JP2008522604A - 敗血症の早期検出 - Google Patents

敗血症の早期検出 Download PDF

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JP2008522604A
JP2008522604A JP2007544987A JP2007544987A JP2008522604A JP 2008522604 A JP2008522604 A JP 2008522604A JP 2007544987 A JP2007544987 A JP 2007544987A JP 2007544987 A JP2007544987 A JP 2007544987A JP 2008522604 A JP2008522604 A JP 2008522604A
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sepsis
analysis
data
clinical
neural network
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JP2008522604A5 (enExample
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マシュー クリストファー ジャクソン
ローマン アントニー ルカソウスキー
アマンダ マリー イェイツ
マーティン ジュリアン ピアス
ティモシー ジョン ギルビー ブルックス
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UK Secretary of State for Defence
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Theoretical Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Evolutionary Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Artificial Intelligence (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Public Health (AREA)
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JP2007544987A 2004-12-09 2005-12-09 敗血症の早期検出 Pending JP2008522604A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0426982.5A GB0426982D0 (en) 2004-12-09 2004-12-09 Early detection of sepsis
PCT/GB2005/004755 WO2006061644A1 (en) 2004-12-09 2005-12-09 Early detection of sepsis

Publications (2)

Publication Number Publication Date
JP2008522604A true JP2008522604A (ja) 2008-07-03
JP2008522604A5 JP2008522604A5 (enExample) 2012-02-23

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JP2007544987A Pending JP2008522604A (ja) 2004-12-09 2005-12-09 敗血症の早期検出

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Country Link
US (1) US20080114576A1 (enExample)
EP (2) EP2458517A1 (enExample)
JP (1) JP2008522604A (enExample)
CN (1) CN101076806B (enExample)
AU (1) AU2005313114B2 (enExample)
CA (1) CA2587270A1 (enExample)
GB (1) GB0426982D0 (enExample)
WO (1) WO2006061644A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140141534A (ko) * 2013-05-31 2014-12-10 가톨릭대학교 산학협력단 패혈증 고위험군 예측 방법 및 시스템
JP2016526888A (ja) * 2013-06-28 2016-09-08 アキュメン リサーチ ラボラトリーズ プライヴェット リミテッドＡｃｕｍｅｎ Ｒｅｓｅａｒｃｈ Ｌａｂｏｒａｔｏｒｉｅｓ Ｐｔｅ． Ｌｔｄ． 敗血症バイオマーカー及びそれらの使用
KR20200114975A (ko) * 2019-03-29 2020-10-07 연세대학교 산학협력단 균혈증 발병 위험도 예측 방법 및 이를 이용한 균혈증 발병 위험도 예측용 디바이스
JP2022540159A (ja) * 2019-07-12 2022-09-14 ベックマン コールター， インコーポレイテッド 収縮期血圧、血液パラメーター、およびこれらの組み合わせを含むバイタルサインを使用して敗血症を検出する方法

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US8068990B2 (en) * 2003-03-25 2011-11-29 Hologic, Inc. Diagnosis of intra-uterine infection by proteomic analysis of cervical-vaginal fluids
BRPI0609302A2 (pt) 2005-04-15 2011-10-11 Becton Dickinson Co métodos para prever o desenvolvimento de sepse e para diagnosticar sepse em um indivìduo a ser testado, microarranjo, kit para prever o desenvolvimento de sepse em um indivìduo a ser testado, produto de programa de computador, computador, sistema de computador para determinar se um indivìduo é susceptìvel de desenvolver sepse, sinal digital embutido em uma onda portadora, e, interface gráfica de usuário para determinar se um indivìduo é susceptìvel de desenvolver sepse
ATE472611T1 (de) * 2005-11-25 2010-07-15 Trinity College Dublin Verfahren zur diagnose von sepsis durch analyse von cytokine mrna expression
JP4661870B2 (ja) 2005-12-14 2011-03-30 日本電気株式会社 ディジタル通信システム、屋内装置及び屋外装置
GB0610078D0 (en) * 2006-05-20 2006-06-28 Secr Defence Sepsis detection microarray
EP1950310A1 (en) * 2007-01-23 2008-07-30 Charite-Universitätsmedizin Berlin Method for risk prediction of a postoperative sepsis in a human
GB0722582D0 (en) * 2007-11-16 2007-12-27 Secr Defence Early detection of sepsis
WO2009123737A2 (en) 2008-04-03 2009-10-08 Becton, Dickinson And Company Advanced detection of sepsis
EP2283443A1 (en) 2008-05-07 2011-02-16 Lynn, Lawrence A. Medical failure pattern search engine
US11728041B2 (en) * 2008-05-07 2023-08-15 Lawrence A. Lynn Real-time time series matrix pathophysiologic pattern processor and quality assessment method
EP2166358A1 (en) * 2008-09-17 2010-03-24 Fundacio Institut de Recerca de l'Hospital Universitari Vall d'Hebron Differential diagnostic biomarkers of stroke mimicking conditions and methods of use thereof
US10460408B2 (en) * 2009-01-31 2019-10-29 Mayo Foundation For Medical Education And Research Presentation of critical patient data
JP5667353B2 (ja) 2009-09-25 2015-02-12 シスメックス株式会社 血球計数装置、診断支援装置、診断支援方法及びコンピュータプログラム
ES2539854T3 (es) * 2010-03-02 2015-07-06 F. Hoffmann-La Roche Ag Diagnóstico y predicción precoces basados en la detección de IL-6 del síndrome de respuesta inflamatoria sistémica y sepsis en pacientes asintomáticos
US9719842B2 (en) * 2010-07-06 2017-08-01 Norman A. Paradis Method for the discovery, validation and clinical application of multiplex biomarker algorithms based on optical, physical and/or electromagnetic patterns
EP2643483A4 (en) * 2010-11-26 2014-04-30 Immunexpress Pty Ltd DIAGNOSTIC AND / OR SCREENING APPROPRIATIONS AND USES THEREFOR
WO2014068018A1 (en) * 2012-10-30 2014-05-08 Abbott Gmbh & Co.Kg Methods of prognosis and diagnosis of sepsis
US9953453B2 (en) 2012-11-14 2018-04-24 Lawrence A. Lynn System for converting biologic particle density data into dynamic images
US10354429B2 (en) 2012-11-14 2019-07-16 Lawrence A. Lynn Patient storm tracker and visualization processor
US20150362509A1 (en) * 2013-01-28 2015-12-17 Vanderbilt University Method for Differentiating Sepsis and Systemic Inflammatory Response Syndrome (SIRS)
WO2014134460A1 (en) 2013-02-28 2014-09-04 Lynn Lawrence A Time lapsable motion image responsive to features of pathophysiologic perturbations
US10260111B1 (en) * 2014-01-20 2019-04-16 Brett Eric Etchebarne Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample
GB201402293D0 (en) * 2014-02-11 2014-03-26 Secr Defence Biomarker signatures for the prediction of onset of sepsis
US11058332B2 (en) * 2014-09-26 2021-07-13 Sofradim Production System and method for early detection of post-surgery infection
US10761093B2 (en) 2014-10-09 2020-09-01 Texas Tech University System Microdevice for cell separation utilizing activation phenotype
US10832134B2 (en) 2015-12-10 2020-11-10 Deepmind Technologies Limited Augmenting neural networks with external memory
EP3408773B1 (en) * 2016-01-28 2023-09-20 Beckman Coulter, Inc. Infection detection and differentiation systems and methods
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EP3806712A1 (en) * 2018-06-15 2021-04-21 Beckman Coulter, Inc. Method of determining sepsis in the presence of blast flagging
CN111374639A (zh) * 2018-12-28 2020-07-07 陈柏龄 败血症的菌种预测系统与方法
US20220299511A1 (en) * 2019-06-17 2022-09-22 The Broad Institute, Inc. Immune cell signature for bacterial sepsis
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JP7754815B2 (ja) * 2019-12-27 2025-10-15 ザ・ヘンリー・エム・ジャクソン・ファンデイション・フォー・ジ・アドヴァンスメント・オヴ・ミリタリー・メディシン，インコーポレイテッド 敗血症を患う個体における重症疾患の予測及び対処
WO2021142479A1 (en) * 2020-01-10 2021-07-15 Prenosis, Inc. A tool for selecting relevant features in precision diagnostics
JP7708769B2 (ja) * 2020-01-10 2025-07-15 プレノシス，インコーポレイテッド ストリーミングデータ環境のための時間依存トリガ
CN114167062B (zh) * 2020-09-10 2024-02-02 北京肿瘤医院(北京大学肿瘤医院) 一种用于早期腹腔内感染性并发症诊断的标记物及方法
TWI803893B (zh) * 2021-06-28 2023-06-01 中國醫藥大學 敗血症之人工智慧輔助醫療診斷方法及其系統
DE102022114248A1 (de) * 2022-06-07 2023-12-07 TCC GmbH Verfahren sowie Vorhersagesystem zur Ermittlung der Eintrittswahrscheinlichkeit einer Sepsis eines Patienten
CN120526862A (zh) * 2025-07-24 2025-08-22 中国疾病预防控制中心传染病预防控制所 一种基于5种标记物的感染病原体类型检测系统

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US20030207278A1 (en) * 2002-04-25 2003-11-06 Javed Khan Methods for analyzing high dimensional data for classifying, diagnosing, prognosticating, and/or predicting diseases and other biological states
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140141534A (ko) * 2013-05-31 2014-12-10 가톨릭대학교 산학협력단 패혈증 고위험군 예측 방법 및 시스템
KR101595784B1 (ko) 2013-05-31 2016-02-26 가톨릭대학교 산학협력단 패혈증 고위험군 예측 방법 및 시스템
JP2016526888A (ja) * 2013-06-28 2016-09-08 アキュメン リサーチ ラボラトリーズ プライヴェット リミテッドＡｃｕｍｅｎ Ｒｅｓｅａｒｃｈ Ｌａｂｏｒａｔｏｒｉｅｓ Ｐｔｅ． Ｌｔｄ． 敗血症バイオマーカー及びそれらの使用
KR20200114975A (ko) * 2019-03-29 2020-10-07 연세대학교 산학협력단 균혈증 발병 위험도 예측 방법 및 이를 이용한 균혈증 발병 위험도 예측용 디바이스
KR102287968B1 (ko) 2019-03-29 2021-08-09 연세대학교 산학협력단 균혈증 발병 위험도 예측 방법 및 이를 이용한 균혈증 발병 위험도 예측용 디바이스
JP2022540159A (ja) * 2019-07-12 2022-09-14 ベックマン コールター， インコーポレイテッド 収縮期血圧、血液パラメーター、およびこれらの組み合わせを含むバイタルサインを使用して敗血症を検出する方法
JP7657195B2 (ja) 2019-07-12 2025-04-04 ベックマン コールター， インコーポレイテッド 収縮期血圧、血液パラメーター、およびこれらの組み合わせを含むバイタルサインを使用して敗血症を検出する方法

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GB0426982D0 (en) 2005-01-12
CA2587270A1 (en) 2006-06-15
US20080114576A1 (en) 2008-05-15
AU2005313114A1 (en) 2006-06-15
EP2458517A1 (en) 2012-05-30
WO2006061644A1 (en) 2006-06-15
AU2005313114B2 (en) 2012-01-19
CN101076806B (zh) 2012-01-11
EP1839218A1 (en) 2007-10-03
CN101076806A (zh) 2007-11-21

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