|
CH652145A5
(de)
|
1982-01-22 |
1985-10-31 |
Sandoz Ag |
Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen.
|
|
US4634666A
(en)
|
1984-01-06 |
1987-01-06 |
The Board Of Trustees Of The Leland Stanford Junior University |
Human-murine hybridoma fusion partner
|
|
IL77243A
(en)
*
|
1984-12-21 |
1996-11-14 |
Procter & Gamble |
Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
|
|
DE3521994A1
(de)
|
1985-06-20 |
1987-01-02 |
Bayer Ag |
N-(2-aminoacylamido-2-desoxy-hexosyl)-amide-, -carbamate und -harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4883666A
(en)
*
|
1987-04-29 |
1989-11-28 |
Massachusetts Institute Of Technology |
Controlled drug delivery system for treatment of neural disorders
|
|
US5583112A
(en)
|
1987-05-29 |
1996-12-10 |
Cambridge Biotech Corporation |
Saponin-antigen conjugates and the use thereof
|
|
US5057540A
(en)
|
1987-05-29 |
1991-10-15 |
Cambridge Biotech Corporation |
Saponin adjuvant
|
|
US6093406A
(en)
*
|
1988-06-02 |
2000-07-25 |
The United States Of America As Represented By The Secretary Of The Army |
Vaccine for induction of immunity to malaria
|
|
US4912094B1
(en)
|
1988-06-29 |
1994-02-15 |
Ribi Immunochem Research Inc. |
Modified lipopolysaccharides and process of preparation
|
|
US5576184A
(en)
*
|
1988-09-06 |
1996-11-19 |
Xoma Corporation |
Production of chimeric mouse-human antibodies with specificity to human tumor antigens
|
|
IL162181A
(en)
|
1988-12-28 |
2006-04-10 |
Pdl Biopharma Inc |
A method of producing humanized immunoglubulin, and polynucleotides encoding the same
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
HU212924B
(en)
|
1989-05-25 |
1996-12-30 |
Chiron Corp |
Adjuvant formulation comprising a submicron oil droplet emulsion
|
|
US5196511A
(en)
*
|
1989-12-01 |
1993-03-23 |
The Scripps Research Institute |
Peptides and antibodies that inhibit integrin-ligand binding
|
|
EP1690934A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US5753624A
(en)
*
|
1990-04-27 |
1998-05-19 |
Milkhaus Laboratory, Inc. |
Materials and methods for treatment of plaquing disease
|
|
ATE153534T1
(de)
|
1990-04-27 |
1997-06-15 |
John Mcmichael |
Verfahren und zusammensetzung zur behandlung von erkrankungen des zns hervorgerufen durch abnormales beta-amyloid-protein
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
AU8081491A
(en)
|
1990-06-01 |
1991-12-31 |
Cetus Corporation |
Compositions and methods for identifying biologically active molecules
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5780587A
(en)
*
|
1990-08-24 |
1998-07-14 |
President And Fellows Of Harvard College |
Compounds and methods for inhibiting β-protein filament formation and neurotoxicity
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5874299A
(en)
|
1990-08-29 |
1999-02-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
ATE300615T1
(de)
|
1990-08-29 |
2005-08-15 |
Genpharm Int |
Transgene mäuse fähig zur produktion heterologer antikörper
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5858657A
(en)
|
1992-05-15 |
1999-01-12 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
US5871907A
(en)
|
1991-05-15 |
1999-02-16 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
EP1400536A1
(en)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
KR0163798B1
(ko)
|
1991-07-03 |
1999-01-15 |
나가따 마사오 |
열가성 폴리우레탄 탄성체, 그의 제조 방법, 그의 제조 장치 및 그로부터 제조한 탄성 섬유
|
|
JP2001524926A
(ja)
|
1991-09-18 |
2001-12-04 |
アフィマックス テクノロジーズ ナームロゼ フェンノートシャップ |
オリゴマーの雑多ライブラリーの集合体を合成する方法
|
|
ES2136092T3
(es)
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
|
CA2124967C
(en)
|
1991-12-17 |
2008-04-08 |
Nils Lonberg |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
EP0620849B1
(en)
|
1992-01-07 |
2003-06-25 |
Elan Pharmaceuticals, Inc. |
Transgenic animal models for alzheimer's disease
|
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
US5604102A
(en)
|
1992-04-15 |
1997-02-18 |
Athena Neurosciences, Inc. |
Methods of screening for β-amyloid peptide production inhibitors
|
|
US5958883A
(en)
*
|
1992-09-23 |
1999-09-28 |
Board Of Regents Of The University Of Washington Office Of Technology |
Animal models of human amyloidoses
|
|
ES2204910T3
(es)
|
1992-10-01 |
2004-05-01 |
The Trustees Of Columbia University In The City Of New York |
Bibliotecas quimicas combinatorias complejas codificadas con señales.
|
|
ATE199392T1
(de)
|
1992-12-04 |
2001-03-15 |
Medical Res Council |
Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
|
|
CA2115900A1
(en)
|
1993-02-22 |
1994-08-23 |
Gerald W. Becker |
Pharmaceutical screens and antibodies
|
|
WO1995006407A1
(en)
*
|
1993-08-30 |
1995-03-09 |
The Regents Of The University Of California |
Novel component of amyloid in alzheimer's disease and methods for use of same
|
|
CN1134156A
(zh)
|
1993-11-02 |
1996-10-23 |
阿菲马克斯技术公司 |
合成和筛选多种分子
|
|
US5877218A
(en)
|
1994-01-10 |
1999-03-02 |
Teva Pharmaceutical Industries, Ltd. |
Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
|
|
US7473423B2
(en)
*
|
1994-04-29 |
2009-01-06 |
Mayo Foundation For Medical Education And Research |
Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system
|
|
JPH10500112A
(ja)
|
1994-05-06 |
1998-01-06 |
ファーマコピーア，インコーポレイテッド |
組合せ ジヒドロベンゾピラン ライブラリー
|
|
US5663046A
(en)
|
1994-06-22 |
1997-09-02 |
Pharmacopeia, Inc. |
Synthesis of combinatorial libraries
|
|
EP1181937A3
(en)
*
|
1994-08-09 |
2004-02-04 |
Cytrx Corporation |
Novel vaccine adjuvant and vaccine
|
|
US5589154A
(en)
*
|
1994-11-22 |
1996-12-31 |
Rutgers, The State University Of New Jersey |
Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease
|
|
US5807741A
(en)
*
|
1995-07-20 |
1998-09-15 |
Brown; Douglas Richard |
Neutralizing monoclonal antibody against botulinum neurotoxin serotype F
|
|
WO1998022120A1
(en)
|
1996-11-19 |
1998-05-28 |
The Wistar Institute Of Anatomy & Biology |
Diagnostic and therapeutic reagents for alzheimer's disease
|
|
AU753688B2
(en)
|
1997-03-10 |
2002-10-24 |
Ottawa Civic Loeb Research Institute |
Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
|
|
EP1001987B1
(en)
|
1997-08-01 |
2010-12-15 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Composition and method for the detection of diseases associated with amyloid-like fibril or protein aggregate formation
|
|
US6761888B1
(en)
*
|
2000-05-26 |
2004-07-13 |
Neuralab Limited |
Passive immunization treatment of Alzheimer's disease
|
|
US6913745B1
(en)
*
|
1997-12-02 |
2005-07-05 |
Neuralab Limited |
Passive immunization of Alzheimer's disease
|
|
US6905686B1
(en)
*
|
1997-12-02 |
2005-06-14 |
Neuralab Limited |
Active immunization for treatment of alzheimer's disease
|
|
TWI239847B
(en)
*
|
1997-12-02 |
2005-09-21 |
Elan Pharm Inc |
N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
|
|
US6923964B1
(en)
*
|
1997-12-02 |
2005-08-02 |
Neuralab Limited |
Active immunization of AScr for prion disorders
|
|
US6710226B1
(en)
*
|
1997-12-02 |
2004-03-23 |
Neuralab Limited |
Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics
|
|
US6787523B1
(en)
*
|
1997-12-02 |
2004-09-07 |
Neuralab Limited |
Prevention and treatment of amyloidogenic disease
|
|
US7964192B1
(en)
*
|
1997-12-02 |
2011-06-21 |
Janssen Alzheimer Immunotherapy |
Prevention and treatment of amyloidgenic disease
|
|
AU2299999A
(en)
|
1998-02-09 |
1999-08-23 |
Yoshikuni Mizuno |
Dnas or genes participating in parkinson's disease
|
|
AU3117799A
(en)
*
|
1998-03-30 |
1999-10-18 |
Trustees Of The University Of Pennsylvania, The |
Method of identifying, diagnosing and treating synuclein positive neurodegenerative disorders
|
|
DE69942274D1
(de)
|
1998-05-21 |
2010-06-02 |
Univ Tennessee Res Foundation |
Methoden zur amyloidentfernung mit anti-amyloid-antikörper
|
|
US6184351B1
(en)
|
1998-09-25 |
2001-02-06 |
Amgen Inc. |
α-synuclein super-mutants accelerate α-synuclein aggregation
|
|
EP1121140B1
(en)
*
|
1998-10-06 |
2008-12-03 |
The Regents of the University of California |
Method for screening for anti-amyloidogenic properties and method for treatment of neurodegenerative disease
|
|
US6172122B1
(en)
*
|
1998-12-17 |
2001-01-09 |
The Lubrizol Corporation |
Stable emulsions from gelled overbased substrates with surfactants and aqueous liquids
|
|
UA81216C2
(en)
|
1999-06-01 |
2007-12-25 |
|
Prevention and treatment of amyloid disease
|
|
US20040146521A1
(en)
*
|
1999-06-01 |
2004-07-29 |
Schenk Dale B. |
Prevention and treatment of synucleinopathic disease
|
|
AU6234700A
(en)
*
|
1999-07-27 |
2001-02-13 |
Abgenix, Inc. |
Methods and compositions for inhibiting polypeptide accumulation associated with neurological disorders
|
|
GB9924513D0
(en)
*
|
1999-10-15 |
1999-12-15 |
Novartis Ag |
Organic compounds
|
|
US20020094335A1
(en)
*
|
1999-11-29 |
2002-07-18 |
Robert Chalifour |
Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases
|
|
WO2001053457A2
(en)
|
2000-01-21 |
2001-07-26 |
University Of Connecticut Health Center |
Vaccines against neurodegenerative disorders
|
|
AU2001238612A1
(en)
|
2000-02-18 |
2001-08-27 |
The Regents Of The University Of California |
Method for screening for anti-amyloidogenic properties and method for treatment of neurodegenerative disease
|
|
CZ20022748A3
(cs)
*
|
2000-02-21 |
2004-03-17 |
Pharmexa A/S |
Nová metoda regulace obsahu amyloidu
|
|
ES2248283T3
(es)
*
|
2000-02-21 |
2006-03-16 |
Pharmexa A/S |
Nuevo procedimiento para reducir los niveles de amiloide.
|
|
AU4819101A
(en)
|
2000-04-13 |
2001-10-30 |
University Of British Columbia, The |
Modulating cell survival by modulating huntingtin function
|
|
US6784291B2
(en)
*
|
2000-05-04 |
2004-08-31 |
Avi Biopharma, Inc. |
Splice-region antisense composition and method
|
|
EP1309341A2
(en)
|
2000-07-07 |
2003-05-14 |
Lars Lannfelt |
Prevention and treatment of alzheimer's disease
|
|
JP2004502781A
(ja)
|
2000-07-07 |
2004-01-29 |
パナシア ファーマシューティカルズ インコーポレーテッド |
神経組織の損傷を予防するため、およびα−シヌクレイン疾患を処置するための方法
|
|
TWI255272B
(en)
*
|
2000-12-06 |
2006-05-21 |
Guriq Basi |
Humanized antibodies that recognize beta amyloid peptide
|
|
AU2002221132A1
(en)
*
|
2000-12-13 |
2002-07-01 |
Taisho Pharmaceutical Co. Ltd. |
Novel antibody
|
|
WO2002059621A2
(en)
*
|
2001-01-24 |
2002-08-01 |
Bayer Corporation |
Regulation of transthyretin to treat obesity
|
|
US6815175B2
(en)
*
|
2001-03-16 |
2004-11-09 |
Cornell Research Foundation, Inc. |
Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder
|
|
WO2003000714A2
(en)
|
2001-06-22 |
2003-01-03 |
Panacea Pharmaceuticals, Inc. |
Compositions and methods for preventing protein aggregation in neurodegenerative diseases
|
|
MY144532A
(en)
*
|
2001-08-20 |
2011-09-30 |
Lundbeck & Co As H |
Novel method for down-regulation of amyloid
|
|
WO2003044051A1
(en)
*
|
2001-11-20 |
2003-05-30 |
Atgen Co., Ltd. |
Novel peptides conferring environmental stress resistance and fusion proteins including said peptides
|
|
US7479482B2
(en)
*
|
2001-11-21 |
2009-01-20 |
New York University |
Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid β, prion protein, amylin, α-synuclein, or polyglutamine repeats for induction of an immune response thereto
|
|
GB0203446D0
(en)
*
|
2002-02-14 |
2002-04-03 |
Univ Lancaster |
Detection and/or monitoring of synuclein-related diseases
|
|
GB0216972D0
(en)
|
2002-07-22 |
2002-08-28 |
Univ Lancaster |
Peptides and peptide derivaties for the treatment of &-synuclein-related diseases
|
|
DE60327347D1
(de)
*
|
2002-09-30 |
2009-06-04 |
Univ Auburn |
Verfahren und isolierung zur selbstzusammenlagerung kleiner proteinpartikel aus blut und anderen biologischen materialien
|
|
US8506959B2
(en)
*
|
2002-11-01 |
2013-08-13 |
Neotope Biosciences Limited |
Prevention and treatment of synucleinopathic and amyloidogenic disease
|
|
US8697082B2
(en)
*
|
2002-11-01 |
2014-04-15 |
Neotope Biosciences Limited |
Prevention and treatment of synucleinopathic and amyloidogenic disease
|
|
US20080014194A1
(en)
*
|
2003-10-31 |
2008-01-17 |
Elan Pharmaceuticals, Inc. |
Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease
|
|
US9034337B2
(en)
*
|
2003-10-31 |
2015-05-19 |
Prothena Biosciences Limited |
Treatment and delay of outset of synucleinopathic and amyloidogenic disease
|
|
TW200509968A
(en)
*
|
2002-11-01 |
2005-03-16 |
Elan Pharm Inc |
Prevention and treatment of synucleinopathic disease
|
|
US7358331B2
(en)
*
|
2003-05-19 |
2008-04-15 |
Elan Pharmaceuticals, Inc. |
Truncated fragments of alpha-synuclein in Lewy body disease
|
|
SI1633189T1
(sl)
*
|
2003-05-19 |
2017-12-29 |
Prothena Biosciences Limited |
Skrajšani fragmenti alfa-sinukleina pri bolezni Lewyjevih telesc
|
|
WO2005047860A2
(en)
*
|
2003-11-08 |
2005-05-26 |
Elan Pharmaceuticals, Inc. |
Antibodies to alpha-synuclein
|
|
WO2005108423A1
(en)
*
|
2004-05-11 |
2005-11-17 |
Atgen Co., Ltd. |
Novel peptides conferring environmental stress resistance and fusion proteins including said peptides
|
|
MX2007001679A
(es)
|
2004-08-09 |
2007-05-23 |
Elan Pharm Inc |
Prevencion y tratamiento de la enfermedad sinucleinopatica y amiloidogenica.
|
|
CA2657953A1
(en)
|
2005-07-19 |
2007-01-25 |
University Of Rochester |
Alpha-synuclein antibodies and methods related thereto
|
|
WO2007021255A1
(en)
|
2005-08-09 |
2007-02-22 |
Elan Pharmaceuticals, Inc. |
Antibodies to alpha-synuclein
|
|
US8147833B2
(en)
*
|
2007-02-23 |
2012-04-03 |
Neotope Biosciences Limited |
Prevention and treatment of synucleinopathic and amyloidogenic disease
|
|
PL2118300T3
(pl)
*
|
2007-02-23 |
2015-11-30 |
Prothena Biosciences Ltd |
Zapobieganie i leczenie synukleinopatii i amyloidozy
|