JP2008522604A5 - - Google Patents
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- JP2008522604A5 JP2008522604A5 JP2007544987A JP2007544987A JP2008522604A5 JP 2008522604 A5 JP2008522604 A5 JP 2008522604A5 JP 2007544987 A JP2007544987 A JP 2007544987A JP 2007544987 A JP2007544987 A JP 2007544987A JP 2008522604 A5 JP2008522604 A5 JP 2008522604A5
- Authority
- JP
- Japan
- Prior art keywords
- analysis
- neural network
- sepsis
- inf
- sirs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 12
- 238000004458 analytical method Methods 0.000 claims description 10
- 238000000540 analysis of variance Methods 0.000 claims description 4
- 238000000491 multivariate analysis Methods 0.000 claims description 2
- 238000013528 artificial neural network Methods 0.000 claims 7
- 206010040047 Sepsis Diseases 0.000 claims 6
- 238000003757 reverse transcription PCR Methods 0.000 claims 5
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 claims 4
- 239000000090 biomarker Substances 0.000 claims 4
- 238000007619 statistical method Methods 0.000 claims 3
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 2
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 2
- 108010039471 Fas Ligand Protein Proteins 0.000 claims 2
- -1 IL-1β Proteins 0.000 claims 2
- 108090000174 Interleukin-10 Proteins 0.000 claims 2
- 108090001005 Interleukin-6 Proteins 0.000 claims 2
- 108090001007 Interleukin-8 Proteins 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 238000000513 principal component analysis Methods 0.000 claims 2
- 238000012216 screening Methods 0.000 claims 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000001134 F-test Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0426982.5A GB0426982D0 (en) | 2004-12-09 | 2004-12-09 | Early detection of sepsis |
| PCT/GB2005/004755 WO2006061644A1 (en) | 2004-12-09 | 2005-12-09 | Early detection of sepsis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008522604A JP2008522604A (ja) | 2008-07-03 |
| JP2008522604A5 true JP2008522604A5 (enExample) | 2012-02-23 |
Family
ID=34073429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007544987A Pending JP2008522604A (ja) | 2004-12-09 | 2005-12-09 | 敗血症の早期検出 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20080114576A1 (enExample) |
| EP (2) | EP2458517A1 (enExample) |
| JP (1) | JP2008522604A (enExample) |
| CN (1) | CN101076806B (enExample) |
| AU (1) | AU2005313114B2 (enExample) |
| CA (1) | CA2587270A1 (enExample) |
| GB (1) | GB0426982D0 (enExample) |
| WO (1) | WO2006061644A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9053222B2 (en) | 2002-05-17 | 2015-06-09 | Lawrence A. Lynn | Patient safety processor |
| US7191068B2 (en) * | 2003-03-25 | 2007-03-13 | Proteogenix, Inc. | Proteomic analysis of biological fluids |
| US8068990B2 (en) * | 2003-03-25 | 2011-11-29 | Hologic, Inc. | Diagnosis of intra-uterine infection by proteomic analysis of cervical-vaginal fluids |
| BRPI0609302A2 (pt) | 2005-04-15 | 2011-10-11 | Becton Dickinson Co | métodos para prever o desenvolvimento de sepse e para diagnosticar sepse em um indivìduo a ser testado, microarranjo, kit para prever o desenvolvimento de sepse em um indivìduo a ser testado, produto de programa de computador, computador, sistema de computador para determinar se um indivìduo é susceptìvel de desenvolver sepse, sinal digital embutido em uma onda portadora, e, interface gráfica de usuário para determinar se um indivìduo é susceptìvel de desenvolver sepse |
| ATE472611T1 (de) * | 2005-11-25 | 2010-07-15 | Trinity College Dublin | Verfahren zur diagnose von sepsis durch analyse von cytokine mrna expression |
| JP4661870B2 (ja) | 2005-12-14 | 2011-03-30 | 日本電気株式会社 | ディジタル通信システム、屋内装置及び屋外装置 |
| GB0610078D0 (en) * | 2006-05-20 | 2006-06-28 | Secr Defence | Sepsis detection microarray |
| EP1950310A1 (en) * | 2007-01-23 | 2008-07-30 | Charite-Universitätsmedizin Berlin | Method for risk prediction of a postoperative sepsis in a human |
| GB0722582D0 (en) * | 2007-11-16 | 2007-12-27 | Secr Defence | Early detection of sepsis |
| WO2009123737A2 (en) | 2008-04-03 | 2009-10-08 | Becton, Dickinson And Company | Advanced detection of sepsis |
| EP2283443A1 (en) | 2008-05-07 | 2011-02-16 | Lynn, Lawrence A. | Medical failure pattern search engine |
| US11728041B2 (en) * | 2008-05-07 | 2023-08-15 | Lawrence A. Lynn | Real-time time series matrix pathophysiologic pattern processor and quality assessment method |
| EP2166358A1 (en) * | 2008-09-17 | 2010-03-24 | Fundacio Institut de Recerca de l'Hospital Universitari Vall d'Hebron | Differential diagnostic biomarkers of stroke mimicking conditions and methods of use thereof |
| US10460408B2 (en) * | 2009-01-31 | 2019-10-29 | Mayo Foundation For Medical Education And Research | Presentation of critical patient data |
| JP5667353B2 (ja) | 2009-09-25 | 2015-02-12 | シスメックス株式会社 | 血球計数装置、診断支援装置、診断支援方法及びコンピュータプログラム |
| ES2539854T3 (es) * | 2010-03-02 | 2015-07-06 | F. Hoffmann-La Roche Ag | Diagnóstico y predicción precoces basados en la detección de IL-6 del síndrome de respuesta inflamatoria sistémica y sepsis en pacientes asintomáticos |
| US9719842B2 (en) * | 2010-07-06 | 2017-08-01 | Norman A. Paradis | Method for the discovery, validation and clinical application of multiplex biomarker algorithms based on optical, physical and/or electromagnetic patterns |
| EP2643483A4 (en) * | 2010-11-26 | 2014-04-30 | Immunexpress Pty Ltd | DIAGNOSTIC AND / OR SCREENING APPROPRIATIONS AND USES THEREFOR |
| WO2014068018A1 (en) * | 2012-10-30 | 2014-05-08 | Abbott Gmbh & Co.Kg | Methods of prognosis and diagnosis of sepsis |
| US9953453B2 (en) | 2012-11-14 | 2018-04-24 | Lawrence A. Lynn | System for converting biologic particle density data into dynamic images |
| US10354429B2 (en) | 2012-11-14 | 2019-07-16 | Lawrence A. Lynn | Patient storm tracker and visualization processor |
| US20150362509A1 (en) * | 2013-01-28 | 2015-12-17 | Vanderbilt University | Method for Differentiating Sepsis and Systemic Inflammatory Response Syndrome (SIRS) |
| WO2014134460A1 (en) | 2013-02-28 | 2014-09-04 | Lynn Lawrence A | Time lapsable motion image responsive to features of pathophysiologic perturbations |
| KR101595784B1 (ko) * | 2013-05-31 | 2016-02-26 | 가톨릭대학교 산학협력단 | 패혈증 고위험군 예측 방법 및 시스템 |
| JP2016526888A (ja) * | 2013-06-28 | 2016-09-08 | アキュメン リサーチ ラボラトリーズ プライヴェット リミテッドＡｃｕｍｅｎ Ｒｅｓｅａｒｃｈ Ｌａｂｏｒａｔｏｒｉｅｓ Ｐｔｅ． Ｌｔｄ． | 敗血症バイオマーカー及びそれらの使用 |
| US10260111B1 (en) * | 2014-01-20 | 2019-04-16 | Brett Eric Etchebarne | Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample |
| GB201402293D0 (en) * | 2014-02-11 | 2014-03-26 | Secr Defence | Biomarker signatures for the prediction of onset of sepsis |
| US11058332B2 (en) * | 2014-09-26 | 2021-07-13 | Sofradim Production | System and method for early detection of post-surgery infection |
| US10761093B2 (en) | 2014-10-09 | 2020-09-01 | Texas Tech University System | Microdevice for cell separation utilizing activation phenotype |
| US10832134B2 (en) | 2015-12-10 | 2020-11-10 | Deepmind Technologies Limited | Augmenting neural networks with external memory |
| EP3408773B1 (en) * | 2016-01-28 | 2023-09-20 | Beckman Coulter, Inc. | Infection detection and differentiation systems and methods |
| SG11201807719SA (en) * | 2016-03-23 | 2018-10-30 | Peach Intellihealth Inc | Use of clinical parameters for the prediction of sirs |
| EP3806712A1 (en) * | 2018-06-15 | 2021-04-21 | Beckman Coulter, Inc. | Method of determining sepsis in the presence of blast flagging |
| CN111374639A (zh) * | 2018-12-28 | 2020-07-07 | 陈柏龄 | 败血症的菌种预测系统与方法 |
| KR102287968B1 (ko) * | 2019-03-29 | 2021-08-09 | 연세대학교 산학협력단 | 균혈증 발병 위험도 예측 방법 및 이를 이용한 균혈증 발병 위험도 예측용 디바이스 |
| US20220299511A1 (en) * | 2019-06-17 | 2022-09-22 | The Broad Institute, Inc. | Immune cell signature for bacterial sepsis |
| JP7657195B2 (ja) * | 2019-07-12 | 2025-04-04 | ベックマン コールター， インコーポレイテッド | 収縮期血圧、血液パラメーター、およびこれらの組み合わせを含むバイタルサインを使用して敗血症を検出する方法 |
| EP4010682B1 (en) * | 2019-08-06 | 2024-07-17 | Beckman Coulter, Inc. | Detecting and reporting subpopulations of neutrophils |
| US20210059597A1 (en) * | 2019-08-30 | 2021-03-04 | Hill-Rom Services, Inc. | Sepsis monitoring system |
| WO2021102776A1 (zh) * | 2019-11-28 | 2021-06-03 | 北京肿瘤医院(北京大学肿瘤医院) | 一种用于早期体腔内感染性并发症诊断的标记物及方法 |
| JP7754815B2 (ja) * | 2019-12-27 | 2025-10-15 | ザ・ヘンリー・エム・ジャクソン・ファンデイション・フォー・ジ・アドヴァンスメント・オヴ・ミリタリー・メディシン，インコーポレイテッド | 敗血症を患う個体における重症疾患の予測及び対処 |
| WO2021142479A1 (en) * | 2020-01-10 | 2021-07-15 | Prenosis, Inc. | A tool for selecting relevant features in precision diagnostics |
| JP7708769B2 (ja) * | 2020-01-10 | 2025-07-15 | プレノシス，インコーポレイテッド | ストリーミングデータ環境のための時間依存トリガ |
| CN114167062B (zh) * | 2020-09-10 | 2024-02-02 | 北京肿瘤医院(北京大学肿瘤医院) | 一种用于早期腹腔内感染性并发症诊断的标记物及方法 |
| TWI803893B (zh) * | 2021-06-28 | 2023-06-01 | 中國醫藥大學 | 敗血症之人工智慧輔助醫療診斷方法及其系統 |
| DE102022114248A1 (de) * | 2022-06-07 | 2023-12-07 | TCC GmbH | Verfahren sowie Vorhersagesystem zur Ermittlung der Eintrittswahrscheinlichkeit einer Sepsis eines Patienten |
| CN120526862A (zh) * | 2025-07-24 | 2025-08-22 | 中国疾病预防控制中心传染病预防控制所 | 一种基于5种标记物的感染病原体类型检测系统 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6190872B1 (en) * | 1994-05-06 | 2001-02-20 | Gus J. Slotman | Method for identifying and monitoring patients at risk for systemic inflammatory conditions and apparatus for use in this method |
| US6804551B2 (en) * | 1998-03-17 | 2004-10-12 | University Of Virginia Patent Foundation | Method and apparatus for the early diagnosis of subacute, potentially catastrophic illness |
| AU5900299A (en) * | 1998-08-24 | 2000-03-14 | Emory University | Method and apparatus for predicting the onset of seizures based on features derived from signals indicative of brain activity |
| WO2000052472A1 (en) | 1999-03-01 | 2000-09-08 | The Board Of Trustees Of The Leland Stanford Junior University | Rapid assay for infection in small children |
| DE10155600B4 (de) * | 2001-11-09 | 2009-08-27 | Oligene Gmbh | Nukleinsäure-Array |
| US20040038201A1 (en) * | 2002-01-22 | 2004-02-26 | Whitehead Institute For Biomedical Research | Diagnostic and therapeutic applications for biomarkers of infection |
| US7774143B2 (en) * | 2002-04-25 | 2010-08-10 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Methods for analyzing high dimensional data for classifying, diagnosing, prognosticating, and/or predicting diseases and other biological states |
| MXPA05005073A (es) * | 2002-11-12 | 2005-11-17 | Becton Dickinson Co | Diagnostico de la sepsis o sirs usando perfiles de biomarcadores. |
| CA2505921A1 (en) * | 2002-11-12 | 2004-05-27 | Becton, Dickinson And Company | Diagnosis of sepsis or sirs using biomarker profiles |
| MXPA05005072A (es) * | 2002-11-12 | 2005-07-22 | Becton Dickinson Co | Diagnostico de la sepsis o sirs usando perfiles de biomarcadores. |
| EP1673465A4 (en) * | 2003-09-29 | 2008-04-30 | Biosite Inc | PROCESS AND COMPOSITIONS FOR SEPSIS DIAGNOSIS |
| TW200519384A (en) * | 2003-12-12 | 2005-06-16 | We Gene Technologies Inc | Sepsis detection chip and fabricating method thereof and method of detecting sepsis |
| US20050196817A1 (en) * | 2004-01-20 | 2005-09-08 | Molecular Staging Inc. | Biomarkers for sepsis |
| GB0610078D0 (en) * | 2006-05-20 | 2006-06-28 | Secr Defence | Sepsis detection microarray |
-
2004
- 2004-12-09 GB GBGB0426982.5A patent/GB0426982D0/en not_active Ceased
-
2005
- 2005-12-09 EP EP11008209A patent/EP2458517A1/en not_active Withdrawn
- 2005-12-09 CN CN2005800424703A patent/CN101076806B/zh not_active Expired - Fee Related
- 2005-12-09 WO PCT/GB2005/004755 patent/WO2006061644A1/en not_active Ceased
- 2005-12-09 US US11/792,724 patent/US20080114576A1/en not_active Abandoned
- 2005-12-09 JP JP2007544987A patent/JP2008522604A/ja active Pending
- 2005-12-09 CA CA002587270A patent/CA2587270A1/en not_active Abandoned
- 2005-12-09 EP EP05825137A patent/EP1839218A1/en not_active Withdrawn
- 2005-12-09 AU AU2005313114A patent/AU2005313114B2/en not_active Ceased
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