JP2008521755A5 - - Google Patents
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- Publication number
- JP2008521755A5 JP2008521755A5 JP2007541612A JP2007541612A JP2008521755A5 JP 2008521755 A5 JP2008521755 A5 JP 2008521755A5 JP 2007541612 A JP2007541612 A JP 2007541612A JP 2007541612 A JP2007541612 A JP 2007541612A JP 2008521755 A5 JP2008521755 A5 JP 2008521755A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- solid product
- mixture
- bioactive substance
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000975 bioactive effect Effects 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 19
- 239000000463 material Substances 0.000 claims description 11
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 claims description 5
- 229960004134 propofol Drugs 0.000 claims description 5
- 230000000087 stabilizing effect Effects 0.000 claims description 5
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims description 4
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 claims description 3
- 239000012265 solid product Substances 0.000 claims 26
- 239000000126 substance Substances 0.000 claims 21
- 239000000203 mixture Substances 0.000 claims 15
- 229920001577 copolymer Polymers 0.000 claims 11
- 238000004519 manufacturing process Methods 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 239000000243 solution Substances 0.000 claims 9
- 239000000693 micelle Substances 0.000 claims 8
- 239000002904 solvent Substances 0.000 claims 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- 239000007864 aqueous solution Substances 0.000 claims 5
- 230000002209 hydrophobic effect Effects 0.000 claims 5
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 4
- SMUQFGGVLNAIOZ-UHFFFAOYSA-N quinaldine Chemical compound C1=CC=CC2=NC(C)=CC=C21 SMUQFGGVLNAIOZ-UHFFFAOYSA-N 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 3
- 239000003960 organic solvent Substances 0.000 claims 3
- -1 poly (ester amide Chemical class 0.000 claims 3
- 229920002557 polyglycidol polymer Polymers 0.000 claims 3
- WDRZVZVXHZNSFG-UHFFFAOYSA-N 1-ethenylpyridin-1-ium Chemical compound C=C[N+]1=CC=CC=C1 WDRZVZVXHZNSFG-UHFFFAOYSA-N 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 229920002845 Poly(methacrylic acid) Polymers 0.000 claims 2
- 229920001710 Polyorthoester Polymers 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 230000003444 anaesthetic effect Effects 0.000 claims 2
- 150000008064 anhydrides Chemical class 0.000 claims 2
- 229920006187 aquazol Polymers 0.000 claims 2
- 239000012861 aquazol Substances 0.000 claims 2
- 238000006703 hydration reaction Methods 0.000 claims 2
- RFKMCNOHBTXSMU-UHFFFAOYSA-N methoxyflurane Chemical compound COC(F)(F)C(Cl)Cl RFKMCNOHBTXSMU-UHFFFAOYSA-N 0.000 claims 2
- 229960002455 methoxyflurane Drugs 0.000 claims 2
- 239000002745 poly(ortho ester) Substances 0.000 claims 2
- 229920002187 poly[N-2-(hydroxypropyl) methacrylamide] polymer Polymers 0.000 claims 2
- 229920002647 polyamide Polymers 0.000 claims 2
- 229920000909 polytetrahydrofuran Polymers 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 claims 1
- 239000012867 bioactive agent Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 239000002577 cryoprotective agent Substances 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000706 filtrate Substances 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 230000000887 hydrating effect Effects 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 229960005323 phenoxyethanol Drugs 0.000 claims 1
- 239000002504 physiological saline solution Substances 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 229940065514 poly(lactide) Drugs 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 claims 1
- 230000001012 protector Effects 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 238000003260 vortexing Methods 0.000 claims 1
- 239000003021 water soluble solvent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63175504P | 2004-11-29 | 2004-11-29 | |
| US60/631,755 | 2004-11-29 | ||
| PCT/CA2005/001790 WO2006056064A1 (en) | 2004-11-29 | 2005-11-28 | Solid formulations of liquid biologically active agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012262276A Division JP2013060456A (ja) | 2004-11-29 | 2012-11-30 | 液体生物活性物質の固体配合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008521755A JP2008521755A (ja) | 2008-06-26 |
| JP2008521755A5 true JP2008521755A5 (enExample) | 2015-01-22 |
| JP5704787B2 JP5704787B2 (ja) | 2015-04-22 |
Family
ID=36497703
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007541612A Expired - Lifetime JP5704787B2 (ja) | 2004-11-29 | 2005-11-28 | 液体生物活性物質の固体配合物 |
| JP2012262276A Withdrawn JP2013060456A (ja) | 2004-11-29 | 2012-11-30 | 液体生物活性物質の固体配合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012262276A Withdrawn JP2013060456A (ja) | 2004-11-29 | 2012-11-30 | 液体生物活性物質の固体配合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US20060198891A1 (enExample) |
| EP (1) | EP1817035B1 (enExample) |
| JP (2) | JP5704787B2 (enExample) |
| KR (1) | KR20070094609A (enExample) |
| CN (1) | CN101065128A (enExample) |
| AU (1) | AU2005309283A1 (enExample) |
| BR (1) | BRPI0518677A2 (enExample) |
| CA (1) | CA2589242C (enExample) |
| ES (1) | ES2764991T3 (enExample) |
| IL (1) | IL183252A0 (enExample) |
| MX (1) | MX2007006243A (enExample) |
| NO (1) | NO20073339L (enExample) |
| NZ (1) | NZ555287A (enExample) |
| RU (1) | RU2007124374A (enExample) |
| WO (1) | WO2006056064A1 (enExample) |
| ZA (1) | ZA200704900B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6939564B2 (en) * | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
| EP3167961A1 (en) | 2004-04-08 | 2017-05-17 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| US20080176209A1 (en) * | 2004-04-08 | 2008-07-24 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| US20060198891A1 (en) | 2004-11-29 | 2006-09-07 | Francois Ravenelle | Solid formulations of liquid biologically active agents |
| CA2634830A1 (en) * | 2005-12-27 | 2007-07-05 | Labopharm Inc. | Degradable polymeric microsphere composition |
| WO2008036858A2 (en) | 2006-09-20 | 2008-03-27 | The Board Of Regents Of The University Of Texas System | Methods for delivering volatile anesthetics for regional anesthesia and/or pain relief |
| EP2081548A2 (en) * | 2006-09-22 | 2009-07-29 | Labopharm Inc. | Compositions and methods for ph targeted drug delivery |
| EP2200588B1 (en) | 2007-09-25 | 2019-03-20 | Solubest Ltd. | Compositions comprising lipophilic active compounds and method for their preparation |
| WO2009094459A1 (en) | 2008-01-22 | 2009-07-30 | The Board Of Regents Of The University Of Texas System | Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief |
| CN102006903A (zh) * | 2008-01-22 | 2011-04-06 | 维波真尼克斯公司 | 挥发性麻醉组合物和应用方法 |
| CA2635187A1 (en) * | 2008-06-05 | 2009-12-05 | The Royal Institution For The Advancement Of Learning/Mcgill University | Oligonucleotide duplexes and uses thereof |
| ES2400210T3 (es) | 2008-10-02 | 2013-04-08 | Mylan Inc. | Método para preparar un laminado de adhesivo multicapa |
| CA3031836A1 (en) | 2009-05-05 | 2010-11-11 | Board Of Regents, The University Of Texas System | Formulations of volatile anesthetics for reducing inflammation |
| WO2011130834A1 (en) * | 2010-04-23 | 2011-10-27 | Labopharm Inc. | Non-intravenous dosage form comprising solid formulation of liquid biologically active agent and uses thereof |
| CA2806670A1 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| WO2012018639A2 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| GB201116271D0 (en) * | 2011-09-21 | 2011-11-02 | Univ Cardiff | Dispersion anaesthetic device |
| HK1217117A1 (zh) | 2012-12-20 | 2016-12-23 | 生物马特里卡公司 | 用於使pcr试剂稳定化的制剂和方法 |
| CA2920835A1 (en) | 2013-08-20 | 2015-02-26 | Anutra Medical, Inc. | Syringe fill system and method |
| USD763433S1 (en) | 2014-06-06 | 2016-08-09 | Anutra Medical, Inc. | Delivery system cassette |
| USD774182S1 (en) | 2014-06-06 | 2016-12-13 | Anutra Medical, Inc. | Anesthetic delivery device |
| USD750768S1 (en) | 2014-06-06 | 2016-03-01 | Anutra Medical, Inc. | Fluid administration syringe |
| EP3942931A1 (en) | 2014-06-10 | 2022-01-26 | Biomatrica, INC. | Stabilization of thrombocytes at ambient temperatures |
| EP4242628B1 (en) | 2015-12-08 | 2025-07-02 | Biomatrica, Inc. | Reduction of erythrocyte sedimentation rate |
| CN111821267B (zh) * | 2020-07-24 | 2022-05-03 | 西南药业股份有限公司 | 注射液用丙泊酚胶束冻干制剂与专用溶剂的组合物 |
| CN114073675A (zh) * | 2020-08-10 | 2022-02-22 | 复旦大学 | 一种丙泊酚混合胶束及其制备方法 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1575343A (en) * | 1977-05-10 | 1980-09-17 | Ici Ltd | Method for preparing liposome compositions containing biologically active compounds |
| US4826689A (en) * | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
| FR2678168B1 (fr) | 1991-06-28 | 1993-09-03 | Rhone Poulenc Rorer Sa | Nanoparticules ayant un temps de capture par le dysteme reticulo endothelial allonge. |
| US5916596A (en) * | 1993-02-22 | 1999-06-29 | Vivorx Pharmaceuticals, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
| US5565215A (en) * | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
| US5543158A (en) * | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| US6143211A (en) * | 1995-07-21 | 2000-11-07 | Brown University Foundation | Process for preparing microparticles through phase inversion phenomena |
| WO1997010814A1 (en) * | 1995-09-18 | 1997-03-27 | Vesifact Ag | Propofol nanodispersions |
| KR0180334B1 (ko) * | 1995-09-21 | 1999-03-20 | 김윤 | 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법 |
| US6306433B1 (en) * | 1997-08-12 | 2001-10-23 | Pharmacia Ab | Method of preparing pharmaceutical compositions |
| HUP9701554D0 (en) * | 1997-09-18 | 1997-11-28 | Human Oltoanyagtermeloe Gyogys | Pharmaceutical composition containing plazma proteins |
| TW592713B (en) * | 1998-05-11 | 2004-06-21 | Ciba Sc Holding Ag | Use of nanodispersions in cosmetic end formulations |
| TWI241915B (en) * | 1998-05-11 | 2005-10-21 | Ciba Sc Holding Ag | A method of preparing a pharmaceutical end formulation using a nanodispersion |
| GB2359747B (en) | 2000-02-29 | 2002-04-24 | Maelor Pharmaceuticals Ltd | Anaesthetic formulations |
| US6338859B1 (en) * | 2000-06-29 | 2002-01-15 | Labopharm Inc. | Polymeric micelle compositions |
| US6623765B1 (en) * | 2000-08-01 | 2003-09-23 | University Of Florida, Research Foundation, Incorporated | Microemulsion and micelle systems for solubilizing drugs |
| IN188917B (enExample) | 2000-12-07 | 2002-11-23 | Bharat Surums & Vaccines Ltd | |
| EP1383445A4 (en) * | 2001-03-20 | 2005-04-13 | Cydex Inc | FORMULATIONS WITH PROPOFOL AND A SULFOALKYL ETHER CYCLODEXTRIN |
| US7034013B2 (en) * | 2001-03-20 | 2006-04-25 | Cydex, Inc. | Formulations containing propofol and a sulfoalkyl ether cyclodextrin |
| US6939564B2 (en) * | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
| US6780428B2 (en) * | 2001-06-08 | 2004-08-24 | Labopharm, Inc. | Unimolecular polymeric micelles with an ionizable inner core |
| US7094810B2 (en) * | 2001-06-08 | 2006-08-22 | Labopharm, Inc. | pH-sensitive block copolymers for pharmaceutical compositions |
| US20060003012A9 (en) * | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| GB0124071D0 (en) | 2001-10-08 | 2001-11-28 | Kbig Ltd | Improvement in the administration of high boiling point aneasthetics |
| GB0124126D0 (en) | 2001-10-08 | 2001-11-28 | Eschmann Holdings Ltd | Surgical tables |
| WO2003063824A2 (en) | 2002-02-01 | 2003-08-07 | Shimoda Biotech (Pty) Ltd | Pharmaceutical composition |
| US7018655B2 (en) * | 2002-03-18 | 2006-03-28 | Labopharm, Inc. | Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions |
| US6780324B2 (en) * | 2002-03-18 | 2004-08-24 | Labopharm, Inc. | Preparation of sterile stabilized nanodispersions |
| CN1206002C (zh) | 2002-12-02 | 2005-06-15 | 天津大学 | 组合聚合物药物胶束及其制备方法 |
| US7262253B2 (en) * | 2003-12-02 | 2007-08-28 | Labopharm, Inc. | Process for the preparation of amphiphilic poly (N-vinyl-2-pyrrolidone) block copolymers |
| CA2548216A1 (en) | 2003-12-17 | 2005-06-30 | Mgi Gp, Inc. | Methods of administering water-soluble prodrugs of propofol for extended sedation |
| DE102004057618A1 (de) | 2004-11-29 | 2006-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen |
| US20060198891A1 (en) | 2004-11-29 | 2006-09-07 | Francois Ravenelle | Solid formulations of liquid biologically active agents |
| CA2634830A1 (en) | 2005-12-27 | 2007-07-05 | Labopharm Inc. | Degradable polymeric microsphere composition |
| EP2081548A2 (en) | 2006-09-22 | 2009-07-29 | Labopharm Inc. | Compositions and methods for ph targeted drug delivery |
| EP2200588B1 (en) | 2007-09-25 | 2019-03-20 | Solubest Ltd. | Compositions comprising lipophilic active compounds and method for their preparation |
| WO2011130834A1 (en) | 2010-04-23 | 2011-10-27 | Labopharm Inc. | Non-intravenous dosage form comprising solid formulation of liquid biologically active agent and uses thereof |
-
2005
- 2005-11-25 US US11/286,301 patent/US20060198891A1/en not_active Abandoned
- 2005-11-28 RU RU2007124374/15A patent/RU2007124374A/ru not_active Application Discontinuation
- 2005-11-28 BR BRPI0518677-3A patent/BRPI0518677A2/pt not_active IP Right Cessation
- 2005-11-28 AU AU2005309283A patent/AU2005309283A1/en not_active Abandoned
- 2005-11-28 CN CNA2005800407233A patent/CN101065128A/zh active Pending
- 2005-11-28 NZ NZ555287A patent/NZ555287A/en unknown
- 2005-11-28 KR KR1020077014083A patent/KR20070094609A/ko not_active Ceased
- 2005-11-28 CA CA2589242A patent/CA2589242C/en not_active Expired - Lifetime
- 2005-11-28 ZA ZA200704900A patent/ZA200704900B/xx unknown
- 2005-11-28 JP JP2007541612A patent/JP5704787B2/ja not_active Expired - Lifetime
- 2005-11-28 ES ES05815074T patent/ES2764991T3/es not_active Expired - Lifetime
- 2005-11-28 EP EP05815074.9A patent/EP1817035B1/en not_active Expired - Lifetime
- 2005-11-28 MX MX2007006243A patent/MX2007006243A/es not_active Application Discontinuation
- 2005-11-28 WO PCT/CA2005/001790 patent/WO2006056064A1/en not_active Ceased
-
2007
- 2007-05-16 IL IL183252A patent/IL183252A0/en unknown
- 2007-06-28 NO NO20073339A patent/NO20073339L/no not_active Application Discontinuation
-
2012
- 2012-07-19 US US13/552,993 patent/US20120289606A1/en not_active Abandoned
- 2012-11-30 JP JP2012262276A patent/JP2013060456A/ja not_active Withdrawn
-
2013
- 2013-12-19 US US14/134,156 patent/US20140323587A1/en not_active Abandoned
-
2015
- 2015-09-03 US US14/844,493 patent/US20160193341A1/en not_active Abandoned
-
2017
- 2017-11-20 US US15/817,907 patent/US10561735B2/en not_active Expired - Lifetime
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