferase Proteins 0.000 description 2
- 102000004860 Dipeptidases Human genes 0.000 description 2
- 108090001081 Dipeptidases Proteins 0.000 description 2
- 102100024101 DnaJ homolog subfamily C member 28 Human genes 0.000 description 2
- 101001094206 Escherichia coli (strain K12) Ribosomal RNA small subunit methyltransferase A Proteins 0.000 description 2
- 101100108235 Escherichia coli (strain K12) adhP gene Proteins 0.000 description 2
- 101100454047 Escherichia coli (strain K12) prkB gene Proteins 0.000 description 2
- 101100536194 Escherichia coli prrB gene Proteins 0.000 description 2
- 108010067157 Ferrichrome Proteins 0.000 description 2
- MBMLMWLHJBBADN-UHFFFAOYSA-N Ferrous sulfide Chemical compound [Fe]=S MBMLMWLHJBBADN-UHFFFAOYSA-N 0.000 description 2
- 101710154643 Filamentous hemagglutinin Proteins 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- 108090000926 GMP synthase (glutamine-hydrolyzing) Proteins 0.000 description 2
- 102100033452 GMP synthase [glutamine-hydrolyzing] Human genes 0.000 description 2
- 102000013446 GTP Phosphohydrolases Human genes 0.000 description 2
- 108010021555 GTP Pyrophosphokinase Proteins 0.000 description 2
- 108091006109 GTPases Proteins 0.000 description 2
- 101100089871 Geobacillus stearothermophilus rpmGA gene Proteins 0.000 description 2
- 108010060309 Glucuronidase Proteins 0.000 description 2
- 102000053187 Glucuronidase Human genes 0.000 description 2
- 102000005133 Glutamate 5-kinase Human genes 0.000 description 2
- 108010015514 Glutamate-tRNA ligase Proteins 0.000 description 2
- 101710155576 Glutamyl-tRNA(Gln) amidotransferase subunit A Proteins 0.000 description 2
- 102000005720 Glutathione transferase Human genes 0.000 description 2
- 108010070675 Glutathione transferase Proteins 0.000 description 2
- 108010035824 Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) Proteins 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- 108010051724 Glycine-tRNA Ligase Proteins 0.000 description 2
- 108010001483 Glycogen Synthase Proteins 0.000 description 2
- 102000019220 Glycyl-tRNA synthetases Human genes 0.000 description 2
- 108091070965 Group 1 family Proteins 0.000 description 2
- 102100023737 GrpE protein homolog 1, mitochondrial Human genes 0.000 description 2
- 108091071273 GtrA family Proteins 0.000 description 2
- 108020004202 Guanylate Kinase Proteins 0.000 description 2
- 108060003803 HSP33 Proteins 0.000 description 2
- 108010042283 HSP40 Heat-Shock Proteins Proteins 0.000 description 2
- 102000004447 HSP40 Heat-Shock Proteins Human genes 0.000 description 2
- 101100275987 Halothiobacillus neapolitanus (strain ATCC 23641 / c2) csoS4B gene Proteins 0.000 description 2
- 101710116987 Heat shock protein 60, mitochondrial Proteins 0.000 description 2
- 241000700721 Hepatitis B virus Species 0.000 description 2
- 108010014594 Heterogeneous Nuclear Ribonucleoprotein A1 Proteins 0.000 description 2
- 102100035621 Heterogeneous nuclear ribonucleoprotein A1 Human genes 0.000 description 2
- 101710138789 Holo-[acyl-carrier-protein] synthase Proteins 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 101001053999 Homo sapiens DnaJ homolog subfamily C member 28 Proteins 0.000 description 2
- 101000829489 Homo sapiens GrpE protein homolog 1, mitochondrial Proteins 0.000 description 2
- 101001138523 Homo sapiens Inosine 5'-monophosphate cyclohydrolase Proteins 0.000 description 2
- 101001131930 Homo sapiens Transcriptional activator protein Pur-beta Proteins 0.000 description 2
- 108010020869 Homocysteine S-Methyltransferase Proteins 0.000 description 2
- 102000004867 Hydro-Lyases Human genes 0.000 description 2
- 108090001042 Hydro-Lyases Proteins 0.000 description 2
- 108010091358 Hypoxanthine Phosphoribosyltransferase Proteins 0.000 description 2
- 102000018251 Hypoxanthine Phosphoribosyltransferase Human genes 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 206010061598 Immunodeficiency Diseases 0.000 description 2
- 229930010555 Inosine Natural products 0.000 description 2
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 2
- 102100020796 Inosine 5'-monophosphate cyclohydrolase Human genes 0.000 description 2
- 102000005298 Iron-Sulfur Proteins Human genes 0.000 description 2
- 108010081409 Iron-Sulfur Proteins Proteins 0.000 description 2
- 102100026384 L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Human genes 0.000 description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 102100026004 Lactoylglutathione lyase Human genes 0.000 description 2
- 108010050765 Lactoylglutathione lyase Proteins 0.000 description 2
- 101100508198 Leptospira borgpetersenii serovar Hardjo-bovis (strain L550) infA2 gene Proteins 0.000 description 2
- 101100419195 Leptospira borgpetersenii serovar Hardjo-bovis (strain L550) rpsC2 gene Proteins 0.000 description 2
- 101100363550 Leptospira borgpetersenii serovar Hardjo-bovis (strain L550) rpsE2 gene Proteins 0.000 description 2
- 101100529965 Leptospira borgpetersenii serovar Hardjo-bovis (strain L550) rpsK2 gene Proteins 0.000 description 2
- 101000741397 Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130) Cyclic adenylate deaminase Proteins 0.000 description 2
- 102000004317 Lyases Human genes 0.000 description 2
- 108090000856 Lyases Proteins 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 description 2
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
- 108010058398 Macrophage Colony-Stimulating Factor Receptor Proteins 0.000 description 2
- 108091006978 Magnesium transporters Proteins 0.000 description 2
- 102100027329 Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Human genes 0.000 description 2
- 102000005741 Metalloproteases Human genes 0.000 description 2
- 108010006035 Metalloproteases Proteins 0.000 description 2
- 101100303649 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) rpl24 gene Proteins 0.000 description 2
- 101100200099 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) rps13 gene Proteins 0.000 description 2
- 101100253802 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) rps14 gene Proteins 0.000 description 2
- 101100254826 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) rps5 gene Proteins 0.000 description 2
- 108010003060 Methionine-tRNA ligase Proteins 0.000 description 2
- 102000000362 Methionyl-tRNA synthetases Human genes 0.000 description 2
- 108050005144 Multidrug resistance proteins Proteins 0.000 description 2
- 102000014842 Multidrug resistance proteins Human genes 0.000 description 2
- 101100354186 Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154) ptcA gene Proteins 0.000 description 2
- 101100304326 Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154) rpmG2 gene Proteins 0.000 description 2
- 108700023220 N-acetylneuraminate lyases Proteins 0.000 description 2
- 102000048245 N-acetylneuraminate lyases Human genes 0.000 description 2
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 2
- 125000000729 N-terminal amino-acid group Chemical group 0.000 description 2
- 108010007843 NADH oxidase Proteins 0.000 description 2
- 102000040845 NRAMP family Human genes 0.000 description 2
- 108091071790 NRAMP family Proteins 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 102000041619 NifU family Human genes 0.000 description 2
- 108091075079 NifU family Proteins 0.000 description 2
- 102000004459 Nitroreductase Human genes 0.000 description 2
- 241001195348 Nusa Species 0.000 description 2
- 108010000240 O-sialoglycoprotein endopeptidase Proteins 0.000 description 2
- 102000007981 Ornithine carbamoyltransferase Human genes 0.000 description 2
- 101710113020 Ornithine transcarbamylase, mitochondrial Proteins 0.000 description 2
- 108010055012 Orotidine-5'-phosphate decarboxylase Proteins 0.000 description 2
- 101710169713 PTS system fructose-specific EIIA component Proteins 0.000 description 2
- 108010021592 Pantothenate kinase Proteins 0.000 description 2
- 101710096750 Penicillin-binding protein 2B Proteins 0.000 description 2
- 101710202686 Penicillin-sensitive transpeptidase Proteins 0.000 description 2
- 102000010562 Peptide Elongation Factor G Human genes 0.000 description 2
- 108010077742 Peptide Elongation Factor G Proteins 0.000 description 2
- 102000005877 Peptide Initiation Factors Human genes 0.000 description 2
- 108010044843 Peptide Initiation Factors Proteins 0.000 description 2
- 108010026809 Peptide deformylase Proteins 0.000 description 2
- 108091093037 Peptide nucleic acid Proteins 0.000 description 2
- 101710163518 Phosphate import ATP-binding protein PstB 1 Proteins 0.000 description 2
- 102000006335 Phosphate-Binding Proteins Human genes 0.000 description 2
- 108010058514 Phosphate-Binding Proteins Proteins 0.000 description 2
- 102000009569 Phosphoglucomutase Human genes 0.000 description 2
- 108090000434 Phosphoribosylaminoimidazolesuccinocarboxamide synthases Proteins 0.000 description 2
- 102000001458 Polyprenyl synthetases Human genes 0.000 description 2
- 108050009666 Polyprenyl synthetases Proteins 0.000 description 2
- 101710101148 Probable 6-oxopurine nucleoside phosphorylase Proteins 0.000 description 2
- 101710130262 Probable Vpr-like protein Proteins 0.000 description 2
- 102100037775 Probable tRNA N6-adenosine threonylcarbamoyltransferase Human genes 0.000 description 2
- 102100034014 Prolyl 3-hydroxylase 3 Human genes 0.000 description 2
- 102000030764 Purine-nucleoside phosphorylase Human genes 0.000 description 2
- 101710126942 Putative D-alanyl-D-alanine carboxypeptidase Proteins 0.000 description 2
- 101710148009 Putative uracil phosphoribosyltransferase Proteins 0.000 description 2
- 102000039009 ROK family Human genes 0.000 description 2
- 108091063673 ROK family Proteins 0.000 description 2
- 102000004879 Racemases and epimerases Human genes 0.000 description 2
- 108090001066 Racemases and epimerases Proteins 0.000 description 2
- 102000016812 Radical SAM Human genes 0.000 description 2
- 108050006523 Radical SAM Proteins 0.000 description 2
- 101100273253 Rhizopus niveus RNAP gene Proteins 0.000 description 2
- 101710185843 Ribonuclease Z Proteins 0.000 description 2
- 102000004285 Ribosomal Protein L3 Human genes 0.000 description 2
- 108090000894 Ribosomal Protein L3 Proteins 0.000 description 2
- 102000004191 Ribosomal protein L1 Human genes 0.000 description 2
- 108090000792 Ribosomal protein L1 Proteins 0.000 description 2
- 102000004387 Ribosomal protein L14 Human genes 0.000 description 2
- 108090000985 Ribosomal protein L14 Proteins 0.000 description 2
- 108090000983 Ribosomal protein L15 Proteins 0.000 description 2
- 102000003926 Ribosomal protein L18 Human genes 0.000 description 2
- 108090000343 Ribosomal protein L18 Proteins 0.000 description 2
- 102000004208 Ribosomal protein L2 Human genes 0.000 description 2
- 108090000775 Ribosomal protein L2 Proteins 0.000 description 2
- 108050001924 Ribosomal protein L23 Proteins 0.000 description 2
- 101150034081 Rpl18 gene Proteins 0.000 description 2
- 241000219287 Saponaria Species 0.000 description 2
- 108091003202 SecA Proteins Proteins 0.000 description 2
- 102100022513 Selenocysteine lyase Human genes 0.000 description 2
- 101710090481 Sensor protein LytS Proteins 0.000 description 2
- LDEBVRIURYMKQS-WISUUJSJSA-N Ser-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@@H](N)CO LDEBVRIURYMKQS-WISUUJSJSA-N 0.000 description 2
- 102000012479 Serine Proteases Human genes 0.000 description 2
- 108010022999 Serine Proteases Proteins 0.000 description 2
- 102100035717 Serine racemase Human genes 0.000 description 2
- 108010006152 Serine racemase Proteins 0.000 description 2
- 101710084578 Short neurotoxin 1 Proteins 0.000 description 2
- 101710165315 Sialidase A Proteins 0.000 description 2
- 102000008063 Small Heat-Shock Proteins Human genes 0.000 description 2
- 108010088928 Small Heat-Shock Proteins Proteins 0.000 description 2
- 241000191940 Staphylococcus Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 101100056029 Staphylococcus aureus (strain NCTC 8325 / PS 47) arcC2 gene Proteins 0.000 description 2
- 101000719822 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) ATP-dependent helicase/nuclease subunit A Proteins 0.000 description 2
- 101100406376 Streptomyces antibioticus orfB gene Proteins 0.000 description 2
- 101100297542 Streptomyces viridochromogenes (strain DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494) phpC gene Proteins 0.000 description 2
- 101710172711 Structural protein Proteins 0.000 description 2
- 101710193546 Tegument protein VP16 homolog Proteins 0.000 description 2
- 102000002933 Thioredoxin Human genes 0.000 description 2
- 102000013090 Thioredoxin-Disulfide Reductase Human genes 0.000 description 2
- 108010079911 Thioredoxin-disulfide reductase Proteins 0.000 description 2
- 239000004473 Threonine Substances 0.000 description 2
- 102000006843 Threonine synthase Human genes 0.000 description 2
- 101710182532 Toxin a Proteins 0.000 description 2
- 108020004530 Transaldolase Proteins 0.000 description 2
- 102100028601 Transaldolase Human genes 0.000 description 2
- 101710198305 Translation initiation factor IF-1 Proteins 0.000 description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 2
- 108010063272 UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase Proteins 0.000 description 2
- 102100021436 UDP-glucose 4-epimerase Human genes 0.000 description 2
- 108010075202 UDP-glucose 4-epimerase Proteins 0.000 description 2
- 108700024326 Undecaprenol kinases Proteins 0.000 description 2
- 102000006943 Uracil-DNA Glycosidase Human genes 0.000 description 2
- 108010072685 Uracil-DNA Glycosidase Proteins 0.000 description 2
- 102000007410 Uridine kinase Human genes 0.000 description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
- 108010067390 Viral Proteins Proteins 0.000 description 2
- 101710097809 Zinc-binding protein AdcA Proteins 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
- HXXFSFRBOHSIMQ-VFUOTHLCSA-N alpha-D-glucose 1-phosphate Chemical compound OC[C@H]1O[C@H](OP(O)(O)=O)[C@H](O)[C@@H](O)[C@@H]1O HXXFSFRBOHSIMQ-VFUOTHLCSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
- 108010073901 aminoacyl-tRNA hydrolase Proteins 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000000692 anti-sense effect Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 101150089779 arcC gene Proteins 0.000 description 2
- 101150089858 arcC1 gene Proteins 0.000 description 2
- 101150056313 argF gene Proteins 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 101150026213 atpB gene Proteins 0.000 description 2
- 101150035600 atpD gene Proteins 0.000 description 2
- 101150103189 atpG gene Proteins 0.000 description 2
- 101150048329 atpH gene Proteins 0.000 description 2
- 230000001588 bifunctional effect Effects 0.000 description 2
- 239000000227 bioadhesive Substances 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000006664 bond formation reaction Methods 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 210000000349 chromosome Anatomy 0.000 description 2
- 101150096566 clpX gene Proteins 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 101150085662 cydA gene Proteins 0.000 description 2
- 101150011637 cysS gene Proteins 0.000 description 2
- 235000018417 cysteine Nutrition 0.000 description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
- 102000030626 cysteine desulfurase Human genes 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- MXHRCPNRJAMMIM-UHFFFAOYSA-N desoxyuridine Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-UHFFFAOYSA-N 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 229960003983 diphtheria toxoid Drugs 0.000 description 2
- 101150008507 dnaE gene Proteins 0.000 description 2
- 101150104165 dnaN gene Proteins 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 101150089204 easF gene Proteins 0.000 description 2
- 239000012636 effector Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 101150090981 fabG gene Proteins 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical group 0.000 description 2
- GGUNGDGGXMHBMJ-UHFFFAOYSA-N ferrichrome Chemical compound [Fe+3].CC(=O)N([O-])CCCC1NC(=O)CNC(=O)CNC(=O)CNC(=O)C(CCCN([O-])C(C)=O)NC(=O)C(CCCN([O-])C(C)=O)NC1=O GGUNGDGGXMHBMJ-UHFFFAOYSA-N 0.000 description 2
- 108010008221 formate C-acetyltransferase Proteins 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 101150117187 glmS gene Proteins 0.000 description 2
- 101150103988 gltX gene Proteins 0.000 description 2
- 229950010772 glucose-1-phosphate Drugs 0.000 description 2
- 101150071168 glyQS gene Proteins 0.000 description 2
- 229930182470 glycoside Natural products 0.000 description 2
- 101150053330 grpE gene Proteins 0.000 description 2
- 108010029040 guanosine 3',5'-polyphosphate synthetases Proteins 0.000 description 2
- 102000006638 guanylate kinase Human genes 0.000 description 2
- 229930186900 holotoxin Natural products 0.000 description 2
- 101150114144 hrcA gene Proteins 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 101150071451 infA gene Proteins 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229960003786 inosine Drugs 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 101150002823 lepB gene Proteins 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000006193 liquid solution Substances 0.000 description 2
- 101150035025 lysC gene Proteins 0.000 description 2
- 101150068528 mabA gene Proteins 0.000 description 2
- 101150088678 manB gene Proteins 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
- 229910052753 mercury Inorganic materials 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- FPBHSTHTCPCNBS-QXMYDWGFSA-N methyl N-[(E)-5-[4-hydroxy-5-[(2E,4E,9E,12E)-8-hydroxy-2,5,9-trimethyltetradeca-2,4,9,12-tetraenoyl]-6-oxopyran-2-yl]hex-1-enyl]carbamate Chemical compound COC(=O)N\C=C\CCC(C)C1=CC(O)=C(C(=O)C(\C)=C\C=C(/C)CCC(O)C(\C)=C\C\C=C\C)C(=O)O1 FPBHSTHTCPCNBS-QXMYDWGFSA-N 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 239000011859 microparticle Substances 0.000 description 2
- 101150055009 mnmE gene Proteins 0.000 description 2
- 102000035118 modified proteins Human genes 0.000 description 2
- 108091005573 modified proteins Proteins 0.000 description 2
- 230000003232 mucoadhesive effect Effects 0.000 description 2
- 239000003471 mutagenic agent Substances 0.000 description 2
- 108020001162 nitroreductase Proteins 0.000 description 2
- 229940066429 octoxynol Drugs 0.000 description 2
- 229920002113 octoxynol Polymers 0.000 description 2
- 229920001542 oligosaccharide Polymers 0.000 description 2
- 150000002482 oligosaccharides Chemical class 0.000 description 2
- UNEIHNMKASENIG-UHFFFAOYSA-N para-chlorophenylpiperazine Chemical compound C1=CC(Cl)=CC=C1N1CCNCC1 UNEIHNMKASENIG-UHFFFAOYSA-N 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 2
- 108700010839 phage proteins Proteins 0.000 description 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
- 101150061261 phoU gene Proteins 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 108091000115 phosphomannomutase Proteins 0.000 description 2
- 108010034343 phosphoribosylamine-glycine ligase Proteins 0.000 description 2
- 102000030592 phosphoserine aminotransferase Human genes 0.000 description 2
- 108010088694 phosphoserine aminotransferase Proteins 0.000 description 2
- DCWXELXMIBXGTH-UHFFFAOYSA-N phosphotyrosine Chemical compound OC(=O)C(N)CC1=CC=C(OP(O)(O)=O)C=C1 DCWXELXMIBXGTH-UHFFFAOYSA-N 0.000 description 2
- 101150052371 plsX gene Proteins 0.000 description 2
- 101150023641 ppc gene Proteins 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 108060006633 protein kinase Proteins 0.000 description 2
- 101150108007 prs gene Proteins 0.000 description 2
- 101150086435 prs1 gene Proteins 0.000 description 2
- 101150070305 prsA gene Proteins 0.000 description 2
- 101150049824 pstA gene Proteins 0.000 description 2
- 101150055035 pstC gene Proteins 0.000 description 2
- 101150033391 pstC1 gene Proteins 0.000 description 2
- 210000004196 psta Anatomy 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 101150028995 purC gene Proteins 0.000 description 2
- 101150105087 purC1 gene Proteins 0.000 description 2
- 101150084005 purD gene Proteins 0.000 description 2
- 101150103875 purH gene Proteins 0.000 description 2
- 239000002510 pyrogen Substances 0.000 description 2
- 108010060146 pyruvate formate-lyase activating enzyme Proteins 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 238000003127 radioimmunoassay Methods 0.000 description 2
- 101150014443 rarD gene Proteins 0.000 description 2
- 101150092209 rbsB gene Proteins 0.000 description 2
- 101150113457 rbsD gene Proteins 0.000 description 2
- 101150079601 recA gene Proteins 0.000 description 2
- 101150027417 recU gene Proteins 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 238000003259 recombinant expression Methods 0.000 description 2
- 101150034434 repE gene Proteins 0.000 description 2
- 108091008146 restriction endonucleases Proteins 0.000 description 2
- 101150051820 ribH gene Proteins 0.000 description 2
- 101150088248 ribH1 gene Proteins 0.000 description 2
- 235000019192 riboflavin Nutrition 0.000 description 2
- 229960002477 riboflavin Drugs 0.000 description 2
- 239000002151 riboflavin Substances 0.000 description 2
- 108010025591 ribosomal protein L16 Proteins 0.000 description 2
- 108010025578 ribosomal protein L17 Proteins 0.000 description 2
- 108010025463 ribosomal protein L24 Proteins 0.000 description 2
- 108010025498 ribosomal protein L29 Proteins 0.000 description 2
- 108010025327 ribosomal protein L30 Proteins 0.000 description 2
- 102000004291 ribosomal protein L6 Human genes 0.000 description 2
- 108090000892 ribosomal protein L6 Proteins 0.000 description 2
- 102000004413 ribosomal protein S11 Human genes 0.000 description 2
- 108090000930 ribosomal protein S11 Proteins 0.000 description 2
- 108010093046 ribosomal protein S19 Proteins 0.000 description 2
- 108010033804 ribosomal protein S3 Proteins 0.000 description 2
- 102000004337 ribosomal protein S5 Human genes 0.000 description 2
- 108090000902 ribosomal protein S5 Proteins 0.000 description 2
- 108010033800 ribosomal protein S8 Proteins 0.000 description 2
- 108010037379 ribosome releasing factor Proteins 0.000 description 2
- 108091092562 ribozyme Proteins 0.000 description 2
- 238000007363 ring formation reaction Methods 0.000 description 2
- 101150027665 rlmD gene Proteins 0.000 description 2
- 101150069752 rnhC gene Proteins 0.000 description 2
- 101150091119 rpl18a gene Proteins 0.000 description 2
- 101150043079 rpl22 gene Proteins 0.000 description 2
- 101150015255 rplB gene Proteins 0.000 description 2
- 101150077293 rplC gene Proteins 0.000 description 2
- 101150028073 rplD gene Proteins 0.000 description 2
- 101150047850 rplN gene Proteins 0.000 description 2
- 101150117577 rplO gene Proteins 0.000 description 2
- 101150053568 rplP gene Proteins 0.000 description 2
- 101150003798 rplQ gene Proteins 0.000 description 2
- 101150066158 rplR gene Proteins 0.000 description 2
- 101150070580 rplV gene Proteins 0.000 description 2
- 101150021143 rplW gene Proteins 0.000 description 2
- 101150075881 rplX gene Proteins 0.000 description 2
- 101150110282 rpmC gene Proteins 0.000 description 2
- 101150045855 rpmD gene Proteins 0.000 description 2
- 101150114173 rpmG gene Proteins 0.000 description 2
- 101150088990 rpmG1 gene Proteins 0.000 description 2
- 101150083552 rpmG3 gene Proteins 0.000 description 2
- 101150014283 rpmGB gene Proteins 0.000 description 2
- 101150018028 rpsC gene Proteins 0.000 description 2
- 101150027173 rpsE gene Proteins 0.000 description 2
- 101150094975 rpsH gene Proteins 0.000 description 2
- 101150039612 rpsK gene Proteins 0.000 description 2
- 101150049069 rpsM gene Proteins 0.000 description 2
- 101150107339 rpsN gene Proteins 0.000 description 2
- 101150061587 rpsS gene Proteins 0.000 description 2
- 101150028844 rpsZ gene Proteins 0.000 description 2
- 101150014817 ruvB gene Proteins 0.000 description 2
- 238000010845 search algorithm Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 150000003432 sterols Chemical class 0.000 description 2
- 102100029783 tRNA pseudouridine synthase A Human genes 0.000 description 2
- 101710194143 tRNA pseudouridine synthase A Proteins 0.000 description 2
- 102000000885 tRNA-binding domains Human genes 0.000 description 2
- 108050007916 tRNA-binding domains Proteins 0.000 description 2
- 229960000814 tetanus toxoid Drugs 0.000 description 2
- 101150019895 thiE gene Proteins 0.000 description 2
- 101150054688 thiM gene Proteins 0.000 description 2
- AYEKOFBPNLCAJY-UHFFFAOYSA-O thiamine pyrophosphate Chemical compound CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N AYEKOFBPNLCAJY-UHFFFAOYSA-O 0.000 description 2
- 229960002663 thioctic acid Drugs 0.000 description 2
- 101150000850 thrC gene Proteins 0.000 description 2
- 229940113082 thymine Drugs 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 238000010361 transduction Methods 0.000 description 2
- 230000026683 transduction Effects 0.000 description 2
- 230000014621 translational initiation Effects 0.000 description 2
- XETCRXVKJHBPMK-MJSODCSWSA-N trehalose 6,6'-dimycolate Chemical compound C([C@@H]1[C@H]([C@H](O)[C@@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](COC(=O)C(CCCCCCCCCCC3C(C3)CCCCCCCCCCCCCCCCCC)C(O)CCCCCCCCCCCCCCCCCCCCCCCCC)O2)O)O1)O)OC(=O)C(C(O)CCCCCCCCCCCCCCCCCCCCCCCCC)CCCCCCCCCCC1CC1CCCCCCCCCCCCCCCCCC XETCRXVKJHBPMK-MJSODCSWSA-N 0.000 description 2
- 101150088238 trmFO gene Proteins 0.000 description 2
- 101150017621 truA gene Proteins 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 241000712461 unidentified influenza virus Species 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 239000003981 vehicle Substances 0.000 description 2
- 101150009557 xseB gene Proteins 0.000 description 2
- WTFXTQVDAKGDEY-UHFFFAOYSA-N (-)-chorismic acid Natural products OC1C=CC(C(O)=O)=CC1OC(=C)C(O)=O WTFXTQVDAKGDEY-UHFFFAOYSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- NNWQLZWAZSJGLY-VKHMYHEASA-N (2s)-2-azaniumyl-4-azidobutanoate Chemical compound OC(=O)[C@@H](N)CCN=[N+]=[N-] NNWQLZWAZSJGLY-VKHMYHEASA-N 0.000 description 1
- YHQZWWDVLJPRIF-JLHRHDQISA-N (4R)-4-[[(2S,3R)-2-[acetyl-[(3R,4R,5S,6R)-3-amino-4-[(1R)-1-carboxyethoxy]-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]amino]-3-hydroxybutanoyl]amino]-5-amino-5-oxopentanoic acid Chemical compound C(C)(=O)N([C@@H]([C@H](O)C)C(=O)N[C@H](CCC(=O)O)C(N)=O)C1[C@H](N)[C@@H](O[C@@H](C(=O)O)C)[C@H](O)[C@H](O1)CO YHQZWWDVLJPRIF-JLHRHDQISA-N 0.000 description 1
- 108010045016 (acyl-carrier-protein) phosphodiesterase Proteins 0.000 description 1
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- KZPYGQFFRCFCPP-UHFFFAOYSA-N 1,1'-bis(diphenylphosphino)ferrocene Chemical compound [Fe+2].C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1 KZPYGQFFRCFCPP-UHFFFAOYSA-N 0.000 description 1
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 description 1
- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 1
- 108010039168 16S rRNA (adenine(1518)-N(6)-adenine(1519)-N(6))-dimethyltransferase Proteins 0.000 description 1
- 101710090429 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase Proteins 0.000 description 1
- 101710182762 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase Proteins 0.000 description 1
- DHCUIDTZCMREHG-UHFFFAOYSA-N 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoic acid Chemical compound OC(=O)CC1(C(O)=O)OC(=O)C=C1 DHCUIDTZCMREHG-UHFFFAOYSA-N 0.000 description 1
- 108090001001 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferases Proteins 0.000 description 1
- QZDDFQLIQRYMBV-UHFFFAOYSA-N 2-[3-nitro-2-(2-nitrophenyl)-4-oxochromen-8-yl]acetic acid Chemical compound OC(=O)CC1=CC=CC(C(C=2[N+]([O-])=O)=O)=C1OC=2C1=CC=CC=C1[N+]([O-])=O QZDDFQLIQRYMBV-UHFFFAOYSA-N 0.000 description 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 1
- PFCLMNDDPTZJHQ-XLPZGREQSA-N 2-amino-7-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1h-pyrrolo[2,3-d]pyrimidin-4-one Chemical compound C1=CC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PFCLMNDDPTZJHQ-XLPZGREQSA-N 0.000 description 1
- 108030003739 2-dehydro-3-deoxygluconokinases Proteins 0.000 description 1
- 108010070495 2-dehydropantoate 2-reductase Proteins 0.000 description 1
- KELWCRGGLWHFEE-UHFFFAOYSA-N 3,7-dihydropurine-2,6-dione;1h-pyrimidine-2,4-dione Chemical compound O=C1C=CNC(=O)N1.O=C1NC(=O)NC2=C1NC=N2 KELWCRGGLWHFEE-UHFFFAOYSA-N 0.000 description 1
- 108050006180 3-dehydroquinate synthase Proteins 0.000 description 1
- 108010093803 3-ketoacyl-acyl carrier protein synthase III Proteins 0.000 description 1
- 108010055468 3-oxoacyl-(acyl-carrier-protein) reductase Proteins 0.000 description 1
- 102000000157 3-oxoacyl-(acyl-carrier-protein) reductase Human genes 0.000 description 1
- 108030003562 3-oxoacyl-[acyl-carrier-protein] reductases Proteins 0.000 description 1
- 101710161460 3-oxoacyl-[acyl-carrier-protein] synthase Proteins 0.000 description 1
- 101710130360 3-oxoacyl-[acyl-carrier-protein] synthase III, chloroplastic Proteins 0.000 description 1
- 108010020183 3-phosphoshikimate 1-carboxyvinyltransferase Proteins 0.000 description 1
- 101710192507 30S ribosomal protein S1 Proteins 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 108091022918 4-carboxymuconolactone decarboxylase Proteins 0.000 description 1
- 101710166309 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase Proteins 0.000 description 1
- 108010071258 4-hydroxy-2-oxoglutarate aldolase Proteins 0.000 description 1
- 108010042260 4-hydroxybenzoate polyprenyltransferase Proteins 0.000 description 1
- 102100023912 40S ribosomal protein S12 Human genes 0.000 description 1
- 102100031571 40S ribosomal protein S16 Human genes 0.000 description 1
- 102100039882 40S ribosomal protein S17 Human genes 0.000 description 1
- 102100023415 40S ribosomal protein S20 Human genes 0.000 description 1
- 102100037710 40S ribosomal protein S21 Human genes 0.000 description 1
- 102100024088 40S ribosomal protein S7 Human genes 0.000 description 1
- 102100027271 40S ribosomal protein SA Human genes 0.000 description 1
- 102000004008 5'-Nucleotidase Human genes 0.000 description 1
- 101710169336 5'-deoxyadenosine deaminase Proteins 0.000 description 1
- 102000007433 5-formyltetrahydrofolate cyclo-ligase Human genes 0.000 description 1
- 108010002610 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase Proteins 0.000 description 1
- 101710190982 50S ribosomal protein L5 Proteins 0.000 description 1
- 101710190981 50S ribosomal protein L6 Proteins 0.000 description 1
- 101710190962 50S ribosomal protein L9 Proteins 0.000 description 1
- 101710099231 51.5 kDa protein Proteins 0.000 description 1
- 108010068996 6,7-dimethyl-8-ribityllumazine synthase Proteins 0.000 description 1
- 108010034869 6-phospho-beta-glucosidase Proteins 0.000 description 1
- 102100038222 60 kDa heat shock protein, mitochondrial Human genes 0.000 description 1
- 101710154868 60 kDa heat shock protein, mitochondrial Proteins 0.000 description 1
- 102100035916 60S ribosomal protein L11 Human genes 0.000 description 1
- 102100021206 60S ribosomal protein L19 Human genes 0.000 description 1
- 101710187808 60S ribosomal protein L19 Proteins 0.000 description 1
- 102100037965 60S ribosomal protein L21 Human genes 0.000 description 1
- 102100025601 60S ribosomal protein L27 Human genes 0.000 description 1
- 102100023777 60S ribosomal protein L31 Human genes 0.000 description 1
- 102100040768 60S ribosomal protein L32 Human genes 0.000 description 1
- 102100040637 60S ribosomal protein L34 Human genes 0.000 description 1
- 102100026926 60S ribosomal protein L4 Human genes 0.000 description 1
- 102100036630 60S ribosomal protein L7a Human genes 0.000 description 1
- 101710182094 8-oxo-dGTP diphosphatase Proteins 0.000 description 1
- 108700014168 ABC-type nickel transporter activity proteins Proteins 0.000 description 1
- 101150034533 ATIC gene Proteins 0.000 description 1
- 102000005416 ATP-Binding Cassette Transporters Human genes 0.000 description 1
- 108050004656 ATP-dependent DNA helicase PcrA Proteins 0.000 description 1
- 101710183434 ATPase Proteins 0.000 description 1
- 108010075752 ATPases Associated with Diverse Cellular Activities Proteins 0.000 description 1
- 102000011932 ATPases Associated with Diverse Cellular Activities Human genes 0.000 description 1
- 108010092060 Acetate kinase Proteins 0.000 description 1
- 108010000700 Acetolactate synthase Proteins 0.000 description 1
- 101100318730 Acidianus bottle-shaped virus (isolate Italy/Pozzuoli) ORF257 gene Proteins 0.000 description 1
- 102100033647 Activity-regulated cytoskeleton-associated protein Human genes 0.000 description 1
- 101710144623 Acyl-[acyl-carrier-protein] hydrolase Proteins 0.000 description 1
- 102000005991 Acylphosphatase Human genes 0.000 description 1
- 108700006311 Acylphosphatases Proteins 0.000 description 1
- 101710142468 Adapter protein MecA Proteins 0.000 description 1
- 108010024223 Adenine phosphoribosyltransferase Proteins 0.000 description 1
- 102100029457 Adenine phosphoribosyltransferase Human genes 0.000 description 1
- 102100036664 Adenosine deaminase Human genes 0.000 description 1
- 108010056443 Adenylosuccinate synthase Proteins 0.000 description 1
- 101710133359 Agglutinin receptor Proteins 0.000 description 1
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 1
- 102000006268 Alanine-tRNA ligase Human genes 0.000 description 1
- 108010058060 Alanine-tRNA ligase Proteins 0.000 description 1
- 229920000310 Alpha glucan Polymers 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 102100031317 Alpha-N-acetylgalactosaminidase Human genes 0.000 description 1
- 101710143182 Alpha-glycerophosphate oxidase Proteins 0.000 description 1
- 101000708493 Alternaria alternata Superoxide dismutase [Mn], mitochondrial Proteins 0.000 description 1
- 102000004092 Amidohydrolases Human genes 0.000 description 1
- 108090000531 Amidohydrolases Proteins 0.000 description 1
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 description 1
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 description 1
- 102100039338 Aminomethyltransferase, mitochondrial Human genes 0.000 description 1
- 102100022749 Aminopeptidase N Human genes 0.000 description 1
- 101710129433 Aminopeptidase PepS Proteins 0.000 description 1
- 108050001492 Ammonium transporters Proteins 0.000 description 1
- 101100389816 Amycolatopsis orientalis evaA gene Proteins 0.000 description 1
- 101710087198 Anthranilate synthase component II Proteins 0.000 description 1
- 108050005734 Antiholin-like protein LrgA Proteins 0.000 description 1
- 108020000948 Antisense Oligonucleotides Proteins 0.000 description 1
- 108091061410 ApbE family Proteins 0.000 description 1
- 241001550224 Apha Species 0.000 description 1
- 101710098866 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase Proteins 0.000 description 1
- 101000804412 Aquifex aeolicus (strain VF5) Uncharacterized RNA pseudouridine synthase aq_1464 Proteins 0.000 description 1
- 101000755376 Aquifex aeolicus (strain VF5) Uncharacterized RNA pseudouridine synthase aq_1758 Proteins 0.000 description 1
- 101000824370 Aquifex aeolicus (strain VF5) Uncharacterized RNA pseudouridine synthase aq_554 Proteins 0.000 description 1
- 108010048816 AraC Transcription Factor Proteins 0.000 description 1
- 101000823228 Arabidopsis thaliana ABC transporter I family member 6, chloroplastic Proteins 0.000 description 1
- 101000879970 Arabidopsis thaliana Late embryogenesis abundant protein ECP63 Proteins 0.000 description 1
- 101000640990 Arabidopsis thaliana Tryptophan-tRNA ligase, chloroplastic/mitochondrial Proteins 0.000 description 1
- 241000180579 Arca Species 0.000 description 1
- 108010082340 Arginine deiminase Proteins 0.000 description 1
- 101710149879 Arginine repressor Proteins 0.000 description 1
- 102100036131 Arginine-tRNA ligase, cytoplasmic Human genes 0.000 description 1
- 241001167018 Aroa Species 0.000 description 1
- 108090000444 Arsenate reductases Proteins 0.000 description 1
- QCWJKJLNCFEVPQ-WHFBIAKZSA-N Asn-Gln Chemical compound NC(=O)C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(N)=O QCWJKJLNCFEVPQ-WHFBIAKZSA-N 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- 102000003924 Asparagine-tRNA ligases Human genes 0.000 description 1
- 108090000314 Asparagine-tRNA ligases Proteins 0.000 description 1
- 102000030907 Aspartate Carbamoyltransferase Human genes 0.000 description 1
- 108010070255 Aspartate-ammonia ligase Proteins 0.000 description 1
- 102000012951 Aspartate-tRNA Ligase Human genes 0.000 description 1
- 108010065272 Aspartate-tRNA ligase Proteins 0.000 description 1
- 101100075927 Aspergillus aculeatus mndA gene Proteins 0.000 description 1
- 101100284003 Aspergillus oryzae (strain ATCC 42149 / RIB 40) gtaA gene Proteins 0.000 description 1
- 101100162204 Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1) aflH gene Proteins 0.000 description 1
- 241000193747 Bacillus firmus Species 0.000 description 1
- 101100442929 Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46) deoC2 gene Proteins 0.000 description 1
- 101000870242 Bacillus phage Nf Tail knob protein gp9 Proteins 0.000 description 1
- 101100427060 Bacillus spizizenii (strain ATCC 23059 / NRRL B-14472 / W23) thyA1 gene Proteins 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 101000948522 Bacillus subtilis (strain 168) 5,10-methylenetetrahydrofolate reductase Proteins 0.000 description 1
- 101001032758 Bacillus subtilis (strain 168) General stress protein 13 Proteins 0.000 description 1
- 101001045777 Bacillus subtilis (strain 168) Homocysteine S-methyltransferase YbgG Proteins 0.000 description 1
- 101000961968 Bacillus subtilis (strain 168) Uncharacterized RNA pseudouridine synthase YhcT Proteins 0.000 description 1
- 101000948581 Bacillus subtilis (strain 168) Uncharacterized RNA pseudouridine synthase YjbO Proteins 0.000 description 1
- 101000819714 Bacillus subtilis (strain 168) Uncharacterized RNA pseudouridine synthase YlyB Proteins 0.000 description 1
- 101000948214 Bacillus subtilis (strain 168) Uncharacterized RNA pseudouridine synthase YtzG Proteins 0.000 description 1
- 101100216993 Bacillus subtilis (strain 168) aroD gene Proteins 0.000 description 1
- 101100059000 Bacillus subtilis (strain 168) capA gene Proteins 0.000 description 1
- 101100222854 Bacillus subtilis (strain 168) czcO gene Proteins 0.000 description 1
- 101100325906 Bacillus subtilis (strain 168) ganA gene Proteins 0.000 description 1
- 101100128225 Bacillus subtilis (strain 168) licT gene Proteins 0.000 description 1
- 101100078797 Bacillus subtilis (strain 168) racE gene Proteins 0.000 description 1
- 101100477308 Bacillus subtilis (strain 168) sepF gene Proteins 0.000 description 1
- 101100431860 Bacillus subtilis (strain 168) yclO gene Proteins 0.000 description 1
- 101100267417 Bacillus subtilis (strain 168) yjgD gene Proteins 0.000 description 1
- 101100376633 Bacillus subtilis (strain 168) ylbB gene Proteins 0.000 description 1
- 101100267521 Bacillus subtilis (strain 168) ylmG gene Proteins 0.000 description 1
- 101100488802 Bacillus subtilis (strain 168) yngF gene Proteins 0.000 description 1
- 101100433085 Bacillus subtilis (strain 168) yydI gene Proteins 0.000 description 1
- 101100539529 Bacillus thuringiensis subsp. konkukian (strain 97-27) uppP2 gene Proteins 0.000 description 1
- 101100155460 Bacillus thuringiensis subsp. konkukian (strain 97-27) uppP3 gene Proteins 0.000 description 1
- 101100155465 Bacillus thuringiensis subsp. konkukian (strain 97-27) uppP4 gene Proteins 0.000 description 1
- 108090000363 Bacterial Luciferases Proteins 0.000 description 1
- 108050007854 Bacterial extracellular solute-binding proteins Proteins 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 231100000699 Bacterial toxin Toxicity 0.000 description 1
- 108700037974 Bacterial transcription activator, effector binding protein Proteins 0.000 description 1
- 108010062877 Bacteriocins Proteins 0.000 description 1
- 108091012467 Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ Proteins 0.000 description 1
- 102100021257 Beta-secretase 1 Human genes 0.000 description 1
- 101710150192 Beta-secretase 1 Proteins 0.000 description 1
- 101710201279 Biotin carboxyl carrier protein Proteins 0.000 description 1
- 108700040198 Biotin synthases Proteins 0.000 description 1
- 102100036200 Bisphosphoglycerate mutase Human genes 0.000 description 1
- 101000804272 Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) Uncharacterized RNA pseudouridine synthase BB_0129 Proteins 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 101710104670 Branched-chain amino acid transport protein AzlD Proteins 0.000 description 1
- 108010088278 Branched-chain-amino-acid transaminase Proteins 0.000 description 1
- 101100280051 Brucella abortus biovar 1 (strain 9-941) eryH gene Proteins 0.000 description 1
- 101100525051 Brucella abortus biovar 1 (strain 9-941) ribH2 gene Proteins 0.000 description 1
- 101100200726 Burkholderia mallei (strain ATCC 23344) rpsU1 gene Proteins 0.000 description 1
- QRHVTEMQQBKPKV-UHFFFAOYSA-N C(=O)O.N(=O)O Chemical compound C(=O)O.N(=O)O QRHVTEMQQBKPKV-UHFFFAOYSA-N 0.000 description 1
- 108010049990 CD13 Antigens Proteins 0.000 description 1
- 108010086940 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Proteins 0.000 description 1
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 description 1
- 108010045403 Calcium-Binding Proteins Proteins 0.000 description 1
- 102000005701 Calcium-Binding Proteins Human genes 0.000 description 1
- 101100245749 Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176) pseF gene Proteins 0.000 description 1
- 108090000565 Capsid Proteins Proteins 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 102000004031 Carboxy-Lyases Human genes 0.000 description 1
- 108090000489 Carboxy-Lyases Proteins 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 101710092648 Catabolite control protein A Proteins 0.000 description 1
- 102000000918 Cation efflux proteins Human genes 0.000 description 1
- 108050007960 Cation efflux proteins Proteins 0.000 description 1
- 101710190067 Cell division ATP-binding protein FtsE Proteins 0.000 description 1
- 108050004294 Cell division protein DivIC Proteins 0.000 description 1
- 101710199179 Cell division protein FtsA Proteins 0.000 description 1
- 108700001249 Cell division protein FtsZ Proteins 0.000 description 1
- 102100023321 Ceruloplasmin Human genes 0.000 description 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
- 108091078748 Cfr family Proteins 0.000 description 1
- 108091006146 Channels Proteins 0.000 description 1
- 102000034573 Channels Human genes 0.000 description 1
- 102000006303 Chaperonin 60 Human genes 0.000 description 1
- 108010058432 Chaperonin 60 Proteins 0.000 description 1
- 108050001186 Chaperonin Cpn60 Proteins 0.000 description 1
- 101710104159 Chaperonin GroEL Proteins 0.000 description 1
- 101710098119 Chaperonin GroEL 2 Proteins 0.000 description 1
- 101710108115 Chaperonin GroEL, chloroplastic Proteins 0.000 description 1
- 101710138795 Chaperonin HSP60, mitochondrial Proteins 0.000 description 1
- 102000052603 Chaperonins Human genes 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 101100499417 Chlamydia pneumoniae dnaA1 gene Proteins 0.000 description 1
- 101100227595 Chlamydia pneumoniae folKP gene Proteins 0.000 description 1
- 101100383746 Chlamydomonas reinhardtii chlL gene Proteins 0.000 description 1
- 108010035563 Chloramphenicol O-acetyltransferase Proteins 0.000 description 1
- 101000965561 Chlorobaculum parvum (strain DSM 263 / NCIMB 8327) Uncharacterized RNA pseudouridine synthase Cpar_0723 Proteins 0.000 description 1
- 101000763297 Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) Uncharacterized RNA pseudouridine synthase Caur_0901 Proteins 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 108010000898 Chorismate mutase Proteins 0.000 description 1
- 108010003662 Chorismate synthase Proteins 0.000 description 1
- 108090000175 Cis-trans-isomerases Proteins 0.000 description 1
- 102000003813 Cis-trans-isomerases Human genes 0.000 description 1
- 101100163308 Clostridium perfringens (strain 13 / Type A) argR1 gene Proteins 0.000 description 1
- 101710094648 Coat protein Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 101710173767 ComE operon protein 2 Proteins 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 101100134884 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) aceF gene Proteins 0.000 description 1
- 101100239133 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) murB1 gene Proteins 0.000 description 1
- 101100299477 Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) phbI gene Proteins 0.000 description 1
- 102100035353 Cyclin-dependent kinase 2-associated protein 1 Human genes 0.000 description 1
- 102000001493 Cyclophilins Human genes 0.000 description 1
- 108010068682 Cyclophilins Proteins 0.000 description 1
- 108030006281 Cyclopropane-fatty-acyl-phospholipid synthases Proteins 0.000 description 1
- 101710170530 Cysteine synthase A Proteins 0.000 description 1
- 108010056652 D-2-hydroxyacid dehydrogenase Proteins 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 101710117191 D-alanyl carrier protein Proteins 0.000 description 1
- DEFJQIDDEAULHB-QWWZWVQMSA-N D-alanyl-D-alanine Chemical compound C[C@@H]([NH3+])C(=O)N[C@H](C)C([O-])=O DEFJQIDDEAULHB-QWWZWVQMSA-N 0.000 description 1
- 101710197960 D-aminoacyl-tRNA deacylase Proteins 0.000 description 1
- 102100029010 D-aminoacyl-tRNA deacylase 1 Human genes 0.000 description 1
- 101710169719 D-mannonate oxidoreductase Proteins 0.000 description 1
- FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 description 1
- 229930182818 D-methionine Natural products 0.000 description 1
- YVGGHNCTFXOJCH-UHFFFAOYSA-N DDT Chemical compound C1=CC(Cl)=CC=C1C(C(Cl)(Cl)Cl)C1=CC=C(Cl)C=C1 YVGGHNCTFXOJCH-UHFFFAOYSA-N 0.000 description 1
- 101150050688 DGKA gene Proteins 0.000 description 1
- 101150090997 DLAT gene Proteins 0.000 description 1
- 108010061982 DNA Ligases Proteins 0.000 description 1
- 102000012410 DNA Ligases Human genes 0.000 description 1
- 102000004594 DNA Polymerase I Human genes 0.000 description 1
- 108010017826 DNA Polymerase I Proteins 0.000 description 1
- 102000001996 DNA Polymerase beta Human genes 0.000 description 1
- 108010001132 DNA Polymerase beta Proteins 0.000 description 1
- 108090000323 DNA Topoisomerases Proteins 0.000 description 1
- 108050004355 DNA gyrase, subunit B Proteins 0.000 description 1
- 101710146788 DNA mismatch repair protein HexB Proteins 0.000 description 1
- 101710200158 DNA packaging protein Proteins 0.000 description 1
- 101710087639 DNA polymerase III subunit gamma Proteins 0.000 description 1
- 101710125157 DNA polymerase III subunit tau Proteins 0.000 description 1
- 239000003155 DNA primer Substances 0.000 description 1
- 230000033616 DNA repair Effects 0.000 description 1
- 101710205923 DNA repair protein RecN Proteins 0.000 description 1
- 101710205925 DNA repair protein RecO Proteins 0.000 description 1
- 101710186032 DNA replication and repair protein RecF Proteins 0.000 description 1
- 101710168187 DNA replication protein DnaD Proteins 0.000 description 1
- 102100024607 DNA topoisomerase 1 Human genes 0.000 description 1
- 108050004047 DNA-3-methyladenine glycosylase I Proteins 0.000 description 1
- 102000016923 DNA-Cytosine Methylases Human genes 0.000 description 1
- 108010014312 DNA-Cytosine Methylases Proteins 0.000 description 1
- 101100180053 Danio rerio isl2b gene Proteins 0.000 description 1
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 description 1
- 108030003689 Deoxynucleoside kinases Proteins 0.000 description 1
- 108700016241 Deoxyribose-phosphate aldolases Proteins 0.000 description 1
- QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical group CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 description 1
- 101100098219 Dictyostelium discoideum argS1 gene Proteins 0.000 description 1
- 101100380328 Dictyostelium discoideum asns gene Proteins 0.000 description 1
- 101100126053 Dictyostelium discoideum impdh gene Proteins 0.000 description 1
- 101100240841 Dictyostelium discoideum noxB gene Proteins 0.000 description 1
- 101100311938 Dictyostelium discoideum phesA gene Proteins 0.000 description 1
- 101100423325 Dictyostelium discoideum phesB gene Proteins 0.000 description 1
- 101100038183 Dictyostelium discoideum polr2a gene Proteins 0.000 description 1
- 101100425816 Dictyostelium discoideum top2mt gene Proteins 0.000 description 1
- 108030007223 Dihydrofolate synthases Proteins 0.000 description 1
- 102000028526 Dihydrolipoamide Dehydrogenase Human genes 0.000 description 1
- 108010028127 Dihydrolipoamide Dehydrogenase Proteins 0.000 description 1
- 102100034581 Dihydroorotase Human genes 0.000 description 1
- 108010052167 Dihydroorotate Dehydrogenase Proteins 0.000 description 1
- 108010070596 Dihydroorotate Oxidase Proteins 0.000 description 1
- 101710096246 Dihydroorotate dehydrogenase (fumarate) Proteins 0.000 description 1
- 101710175803 Dihydroorotate dehydrogenase (quinone) Proteins 0.000 description 1
- 101710084265 Dihydroorotate dehydrogenase (quinone), mitochondrial Proteins 0.000 description 1
- 108700016256 Dihydropteroate synthases Proteins 0.000 description 1
- 102100038390 Diphosphomevalonate decarboxylase Human genes 0.000 description 1
- 101710183613 Diphosphomevalonate decarboxylase Proteins 0.000 description 1
- 101000938675 Dothistroma septosporum (strain NZE10 / CBS 128990) Versiconal hemiacetal acetate esterase Proteins 0.000 description 1
- 108700034323 EC 2.7.1.112 Proteins 0.000 description 1
- 102100030801 Elongation factor 1-alpha 1 Human genes 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 101100491986 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) aromA gene Proteins 0.000 description 1
- 101100498063 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) cysB gene Proteins 0.000 description 1
- 101710158030 Endonuclease Proteins 0.000 description 1
- 101710081048 Endonuclease III Proteins 0.000 description 1
- 102100030011 Endoribonuclease Human genes 0.000 description 1
- 108010093099 Endoribonucleases Proteins 0.000 description 1
- 108010023922 Enoyl-CoA hydratase Proteins 0.000 description 1
- 102000011426 Enoyl-CoA hydratase Human genes 0.000 description 1
- 241000305071 Enterobacterales Species 0.000 description 1
- 241000194032 Enterococcus faecalis Species 0.000 description 1
- 101100480329 Enterococcus faecalis (strain TX4000 / JH2-2) tyrS1 gene Proteins 0.000 description 1
- 101710146739 Enterotoxin Proteins 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 101000851897 Escherichia coli (strain K12) GTPase Era Proteins 0.000 description 1
- 101001051164 Escherichia coli (strain K12) Homocysteine S-methyltransferase Proteins 0.000 description 1
- 101001090039 Escherichia coli (strain K12) Primosomal protein N' Proteins 0.000 description 1
- 101000714188 Escherichia coli (strain K12) Tellurite methyltransferase Proteins 0.000 description 1
- 101100323025 Escherichia coli (strain K12) allC gene Proteins 0.000 description 1
- 101100218845 Escherichia coli (strain K12) bioH gene Proteins 0.000 description 1
- 101100337176 Escherichia coli (strain K12) gltB gene Proteins 0.000 description 1
- 101100505027 Escherichia coli (strain K12) gltD gene Proteins 0.000 description 1
- 101100155531 Escherichia coli (strain K12) ispU gene Proteins 0.000 description 1
- 101100405147 Escherichia coli (strain K12) nrdG gene Proteins 0.000 description 1
- 101100027352 Escherichia coli (strain K12) nudE gene Proteins 0.000 description 1
- 101100350711 Escherichia coli (strain K12) paaI gene Proteins 0.000 description 1
- 101100083051 Escherichia coli (strain K12) pflC gene Proteins 0.000 description 1
- 101100194170 Escherichia coli (strain K12) recG gene Proteins 0.000 description 1
- 101100469067 Escherichia coli (strain K12) ribE gene Proteins 0.000 description 1
- 101100306733 Escherichia coli (strain K12) rraB gene Proteins 0.000 description 1
- 101100326871 Escherichia coli (strain K12) ygbF gene Proteins 0.000 description 1
- 101100053061 Escherichia coli (strain K12) yjdN gene Proteins 0.000 description 1
- 101100022281 Escherichia coli O157:H7 manC1 gene Proteins 0.000 description 1
- 101100183158 Escherichia coli mccF gene Proteins 0.000 description 1
- 101100153154 Escherichia phage T5 thy gene Proteins 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 102100039466 Eukaryotic translation initiation factor 5B Human genes 0.000 description 1
- 108050001049 Extracellular proteins Proteins 0.000 description 1
- 108010014531 FMN Reductase Proteins 0.000 description 1
- 102000031716 FMN binding proteins Human genes 0.000 description 1
- 101710106548 FMN-binding protein Proteins 0.000 description 1
- 229910002551 Fe-Mn Inorganic materials 0.000 description 1
- 108010012088 Fibrinogen Receptors Proteins 0.000 description 1
- 101710128530 Fibrinogen-binding protein Proteins 0.000 description 1
- 108010057366 Flavodoxin Proteins 0.000 description 1
- 101710090603 Foldase protein PrsA Proteins 0.000 description 1
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 1
- 102100025413 Formyltetrahydrofolate synthetase Human genes 0.000 description 1
- 102000003793 Fructokinases Human genes 0.000 description 1
- 108090000156 Fructokinases Proteins 0.000 description 1
- 108010017464 Fructose-Bisphosphatase Proteins 0.000 description 1
- 102000027487 Fructose-Bisphosphatase Human genes 0.000 description 1
- 108010058643 Fungal Proteins Proteins 0.000 description 1
- 102000012074 GAF domains Human genes 0.000 description 1
- 108050002598 GAF domains Proteins 0.000 description 1
- 101150099894 GDHA gene Proteins 0.000 description 1
- 108010013942 GMP Reductase Proteins 0.000 description 1
- 102100021188 GMP reductase 1 Human genes 0.000 description 1
- 108010023555 GTP Cyclohydrolase Proteins 0.000 description 1
- 102100027346 GTP cyclohydrolase 1 Human genes 0.000 description 1
- 101710194190 GTPase Der Proteins 0.000 description 1
- 101710201719 GTPase HflX Proteins 0.000 description 1
- 101710090046 Galactose-1-phosphate uridylyltransferase Proteins 0.000 description 1
- 102100036291 Galactose-1-phosphate uridylyltransferase Human genes 0.000 description 1
- 108010046584 Galactose-6-phosphate isomerase Proteins 0.000 description 1
- 108010093031 Galactosidases Proteins 0.000 description 1
- 102000002464 Galactosidases Human genes 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 102100034013 Gamma-glutamyl phosphate reductase Human genes 0.000 description 1
- 101710198928 Gamma-glutamyl phosphate reductase Proteins 0.000 description 1
- 101710160913 GemA protein Proteins 0.000 description 1
- 101000892220 Geobacillus thermodenitrificans (strain NG80-2) Long-chain-alcohol dehydrogenase 1 Proteins 0.000 description 1
- 108010026318 Geranyltranstransferase Proteins 0.000 description 1
- 102000013404 Geranyltranstransferase Human genes 0.000 description 1
- 108010021582 Glucokinase Proteins 0.000 description 1
- 108020004469 Glucose-1-phosphate thymidylyltransferase Proteins 0.000 description 1
- 108010070600 Glucose-6-phosphate isomerase Proteins 0.000 description 1
- 102000005731 Glucose-6-phosphate isomerase Human genes 0.000 description 1
- 108010052375 Glutamate Dehydrogenase (NADP+) Proteins 0.000 description 1
- 108010064766 Glutamate formimidoyltransferase Proteins 0.000 description 1
- 108010016106 Glutamate-5-semialdehyde dehydrogenase Proteins 0.000 description 1
- 102000017722 Glutamine amidotransferases Human genes 0.000 description 1
- 108050005901 Glutamine amidotransferases Proteins 0.000 description 1
- 108010058940 Glutamyl Aminopeptidase Proteins 0.000 description 1
- 102000006485 Glutamyl Aminopeptidase Human genes 0.000 description 1
- 101710095777 Glutamyl-tRNA(Gln) amidotransferase subunit A, chloroplastic/mitochondrial Proteins 0.000 description 1
- 102100036646 Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial Human genes 0.000 description 1
- 101710090527 Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial Proteins 0.000 description 1
- 108010063907 Glutathione Reductase Proteins 0.000 description 1
- 102100036442 Glutathione reductase, mitochondrial Human genes 0.000 description 1
- 102000008989 Glyceraldehyde-3-phosphate dehydrogenase, type I Human genes 0.000 description 1
- 108050000959 Glyceraldehyde-3-phosphate dehydrogenase, type I Proteins 0.000 description 1
- 102100025591 Glycerate kinase Human genes 0.000 description 1
- 102000057621 Glycerol kinases Human genes 0.000 description 1
- 108700016170 Glycerol kinases Proteins 0.000 description 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
- 108010086382 Glycine Decarboxylase Complex H-Protein Proteins 0.000 description 1
- 102000009279 Glycine cleavage system H-proteins Human genes 0.000 description 1
- 108010043428 Glycine hydroxymethyltransferase Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 description 1
- 108091029499 Group II intron Proteins 0.000 description 1
- 240000003824 Gypsophila paniculata Species 0.000 description 1
- 102100032821 HIG1 domain family member 1C Human genes 0.000 description 1
- 102000040061 HIT family Human genes 0.000 description 1
- 108091069668 HIT family Proteins 0.000 description 1
- 101150007068 HSP81-1 gene Proteins 0.000 description 1
- 101150087422 HSP82 gene Proteins 0.000 description 1
- 241000606768 Haemophilus influenzae Species 0.000 description 1
- 101000781192 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Uncharacterized RNA pseudouridine synthase HI_0042 Proteins 0.000 description 1
- 101100060915 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) comF gene Proteins 0.000 description 1
- 101100399279 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) licD gene Proteins 0.000 description 1
- 101100076794 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) metQ gene Proteins 0.000 description 1
- 101001056976 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) Catalase-peroxidase Proteins 0.000 description 1
- 101100277701 Halobacterium salinarum gdhX gene Proteins 0.000 description 1
- 101100443653 Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) lig gene Proteins 0.000 description 1
- 101100010081 Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) ligN gene Proteins 0.000 description 1
- 101100520453 Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) mvaD gene Proteins 0.000 description 1
- 101710178376 Heat shock 70 kDa protein Proteins 0.000 description 1
- 101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 description 1
- 101710113975 Heat shock protein 15 Proteins 0.000 description 1
- 101710167268 Heat shock protein 15 homolog Proteins 0.000 description 1
- 101710122080 Heat-inducible transcription repressor HrcA Proteins 0.000 description 1
- 101000813574 Helicobacter pylori (strain ATCC 700392 / 26695) Uncharacterized RNA pseudouridine synthase HP_0347 Proteins 0.000 description 1
- 101000824754 Helicobacter pylori (strain ATCC 700392 / 26695) Uncharacterized RNA pseudouridine synthase HP_0745 Proteins 0.000 description 1
- 101000812621 Helicobacter pylori (strain ATCC 700392 / 26695) Uncharacterized RNA pseudouridine synthase HP_0956 Proteins 0.000 description 1
- 101000781447 Helicobacter pylori (strain ATCC 700392 / 26695) Uncharacterized RNA pseudouridine synthase HP_1459 Proteins 0.000 description 1
- 101000813575 Helicobacter pylori (strain J99 / ATCC 700824) Uncharacterized RNA pseudouridine synthase jhp_0321 Proteins 0.000 description 1
- 101000824753 Helicobacter pylori (strain J99 / ATCC 700824) Uncharacterized RNA pseudouridine synthase jhp_0682 Proteins 0.000 description 1
- 101000812623 Helicobacter pylori (strain J99 / ATCC 700824) Uncharacterized RNA pseudouridine synthase jhp_0890 Proteins 0.000 description 1
- 101000748285 Helicobacter pylori (strain J99 / ATCC 700824) Uncharacterized RNA pseudouridine synthase jhp_1352 Proteins 0.000 description 1
- 101710154606 Hemagglutinin Proteins 0.000 description 1
- 101710147195 Hemolysin A Proteins 0.000 description 1
- 108010006464 Hemolysin Proteins Proteins 0.000 description 1
- 241000724675 Hepatitis E virus Species 0.000 description 1
- 241000709721 Hepatovirus A Species 0.000 description 1
- 102000029746 Histidine-tRNA Ligase Human genes 0.000 description 1
- 101710177011 Histidine-tRNA ligase, cytoplasmic Proteins 0.000 description 1
- 108010003774 Histidinol-phosphatase Proteins 0.000 description 1
- 101710194335 Histone acetyltransferase HPA2 Proteins 0.000 description 1
- 101700012268 Holin Proteins 0.000 description 1
- 108090000074 Holo-[acyl-carrier-protein] synthases Proteins 0.000 description 1
- 101000853243 Homo sapiens 60S ribosomal protein L7a Proteins 0.000 description 1
- 101100005713 Homo sapiens CD4 gene Proteins 0.000 description 1
- 101000760620 Homo sapiens Cell adhesion molecule 1 Proteins 0.000 description 1
- 101000737813 Homo sapiens Cyclin-dependent kinase 2-associated protein 1 Proteins 0.000 description 1
- 101001036496 Homo sapiens Eukaryotic translation initiation factor 5B Proteins 0.000 description 1
- 101100284913 Homo sapiens HIGD1C gene Proteins 0.000 description 1
- 101000878213 Homo sapiens Inactive peptidyl-prolyl cis-trans isomerase FKBP6 Proteins 0.000 description 1
- 101000937642 Homo sapiens Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Proteins 0.000 description 1
- 101001066878 Homo sapiens Polyribonucleotide nucleotidyltransferase 1, mitochondrial Proteins 0.000 description 1
- 101000702559 Homo sapiens Probable global transcription activator SNF2L2 Proteins 0.000 description 1
- 101000652805 Homo sapiens Protein shisa-8 Proteins 0.000 description 1
- 101000594820 Homo sapiens Purine nucleoside phosphorylase Proteins 0.000 description 1
- 101001125551 Homo sapiens Ribose-phosphate pyrophosphokinase 1 Proteins 0.000 description 1
- 101001125547 Homo sapiens Ribose-phosphate pyrophosphokinase 2 Proteins 0.000 description 1
- 101001041393 Homo sapiens Serine protease HTRA1 Proteins 0.000 description 1
- 101000702545 Homo sapiens Transcription activator BRG1 Proteins 0.000 description 1
- 108010064711 Homoserine dehydrogenase Proteins 0.000 description 1
- 101150028525 Hsp83 gene Proteins 0.000 description 1
- 241000701806 Human papillomavirus Species 0.000 description 1
- 108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 description 1
- 102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 description 1
- 102000002284 Hydroxymethylglutaryl-CoA Synthase Human genes 0.000 description 1
- 108010000775 Hydroxymethylglutaryl-CoA synthase Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 108010042653 IgA receptor Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 206010021531 Impetigo Diseases 0.000 description 1
- 102100036984 Inactive peptidyl-prolyl cis-trans isomerase FKBP6 Human genes 0.000 description 1
- 102100027050 Inorganic pyrophosphatase Human genes 0.000 description 1
- 102000016600 Inosine-5'-monophosphate dehydrogenases Human genes 0.000 description 1
- 108050006182 Inosine-5'-monophosphate dehydrogenases Proteins 0.000 description 1
- 102100021496 Insulin-degrading enzyme Human genes 0.000 description 1
- 108090000828 Insulysin Proteins 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- 108010002616 Interleukin-5 Proteins 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 108010002586 Interleukin-7 Proteins 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 102000004310 Ion Channels Human genes 0.000 description 1
- 108090000862 Ion Channels Proteins 0.000 description 1
- 102000008133 Iron-Binding Proteins Human genes 0.000 description 1
- 108010035210 Iron-Binding Proteins Proteins 0.000 description 1
- 108010065958 Isopentenyl-diphosphate Delta-isomerase Proteins 0.000 description 1
- 102100027665 Isopentenyl-diphosphate Delta-isomerase 1 Human genes 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- 150000008575 L-amino acids Chemical class 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 1
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 108090000416 L-ribulose-5-phosphate 4-epimerases Proteins 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- 101150008329 LPPB gene Proteins 0.000 description 1
- 101100463438 Lactobacillus delbrueckii subsp. lactis pepV gene Proteins 0.000 description 1
- 101100463411 Lactococcus lactis subsp. cremoris pepF1 gene Proteins 0.000 description 1
- 101100258806 Lactococcus lactis subsp. lactis (strain IL1403) glyQ gene Proteins 0.000 description 1
- 241000724192 Lactococcus phage phiLC3 Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 108050008512 Large-conductance mechanosensitive channels Proteins 0.000 description 1
- 101100433987 Latilactobacillus sakei subsp. sakei (strain 23K) ackA1 gene Proteins 0.000 description 1
- 229920002884 Laureth 4 Polymers 0.000 description 1
- 241000589242 Legionella pneumophila Species 0.000 description 1
- 101100088535 Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) rplP gene Proteins 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 108010006444 Leucine-Rich Repeat Proteins Proteins 0.000 description 1
- 101710201625 Leucine-rich protein Proteins 0.000 description 1
- 108010071170 Leucine-tRNA ligase Proteins 0.000 description 1
- 102100023342 Leucine-tRNA ligase, mitochondrial Human genes 0.000 description 1
- 101710105045 Lipoprotein E Proteins 0.000 description 1
- 101100266455 Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) lmo0164 gene Proteins 0.000 description 1
- 102000008826 LysM domains Human genes 0.000 description 1
- 108050000721 LysM domains Proteins 0.000 description 1
- 102000017737 Lysine-tRNA Ligase Human genes 0.000 description 1
- 108010092041 Lysine-tRNA Ligase Proteins 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 101710125418 Major capsid protein Proteins 0.000 description 1
- 108010026217 Malate Dehydrogenase Proteins 0.000 description 1
- 102000013460 Malate Dehydrogenase Human genes 0.000 description 1
- 108050003365 Malonyl CoA-acyl carrier protein transacylases Proteins 0.000 description 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- 101710147435 Manganese-dependent inorganic pyrophosphatase Proteins 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 101710161955 Mannitol-specific phosphotransferase enzyme IIA component Proteins 0.000 description 1
- 108091022912 Mannose-6-Phosphate Isomerase Proteins 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 241000712079 Measles morbillivirus Species 0.000 description 1
- 108090000112 Mercury(II) reductases Proteins 0.000 description 1
- 101100037096 Methanococcus maripaludis (strain S2 / LL) rpl6 gene Proteins 0.000 description 1
- 101100038261 Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) rpo2C gene Proteins 0.000 description 1
- 101100253930 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) rps15 gene Proteins 0.000 description 1
- 101100327514 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) cfbE gene Proteins 0.000 description 1
- 101100537961 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) trkA2 gene Proteins 0.000 description 1
- 101100023016 Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) mat gene Proteins 0.000 description 1
- 108010010685 Methenyltetrahydrofolate cyclohydrolase Proteins 0.000 description 1
- 108010041559 Methionine Sulfoxide Reductases Proteins 0.000 description 1
- 102000000532 Methionine Sulfoxide Reductases Human genes 0.000 description 1
- 108010007784 Methionine adenosyltransferase Proteins 0.000 description 1
- 101710181812 Methionine aminopeptidase Proteins 0.000 description 1
- 101710163328 Methionine synthase Proteins 0.000 description 1
- 102100031551 Methionine synthase Human genes 0.000 description 1
- 108010013690 Methyl-Accepting Chemotaxis Proteins Proteins 0.000 description 1
- 108700040132 Mevalonate kinases Proteins 0.000 description 1
- 241001300083 Milax Species 0.000 description 1
- 101710187546 Minor extracellular protease Epr Proteins 0.000 description 1
- 102100022450 Mitochondrial tRNA-specific 2-thiouridylase 1 Human genes 0.000 description 1
- 108010006519 Molecular Chaperones Proteins 0.000 description 1
- 241001092142 Molina Species 0.000 description 1
- 241000588655 Moraxella catarrhalis Species 0.000 description 1
- 101710151833 Movement protein TGBp3 Proteins 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- 108030003249 Muramoyltetrapeptide carboxypeptidases Proteins 0.000 description 1
- 101100459248 Mus musculus Mxra8 gene Proteins 0.000 description 1
- 101100191164 Mus musculus Ppcs gene Proteins 0.000 description 1
- 108010010259 MutS DNA Mismatch-Binding Protein Proteins 0.000 description 1
- 108091066199 MutS2 family Proteins 0.000 description 1
- 101000618631 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) Uncharacterized RNA pseudouridine synthase Mb1567 Proteins 0.000 description 1
- 101000950524 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) Uncharacterized RNA pseudouridine synthase Mb1738 Proteins 0.000 description 1
- 101100129095 Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019) lysX gene Proteins 0.000 description 1
- 101000758542 Mycobacterium leprae (strain TN) Uncharacterized RNA pseudouridine synthase ML1370 Proteins 0.000 description 1
- 101100063392 Mycobacterium leprae (strain TN) folP1 gene Proteins 0.000 description 1
- 101000949898 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Uncharacterized RNA pseudouridine synthase Rv1540 Proteins 0.000 description 1
- 101000810712 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Uncharacterized RNA pseudouridine synthase Rv1711 Proteins 0.000 description 1
- 101100083407 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) pgsA1 gene Proteins 0.000 description 1
- 101000949896 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) Uncharacterized RNA pseudouridine synthase MT1592 Proteins 0.000 description 1
- 101000810713 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) Uncharacterized RNA pseudouridine synthase MT1751.1 Proteins 0.000 description 1
- 101100235161 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) lerI gene Proteins 0.000 description 1
- 101000750408 Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154) Uncharacterized RNA pseudouridine synthase MCAP_0714 Proteins 0.000 description 1
- 101100155954 Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154) uvrD gene Proteins 0.000 description 1
- 101000809925 Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) Uncharacterized RNA pseudouridine synthase MG209 Proteins 0.000 description 1
- 101000778054 Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) Uncharacterized RNA pseudouridine synthase MG370 Proteins 0.000 description 1
- 101000815818 Mycoplasma pneumoniae (strain ATCC 29342 / M129) Uncharacterized RNA pseudouridine synthase MG209 homolog Proteins 0.000 description 1
- 101000791066 Mycoplasma pneumoniae (strain ATCC 29342 / M129) Uncharacterized RNA pseudouridine synthase MG370 homolog Proteins 0.000 description 1
- 101100426292 Myxococcus xanthus (strain DK1622) trmFO gene Proteins 0.000 description 1
- 108010046068 N-Acetyllactosamine Synthase Proteins 0.000 description 1
- DEFJQIDDEAULHB-UHFFFAOYSA-N N-D-alanyl-D-alanine Natural products CC(N)C(=O)NC(C)C(O)=O DEFJQIDDEAULHB-UHFFFAOYSA-N 0.000 description 1
- 108010069483 N-acetylglucosamine-6-phosphate deacetylase Proteins 0.000 description 1
- 108010010750 N-acetylmannosamine-6-phosphate epimerase Proteins 0.000 description 1
- 108700020354 N-acetylmuramyl-threonyl-isoglutamine Proteins 0.000 description 1
- PYUSHNKNPOHWEZ-YFKPBYRVSA-N N-formyl-L-methionine Chemical group CSCC[C@@H](C(O)=O)NC=O PYUSHNKNPOHWEZ-YFKPBYRVSA-N 0.000 description 1
- 241001644525 Nastus productus Species 0.000 description 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 description 1
- 206010028885 Necrotising fasciitis Diseases 0.000 description 1
- 101100022193 Neisseria meningitidis serogroup B (strain MC58) macB gene Proteins 0.000 description 1
- 208000006816 Neonatal Sepsis Diseases 0.000 description 1
- 206010061308 Neonatal infection Diseases 0.000 description 1
- 108010006232 Neuraminidase Proteins 0.000 description 1
- 102000005348 Neuraminidase Human genes 0.000 description 1
- 102000000780 Nicotinate phosphoribosyltransferase Human genes 0.000 description 1
- 108700040046 Nicotinate phosphoribosyltransferases Proteins 0.000 description 1
- 101100261469 Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298) trmD gene Proteins 0.000 description 1
- 238000000636 Northern blotting Methods 0.000 description 1
- 241000714209 Norwalk virus Species 0.000 description 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
- 101710141454 Nucleoprotein Proteins 0.000 description 1
- 102000013901 Nucleoside diphosphate kinase Human genes 0.000 description 1
- 101710138316 O-acetylserine sulfhydrylase Proteins 0.000 description 1
- 108010068056 Oligoendopeptidase F Proteins 0.000 description 1
- 101100126319 Oncorhynchus tshawytscha isl3 gene Proteins 0.000 description 1
- 108700026244 Open Reading Frames Proteins 0.000 description 1
- 102000029785 Orotate phosphoribosyltransferase Human genes 0.000 description 1
- 102100037214 Orotidine 5'-phosphate decarboxylase Human genes 0.000 description 1
- 108010016852 Orthophosphate Dikinase Pyruvate Proteins 0.000 description 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 1
- 101710116435 Outer membrane protein Proteins 0.000 description 1
- 102100039792 Oxidized purine nucleoside triphosphate hydrolase Human genes 0.000 description 1
- 101710169326 Oxidized purine nucleoside triphosphate hydrolase Proteins 0.000 description 1
- 101710146072 Oxygen-independent coproporphyrinogen III oxidase Proteins 0.000 description 1
- BQJJESVOLZGHQH-UHNVWZDZSA-N P(=O)(O)(O)O[C@@H](CC(C(=O)O)=O)[C@H](O)CO Chemical compound P(=O)(O)(O)O[C@@H](CC(C(=O)O)=O)[C@H](O)CO BQJJESVOLZGHQH-UHNVWZDZSA-N 0.000 description 1
- 102000000470 PDZ domains Human genes 0.000 description 1
- 108050008994 PDZ domains Proteins 0.000 description 1
- 101710148592 PTS system fructose-like EIIA component Proteins 0.000 description 1
- 101710096749 Penicillin-binding protein 2A Proteins 0.000 description 1
- 101710096751 Penicillin-binding protein 2x Proteins 0.000 description 1
- 102000014419 Peptidase M24 Human genes 0.000 description 1
- 108050003467 Peptidase M24 Proteins 0.000 description 1
- 108010049977 Peptide Elongation Factor Tu Proteins 0.000 description 1
- 101710175727 Peptide chain release factor 1 Proteins 0.000 description 1
- 101710175752 Peptide chain release factor 2 Proteins 0.000 description 1
- 102100021418 Peptide deformylase, mitochondrial Human genes 0.000 description 1
- 108010092494 Periplasmic binding proteins Proteins 0.000 description 1
- 102000007456 Peroxiredoxin Human genes 0.000 description 1
- 108010081690 Pertussis Toxin Proteins 0.000 description 1
- 108050000955 Phage portal protein, HK97 Proteins 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 108091081829 PhoH family Proteins 0.000 description 1
- 108700023175 Phosphate acetyltransferases Proteins 0.000 description 1
- 102100037170 Phosphate carrier protein, mitochondrial Human genes 0.000 description 1
- 101710128683 Phosphate carrier protein, mitochondrial Proteins 0.000 description 1
- 108700023478 Phospho-N-acetylmuramoyl-pentapeptide-transferases Proteins 0.000 description 1
- 108010074307 Phosphoacetylglucosamine mutase Proteins 0.000 description 1
- 102100024440 Phosphoacetylglucosamine mutase Human genes 0.000 description 1
- 108091000041 Phosphoenolpyruvate Carboxylase Proteins 0.000 description 1
- 108050008598 Phosphoesterases Proteins 0.000 description 1
- 108010069341 Phosphofructokinases Proteins 0.000 description 1
- 102000001105 Phosphofructokinases Human genes 0.000 description 1
- 102000011755 Phosphoglycerate Kinase Human genes 0.000 description 1
- 102100035362 Phosphomannomutase 2 Human genes 0.000 description 1
- 102100024279 Phosphomevalonate kinase Human genes 0.000 description 1
- 108010047871 Phosphopantothenoyl-cysteine decarboxylase Proteins 0.000 description 1
- 102100033809 Phosphopantothenoylcysteine decarboxylase Human genes 0.000 description 1
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 description 1
- 102000012288 Phosphopyruvate Hydratase Human genes 0.000 description 1
- 101710205332 Phosphoribosyl-dephospho-CoA transferase Proteins 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- 102100021762 Phosphoserine phosphatase Human genes 0.000 description 1
- 101100392454 Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) gdh2 gene Proteins 0.000 description 1
- 101100274323 Pinus contorta chlN gene Proteins 0.000 description 1
- 101710091831 Pneumococcal vaccine antigen A homolog Proteins 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 208000000474 Poliomyelitis Diseases 0.000 description 1
- 229920002732 Polyanhydride Polymers 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 229920001710 Polyorthoester Polymers 0.000 description 1
- 102000002681 Polyribonucleotide nucleotidyltransferase Human genes 0.000 description 1
- 102100034410 Polyribonucleotide nucleotidyltransferase 1, mitochondrial Human genes 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 101710143843 Primosomal protein DnaI Proteins 0.000 description 1
- 101710087545 Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase Proteins 0.000 description 1
- 101710083689 Probable capsid protein Proteins 0.000 description 1
- 101710096715 Probable histidine-tRNA ligase, cytoplasmic Proteins 0.000 description 1
- 101710113072 Probable methionine synthase Proteins 0.000 description 1
- 108050008853 Probable peptidoglycan glycosyltransferase FtsW Proteins 0.000 description 1
- 101710159957 Probable ribosomal RNA small subunit methyltransferase A Proteins 0.000 description 1
- 101710146427 Probable tyrosine-tRNA ligase, cytoplasmic Proteins 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 101710176177 Protein A56 Proteins 0.000 description 1
- 101710188053 Protein D Proteins 0.000 description 1
- 102000009516 Protein Serine-Threonine Kinases Human genes 0.000 description 1
- 108010009341 Protein Serine-Threonine Kinases Proteins 0.000 description 1
- 101710148278 Protein SprT-like Proteins 0.000 description 1
- 102000002727 Protein Tyrosine Phosphatase Human genes 0.000 description 1
- 101710150114 Protein rep Proteins 0.000 description 1
- 102100030890 Protein shisa-8 Human genes 0.000 description 1
- 108010090931 Proto-Oncogene Proteins c-bcl-2 Proteins 0.000 description 1
- 102000013535 Proto-Oncogene Proteins c-bcl-2 Human genes 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 101710154508 Purine nucleoside phosphorylase 1 Proteins 0.000 description 1
- 101710090776 Putative ribonuclease Z Proteins 0.000 description 1
- 101710086787 Putative ribose-phosphate pyrophosphokinase 2 Proteins 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 108010070648 Pyridoxal Kinase Proteins 0.000 description 1
- 102000002650 Pyridoxamine 5'-phosphate oxidase Human genes 0.000 description 1
- 102000004477 Pyridoxine kinase Human genes 0.000 description 1
- 108010009413 Pyrophosphatases Proteins 0.000 description 1
- 102000009609 Pyrophosphatases Human genes 0.000 description 1
- 102000004518 Pyrroline-5-carboxylate reductase Human genes 0.000 description 1
- 108020005115 Pyruvate Kinase Proteins 0.000 description 1
- 102000013009 Pyruvate Kinase Human genes 0.000 description 1
- 102000002185 R3H domains Human genes 0.000 description 1
- 108050009559 R3H domains Proteins 0.000 description 1
- 108010049094 RNA Recognition Motif Proteins Proteins 0.000 description 1
- 102000008991 RNA Recognition Motif Proteins Human genes 0.000 description 1
- 108010001294 RNase Z Proteins 0.000 description 1
- 102000002150 RNase Z Human genes 0.000 description 1
- 101001095491 Rattus norvegicus 2-iminobutanoate/2-iminopropanoate deaminase Proteins 0.000 description 1
- 101000605535 Rattus norvegicus Tonin Proteins 0.000 description 1
- 101710130905 Regulatory protein RecX Proteins 0.000 description 1
- 108091081062 Repeated sequence (DNA) Proteins 0.000 description 1
- 101710195674 Replication initiator protein Proteins 0.000 description 1
- 101710152114 Replication protein Proteins 0.000 description 1
- 101710132893 Resolvase Proteins 0.000 description 1
- 101100418717 Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) rbsR gene Proteins 0.000 description 1
- 108010086211 Riboflavin synthase Proteins 0.000 description 1
- 108090000151 Ribonuclease BN Proteins 0.000 description 1
- 108090000377 Ribonuclease HIII Proteins 0.000 description 1
- 102000003661 Ribonuclease III Human genes 0.000 description 1
- 108010057163 Ribonuclease III Proteins 0.000 description 1
- 101710089766 Ribonuclease P protein component Proteins 0.000 description 1
- 108090000638 Ribonuclease R Proteins 0.000 description 1
- 108091028664 Ribonucleotide Proteins 0.000 description 1
- 102100031139 Ribose-5-phosphate isomerase Human genes 0.000 description 1
- 101710088476 Ribose-5-phosphate isomerase A Proteins 0.000 description 1
- 102100029508 Ribose-phosphate pyrophosphokinase 1 Human genes 0.000 description 1
- 101710194802 Ribose-phosphate pyrophosphokinase 1 Proteins 0.000 description 1
- 102100029509 Ribose-phosphate pyrophosphokinase 2 Human genes 0.000 description 1
- 101710194801 Ribose-phosphate pyrophosphokinase 2 Proteins 0.000 description 1
- 102000013817 Ribosomal protein L13 Human genes 0.000 description 1
- 108050003655 Ribosomal protein L13 Proteins 0.000 description 1
- 108090000180 Ribosomal protein L31 Proteins 0.000 description 1
- 102000017528 Ribosomal protein L35 Human genes 0.000 description 1
- 108050005789 Ribosomal protein L35 Proteins 0.000 description 1
- 102000004209 Ribosomal protein L5 Human genes 0.000 description 1
- 108090000776 Ribosomal protein L5 Proteins 0.000 description 1
- 102000004394 Ribosomal protein S10 Human genes 0.000 description 1
- 108090000928 Ribosomal protein S10 Proteins 0.000 description 1
- 102000004093 Ribosomal protein S15 Human genes 0.000 description 1
- 108090000530 Ribosomal protein S15 Proteins 0.000 description 1
- 102000004339 Ribosomal protein S2 Human genes 0.000 description 1
- 108090000904 Ribosomal protein S2 Proteins 0.000 description 1
- 102000003861 Ribosomal protein S6 Human genes 0.000 description 1
- 108090000221 Ribosomal protein S6 Proteins 0.000 description 1
- 102000004282 Ribosomal protein S9 Human genes 0.000 description 1
- 108090000878 Ribosomal protein S9 Proteins 0.000 description 1
- 102000008923 Ribosome-binding factor A Human genes 0.000 description 1
- 108050000877 Ribosome-binding factor A Proteins 0.000 description 1
- 108060007030 Ribulose-phosphate 3-epimerase Proteins 0.000 description 1
- 101000815909 Rickettsia bellii (strain RML369-C) Uncharacterized RNA pseudouridine synthase RBE_0321 Proteins 0.000 description 1
- 101000791439 Rickettsia conorii (strain ATCC VR-613 / Malish 7) Uncharacterized RNA pseudouridine synthase RC0807 Proteins 0.000 description 1
- 101100313751 Rickettsia conorii (strain ATCC VR-613 / Malish 7) thyX gene Proteins 0.000 description 1
- 101000815366 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) Uncharacterized RNA pseudouridine synthase RF_0863 Proteins 0.000 description 1
- 101000813845 Rickettsia prowazekii (strain Madrid E) Uncharacterized RNA pseudouridine synthase RP544 Proteins 0.000 description 1
- 101000965828 Rickettsia typhi (strain ATCC VR-144 / Wilmington) Uncharacterized RNA pseudouridine synthase RT0532 Proteins 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 241000702670 Rotavirus Species 0.000 description 1
- 101150102982 RpS10 gene Proteins 0.000 description 1
- 102100026115 S-adenosylmethionine synthase isoform type-1 Human genes 0.000 description 1
- 108030000386 S-adenosylmethionine:tRNA ribosyltransferase-isomerases Proteins 0.000 description 1
- 101710190423 S-ribosylhomocysteine lyase Proteins 0.000 description 1
- 101150088541 SCPA gene Proteins 0.000 description 1
- 102000018673 SEC Translocation Channels Human genes 0.000 description 1
- 108010091732 SEC Translocation Channels Proteins 0.000 description 1
- 108091006275 SLC5A7 Proteins 0.000 description 1
- 101150085962 SPT5 gene Proteins 0.000 description 1
- 101100005430 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) cpsA1 gene Proteins 0.000 description 1
- 101100116769 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) gdhA-2 gene Proteins 0.000 description 1
- 101100423624 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) leuS2 gene Proteins 0.000 description 1
- 101000988102 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ATP-dependent molecular chaperone HSP82 Proteins 0.000 description 1
- 101100071291 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HOT13 gene Proteins 0.000 description 1
- 101000832034 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Inactive diphosphatase DCS2 Proteins 0.000 description 1
- ACQJWVPNGVNRCD-UHFFFAOYSA-N Sakacin A Chemical compound CC(C)(C)N(C)C(=O)NC(C)NC(=O)C(N)CC(O)=O ACQJWVPNGVNRCD-UHFFFAOYSA-N 0.000 description 1
- 101100399642 Salmonella paratyphi A (strain ATCC 9150 / SARB42) lpp3 gene Proteins 0.000 description 1
- 206010039587 Scarlet Fever Diseases 0.000 description 1
- 101000994877 Schizosaccharomyces pombe (strain 972 / ATCC 24843) Putative inorganic pyrophosphatase C3A12.02 Proteins 0.000 description 1
- 101100353039 Schizosaccharomyces pombe (strain 972 / ATCC 24843) ppe1 gene Proteins 0.000 description 1
- 101100042789 Schizosaccharomyces pombe (strain 972 / ATCC 24843) psm1 gene Proteins 0.000 description 1
- 108091058545 Secretory proteins Proteins 0.000 description 1
- 102000040739 Secretory proteins Human genes 0.000 description 1
- 101710105498 Sensor protein DltS Proteins 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 108091022908 Serine O-acetyltransferase Proteins 0.000 description 1
- 102000019394 Serine hydroxymethyltransferases Human genes 0.000 description 1
- 108090000899 Serralysin Proteins 0.000 description 1
- 108050008280 Shikimate dehydrogenase Proteins 0.000 description 1
- 108010051611 Signal Recognition Particle Proteins 0.000 description 1
- 108090000233 Signal peptidase II Proteins 0.000 description 1
- 102000013598 Signal recognition particle Human genes 0.000 description 1
- 241000710960 Sindbis virus Species 0.000 description 1
- 101710141933 Single-stranded DNA-binding protein 1 Proteins 0.000 description 1
- 101710141938 Single-stranded DNA-binding protein 2 Proteins 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 239000004147 Sorbitan trioleate Substances 0.000 description 1
- 238000002105 Southern blotting Methods 0.000 description 1
- 101100514903 Staphylococcus haemolyticus (strain JCSC1435) murA1 gene Proteins 0.000 description 1
- 101000891118 Staphylococcus phage phiMR25 Putative tail protein Proteins 0.000 description 1
- 101100095302 Streptococcus gordonii secA1 gene Proteins 0.000 description 1
- 101100083037 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) act gene Proteins 0.000 description 1
- 101100380695 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) atpB gene Proteins 0.000 description 1
- 101100006983 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) coaC gene Proteins 0.000 description 1
- 101100342648 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) lacD1 gene Proteins 0.000 description 1
- 101100408982 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) ppaC gene Proteins 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 241000193996 Streptococcus pyogenes Species 0.000 description 1
- 101100443856 Streptococcus pyogenes serotype M18 (strain MGAS8232) polC gene Proteins 0.000 description 1
- 241001505901 Streptococcus sp. 'group A' Species 0.000 description 1
- 101100221861 Streptococcus thermophilus cpsJ gene Proteins 0.000 description 1
- 101100197084 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) rpmF1 gene Proteins 0.000 description 1
- 101100114901 Streptomyces griseus crtI gene Proteins 0.000 description 1
- 101710135785 Subtilisin-like protease Proteins 0.000 description 1
- 102000005262 Sulfatase Human genes 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 101100156073 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) atpD gene Proteins 0.000 description 1
- 102000008221 Superoxide Dismutase-1 Human genes 0.000 description 1
- 108010021188 Superoxide Dismutase-1 Proteins 0.000 description 1
- 101100147268 Symbiobacterium thermophilum (strain T / IAM 14863) rpsD1 gene Proteins 0.000 description 1
- 101000774386 Synechocystis sp. (strain PCC 6803 / Kazusa) Uncharacterized RNA pseudouridine synthase slr0361 Proteins 0.000 description 1
- 101000965702 Synechocystis sp. (strain PCC 6803 / Kazusa) Uncharacterized RNA pseudouridine synthase slr0612 Proteins 0.000 description 1
- 101000949878 Synechocystis sp. (strain PCC 6803 / Kazusa) Uncharacterized RNA pseudouridine synthase slr1592 Proteins 0.000 description 1
- 101000758840 Synechocystis sp. (strain PCC 6803 / Kazusa) Uncharacterized RNA pseudouridine synthase slr1629 Proteins 0.000 description 1
- 230000029662 T-helper 1 type immune response Effects 0.000 description 1
- 101710199973 Tail tube protein Proteins 0.000 description 1
- 101100057034 Talaromyces wortmannii astB gene Proteins 0.000 description 1
- 101710204224 Tape measure protein Proteins 0.000 description 1
- 108091073674 TatD family Proteins 0.000 description 1
- 108091085146 TenA family Proteins 0.000 description 1
- 241000623377 Terminalia elliptica Species 0.000 description 1
- 101100111413 Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) lacZ gene Proteins 0.000 description 1
- 101001099217 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) Triosephosphate isomerase Proteins 0.000 description 1
- 101100064634 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) ecfA1 gene Proteins 0.000 description 1
- 101100002724 Thermus thermophilus aroH gene Proteins 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 102000002932 Thiolase Human genes 0.000 description 1
- 108060008225 Thiolase Proteins 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical class OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 description 1
- 102100036407 Thioredoxin Human genes 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 102000001618 Threonine-tRNA Ligase Human genes 0.000 description 1
- 108010029287 Threonine-tRNA ligase Proteins 0.000 description 1
- 102000006601 Thymidine Kinase Human genes 0.000 description 1
- 108020004440 Thymidine kinase Proteins 0.000 description 1
- 102000005497 Thymidylate Synthase Human genes 0.000 description 1
- 102100037357 Thymidylate kinase Human genes 0.000 description 1
- 102100033451 Thyroid hormone receptor beta Human genes 0.000 description 1
- 206010044248 Toxic shock syndrome Diseases 0.000 description 1
- 231100000650 Toxic shock syndrome Toxicity 0.000 description 1
- 101710182223 Toxin B Proteins 0.000 description 1
- 102100031027 Transcription activator BRG1 Human genes 0.000 description 1
- 101710165381 Transcription antitermination protein NusB Proteins 0.000 description 1
- 108050009175 Transcription elongation factor GreA Proteins 0.000 description 1
- 101710153581 Transcriptional regulator CtsR Proteins 0.000 description 1
- 101710122162 Transcriptional regulatory protein CiaR Proteins 0.000 description 1
- 101710163762 Transcriptional regulatory protein DltR Proteins 0.000 description 1
- 108050005726 Translation elongation factor P Proteins 0.000 description 1
- 101710198306 Translation initiation factor IF-3 Proteins 0.000 description 1
- 101100354953 Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104) pyrBI gene Proteins 0.000 description 1
- 101100538210 Treponema pallidum (strain Nichols) troB gene Proteins 0.000 description 1
- 102000005924 Triose-Phosphate Isomerase Human genes 0.000 description 1
- 108700015934 Triose-phosphate isomerases Proteins 0.000 description 1
- 108010070926 Tripeptide aminopeptidase Proteins 0.000 description 1
- 108091068390 TrmA family Proteins 0.000 description 1
- 102000002501 Tryptophan-tRNA Ligase Human genes 0.000 description 1
- 108050005497 Tyrosine recombinase XerC Proteins 0.000 description 1
- 108050005498 Tyrosine recombinase XerD Proteins 0.000 description 1
- 101710185366 Tyrosine-protein kinase CpsD Proteins 0.000 description 1
- 102000018378 Tyrosine-tRNA ligase Human genes 0.000 description 1
- 101710107268 Tyrosine-tRNA ligase, mitochondrial Proteins 0.000 description 1
- 101710091363 UDP-N-acetylglucosamine 2-epimerase Proteins 0.000 description 1
- 102100037921 UDP-N-acetylglucosamine pyrophosphorylase Human genes 0.000 description 1
- 108010044041 UDP-N-acetylmuramate dehydrogenase Proteins 0.000 description 1
- 101710106680 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase Proteins 0.000 description 1
- 108030007220 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligases Proteins 0.000 description 1
- 101710114328 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase Proteins 0.000 description 1
- 108010040921 UDP-N-acetylmuramoylalanine-D-glutamate ligase Proteins 0.000 description 1
- 101710191941 UDP-N-acetylmuramyl-tripeptide synthetase Proteins 0.000 description 1
- 108010061048 UDPacetylglucosamine pyrophosphorylase Proteins 0.000 description 1
- 101710100179 UMP-CMP kinase Proteins 0.000 description 1
- 101710119674 UMP-CMP kinase 2, mitochondrial Proteins 0.000 description 1
- 101710199192 Uncharacterized membrane protein Proteins 0.000 description 1
- 101710117260 Uracil permease Proteins 0.000 description 1
- 108010019092 Uridine phosphorylase Proteins 0.000 description 1
- 102100020892 Uridine phosphorylase 1 Human genes 0.000 description 1
- 108010038900 X-Pro aminopeptidase Proteins 0.000 description 1
- 102100039662 Xaa-Pro dipeptidase Human genes 0.000 description 1
- 108030005913 Xaa-Pro dipeptidyl-peptidases Proteins 0.000 description 1
- 101710090739 Xanthine permease Proteins 0.000 description 1
- 108010027570 Xanthine phosphoribosyltransferase Proteins 0.000 description 1
- 101710204001 Zinc metalloprotease Proteins 0.000 description 1
- FYIPKJHNWFVEIR-UHFFFAOYSA-N Zwittermicin A Natural products OCC(N)C(O)CC(O)C(N)C(O)C(O)C(=O)NC(C(N)=O)CNC(N)=O FYIPKJHNWFVEIR-UHFFFAOYSA-N 0.000 description 1
- 101000631380 Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) Uncharacterized RNA pseudouridine synthase ZMO0505 Proteins 0.000 description 1
- 101150013885 accB gene Proteins 0.000 description 1
- IPBVNPXQWQGGJP-UHFFFAOYSA-N acetic acid phenyl ester Natural products CC(=O)OC1=CC=CC=C1 IPBVNPXQWQGGJP-UHFFFAOYSA-N 0.000 description 1
- 108010084631 acetolactate decarboxylase Proteins 0.000 description 1
- 230000021736 acetylation Effects 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 108010093941 acetylxylan esterase Proteins 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 101150006213 ackA gene Proteins 0.000 description 1
- 108091006088 activator proteins Proteins 0.000 description 1
- 108700021044 acyl-ACP thioesterase Proteins 0.000 description 1
- 101150090369 adcR gene Proteins 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 108010039040 adenine glycosylase Proteins 0.000 description 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 1
- 102000030621 adenylate cyclase Human genes 0.000 description 1
- 108060000200 adenylate cyclase Proteins 0.000 description 1
- 102000005130 adenylosuccinate synthetase Human genes 0.000 description 1
- 101150024743 adhA gene Proteins 0.000 description 1
- 230000000240 adjuvant effect Effects 0.000 description 1
- 108010056243 alanylalanine Proteins 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 125000005600 alkyl phosphonate group Chemical group 0.000 description 1
- NWMHDZMRVUOQGL-CZEIJOLGSA-N almurtide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)CO[C@@H]([C@H](O)[C@H](O)CO)[C@@H](NC(C)=O)C=O NWMHDZMRVUOQGL-CZEIJOLGSA-N 0.000 description 1
- 229940061720 alpha hydroxy acid Drugs 0.000 description 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 1
- 108010013829 alpha subunit DNA polymerase III Proteins 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229940047712 aluminum hydroxyphosphate Drugs 0.000 description 1
- 108010076762 aminoglycoside 6-adenylyltransferase Proteins 0.000 description 1
- 108010020881 anaerobic ribonucleotide reductase Proteins 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003302 anti-idiotype Effects 0.000 description 1
- 238000010913 antigen-directed enzyme pro-drug therapy Methods 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000000074 antisense oligonucleotide Substances 0.000 description 1
- 238000012230 antisense oligonucleotides Methods 0.000 description 1
- 101150075954 apeB gene Proteins 0.000 description 1
- 101150118463 argG gene Proteins 0.000 description 1
- 101150089004 argR gene Proteins 0.000 description 1
- 101150024756 argS gene Proteins 0.000 description 1
- 101150037081 aroA gene Proteins 0.000 description 1
- 101150090235 aroB gene Proteins 0.000 description 1
- 101150042732 aroC gene Proteins 0.000 description 1
- 101150102858 aroD gene Proteins 0.000 description 1
- 101150040872 aroE gene Proteins 0.000 description 1
- 101150076125 aroG gene Proteins 0.000 description 1
- 101150083869 aroK gene Proteins 0.000 description 1
- 101150108612 aroQ gene Proteins 0.000 description 1
- 101150046576 arsC gene Proteins 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 238000013528 artificial neural network Methods 0.000 description 1
- 101150062095 asnA gene Proteins 0.000 description 1
- 101150014732 asnS gene Proteins 0.000 description 1
- 101150070145 aspB gene Proteins 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 101150088806 atpA gene Proteins 0.000 description 1
- 101150090348 atpC gene Proteins 0.000 description 1
- 101150084317 bacA gene Proteins 0.000 description 1
- 229940005348 bacillus firmus Drugs 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000000688 bacterial toxin Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 108010051210 beta-Fructofuranosidase Proteins 0.000 description 1
- 102000006995 beta-Glucosidase Human genes 0.000 description 1
- 108010047754 beta-Glucosidase Proteins 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- UUQMNUMQCIQDMZ-UHFFFAOYSA-N betahistine Chemical compound CNCCC1=CC=CC=N1 UUQMNUMQCIQDMZ-UHFFFAOYSA-N 0.000 description 1
- 101150029327 bioB gene Proteins 0.000 description 1
- 230000035587 bioadhesion Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 238000010170 biological method Methods 0.000 description 1
- 108010032108 biotin repressor Proteins 0.000 description 1
- 101150110896 bipA gene Proteins 0.000 description 1
- 101150031021 birA gene Proteins 0.000 description 1
- 101150098189 brnQ gene Proteins 0.000 description 1
- 229910052793 cadmium Inorganic materials 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 108010057927 carboxymethylenebutenolidase Proteins 0.000 description 1
- 108700006117 cardiolipin synthetase Proteins 0.000 description 1
- 101150117416 cas2 gene Proteins 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 101150008949 cbiO gene Proteins 0.000 description 1
- 101150016646 cdsA gene Proteins 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 108010080434 cephalosporin-C deacetylase Proteins 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- WTFXTQVDAKGDEY-HTQZYQBOSA-L chorismate(2-) Chemical compound O[C@@H]1C=CC(C([O-])=O)=C[C@H]1OC(=C)C([O-])=O WTFXTQVDAKGDEY-HTQZYQBOSA-L 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 229960002173 citrulline Drugs 0.000 description 1
- 235000013477 citrulline Nutrition 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000013599 cloning vector Substances 0.000 description 1
- 101150074451 clpP gene Proteins 0.000 description 1
- 101150043719 clpP1 gene Proteins 0.000 description 1
- 101150102296 clpP2 gene Proteins 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 235000021310 complex sugar Nutrition 0.000 description 1
- 101150023807 copB gene Proteins 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 201000003740 cowpox Diseases 0.000 description 1
- 101150007330 cpdB gene Proteins 0.000 description 1
- 101150027335 cpsB gene Proteins 0.000 description 1
- 101150091586 cpsC gene Proteins 0.000 description 1
- 101150094781 cpsE gene Proteins 0.000 description 1
- 101150032490 cpsY gene Proteins 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 101150000046 crtE gene Proteins 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 101150055944 cvpA gene Proteins 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 101150016170 cydB gene Proteins 0.000 description 1
- 101150111114 cysE gene Proteins 0.000 description 1
- 101150094831 cysK gene Proteins 0.000 description 1
- 101150112941 cysK1 gene Proteins 0.000 description 1
- 101150029709 cysM gene Proteins 0.000 description 1
- 108010032065 cysteine aminopeptidase Proteins 0.000 description 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical class NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 1
- 101150096588 czcR gene Proteins 0.000 description 1
- 108060002399 dTDP-4-dehydrorhamnose 3,5-epimerase Proteins 0.000 description 1
- 102000029589 dTDPglucose 4,6-dehydratase Human genes 0.000 description 1
- 108091000032 dTDPglucose 4,6-dehydratase Proteins 0.000 description 1
- 108010000742 dTMP kinase Proteins 0.000 description 1
- 101150100742 dapL gene Proteins 0.000 description 1
- 238000006114 decarboxylation reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 101150062753 deoB gene Proteins 0.000 description 1
- 101150013644 deoC gene Proteins 0.000 description 1
- 101150072043 deoD gene Proteins 0.000 description 1
- 102000030794 deoxyribose-phosphate aldolase Human genes 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000024531 detection of redox state Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 102000004419 dihydrofolate reductase Human genes 0.000 description 1
- 108010089355 dihydroneopterin aldolase Proteins 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 101150096961 dltA gene Proteins 0.000 description 1
- 101150016902 dltC gene Proteins 0.000 description 1
- 101150075463 dltD gene Proteins 0.000 description 1
- 101150020338 dnaA gene Proteins 0.000 description 1
- 101150076598 dnaB gene Proteins 0.000 description 1
- 101150035285 dnaE1 gene Proteins 0.000 description 1
- 101150003155 dnaG gene Proteins 0.000 description 1
- 101150016422 dnaX gene Proteins 0.000 description 1
- 101150105616 dppF gene Proteins 0.000 description 1
- 101150109576 dprA gene Proteins 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 101150032177 ecfA gene Proteins 0.000 description 1
- 108010063460 elongation factor T Proteins 0.000 description 1
- 230000013020 embryo development Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 229940032049 enterococcus faecalis Drugs 0.000 description 1
- 239000000147 enterotoxin Substances 0.000 description 1
- 231100000655 enterotoxin Toxicity 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 108010055265 exo-1,6-alpha-glucosidase Proteins 0.000 description 1
- 108010052305 exodeoxyribonuclease III Proteins 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000013213 extrapolation Methods 0.000 description 1
- 101150004992 fadA gene Proteins 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 102000025748 fibrinogen binding proteins Human genes 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 101150011175 folB gene Proteins 0.000 description 1
- 101150045875 folP gene Proteins 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 230000037433 frameshift Effects 0.000 description 1
- 101150101609 ftsA gene Proteins 0.000 description 1
- 101150054895 ftsH gene Proteins 0.000 description 1
- 101150098503 ftsX gene Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 101150048660 gatB gene Proteins 0.000 description 1
- 101150110946 gatC gene Proteins 0.000 description 1
- 238000012268 genome sequencing Methods 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 101150019926 glgA gene Proteins 0.000 description 1
- 101150065899 glgA1 gene Proteins 0.000 description 1
- 101150070444 glgB gene Proteins 0.000 description 1
- 101150013858 glgC gene Proteins 0.000 description 1
- 101150072146 glgD gene Proteins 0.000 description 1
- 101150037310 glgM gene Proteins 0.000 description 1
- 101150073660 glmM gene Proteins 0.000 description 1
- 101150115690 gloA gene Proteins 0.000 description 1
- 101150056064 glpK gene Proteins 0.000 description 1
- 101150040073 glpK2 gene Proteins 0.000 description 1
- 101150095702 glpT gene Proteins 0.000 description 1
- 108090001082 glucan-binding proteins Proteins 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 108010082465 gluconate 5-dehydrogenase Proteins 0.000 description 1
- 230000004190 glucose uptake Effects 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 102000005396 glutamine synthetase Human genes 0.000 description 1
- 108020002326 glutamine synthetase Proteins 0.000 description 1
- 108010064177 glutamine synthetase I Proteins 0.000 description 1
- 101150097303 glyA gene Proteins 0.000 description 1
- 101150079604 glyA1 gene Proteins 0.000 description 1
- 101150055337 glyQ gene Proteins 0.000 description 1
- 101150049851 glyS gene Proteins 0.000 description 1
- 150000004676 glycans Polymers 0.000 description 1
- 108010086476 glycerate kinase Proteins 0.000 description 1
- 108010044713 glycerol-3-phosphate dehydrogenase (NAD(P)+) Proteins 0.000 description 1
- 230000034659 glycolysis Effects 0.000 description 1
- 125000003147 glycosyl group Chemical group 0.000 description 1
- 101150084612 gpmA gene Proteins 0.000 description 1
- 101150104722 gpmI gene Proteins 0.000 description 1
- 101150004480 greA gene Proteins 0.000 description 1
- 101150006844 groES gene Proteins 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 101150035744 guaB gene Proteins 0.000 description 1
- 101150090752 guaC gene Proteins 0.000 description 1
- 101150070420 gyrA gene Proteins 0.000 description 1
- 101150013736 gyrB gene Proteins 0.000 description 1
- 229940047650 haemophilus influenzae Drugs 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 239000000185 hemagglutinin Substances 0.000 description 1
- 239000003228 hemolysin Substances 0.000 description 1
- 108010025743 hexose phosphate synthetase Proteins 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 108700039582 histidine triad Proteins 0.000 description 1
- 108010071598 homoserine kinase Proteins 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 101150027445 hprK gene Proteins 0.000 description 1
- 101150059304 hup gene Proteins 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 101150099953 ilvE gene Proteins 0.000 description 1
- HOPZBJPSUKPLDT-UHFFFAOYSA-N imidazo[4,5-h]quinolin-2-one Chemical class C1=CN=C2C3=NC(=O)N=C3C=CC2=C1 HOPZBJPSUKPLDT-UHFFFAOYSA-N 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 229940124644 immune regulator Drugs 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000003119 immunoblot Methods 0.000 description 1
- 230000004957 immunoregulator effect Effects 0.000 description 1
- 229960001438 immunostimulant agent Drugs 0.000 description 1
- 239000003022 immunostimulating agent Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 101150077178 infC gene Proteins 0.000 description 1
- 108091006086 inhibitor proteins Proteins 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 230000015788 innate immune response Effects 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 102000006029 inositol monophosphatase Human genes 0.000 description 1
- 108700014864 inositol monophosphatase family Proteins 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 230000010468 interferon response Effects 0.000 description 1
- 229940047122 interleukins Drugs 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 238000006317 isomerization reaction Methods 0.000 description 1
- 101150068863 ispE gene Proteins 0.000 description 1
- 101150004863 ksgA gene Proteins 0.000 description 1
- 229940116298 l- malic acid Drugs 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 101150086432 lacA gene Proteins 0.000 description 1
- 101150001540 lacB gene Proteins 0.000 description 1
- 101150007118 lacD gene Proteins 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229940062711 laureth-9 Drugs 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 229940115932 legionella pneumophila Drugs 0.000 description 1
- 101150021684 leuS gene Proteins 0.000 description 1
- 210000004901 leucine-rich repeat Anatomy 0.000 description 1
- 101150107488 ligA gene Proteins 0.000 description 1
- 230000029226 lipidation Effects 0.000 description 1
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 description 1
- 235000019136 lipoic acid Nutrition 0.000 description 1
- 125000003977 lipoyl group Chemical group S1SC(C([H])([H])C(C(C(C(=O)[*])([H])[H])([H])[H])([H])[H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 101150005075 lpp2 gene Proteins 0.000 description 1
- 101150054032 lspA gene Proteins 0.000 description 1
- 101150078797 luxS gene Proteins 0.000 description 1
- 101150110767 lysS gene Proteins 0.000 description 1
- 101150056234 lysS1 gene Proteins 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 101150032120 manC gene Proteins 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 108010040533 mannonate dehydratase Proteins 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 101150106833 metG gene Proteins 0.000 description 1
- 101150062025 metG1 gene Proteins 0.000 description 1
- 101150095438 metK gene Proteins 0.000 description 1
- 108010020410 methionine sulfoxide reductase Proteins 0.000 description 1
- 108010057757 methionyl-tRNA formyltransferase Proteins 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 102000002678 mevalonate kinase Human genes 0.000 description 1
- 101150094029 miaA gene Proteins 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 101150051633 mnmA gene Proteins 0.000 description 1
- 101150034648 mnmG gene Proteins 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- QUSNBJAOOMFDIB-UHFFFAOYSA-N monoethyl amine Natural products CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 1
- ZLVYMPOQNJTFSG-QMMMGPOBSA-N monoiodotyrosine Chemical compound OC(=O)[C@@H](NI)CC1=CC=C(O)C=C1 ZLVYMPOQNJTFSG-QMMMGPOBSA-N 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 101150074096 mraY gene Proteins 0.000 description 1
- 101150035917 mreB gene Proteins 0.000 description 1
- 101150071774 mscL gene Proteins 0.000 description 1
- 101150068440 msrB gene Proteins 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 101150095093 murB gene Proteins 0.000 description 1
- 101150034514 murC gene Proteins 0.000 description 1
- 101150093075 murD gene Proteins 0.000 description 1
- 101150037968 murG gene Proteins 0.000 description 1
- 101150047269 murI gene Proteins 0.000 description 1
- 101150013854 mutS gene Proteins 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 229930187734 mycinamicin Natural products 0.000 description 1
- 101150049023 nadE gene Proteins 0.000 description 1
- 201000007970 necrotizing fasciitis Diseases 0.000 description 1
- 230000017066 negative regulation of growth Effects 0.000 description 1
- 101150019075 neuA gene Proteins 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 101150035869 nrdD gene Proteins 0.000 description 1
- 239000002853 nucleic acid probe Substances 0.000 description 1
- 102000037831 nucleoside transporters Human genes 0.000 description 1
- 108091006527 nucleoside transporters Proteins 0.000 description 1
- 102000026415 nucleotide binding proteins Human genes 0.000 description 1
- 108091014756 nucleotide binding proteins Proteins 0.000 description 1
- 101150048443 nusB gene Proteins 0.000 description 1
- 101150115599 nusG gene Proteins 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 101150078036 odhB gene Proteins 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 108010008567 oligopeptidase PepO Proteins 0.000 description 1
- 102000022744 oligopeptide binding proteins Human genes 0.000 description 1
- 108091013547 oligopeptide binding proteins Proteins 0.000 description 1
- 101150007977 oppD gene Proteins 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000006179 pH buffering agent Substances 0.000 description 1
- 101150013947 pabB gene Proteins 0.000 description 1
- 101150012629 parE gene Proteins 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 101150028617 pcn gene Proteins 0.000 description 1
- 101150025785 pcn1 gene Proteins 0.000 description 1
- 101150027434 pcrA gene Proteins 0.000 description 1
- 101150094986 pepC gene Proteins 0.000 description 1
- 101150047280 pepF gene Proteins 0.000 description 1
- 101150095025 pepX gene Proteins 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 108030002458 peroxiredoxin Proteins 0.000 description 1
- 108010021711 pertactin Proteins 0.000 description 1
- 101150049339 pflA gene Proteins 0.000 description 1
- 101150111581 pflB gene Proteins 0.000 description 1
- 101150076330 pgsA gene Proteins 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- 108010083127 phage repressor proteins Proteins 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 101150080777 pheS gene Proteins 0.000 description 1
- 101150016769 pheT gene Proteins 0.000 description 1
- 229940049953 phenylacetate Drugs 0.000 description 1
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 1
- 101150076762 phnB gene Proteins 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 108010055837 phosphocarrier protein HPr Proteins 0.000 description 1
- 229930029653 phosphoenolpyruvate Natural products 0.000 description 1
- 108010045020 phosphoenolpyruvate-protein phosphotransferase Proteins 0.000 description 1
- 108010032867 phosphoglucosamine mutase Proteins 0.000 description 1
- 108091000116 phosphomevalonate kinase Proteins 0.000 description 1
- DTBNBXWJWCWCIK-UHFFFAOYSA-K phosphonatoenolpyruvate Chemical compound [O-]C(=O)C(=C)OP([O-])([O-])=O DTBNBXWJWCWCIK-UHFFFAOYSA-K 0.000 description 1
- 108010029331 phosphonoacetate hydrolase Proteins 0.000 description 1
- 150000008300 phosphoramidites Chemical class 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 108010076573 phosphoserine phosphatase Proteins 0.000 description 1
- 235000021118 plant-derived protein Nutrition 0.000 description 1
- 101150060505 polC gene Proteins 0.000 description 1
- ONJQDTZCDSESIW-UHFFFAOYSA-N polidocanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ONJQDTZCDSESIW-UHFFFAOYSA-N 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
- 229920002627 poly(phosphazenes) Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 239000004632 polycaprolactone Substances 0.000 description 1
- 108010094020 polyglycine Proteins 0.000 description 1
- 229920000232 polyglycine polymer Polymers 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 229940051841 polyoxyethylene ether Drugs 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000001323 posttranslational effect Effects 0.000 description 1
- 101150016899 potA gene Proteins 0.000 description 1
- 101150088506 potB gene Proteins 0.000 description 1
- 101150022581 potC gene Proteins 0.000 description 1
- 101150063097 ppdK gene Proteins 0.000 description 1
- 101150061147 preA gene Proteins 0.000 description 1
- 229940071643 prefilled syringe Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 101150093386 prfA gene Proteins 0.000 description 1
- 101150032960 prfB gene Proteins 0.000 description 1
- 101150037668 prmA gene Proteins 0.000 description 1
- 108010066823 proline dipeptidase Proteins 0.000 description 1
- 108010042589 prolyl T RNA synthetase Proteins 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 108010043671 prostatic acid phosphatase Proteins 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 108020000494 protein-tyrosine phosphatase Proteins 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 101150118630 ptsI gene Proteins 0.000 description 1
- 101150042478 punA gene Proteins 0.000 description 1
- 101150002764 purA gene Proteins 0.000 description 1
- 101150076045 purF gene Proteins 0.000 description 1
- 101150035806 purK gene Proteins 0.000 description 1
- 101150098691 pyrB gene Proteins 0.000 description 1
- 101150107042 pyrD gene Proteins 0.000 description 1
- 101150092104 pyrDB gene Proteins 0.000 description 1
- 101150116440 pyrF gene Proteins 0.000 description 1
- 101150054232 pyrG gene Proteins 0.000 description 1
- 101150006862 pyrH gene Proteins 0.000 description 1
- 108700015923 pyridoxamine 5'-phosphate oxidase family Proteins 0.000 description 1
- 150000003230 pyrimidines Chemical class 0.000 description 1
- 108020001898 pyrroline-5-carboxylate reductase Proteins 0.000 description 1
- 101150007176 qacE gene Proteins 0.000 description 1
- 101150063978 queA gene Proteins 0.000 description 1
- 108010061997 queuine tRNA-ribosyltransferase Proteins 0.000 description 1
- 102000005499 queuine tRNA-ribosyltransferase Human genes 0.000 description 1
- 101150074763 radC gene Proteins 0.000 description 1
- 101150060756 rbfA gene Proteins 0.000 description 1
- 101150042846 rbsA gene Proteins 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 101150037928 recN gene Proteins 0.000 description 1
- 101150103919 recO gene Proteins 0.000 description 1
- 101150033993 recR gene Proteins 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000009711 regulatory function Effects 0.000 description 1
- 101150055347 repA2 gene Proteins 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 210000001995 reticulocyte Anatomy 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 101150112345 rfbA gene Proteins 0.000 description 1
- 101150055510 rfbB gene Proteins 0.000 description 1
- 101150036579 ribBA gene Proteins 0.000 description 1
- 101150003625 ribD gene Proteins 0.000 description 1
- 101150073450 ribE gene Proteins 0.000 description 1
- 108090000731 ribonuclease HII Proteins 0.000 description 1
- 239000002336 ribonucleotide Substances 0.000 description 1
- 125000002652 ribonucleotide group Chemical group 0.000 description 1
- 108010025552 ribosomal protein L11 Proteins 0.000 description 1
- 108090000327 ribosomal protein L21 Proteins 0.000 description 1
- 108010025325 ribosomal protein L32 Proteins 0.000 description 1
- 108010025396 ribosomal protein L34 Proteins 0.000 description 1
- 108090000893 ribosomal protein L4 Proteins 0.000 description 1
- 108010037046 ribosomal protein L7-L12 Proteins 0.000 description 1
- 108010092841 ribosomal protein S12 Proteins 0.000 description 1
- 108010092955 ribosomal protein S16 Proteins 0.000 description 1
- 108010093121 ribosomal protein S17 Proteins 0.000 description 1
- 102000004296 ribosomal protein S18 Human genes 0.000 description 1
- 108090000842 ribosomal protein S18 Proteins 0.000 description 1
- 108010092942 ribosomal protein S20 Proteins 0.000 description 1
- 108010092936 ribosomal protein S21 Proteins 0.000 description 1
- 108010033786 ribosomal protein S4 Proteins 0.000 description 1
- 108010033405 ribosomal protein S7 Proteins 0.000 description 1
- 108010067528 ribosomal proteins L27 Proteins 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- 210000004708 ribosome subunit Anatomy 0.000 description 1
- 102000004688 ribulosephosphate 3-epimerase Human genes 0.000 description 1
- 101150006434 rimI gene Proteins 0.000 description 1
- 101150099889 rmlA gene Proteins 0.000 description 1
- 101150043440 rmlB gene Proteins 0.000 description 1
- 101150014148 rnhB gene Proteins 0.000 description 1
- 101150051303 rnpA gene Proteins 0.000 description 1
- 101150003316 rpiA gene Proteins 0.000 description 1
- 101150060526 rpl1 gene Proteins 0.000 description 1
- 101150079275 rplA gene Proteins 0.000 description 1
- 101150034310 rplF gene Proteins 0.000 description 1
- 101150101962 rplI gene Proteins 0.000 description 1
- 101150100282 rplK gene Proteins 0.000 description 1
- 101150118024 rplK1 gene Proteins 0.000 description 1
- 101150050931 rplL gene Proteins 0.000 description 1
- 101150104526 rplM gene Proteins 0.000 description 1
- 101150001987 rplS gene Proteins 0.000 description 1
- 101150071779 rplT gene Proteins 0.000 description 1
- 101150008233 rplU gene Proteins 0.000 description 1
- 101150096944 rpmA gene Proteins 0.000 description 1
- 101150115705 rpmE gene Proteins 0.000 description 1
- 101150063110 rpmE2 gene Proteins 0.000 description 1
- 101150059313 rpmF gene Proteins 0.000 description 1
- 101150047139 rpo1N gene Proteins 0.000 description 1
- 101150085857 rpo2 gene Proteins 0.000 description 1
- 101150037064 rpoA gene Proteins 0.000 description 1
- 101150090202 rpoB gene Proteins 0.000 description 1
- 101150063255 rps17 gene Proteins 0.000 description 1
- 101150078369 rpsB gene Proteins 0.000 description 1
- 101150087540 rpsD gene Proteins 0.000 description 1
- 101150114376 rpsD2 gene Proteins 0.000 description 1
- 101150085492 rpsF gene Proteins 0.000 description 1
- 101150036132 rpsG gene Proteins 0.000 description 1
- 101150030614 rpsI gene Proteins 0.000 description 1
- 101150103887 rpsJ gene Proteins 0.000 description 1
- 101150098466 rpsL gene Proteins 0.000 description 1
- 101150058136 rpsO gene Proteins 0.000 description 1
- 101150116648 rpsP gene Proteins 0.000 description 1
- 101150052647 rpsQ gene Proteins 0.000 description 1
- 101150006569 rpsR gene Proteins 0.000 description 1
- 101150029588 rpsR1 gene Proteins 0.000 description 1
- 101150001070 rpsT gene Proteins 0.000 description 1
- 101150070968 rpsU gene Proteins 0.000 description 1
- 101150085310 rsmA gene Proteins 0.000 description 1
- 101150070825 rsmG gene Proteins 0.000 description 1
- 101150014273 rsmH gene Proteins 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 101150061752 ruvA gene Proteins 0.000 description 1
- 108010027327 sakacin A Proteins 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 101150047761 sdhA gene Proteins 0.000 description 1
- 101150108347 sdhB gene Proteins 0.000 description 1
- 101150108659 secA gene Proteins 0.000 description 1
- 101150114545 secE gene Proteins 0.000 description 1
- 101150003830 serC gene Proteins 0.000 description 1
- 229960001153 serine Drugs 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 108020001482 shikimate kinase Proteins 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000013605 shuttle vector Substances 0.000 description 1
- 101150038679 skp gene Proteins 0.000 description 1
- 108010070073 small protein B Proteins 0.000 description 1
- 101150073293 smpB gene Proteins 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 101150033155 sspP gene Proteins 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 229940031626 subunit vaccine Drugs 0.000 description 1
- 101150055132 sucB gene Proteins 0.000 description 1
- UIUJIQZEACWQSV-UHFFFAOYSA-N succinic semialdehyde Chemical compound OC(=O)CCC=O UIUJIQZEACWQSV-UHFFFAOYSA-N 0.000 description 1
- 101150102101 sufB gene Proteins 0.000 description 1
- 101150043376 sufC gene Proteins 0.000 description 1
- 101150018576 sufD gene Proteins 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 108060007951 sulfatase Proteins 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 108010090240 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Proteins 0.000 description 1
- 102100025028 tRNA (guanine-N(7)-)-methyltransferase Human genes 0.000 description 1
- 101710112043 tRNA (guanine-N(7)-)-methyltransferase Proteins 0.000 description 1
- 108010015311 tRNA (guanine-N1-)-methyltransferase Proteins 0.000 description 1
- 108010058071 tagatose 1,6-diphosphate aldolase Proteins 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 101150110679 tehB gene Proteins 0.000 description 1
- 229940081330 tena Drugs 0.000 description 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 1
- 101150043604 thiI gene Proteins 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 102000043145 thiamine pyrophosphokinase family Human genes 0.000 description 1
- 108091085035 thiamine pyrophosphokinase family Proteins 0.000 description 1
- SRVJKTDHMYAMHA-WUXMJOGZSA-N thioacetazone Chemical compound CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1 SRVJKTDHMYAMHA-WUXMJOGZSA-N 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 229940094937 thioredoxin Drugs 0.000 description 1
- 150000003584 thiosemicarbazones Chemical class 0.000 description 1
- 101150072448 thrB gene Proteins 0.000 description 1
- 101150046628 thrS gene Proteins 0.000 description 1
- 101150031421 thrS-cat gene Proteins 0.000 description 1
- 101150072314 thyA gene Proteins 0.000 description 1
- 101150082896 topA gene Proteins 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 101150080369 tpiA gene Proteins 0.000 description 1
- 101150004556 traE gene Proteins 0.000 description 1
- 101150021302 traK gene Proteins 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- 108091006107 transcriptional repressors Proteins 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000032895 transmembrane transport Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 102000022575 tripeptide aminopeptidase activity proteins Human genes 0.000 description 1
- 101150025395 trkA gene Proteins 0.000 description 1
- 101150113435 trkA1 gene Proteins 0.000 description 1
- 101150102955 trkH gene Proteins 0.000 description 1
- 101150005388 trmB gene Proteins 0.000 description 1
- 101150003415 trmD gene Proteins 0.000 description 1
- 101150059846 trpS gene Proteins 0.000 description 1
- 101150004782 trpS2 gene Proteins 0.000 description 1
- 101150057627 trxB gene Proteins 0.000 description 1
- 238000010396 two-hybrid screening Methods 0.000 description 1
- 101150101943 tyrS gene Proteins 0.000 description 1
- 108010013280 ubiquinol oxidase Proteins 0.000 description 1
- 108010028731 undecaprenyl pyrophosphate synthetase Proteins 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 108010054539 unsaturated glucuronyl hydrolase Proteins 0.000 description 1
- 101150020973 uppP gene Proteins 0.000 description 1
- 101150058431 uppP1 gene Proteins 0.000 description 1
- 101150103517 uppS gene Proteins 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 101150005573 uvrA gene Proteins 0.000 description 1
- 101150060445 uvrB gene Proteins 0.000 description 1
- 101150108755 uvrD1 gene Proteins 0.000 description 1
- 101150066858 uxaC gene Proteins 0.000 description 1
- 101150107825 uxuA gene Proteins 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 229940120293 vaginal suppository Drugs 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 101150112181 valS gene Proteins 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000000304 virulence factor Substances 0.000 description 1
- 230000007923 virulence factor Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- 101150067803 xseA gene Proteins 0.000 description 1
- 101150038987 xylR gene Proteins 0.000 description 1
- 229920001221 xylan Polymers 0.000 description 1
- 150000004823 xylans Chemical class 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- 108010061078 zwittermicin A Proteins 0.000 description 1
- FYIPKJHNWFVEIR-VTAUKWRXSA-N zwittermicin a Chemical compound OC[C@H](N)[C@H](O)C[C@@H](O)[C@@H](N)[C@@H](O)[C@H](O)C(=O)N[C@H](C(N)=O)CNC(N)=O FYIPKJHNWFVEIR-VTAUKWRXSA-N 0.000 description 1
- 150000003952 β-lactams Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63894304P | 2004-12-22 | 2004-12-22 | |
| US64043804P | 2004-12-30 | 2004-12-30 | |
| PCT/US2005/046491 WO2006069200A2 (en) | 2004-12-22 | 2005-12-21 | Group b streptococcus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008525033A true JP2008525033A (ja) | 2008-07-17 |
| JP2008525033A5 JP2008525033A5 (cg-RX-API-DMAC7.html) | 2009-07-23 |
Family
ID=36602309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548453A Pending JP2008525033A (ja) | 2004-12-22 | 2005-12-21 | Ｂ群連鎖球菌 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20090104218A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1828231A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2008525033A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2005319174A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2591510A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL183830A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2007007033A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006069200A2 (cg-RX-API-DMAC7.html) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015520605A (ja) * | 2012-03-30 | 2015-07-23 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | 過酸生成に有用な酵素 |
| JP5986931B2 (ja) * | 2011-02-02 | 2016-09-06 | 公益財団法人微生物化学研究会 | 血液脳関門を透過する薬物輸送体、ペプチド及びその用途 |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6890539B2 (en) | 1998-12-22 | 2005-05-10 | Microscience, Ltd. | Genes and proteins, and their use |
| KR100790653B1 (ko) | 1998-12-22 | 2007-12-31 | 마이크로싸이언스 리미티드 | 유전자와 단백질들, 및 그들의 사용 |
| EP1328543B1 (en) | 2000-10-27 | 2009-08-12 | Novartis Vaccines and Diagnostics S.r.l. | Nucleic acids and proteins from streptococcus groups a & b |
| JP4875490B2 (ja) | 2003-07-31 | 2012-02-15 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | ＳｔｒｅｐｔｏｃｏｃｃｕｓＰｙｏｇｅｎｅｓについての免疫原組成物 |
| US8945589B2 (en) | 2003-09-15 | 2015-02-03 | Novartis Vaccines And Diagnostics, Srl | Immunogenic compositions for Streptococcus agalactiae |
| EP1807446A2 (en) * | 2004-10-08 | 2007-07-18 | Novartis Vaccines and Diagnostics, Inc. | Immunogenic and therapeutic compositions for streptococcus pyogenes |
| EP1801235A1 (en) * | 2005-12-20 | 2007-06-27 | Institut Pasteur | Rapid detection of the "high virulent" ST-17 clone of Group B streptococcus |
| JP2009540819A (ja) * | 2006-06-19 | 2009-11-26 | ミュタビリス エス アー | Ｂ群レンサ球菌の病原性に関与する遺伝子の同定 |
| US20100150943A1 (en) * | 2006-07-26 | 2010-06-17 | Novartis Ag | Immunogenic compositions for gram positive bacteria |
| JP5653215B2 (ja) | 2007-09-12 | 2015-01-14 | ノバルティス アーゲー | Ｇａｓ５７変異体抗原およびｇａｓ５７抗体 |
| EP2135877A1 (en) | 2008-06-19 | 2009-12-23 | Helmholtz-Zentrum für Infektionsforschung GmbH | Marker of steptococcus anginosus/Streptococcus constellatus (Moac) and uses thereof |
| US8147849B2 (en) | 2009-02-20 | 2012-04-03 | Novartis Ag | Protective antigens for group B Streptococcus hypervirulent strains |
| ITMI20090946A1 (it) | 2009-05-28 | 2010-11-29 | Novartis Ag | Espressione di proteine ricombinanti |
| AU2010273708B2 (en) | 2009-06-29 | 2015-10-01 | Children's Medical Center Corporation | Vaccines and compositions against Streptococcus pneumoniae |
| GB201101665D0 (en) | 2011-01-31 | 2011-03-16 | Novartis Ag | Immunogenic compositions |
| MY163871A (en) | 2011-01-20 | 2017-10-31 | Genocea Biosciences Inc | Vaccines and compositions against streptococcus pneumoniae |
| EP2557424A1 (en) * | 2011-08-11 | 2013-02-13 | InGen Biosciences | Method for diagnosing Streptococcus, Enterococcus and Pepstostreptococcus genera infections |
| WO2013124473A1 (en) * | 2012-02-24 | 2013-08-29 | Novartis Ag | Pilus proteins and compositions |
| RU2015106791A (ru) | 2012-10-03 | 2016-11-20 | Глэксосмитиклайн Байолоджикалз Са | Иммуногенные композиции |
| EP3021864A1 (en) * | 2013-07-16 | 2016-05-25 | Université de Lausanne | Bacterial lysins and uses thereof |
| AR101455A1 (es) * | 2014-08-05 | 2016-12-21 | Glaxosmithkline Biologicals Sa | Molécula portadora |
| SG11201806639VA (en) | 2016-02-04 | 2018-09-27 | Genovis Ab | New streptococcal proteases |
| WO2018204153A1 (en) * | 2017-05-02 | 2018-11-08 | Venomyx, Inc. | Composition and methods for treating snake envenomation |
| WO2018237010A2 (en) * | 2017-06-20 | 2018-12-27 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Vaccine compositions and methods of using the same |
| PL239045B1 (pl) * | 2018-01-09 | 2021-11-02 | Inst Immunologii I Terapii Doswiadczalnej Polskiej Akademii Nauk | Epitop specyficzny dla zakaźnych Streptococcus agalactiae oraz sposób wykrywania zakażenia pacjenta szczepem Streptococcus agalactiae |
| GB2590210B (en) * | 2018-06-13 | 2023-01-25 | Gen Probe Inc | Compositions and methods for detecting group B Streptococcus nucleic acid |
| RU2021105821A (ru) | 2018-08-06 | 2021-05-27 | Медикайн, Инк. | Соединения, связывающие рецептор il-2 |
| WO2021092075A1 (en) | 2019-11-05 | 2021-05-14 | Medikine Inc. | IL-2RβγC BINDING COMPOUNDS |
| WO2021108929A1 (en) * | 2019-12-06 | 2021-06-10 | Theratechnologies Inc. | Sortilin binding conjugate compounds, compositions and uses thereof for treating cancer |
| WO2021158623A1 (en) | 2020-02-03 | 2021-08-12 | Medikine, Inc. | IL-7Rαγc BINDING COMPOUNDS |
| AU2021219847A1 (en) * | 2020-02-12 | 2022-10-13 | Massachusetts Institute Of Technology | Field deployable CRISPR-Cas diagnostics and methods of use thereof |
| US11453907B2 (en) | 2020-03-23 | 2022-09-27 | The Broad Institute, Inc. | Crispr effector system based coronavirus diagnostics |
| WO2022026534A1 (en) * | 2020-07-28 | 2022-02-03 | Kansas State University Research Foundation | Sars-cov-2 immunogenic compositions and methods for protecting against sars-cov-2 clinical signs |
| CA3197344A1 (en) * | 2020-11-04 | 2022-05-12 | William J. Dower | Il-2r.beta.yc binding compounds and uses thereof |
| US11999771B2 (en) | 2022-04-07 | 2024-06-04 | Medikine, Inc. | IL-7Rαγc ligand immunoglobulin fusion proteins |
| WO2025017062A1 (en) * | 2023-07-18 | 2025-01-23 | Intervet International B.V. | New type of streptococcus agalactiae serotype ia bacterium and vaccines thereof |
| WO2025151408A1 (en) * | 2024-01-08 | 2025-07-17 | Denali Therapeutics Inc. | Compositions and methods for modulating tau expression |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001309795A (ja) * | 1989-09-15 | 2001-11-06 | General Hospital Corp:The | Ｂ群連鎖球菌に対する複合ワクチンを製造するための防御的タンパク質抗原をコードする遺伝子配列からなる組換え分子 |
| JP2002512026A (ja) * | 1998-04-20 | 2002-04-23 | カイロン エセ．ピー．アー． | Ｂ群連鎖球菌の糖質を免疫学的に模倣する抗イディオタイプ抗体を含むワクチン処方物 |
| JP2002531054A (ja) * | 1998-07-27 | 2002-09-24 | マイクロビアル テクニクス リミティッド | Ｂ群連鎖球菌由来の核酸およびタンパク質 |
| JP2003527100A (ja) * | 1999-09-07 | 2003-09-16 | ミクロバイアル・テクニクス・リミテッド | タンパク質 |
| WO2004048404A2 (en) * | 2002-11-22 | 2004-06-10 | Chiron Srl | Multiple variants of meningococcal protein nmb1870 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1328543B1 (en) * | 2000-10-27 | 2009-08-12 | Novartis Vaccines and Diagnostics S.r.l. | Nucleic acids and proteins from streptococcus groups a & b |
| FR2824074A1 (fr) * | 2001-04-26 | 2002-10-31 | Pasteur Institut | Sequence du genome streptococcus agalactiae, application au developpement de vaccins, d'outils de diagnostic, et a l'identification de cibles therapeutiques |
| CN1705679B (zh) * | 2002-10-15 | 2011-04-06 | 英特塞尔股份公司 | 编码b族链球菌粘着因子的核酸、b族链球菌的粘着因子和它们的用途 |
-
2005
- 2005-12-21 WO PCT/US2005/046491 patent/WO2006069200A2/en not_active Ceased
- 2005-12-21 AU AU2005319174A patent/AU2005319174A1/en not_active Abandoned
- 2005-12-21 US US11/793,435 patent/US20090104218A1/en not_active Abandoned
- 2005-12-21 CA CA002591510A patent/CA2591510A1/en not_active Abandoned
- 2005-12-21 EP EP05857170A patent/EP1828231A2/en not_active Withdrawn
- 2005-12-21 MX MX2007007033A patent/MX2007007033A/es not_active Application Discontinuation
- 2005-12-21 JP JP2007548453A patent/JP2008525033A/ja active Pending
-
2007
- 2007-06-11 IL IL183830A patent/IL183830A0/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001309795A (ja) * | 1989-09-15 | 2001-11-06 | General Hospital Corp:The | Ｂ群連鎖球菌に対する複合ワクチンを製造するための防御的タンパク質抗原をコードする遺伝子配列からなる組換え分子 |
| JP2002512026A (ja) * | 1998-04-20 | 2002-04-23 | カイロン エセ．ピー．アー． | Ｂ群連鎖球菌の糖質を免疫学的に模倣する抗イディオタイプ抗体を含むワクチン処方物 |
| JP2002531054A (ja) * | 1998-07-27 | 2002-09-24 | マイクロビアル テクニクス リミティッド | Ｂ群連鎖球菌由来の核酸およびタンパク質 |
| JP2003527100A (ja) * | 1999-09-07 | 2003-09-16 | ミクロバイアル・テクニクス・リミテッド | タンパク質 |
| WO2004048404A2 (en) * | 2002-11-22 | 2004-06-10 | Chiron Srl | Multiple variants of meningococcal protein nmb1870 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5986931B2 (ja) * | 2011-02-02 | 2016-09-06 | 公益財団法人微生物化学研究会 | 血液脳関門を透過する薬物輸送体、ペプチド及びその用途 |
| JP2015520605A (ja) * | 2012-03-30 | 2015-07-23 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | 過酸生成に有用な酵素 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20090104218A1 (en) | 2009-04-23 |
| IL183830A0 (en) | 2007-10-31 |
| MX2007007033A (es) | 2007-08-03 |
| AU2005319174A1 (en) | 2006-06-29 |
| WO2006069200A2 (en) | 2006-06-29 |
| CA2591510A1 (en) | 2006-06-29 |
| EP1828231A2 (en) | 2007-09-05 |
| WO2006069200A3 (en) | 2007-03-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008525033A (ja) | Ｂ群連鎖球菌 | |
| US10428121B2 (en) | Nucleic acids and proteins from streptococcus groups A and B | |
| US7749518B2 (en) | Polypeptides from non-typeable Haemophilus influenzae | |
| US9034642B2 (en) | Genes of an otitis media isolate of nontypeable Haemophilus influenzae | |
| ES2569654T3 (es) | Proteínas y ácidos nucleicos de la meningitis / sepsis asociada a la Escherichia coli | |
| US6617156B1 (en) | Nucleic acid and amino acid sequences relating to Enterococcus faecalis for diagnostics and therapeutics | |
| US7090973B1 (en) | Nucleic acid sequences relating to Bacteroides fragilis for diagnostics and therapeutics | |
| US20120093868A1 (en) | Haemophilus influenzae type b | |
| CN101203529A (zh) | 来自脑膜炎/脓毒症相关性大肠杆菌的蛋白质和核酸 | |
| WO2004018646A2 (en) | Conserved and specific streptococcal genomes | |
| AU2012207041A1 (en) | Proteins and nucleic acids from meningitis/sepsis-associated Escherichia Coli | |
| EP1980266A1 (en) | New virulence factors of Streptococcus pneumoniae | |
| HK1133019A (en) | Genes of an otitis media isolate of nontypeable haemophilus influenzae |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20080418 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20080418 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20081219 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20081219 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090601 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110728 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20120112 |