JP2008524329A5 - - Google Patents
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- Publication number
- JP2008524329A5 JP2008524329A5 JP2007548319A JP2007548319A JP2008524329A5 JP 2008524329 A5 JP2008524329 A5 JP 2008524329A5 JP 2007548319 A JP2007548319 A JP 2007548319A JP 2007548319 A JP2007548319 A JP 2007548319A JP 2008524329 A5 JP2008524329 A5 JP 2008524329A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutical composition
- mammal
- pharmaceutically acceptable
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000005249 lung adenocarcinoma Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 201000006845 reticulosarcoma Diseases 0.000 claims 1
- 208000029922 reticulum cell sarcoma Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 230000020347 spindle assembly Effects 0.000 claims 1
Claims (3)
- 請求項1ないし4のいずれか1項記載の化合物と薬学的に許容される担体とを含有する、治療を必要とするほ乳類において癌を治療又は予防するための医薬組成物。
- 癌が、組織球性リンパ腫、肺腺癌、小細胞肺癌、膵臓癌、グリア芽腫及び乳癌から選択される、請求項7記載の医薬組成物。
- 請求項1ないし4のいずれか1項記載の化合物と薬学的に許容される担体とを含有する、治療を必要とするほ乳類において紡錘体形成を調節するための医薬組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63772204P | 2004-12-21 | 2004-12-21 | |
PCT/US2005/045563 WO2006068933A2 (en) | 2004-12-21 | 2005-12-15 | Mitotic kinesin inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2008524329A JP2008524329A (ja) | 2008-07-10 |
JP2008524329A5 true JP2008524329A5 (ja) | 2008-12-11 |
Family
ID=36602225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007548319A Withdrawn JP2008524329A (ja) | 2004-12-21 | 2005-12-15 | 有糸分裂キネシン阻害剤 |
Country Status (7)
Country | Link |
---|---|
US (1) | US20080045492A1 (ja) |
EP (1) | EP1831176A2 (ja) |
JP (1) | JP2008524329A (ja) |
CN (1) | CN101084194A (ja) |
AU (1) | AU2005319455A1 (ja) |
CA (1) | CA2589827A1 (ja) |
WO (1) | WO2006068933A2 (ja) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007011647A2 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin ksp |
EP1950202A1 (en) * | 2007-01-24 | 2008-07-30 | Laboratorios del Dr. Esteve S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments with ACAT inhibition activity |
EP2114891A1 (en) * | 2007-01-17 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | Substituted pyrazoline compounds with acat inhibition activity |
BRPI0818605A2 (pt) | 2007-10-19 | 2015-04-22 | Schering Corp | Derivados de 1,3,4-tiadiazl espiro-condensados para inibir a atividade de ksp cinesima |
BRPI0817897A2 (pt) * | 2007-11-02 | 2019-09-24 | Methylgene Inc | composto, composição, e, métodos de inibição da atividade hdac, e de tratamento de uma doença responsiva a um inibidor de atividade hdac |
JP5581219B2 (ja) | 2008-01-25 | 2014-08-27 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | チオフェンおよびホスファチジルイノシトール3−キナーゼ(pi3k)阻害薬としてのその使用 |
CN102395585A (zh) | 2009-01-30 | 2012-03-28 | 米伦纽姆医药公司 | 杂芳基化合物和其作为pi3k抑制剂的用途 |
US8796314B2 (en) | 2009-01-30 | 2014-08-05 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
US9090601B2 (en) | 2009-01-30 | 2015-07-28 | Millennium Pharmaceuticals, Inc. | Thiazole derivatives |
TW201217365A (en) | 2010-08-11 | 2012-05-01 | Millennium Pharm Inc | Heteroaryls and uses thereof |
WO2012021611A1 (en) | 2010-08-11 | 2012-02-16 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
US8859768B2 (en) | 2010-08-11 | 2014-10-14 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
PE20141044A1 (es) | 2010-10-13 | 2014-09-07 | Millennium Pharm Inc | Heteroarilos y sus usos |
AR087971A1 (es) | 2011-09-23 | 2014-04-30 | Bayer Ip Gmbh | Uso de derivados del acido 1-fenil-pirazol-3-carboxilico 4-sustituidos como principios activos contra estres abiotico de plantas |
WO2013096637A1 (en) * | 2011-12-23 | 2013-06-27 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
US9828345B2 (en) | 2013-02-28 | 2017-11-28 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors |
TW201444798A (zh) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | 作爲強效rock1及rock2抑制劑之苯基吡唑衍生物 |
CN103992274A (zh) * | 2014-04-18 | 2014-08-20 | 南京安美科技有限公司 | 合成选择性非甾体抗炎镇痛药Celebrex(塞来昔布)的方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005533119A (ja) * | 2002-07-17 | 2005-11-04 | サイトキネティクス・インコーポレーテッド | 化合物、組成物、及び方法 |
CN1980662A (zh) * | 2004-07-01 | 2007-06-13 | 默克公司 | 有丝分裂驱动蛋白抑制剂 |
WO2006110390A1 (en) * | 2005-04-07 | 2006-10-19 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
-
2005
- 2005-12-15 CA CA002589827A patent/CA2589827A1/en not_active Abandoned
- 2005-12-15 EP EP05854311A patent/EP1831176A2/en not_active Withdrawn
- 2005-12-15 US US11/793,090 patent/US20080045492A1/en not_active Abandoned
- 2005-12-15 JP JP2007548319A patent/JP2008524329A/ja not_active Withdrawn
- 2005-12-15 WO PCT/US2005/045563 patent/WO2006068933A2/en active Application Filing
- 2005-12-15 CN CNA200580043954XA patent/CN101084194A/zh active Pending
- 2005-12-15 AU AU2005319455A patent/AU2005319455A1/en not_active Abandoned
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