JP2008518905A5 - - Google Patents
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- Publication number
- JP2008518905A5 JP2008518905A5 JP2007538543A JP2007538543A JP2008518905A5 JP 2008518905 A5 JP2008518905 A5 JP 2008518905A5 JP 2007538543 A JP2007538543 A JP 2007538543A JP 2007538543 A JP2007538543 A JP 2007538543A JP 2008518905 A5 JP2008518905 A5 JP 2008518905A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- substituted
- dimethylpropyl
- benzimidazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 125000003277 amino group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical class 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- VMDNUKQYFURWNP-UHFFFAOYSA-N 1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-5-(trifluoromethylsulfonyl)benzimidazole Chemical compound CC(C)(C)CC1=NC2=CC(S(=O)(=O)C(F)(F)F)=CC=C2N1CC1CC1 VMDNUKQYFURWNP-UHFFFAOYSA-N 0.000 claims 1
- IAJXCUDLAWNZSP-UHFFFAOYSA-N 1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-5-ethylsulfonylbenzimidazole Chemical compound CC(C)(C)CC1=NC2=CC(S(=O)(=O)CC)=CC=C2N1CC1CC1 IAJXCUDLAWNZSP-UHFFFAOYSA-N 0.000 claims 1
- NFCGJYHKIUUMHJ-UHFFFAOYSA-N 1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-5-methylsulfonylbenzimidazole Chemical compound CC(C)(C)CC1=NC2=CC(S(C)(=O)=O)=CC=C2N1CC1CC1 NFCGJYHKIUUMHJ-UHFFFAOYSA-N 0.000 claims 1
- QOIHZTWJPUIHKH-UHFFFAOYSA-N 1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-5-propan-2-ylsulfonylbenzimidazole Chemical compound CC(C)(C)CC1=NC2=CC(S(=O)(=O)C(C)C)=CC=C2N1CC1CC1 QOIHZTWJPUIHKH-UHFFFAOYSA-N 0.000 claims 1
- WAQPCHCSUWRSEX-UHFFFAOYSA-N 1-[(2-tert-butyl-5-propan-2-ylsulfonylbenzimidazol-1-yl)methyl]cyclopentan-1-ol Chemical compound CC(C)(C)C1=NC2=CC(S(=O)(=O)C(C)C)=CC=C2N1CC1(O)CCCC1 WAQPCHCSUWRSEX-UHFFFAOYSA-N 0.000 claims 1
- NVRUPYPCQDLPFB-UHFFFAOYSA-N 1-[1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)benzimidazol-5-yl]sulfonyl-2-methylpropan-2-ol Chemical compound CC(C)(C)CC1=NC2=CC(S(=O)(=O)CC(C)(C)O)=CC=C2N1CC1CC1 NVRUPYPCQDLPFB-UHFFFAOYSA-N 0.000 claims 1
- CWOCNAQYXGPFLF-UHFFFAOYSA-N 1-[2-tert-butyl-1-(cyclopropylmethyl)benzimidazol-5-yl]sulfonyl-2-methylpropan-2-ol Chemical compound CC(C)(C)C1=NC2=CC(S(=O)(=O)CC(C)(O)C)=CC=C2N1CC1CC1 CWOCNAQYXGPFLF-UHFFFAOYSA-N 0.000 claims 1
- SOWZZBKSIOEFNM-UHFFFAOYSA-N 1-[2-tert-butyl-1-(oxan-4-ylmethyl)benzimidazol-5-yl]sulfonyl-2-methylpropan-2-ol Chemical compound CC(C)(C)C1=NC2=CC(S(=O)(=O)CC(C)(O)C)=CC=C2N1CC1CCOCC1 SOWZZBKSIOEFNM-UHFFFAOYSA-N 0.000 claims 1
- PVCSVRLFAQMRQJ-UHFFFAOYSA-N 1-[[2-(2,2-dimethylpropyl)-5-ethylsulfonylbenzimidazol-1-yl]methyl]cyclopentan-1-ol Chemical compound CC(C)(C)CC1=NC2=CC(S(=O)(=O)CC)=CC=C2N1CC1(O)CCCC1 PVCSVRLFAQMRQJ-UHFFFAOYSA-N 0.000 claims 1
- IJJDNRKMCVLSNA-UHFFFAOYSA-N 1-[[2-tert-butyl-5-(1-hydroxy-2-methylpropan-2-yl)sulfonylbenzimidazol-1-yl]methyl]cyclopentan-1-ol Chemical compound CC(C)(C)C1=NC2=CC(S(=O)(=O)C(C)(C)CO)=CC=C2N1CC1(O)CCCC1 IJJDNRKMCVLSNA-UHFFFAOYSA-N 0.000 claims 1
- BSMWENLGCVUPEU-UHFFFAOYSA-N 2-(2,2-dimethylpropyl)-3-(oxan-4-ylmethyl)-6-propan-2-ylsulfonylimidazo[4,5-b]pyridine Chemical compound CC(C)(C)CC1=NC2=CC(S(=O)(=O)C(C)C)=CN=C2N1CC1CCOCC1 BSMWENLGCVUPEU-UHFFFAOYSA-N 0.000 claims 1
- QUPQCDRZCLTJIB-UHFFFAOYSA-N 2-(2,2-dimethylpropyl)-5-ethylsulfonyl-1-[2-(trifluoromethoxy)ethyl]benzimidazole Chemical compound CCS(=O)(=O)C1=CC=C2N(CCOC(F)(F)F)C(CC(C)(C)C)=NC2=C1 QUPQCDRZCLTJIB-UHFFFAOYSA-N 0.000 claims 1
- RZBRHMJPJZUQHQ-UHFFFAOYSA-N 2-(2,2-dimethylpropyl)-5-propan-2-ylsulfonyl-1-(2-pyrrolidin-1-ylethyl)benzimidazole Chemical compound CC(C)(C)CC1=NC2=CC(S(=O)(=O)C(C)C)=CC=C2N1CCN1CCCC1 RZBRHMJPJZUQHQ-UHFFFAOYSA-N 0.000 claims 1
- ZUCSYLRZUIFQRF-UHFFFAOYSA-N 2-(2,2-dimethylpropyl)-6-ethylsulfonyl-3-(oxan-4-ylmethyl)imidazo[4,5-b]pyridine Chemical compound CC(C)(C)CC1=NC2=CC(S(=O)(=O)CC)=CN=C2N1CC1CCOCC1 ZUCSYLRZUIFQRF-UHFFFAOYSA-N 0.000 claims 1
- PULUCWGTNASYGC-UHFFFAOYSA-N 2-(2,2-dimethylpropyl)-6-ethylsulfonyl-3-[2-(trifluoromethoxy)ethyl]imidazo[4,5-b]pyridine Chemical compound CCS(=O)(=O)C1=CN=C2N(CCOC(F)(F)F)C(CC(C)(C)C)=NC2=C1 PULUCWGTNASYGC-UHFFFAOYSA-N 0.000 claims 1
- XHXDTYJRUSMUCP-UHFFFAOYSA-N 2-(2,2-dimethylpropyl)-6-propan-2-ylsulfonyl-3-[2-(trifluoromethoxy)ethyl]imidazo[4,5-b]pyridine Chemical compound CC(C)S(=O)(=O)C1=CN=C2N(CCOC(F)(F)F)C(CC(C)(C)C)=NC2=C1 XHXDTYJRUSMUCP-UHFFFAOYSA-N 0.000 claims 1
- WQQOWRVDEINLDE-UHFFFAOYSA-N 2-[1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)benzimidazol-5-yl]sulfonyl-2-methylpropan-1-ol Chemical compound CC(C)(C)CC1=NC2=CC(S(=O)(=O)C(C)(C)CO)=CC=C2N1CC1CC1 WQQOWRVDEINLDE-UHFFFAOYSA-N 0.000 claims 1
- JDYFPOCQOQRBHH-UHFFFAOYSA-N 2-[2-(2,2-dimethylpropyl)-1-[2-(trifluoromethoxy)ethyl]benzimidazol-5-yl]sulfonyl-2-methylpropan-1-ol Chemical compound OCC(C)(C)S(=O)(=O)C1=CC=C2N(CCOC(F)(F)F)C(CC(C)(C)C)=NC2=C1 JDYFPOCQOQRBHH-UHFFFAOYSA-N 0.000 claims 1
- LOTFQFQGPFCYDC-UHFFFAOYSA-N 2-[2-(2,2-dimethylpropyl)-5-propan-2-ylsulfonylbenzimidazol-1-yl]-n,n-dimethylethanamine Chemical compound CC(C)S(=O)(=O)C1=CC=C2N(CCN(C)C)C(CC(C)(C)C)=NC2=C1 LOTFQFQGPFCYDC-UHFFFAOYSA-N 0.000 claims 1
- LXCYJXHOXQWGKT-UHFFFAOYSA-N 2-[2-(2,2-dimethylpropyl)-6-propan-2-ylsulfonylimidazo[4,5-b]pyridin-3-yl]-n,n-dimethylethanamine Chemical compound CC(C)S(=O)(=O)C1=CN=C2N(CCN(C)C)C(CC(C)(C)C)=NC2=C1 LXCYJXHOXQWGKT-UHFFFAOYSA-N 0.000 claims 1
- XYHCDXYBKBJRPC-UHFFFAOYSA-N 2-[2-tert-butyl-1-(cyclopropylmethyl)benzimidazol-5-yl]sulfonyl-2-methylpropan-1-ol Chemical compound CC(C)(C)C1=NC2=CC(S(=O)(=O)C(C)(C)CO)=CC=C2N1CC1CC1 XYHCDXYBKBJRPC-UHFFFAOYSA-N 0.000 claims 1
- KBTFBZPPPXFERJ-UHFFFAOYSA-N 2-tert-butyl-1-(cyclopropylmethyl)-5-propan-2-ylsulfonylbenzimidazole Chemical compound CC(C)(C)C1=NC2=CC(S(=O)(=O)C(C)C)=CC=C2N1CC1CC1 KBTFBZPPPXFERJ-UHFFFAOYSA-N 0.000 claims 1
- MHGOYTPUMGRCGN-UHFFFAOYSA-N 2-tert-butyl-1-(oxan-4-ylmethyl)-5-(propan-2-ylsulfonylmethyl)benzimidazole Chemical compound CC(C)(C)C1=NC2=CC(CS(=O)(=O)C(C)C)=CC=C2N1CC1CCOCC1 MHGOYTPUMGRCGN-UHFFFAOYSA-N 0.000 claims 1
- MOASUYKEWRFBHZ-UHFFFAOYSA-N 2-tert-butyl-3-(oxan-4-ylmethyl)-6-propan-2-ylsulfonylimidazo[4,5-b]pyridine Chemical compound CC(C)(C)C1=NC2=CC(S(=O)(=O)C(C)C)=CN=C2N1CC1CCOCC1 MOASUYKEWRFBHZ-UHFFFAOYSA-N 0.000 claims 1
- WGIXCJGYRLRVKG-UHFFFAOYSA-N 2-tert-butyl-5-ethylsulfonyl-1-(oxan-2-ylmethyl)benzimidazole Chemical compound CC(C)(C)C1=NC2=CC(S(=O)(=O)CC)=CC=C2N1CC1CCCCO1 WGIXCJGYRLRVKG-UHFFFAOYSA-N 0.000 claims 1
- QKMYBDCEPKMNCO-UHFFFAOYSA-N 2-tert-butyl-5-ethylsulfonyl-1-(oxan-4-ylmethyl)benzimidazole Chemical compound CC(C)(C)C1=NC2=CC(S(=O)(=O)CC)=CC=C2N1CC1CCOCC1 QKMYBDCEPKMNCO-UHFFFAOYSA-N 0.000 claims 1
- YBYNIALTVJBQES-UHFFFAOYSA-N 4-[[2-(2,2-dimethylpropyl)-5-propan-2-ylsulfonylbenzimidazol-1-yl]methyl]oxan-4-ol Chemical compound CC(C)(C)CC1=NC2=CC(S(=O)(=O)C(C)C)=CC=C2N1CC1(O)CCOCC1 YBYNIALTVJBQES-UHFFFAOYSA-N 0.000 claims 1
- RWALICDEUJFFIX-UHFFFAOYSA-N 4-[[2-(2,2-dimethylpropyl)-6-propan-2-ylsulfonylimidazo[4,5-b]pyridin-3-yl]methyl]oxan-4-ol Chemical compound CC(C)(C)CC1=NC2=CC(S(=O)(=O)C(C)C)=CN=C2N1CC1(O)CCOCC1 RWALICDEUJFFIX-UHFFFAOYSA-N 0.000 claims 1
- VJNRFBIWHFQUSE-UHFFFAOYSA-N 5-(benzenesulfonyl)-1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)benzimidazole Chemical compound CC(C)(C)CC1=NC2=CC(S(=O)(=O)C=3C=CC=CC=3)=CC=C2N1CC1CC1 VJNRFBIWHFQUSE-UHFFFAOYSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000006125 ethylsulfonyl group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 229910052757 nitrogen Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- LMYJGUNNJIDROI-UHFFFAOYSA-N oxan-4-ol Chemical compound OC1CCOCC1 LMYJGUNNJIDROI-UHFFFAOYSA-N 0.000 claims 1
- -1 t-butylsulfonyl Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62457804P | 2004-11-02 | 2004-11-02 | |
| US69635805P | 2005-06-30 | 2005-06-30 | |
| PCT/IB2005/003325 WO2006048754A1 (en) | 2004-11-02 | 2005-10-19 | Sulfonyl benzimidazole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008518905A JP2008518905A (ja) | 2008-06-05 |
| JP2008518905A5 true JP2008518905A5 (enExample) | 2008-11-27 |
Family
ID=35915103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007538543A Pending JP2008518905A (ja) | 2004-11-02 | 2005-10-19 | スルホニルベンゾイミダゾール誘導体 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7598393B2 (enExample) |
| EP (1) | EP1809607B1 (enExample) |
| JP (1) | JP2008518905A (enExample) |
| AR (1) | AR053774A1 (enExample) |
| AT (1) | ATE417830T1 (enExample) |
| BR (1) | BRPI0517925A (enExample) |
| CA (1) | CA2586179C (enExample) |
| DE (1) | DE602005011844D1 (enExample) |
| DO (1) | DOP2005000221A (enExample) |
| ES (1) | ES2318556T3 (enExample) |
| GT (1) | GT200500309A (enExample) |
| MX (1) | MX2007005290A (enExample) |
| NL (1) | NL1030324C2 (enExample) |
| PA (1) | PA8651501A1 (enExample) |
| PE (1) | PE20060937A1 (enExample) |
| TW (1) | TW200621724A (enExample) |
| UY (1) | UY29184A1 (enExample) |
| WO (1) | WO2006048754A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0934061B3 (en) | 1996-07-24 | 2015-01-21 | Warner-Lambert Company LLC | Isobutylgaba and its derivatives for the treatment of pain |
| SE0302573D0 (sv) | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| BRPI0515897A (pt) | 2004-09-24 | 2008-08-12 | Astrazeneca Ab | composto, uso do mesmo, composição farmacêutica, e, método para a terapia de dor em um animal de sangue quente, e para a preparação de um composto |
| EA016286B1 (ru) * | 2005-09-30 | 2012-03-30 | Глэксо Груп Лимитед | Соединения, которые обладают активностью по отношению к рецепторам м, и их применения в медицине |
| WO2007036711A1 (en) * | 2005-09-30 | 2007-04-05 | Glaxo Group Limited | BENZIMIDAZOLONES WHICH HAVE ACTIVITY AT Ml RECEPTOR |
| EP1960389B1 (en) * | 2005-09-30 | 2012-08-15 | Glaxo Group Limited | Compounds which have activity at m1 receptor and their uses in medicine |
| US7700618B2 (en) | 2006-03-06 | 2010-04-20 | Pfizer Inc | Sulfonyl benzimidazole derivatives |
| TW200745049A (en) | 2006-03-23 | 2007-12-16 | Astrazeneca Ab | New crystalline forms |
| TW200808769A (en) | 2006-04-18 | 2008-02-16 | Astrazeneca Ab | Therapeutic compounds |
| CA2654246A1 (en) * | 2006-07-04 | 2008-01-10 | Janssen Pharmaceutica N.V. | Benzimidazole cannabinoid agonists bearing a substituted heterocyclic group |
| EP2120938A4 (en) * | 2006-12-20 | 2010-12-08 | Merck Sharp & Dohme | IMIDAZOPYRIDINE ANALOGUE AS CB2 RECEPTOR MODULATORS FOR THE TREATMENT OF PAIN, RESPIRATORY AND NON-RESPIRATORY DISEASES |
| ES2548764T3 (es) | 2007-03-30 | 2015-10-20 | Janssen Pharmaceutica N.V. | Agonistas de cannabinoides de bencimidazol |
| US8541476B2 (en) * | 2007-09-14 | 2013-09-24 | The Trustees Of The University Of Pennsylvania | Compounds for treatment of malignant tumors |
| GB0718415D0 (en) * | 2007-09-20 | 2007-10-31 | Glaxo Group Ltd | Compounds |
| ES2574130T3 (es) * | 2007-12-17 | 2016-06-15 | Janssen Pharmaceutica, N.V. | Bencimidazoles sustituidos con fluoroalquilo como agonistas cannabinoides |
| WO2010084767A1 (en) * | 2009-01-22 | 2010-07-29 | Raqualia Pharma Inc. | N-substituted saturated heterocyclic sulfone compounds with cb2 receptor agonistic activity |
| RU2636614C2 (ru) * | 2009-05-19 | 2017-11-24 | Вивия Байотек С.Л. | Способы персонализированного медицинского тестирования ex vivo на гематологические новообразования |
| US20110086853A1 (en) * | 2009-10-08 | 2011-04-14 | William Brown | Therapeutic Compounds |
| MX2012005248A (es) | 2009-11-06 | 2012-06-14 | Univ Vanderbilt | Aril- y heteroaril-sulfonas como potenciadores alostericos de mglur4, composiciones y metodos de tratamiento de la disfuncion neurologica. |
| RU2414899C1 (ru) * | 2009-12-29 | 2011-03-27 | Аверин Константин Михайлович | Средства для лечения рассеянного склероза |
| CN105566182B (zh) * | 2016-02-24 | 2018-02-13 | 苏州天马精细化学品股份有限公司 | 一种2‑氨基‑4‑（乙磺酰基）苯酚的合成方法 |
| GB201811169D0 (en) | 2018-07-06 | 2018-08-29 | Kancera Ab | New compounds |
| US10569189B1 (en) * | 2019-05-17 | 2020-02-25 | NextLeaf Solutions Ltd. | Method for acetylation of cannabinoids |
| WO2022128050A1 (en) | 2020-12-14 | 2022-06-23 | Symrise Ag | Medicament for fighting inflammation and pain |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1481049A (fr) * | 1965-11-25 | 1967-05-19 | France Ministre Des Armees | Nouveaux dialkylaminoalkyl-1 p-alkoxyphényl alkyl-2 benzimidazoles 5-substitués |
| GB1198633A (en) | 1967-11-24 | 1970-07-15 | Ilford Ltd | Phenyl-Sulphonated Benzimidazoles |
| US4177057A (en) * | 1977-10-25 | 1979-12-04 | United States Borax & Chemical Corporation | Herbicidal benzimidazoles |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| DE19507913C2 (de) * | 1995-03-07 | 1998-04-16 | Agfa Gevaert Ag | Farbfotografisches Silberhalogenidmaterial |
| GB9518953D0 (en) * | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| EP0882718B1 (en) * | 1995-12-28 | 2005-08-31 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
| FR2751649B1 (fr) * | 1996-07-26 | 1998-08-28 | Adir | Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2000035298A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing gum containing medicament active agents |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| WO1999040072A1 (de) * | 1998-02-03 | 1999-08-12 | Boehringer Ingelheim Pharma Kg | 5-gliedrige benzokondensierte heterocyclen als antithrombotika |
| DE60023920T2 (de) | 1999-08-27 | 2006-07-20 | Sugen, Inc., South San Francisco | Phosphatmimetika und Verfahren zur Behandlung mit Phosphataseinhibitoren HIBITOREN |
| AU2001236605A1 (en) | 2000-02-01 | 2001-08-14 | Cor Therapeutics, Inc. | Indole and benzimidazole inhibitors of factor xa |
| JP2004515496A (ja) | 2000-12-07 | 2004-05-27 | アストラゼネカ・アクチエボラーグ | ベンズイミダゾール治療剤 |
| TW593278B (en) | 2001-01-23 | 2004-06-21 | Wyeth Corp | 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands |
| SE0101387D0 (sv) * | 2001-04-20 | 2001-04-20 | Astrazeneca Ab | Novel compounds |
| KR20030088508A (ko) * | 2001-04-20 | 2003-11-19 | 와이어쓰 | 5-하이드록시트립타민-6 리간드로서의헤테로사이클릴옥시-, -티옥시- 및 -아미노벤즈아졸 유도체 |
| EP1403255A4 (en) * | 2001-06-12 | 2005-04-06 | Sumitomo Pharma | RHO KINASE INHIBITORS |
| SE0203070D0 (en) * | 2002-10-16 | 2002-10-16 | Astrazeneca Ab | Novel compounds |
| EP1646614A4 (en) | 2003-07-01 | 2008-09-10 | Merck & Co Inc | OPHTHALMIC COMPOSITIONS FOR THE TREATMENT OF OCCULAR HYPERTONIA |
| SE0302571D0 (sv) | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0302570D0 (sv) | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0302573D0 (sv) | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0302572D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| JP4953455B2 (ja) * | 2004-09-30 | 2012-06-13 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 選択的アンドロゲン受容体モジュレーター（ｓａｒｍ）として有用な新規なベンゾイミダゾール誘導体 |
| CA2582356A1 (en) * | 2004-09-30 | 2006-04-13 | Janssen Pharmaceutica N.V. | Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms) |
-
2005
- 2005-10-19 CA CA2586179A patent/CA2586179C/en not_active Expired - Fee Related
- 2005-10-19 BR BRPI0517925-4A patent/BRPI0517925A/pt not_active IP Right Cessation
- 2005-10-19 EP EP05800583A patent/EP1809607B1/en not_active Expired - Lifetime
- 2005-10-19 WO PCT/IB2005/003325 patent/WO2006048754A1/en not_active Ceased
- 2005-10-19 DE DE602005011844T patent/DE602005011844D1/de not_active Expired - Lifetime
- 2005-10-19 ES ES05800583T patent/ES2318556T3/es not_active Expired - Lifetime
- 2005-10-19 AT AT05800583T patent/ATE417830T1/de not_active IP Right Cessation
- 2005-10-19 MX MX2007005290A patent/MX2007005290A/es active IP Right Grant
- 2005-10-19 JP JP2007538543A patent/JP2008518905A/ja active Pending
- 2005-10-27 DO DO2005000221A patent/DOP2005000221A/es unknown
- 2005-10-28 PE PE2005001266A patent/PE20060937A1/es not_active Application Discontinuation
- 2005-10-28 GT GT200500309A patent/GT200500309A/es unknown
- 2005-10-31 UY UY29184A patent/UY29184A1/es not_active Application Discontinuation
- 2005-11-01 AR ARP050104571A patent/AR053774A1/es unknown
- 2005-11-01 NL NL1030324A patent/NL1030324C2/nl not_active IP Right Cessation
- 2005-11-01 TW TW094138221A patent/TW200621724A/zh unknown
- 2005-11-02 US US11/266,107 patent/US7598393B2/en not_active Expired - Fee Related
- 2005-11-02 PA PA20058651501A patent/PA8651501A1/es unknown