JP2008521809A5 - - Google Patents

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Publication number
JP2008521809A5
JP2008521809A5 JP2007543346A JP2007543346A JP2008521809A5 JP 2008521809 A5 JP2008521809 A5 JP 2008521809A5 JP 2007543346 A JP2007543346 A JP 2007543346A JP 2007543346 A JP2007543346 A JP 2007543346A JP 2008521809 A5 JP2008521809 A5 JP 2008521809A5
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JP
Japan
Prior art keywords
aliphatic
aryl
heteroaryl
heterocyclyl
alicyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007543346A
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English (en)
Japanese (ja)
Other versions
JP5055129B2 (ja
JP2008521809A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2005/042139 external-priority patent/WO2006057961A1/en
Publication of JP2008521809A publication Critical patent/JP2008521809A/ja
Publication of JP2008521809A5 publication Critical patent/JP2008521809A5/ja
Application granted granted Critical
Publication of JP5055129B2 publication Critical patent/JP5055129B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2007543346A 2004-11-24 2005-11-21 3−[2−(3−アシルアミノ−2−オキソ−2h−ピリジン−1−イル)−アセチルアミノ]−4−オキソ−ペンタン酸誘導体、およびカスパーゼ阻害剤としてのそれらの使用 Expired - Fee Related JP5055129B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63092604P 2004-11-24 2004-11-24
US60/630,926 2004-11-24
PCT/US2005/042139 WO2006057961A1 (en) 2004-11-24 2005-11-21 3-[2-(3-acylamino-2-oxo-2h-pyridin-1-yl)-acetylamino]-4-oxo-pentanoic acid derivatives and their use as caspase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008280573A Division JP2009108067A (ja) 2004-11-24 2008-10-30 3−[2−(3−アシルアミノ−2−オキソ−2h−ピリジン−1−イル)−アセチルアミノ]−4−オキソ−ペンタン酸誘導体、およびカスパーゼ阻害剤としてのそれらの使用

Publications (3)

Publication Number Publication Date
JP2008521809A JP2008521809A (ja) 2008-06-26
JP2008521809A5 true JP2008521809A5 (enExample) 2012-05-31
JP5055129B2 JP5055129B2 (ja) 2012-10-24

Family

ID=36021822

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2007543346A Expired - Fee Related JP5055129B2 (ja) 2004-11-24 2005-11-21 3−[2−(3−アシルアミノ−2−オキソ−2h−ピリジン−1−イル)−アセチルアミノ]−4−オキソ−ペンタン酸誘導体、およびカスパーゼ阻害剤としてのそれらの使用
JP2008280573A Pending JP2009108067A (ja) 2004-11-24 2008-10-30 3−[2−(3−アシルアミノ−2−オキソ−2h−ピリジン−1−イル)−アセチルアミノ]−4−オキソ−ペンタン酸誘導体、およびカスパーゼ阻害剤としてのそれらの使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008280573A Pending JP2009108067A (ja) 2004-11-24 2008-10-30 3−[2−(3−アシルアミノ−2−オキソ−2h−ピリジン−1−イル)−アセチルアミノ]−4−オキソ−ペンタン酸誘導体、およびカスパーゼ阻害剤としてのそれらの使用

Country Status (16)

Country Link
US (1) US8362043B2 (enExample)
EP (1) EP1833794B1 (enExample)
JP (2) JP5055129B2 (enExample)
KR (1) KR20070086610A (enExample)
CN (1) CN101098855B (enExample)
AT (1) ATE543803T1 (enExample)
AU (1) AU2005309776B2 (enExample)
CA (1) CA2588713A1 (enExample)
ES (1) ES2380632T3 (enExample)
IL (1) IL183373A0 (enExample)
MX (1) MX2007006258A (enExample)
NO (1) NO20073170L (enExample)
NZ (1) NZ555565A (enExample)
RU (1) RU2412936C2 (enExample)
WO (1) WO2006057961A1 (enExample)
ZA (1) ZA200704913B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0312232A (pt) 2002-06-28 2005-05-10 Vertex Pharma Inibidores de caspases e seus usos
JP4675628B2 (ja) 2002-12-20 2011-04-27 バーテックス ファーマシューティカルズ インコーポレイテッド 4−オキソ−3−(1−オキソ−1h−イソキノリン−2−イルアセチルアミノ)−ペンタン酸のエステル誘導体およびアミド誘導体、ならびにカスパーゼインヒビターとしてのそれらの使用
PE20050159A1 (es) 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
CN102362867A (zh) * 2004-05-15 2012-02-29 沃泰克斯药物股份有限公司 使用ice抑制剂治疗癫痫发作
PH12012502411A1 (en) 2005-05-10 2019-07-17 Intermune Inc Method of modulating stress-activated protein kinase system
US8304413B2 (en) 2008-06-03 2012-11-06 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
IN2014CN04676A (enExample) 2011-12-21 2015-09-18 Ono Pharmaceutical Co
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
RU2692485C2 (ru) 2014-04-02 2019-06-25 Интермьюн, Инк. Противофиброзные пиридиноны
WO2020006341A1 (en) 2018-06-29 2020-01-02 Conatus Pharmaceuticals, Inc. (s)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases
WO2023215559A1 (en) * 2022-05-05 2023-11-09 Aria Pharmaceuticals, Inc. Compounds, compositions, and methods

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9207145D0 (en) 1991-04-18 1992-05-13 Ici Plc Heterocyclic amides
CN1504462A (zh) * 1994-03-31 2004-06-16 ������˹ҩƷ��˾ 作为白细胞介素抑制剂的嘧啶基衍生物
US5847135A (en) * 1994-06-17 1998-12-08 Vertex Pharmaceuticals, Incorporated Inhibitors of interleukin-1β converting enzyme
US5756466A (en) 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
WO1996033974A1 (en) 1995-04-27 1996-10-31 The Green Cross Corporation Heterocyclic amide compounds and medicinal use of the same
AU738341B2 (en) 1996-10-11 2001-09-13 Abbott Gmbh & Co. Kg Asparate ester inhibitors of interleukin-1beta converting enzyme
US6184244B1 (en) 1996-12-16 2001-02-06 Idun Pharmaceuticals, Inc. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6197750B1 (en) 1998-07-02 2001-03-06 Idun Pharmaceuticals, Inc. C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6242422B1 (en) * 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
WO2000061542A1 (en) 1999-04-09 2000-10-19 Cytovia, Inc. Caspase inhibitors and the use thereof
AR026748A1 (es) * 1999-12-08 2003-02-26 Vertex Pharma Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis
US6878743B2 (en) * 2001-09-18 2005-04-12 Sunesis Pharmaceuticals, Inc. Small molecule inhibitors of caspases
AU2003225088A1 (en) * 2002-04-19 2003-11-03 Vertex Pharmaceuticals Incorporated Regulation of tnf-alpha
BR0312232A (pt) * 2002-06-28 2005-05-10 Vertex Pharma Inibidores de caspases e seus usos
JP4675628B2 (ja) * 2002-12-20 2011-04-27 バーテックス ファーマシューティカルズ インコーポレイテッド 4−オキソ−3−(1−オキソ−1h−イソキノリン−2−イルアセチルアミノ)−ペンタン酸のエステル誘導体およびアミド誘導体、ならびにカスパーゼインヒビターとしてのそれらの使用
PE20050159A1 (es) * 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
JP2009502922A (ja) * 2005-07-28 2009-01-29 バーテックス ファーマシューティカルズ インコーポレイテッド カスパーゼ阻害剤プロドラッグ

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