JP2008517032A - 新規なジアザ二環式アリール誘導体及びその医薬用途 - Google Patents
新規なジアザ二環式アリール誘導体及びその医薬用途 Download PDFInfo
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- JP2008517032A JP2008517032A JP2007537263A JP2007537263A JP2008517032A JP 2008517032 A JP2008517032 A JP 2008517032A JP 2007537263 A JP2007537263 A JP 2007537263A JP 2007537263 A JP2007537263 A JP 2007537263A JP 2008517032 A JP2008517032 A JP 2008517032A
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- Prior art keywords
- bicyclo
- octane
- methyl
- diaza
- phenyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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| US62032704P | 2004-10-21 | 2004-10-21 | |
| PCT/EP2005/055333 WO2006045716A1 (en) | 2004-10-20 | 2005-10-18 | Novel diazabicyclic aryl derivatives and their medical use |
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| JP2008517032A true JP2008517032A (ja) | 2008-05-22 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014515754A (ja) * | 2011-04-20 | 2014-07-03 | サントル ナスィオナル ド ラ ルシェルシュ スィアンティフィク（セ．エン．エル．エス．） | １，４−二置換１，２，３−トリアゾール、その調製方法、ならびにその診断的および治療的使用 |
| WO2022014680A1 (ja) * | 2020-07-17 | 2022-01-20 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 置換ピペリジン化合物及びその用途 |
| JP2023103981A (ja) * | 2022-01-14 | 2023-07-27 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 置換ピペリジン化合物を含有する医薬 |
| RU2840772C1 (ru) * | 2020-07-17 | 2025-05-28 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Замещенные пиперидиновые соединения и их применение |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4931823B2 (ja) | 2004-10-18 | 2012-05-16 | アムジエン・インコーポレーテツド | チアジアゾール化合物及び使用方法 |
| DE602006019561D1 (de) | 2005-02-16 | 2011-02-24 | Neurosearch As | Diazabicyclische arylderivate und ihre verwendung als chinolinergische liganden an nikotin-acetylcholin-rezeptoren |
| CA2632642A1 (en) | 2005-12-06 | 2007-06-14 | Neurosearch A/S | Novel diazabicyclic aryl derivatives and their medical use |
| EP1984365A1 (en) | 2006-02-10 | 2008-10-29 | NeuroSearch A/S | 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| WO2007090887A1 (en) | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3, 9-diazabicyclo [3.3. 1]nonane derivatives and their use as monoamine?neurotransmitter re-uptake inhibitors |
| US7687523B2 (en) | 2006-02-10 | 2010-03-30 | Neurosearch A/S | 3-heteroaryl-3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists |
| WO2007093601A1 (en) | 2006-02-14 | 2007-08-23 | Neurosearch A/S | 3, 9-diazabicyclo(3.3.1)non-3-yl-aryl methanone derivatives as nicotinic acetylcholine receptor agonists |
| JP2009537599A (ja) | 2006-05-23 | 2009-10-29 | ノイロサーチ アクティーゼルスカブ | 新規８，１０−ジアザ−ビシクロ［４．３．１］デカン誘導体及びそれらの医学的使用 |
| US8314119B2 (en) * | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
| US7897619B2 (en) | 2007-07-17 | 2011-03-01 | Amgen Inc. | Heterocyclic modulators of PKB |
| US7919504B2 (en) | 2007-07-17 | 2011-04-05 | Amgen Inc. | Thiadiazole modulators of PKB |
| SA08290475B1 (ar) * | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
| FR2937641A1 (fr) | 2008-10-28 | 2010-04-30 | Sanofi Aventis | Derives d'urees de tropane, leur preparation et leur application en therapeutique |
| EP2619205B1 (en) | 2010-09-23 | 2017-05-17 | AbbVie Bahamas Ltd. | Monohydrate of an azaadamantane derivative |
| TW201311698A (zh) * | 2011-08-22 | 2013-03-16 | Targacept Inc | 作為神經元菸鹼乙醯膽鹼受體配位體之１，４－二氮雜雙環［３．２．２］壬烷 |
| US8729263B2 (en) * | 2012-08-13 | 2014-05-20 | Novartis Ag | 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions |
| JP2021521200A (ja) * | 2018-04-10 | 2021-08-26 | スカイホーク・セラピューティクス・インコーポレーテッド | 癌の処置のための化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7265115B2 (en) * | 1999-01-29 | 2007-09-04 | Abbott Laboratories | Diazabicyclic CNS active agents |
| NZ513575A (en) * | 1999-05-04 | 2003-07-25 | Neurosearch As | Heteroaryl diazabicycloalkanes useful for treating or preventing a disease or a disorder responsive to the activity of nAChR modulators |
| US20050065178A1 (en) * | 2003-09-19 | 2005-03-24 | Anwer Basha | Substituted diazabicycloakane derivatives |
| US7399765B2 (en) * | 2003-09-19 | 2008-07-15 | Abbott Laboratories | Substituted diazabicycloalkane derivatives |
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2005
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- 2005-10-18 EP EP05801524A patent/EP1805183B1/en not_active Expired - Lifetime
- 2005-10-18 AT AT05801524T patent/ATE493415T1/de not_active IP Right Cessation
- 2005-10-18 CA CA002584838A patent/CA2584838A1/en not_active Abandoned
- 2005-10-18 US US11/665,387 patent/US20080153806A1/en not_active Abandoned
- 2005-10-18 MX MX2007004269A patent/MX2007004269A/es active IP Right Grant
- 2005-10-18 CN CN2005800337300A patent/CN101035792B/zh not_active Expired - Fee Related
- 2005-10-18 WO PCT/EP2005/055333 patent/WO2006045716A1/en not_active Ceased
- 2005-10-18 DE DE602005025667T patent/DE602005025667D1/de not_active Expired - Lifetime
- 2005-10-18 JP JP2007537263A patent/JP2008517032A/ja not_active Abandoned
- 2005-10-18 NZ NZ553622A patent/NZ553622A/en unknown
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014515754A (ja) * | 2011-04-20 | 2014-07-03 | サントル ナスィオナル ド ラ ルシェルシュ スィアンティフィク（セ．エン．エル．エス．） | １，４−二置換１，２，３−トリアゾール、その調製方法、ならびにその診断的および治療的使用 |
| WO2022014680A1 (ja) * | 2020-07-17 | 2022-01-20 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 置換ピペリジン化合物及びその用途 |
| JPWO2022014680A1 (enExample) * | 2020-07-17 | 2022-01-20 | ||
| US11479552B2 (en) | 2020-07-17 | 2022-10-25 | Eisai R&D Management Co., Ltd. | Substituted piperidine compounds and their use |
| JP7190612B2 (ja) | 2020-07-17 | 2022-12-15 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 置換ピペリジン化合物及びその用途 |
| RU2840772C1 (ru) * | 2020-07-17 | 2025-05-28 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Замещенные пиперидиновые соединения и их применение |
| TWI888599B (zh) * | 2020-07-17 | 2025-07-01 | 日商衛材R&D企管股份有限公司 | 取代哌啶化合物及其用途 |
| TWI922338B (zh) * | 2020-07-17 | 2026-04-11 | 日商衛材R&D企管股份有限公司 | 取代哌啶化合物及其用途 |
| JP2023103981A (ja) * | 2022-01-14 | 2023-07-27 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 置換ピペリジン化合物を含有する医薬 |
| JP7591592B2 (ja) | 2022-01-14 | 2024-11-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 置換ピペリジン化合物を含有する医薬 |
Also Published As
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|---|---|
| MX2007004269A (es) | 2007-06-15 |
| US20080153806A1 (en) | 2008-06-26 |
| NZ553622A (en) | 2010-08-27 |
| WO2006045716A1 (en) | 2006-05-04 |
| CN101035792B (zh) | 2010-09-15 |
| EP1805183B1 (en) | 2010-12-29 |
| CA2584838A1 (en) | 2006-05-04 |
| AU2005298693A1 (en) | 2006-05-04 |
| ATE493415T1 (de) | 2011-01-15 |
| DE602005025667D1 (de) | 2011-02-10 |
| CN101035792A (zh) | 2007-09-12 |
| EP1805183A1 (en) | 2007-07-11 |
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