JP2008515801A5 - - Google Patents
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- Publication number
- JP2008515801A5 JP2008515801A5 JP2007534882A JP2007534882A JP2008515801A5 JP 2008515801 A5 JP2008515801 A5 JP 2008515801A5 JP 2007534882 A JP2007534882 A JP 2007534882A JP 2007534882 A JP2007534882 A JP 2007534882A JP 2008515801 A5 JP2008515801 A5 JP 2008515801A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- mammal
- medicament
- morphine
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 69
- 241000124008 Mammalia Species 0.000 claims 53
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 50
- 229960005181 morphine Drugs 0.000 claims 25
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims 20
- 230000037396 body weight Effects 0.000 claims 17
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims 16
- BHLYRWXGMIUIHG-HNNXBMFYSA-N (S)-reticuline Chemical compound C1=C(O)C(OC)=CC=C1C[C@H]1C2=CC(O)=C(OC)C=C2CCN1C BHLYRWXGMIUIHG-HNNXBMFYSA-N 0.000 claims 12
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 11
- 229910052791 calcium Inorganic materials 0.000 claims 11
- 239000011575 calcium Substances 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 10
- 229960004126 codeine Drugs 0.000 claims 10
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims 10
- FQXXSQDCDRQNQE-UHFFFAOYSA-N markiertes Thebain Natural products COC1=CC=C2C(N(CC3)C)CC4=CC=C(OC)C5=C4C23C1O5 FQXXSQDCDRQNQE-UHFFFAOYSA-N 0.000 claims 10
- 229930003945 thebaine Natural products 0.000 claims 10
- FQXXSQDCDRQNQE-VMDGZTHMSA-N thebaine Chemical compound C([C@@H](N(CC1)C)C2=CC=C3OC)C4=CC=C(OC)C5=C4[C@@]21[C@H]3O5 FQXXSQDCDRQNQE-VMDGZTHMSA-N 0.000 claims 10
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 8
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 8
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 8
- 229960003638 dopamine Drugs 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 8
- 229910052711 selenium Inorganic materials 0.000 claims 8
- 239000011669 selenium Substances 0.000 claims 8
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 7
- RUPUUZZJJXCDHS-UHFFFAOYSA-N (+)-orientaline Natural products C1=C(O)C(OC)=CC(CC2C3=CC(O)=C(OC)C=C3CCN2C)=C1 RUPUUZZJJXCDHS-UHFFFAOYSA-N 0.000 claims 6
- ABXZOXDTHTTZJW-UHFFFAOYSA-N norlaudanosoline Chemical compound C1=C(O)C(O)=CC=C1CC1C2=CC(O)=C(O)C=C2CCN1 ABXZOXDTHTTZJW-UHFFFAOYSA-N 0.000 claims 6
- BNUZUOWRDKPBQR-UHFFFAOYSA-N reticuline Natural products CN1CCC2=CC(OC)=CC=C2C1CC1=CC=C(OC)C(O)=C1 BNUZUOWRDKPBQR-UHFFFAOYSA-N 0.000 claims 6
- 239000004475 Arginine Substances 0.000 claims 5
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 5
- 229930064664 L-arginine Natural products 0.000 claims 5
- 235000014852 L-arginine Nutrition 0.000 claims 5
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 5
- 235000009697 arginine Nutrition 0.000 claims 5
- 210000002865 immune cell Anatomy 0.000 claims 5
- 230000001939 inductive effect Effects 0.000 claims 4
- -1 sartaridin Chemical compound 0.000 claims 4
- KUZSVETULYBCPD-UHFFFAOYSA-N 2,2-dihydroxy-2-phenylacetaldehyde Chemical compound O=CC(O)(O)C1=CC=CC=C1 KUZSVETULYBCPD-UHFFFAOYSA-N 0.000 claims 2
- LQQFFJFGLSKYIR-UHFFFAOYSA-N 3,4-dihydroxyphenylpyruvic acid Chemical compound OC(=O)C(=O)CC1=CC=C(O)C(O)=C1 LQQFFJFGLSKYIR-UHFFFAOYSA-N 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 206010003805 Autism Diseases 0.000 claims 2
- 208000020706 Autistic disease Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- 108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 claims 2
- 102100021704 Cytochrome P450 2D6 Human genes 0.000 claims 2
- 206010012335 Dependence Diseases 0.000 claims 2
- 206010017943 Gastrointestinal conditions Diseases 0.000 claims 2
- 206010018612 Gonorrhoea Diseases 0.000 claims 2
- 101000896576 Homo sapiens Putative cytochrome P450 2D7 Proteins 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 206010033864 Paranoia Diseases 0.000 claims 2
- 208000027099 Paranoid disease Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000028017 Psychotic disease Diseases 0.000 claims 2
- 102100021702 Putative cytochrome P450 2D7 Human genes 0.000 claims 2
- DZGWFCGJZKJUFP-UHFFFAOYSA-N Tyramine Natural products NCCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-N 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical group [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims 2
- 239000001354 calcium citrate Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000001786 gonorrhea Diseases 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 206010025135 lupus erythematosus Diseases 0.000 claims 2
- 230000001537 neural effect Effects 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- 230000000770 proinflammatory effect Effects 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 230000008354 tissue degradation Effects 0.000 claims 2
- 235000013337 tricalcium citrate Nutrition 0.000 claims 2
- 229960003732 tyramine Drugs 0.000 claims 2
- DZGWFCGJZKJUFP-UHFFFAOYSA-O tyraminium Chemical compound [NH3+]CCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-O 0.000 claims 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 2
- OFNXOACBUMGOPC-HZYVHMACSA-N 5'-hydroxystreptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](CO)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O OFNXOACBUMGOPC-HZYVHMACSA-N 0.000 claims 1
- 108010081750 Reticulin Proteins 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- MHUWZNTUIIFHAS-CLFAGFIQSA-N dioleoyl phosphatidic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MHUWZNTUIIFHAS-CLFAGFIQSA-N 0.000 claims 1
- OFNXOACBUMGOPC-UHFFFAOYSA-N hydroxystreptomycin Natural products CNC1C(O)C(O)C(CO)OC1OC1C(C=O)(O)C(CO)OC1OC1C(N=C(N)N)C(O)C(N=C(N)N)C(O)C1O OFNXOACBUMGOPC-UHFFFAOYSA-N 0.000 claims 1
- OKPOKMCPHKVCPP-UHFFFAOYSA-N isoorientaline Natural products C1=C(O)C(OC)=CC(CC2C3=CC(OC)=C(O)C=C3CCN2C)=C1 OKPOKMCPHKVCPP-UHFFFAOYSA-N 0.000 claims 1
- 229960004502 levodopa Drugs 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- JTQHYPFKHZLTSH-UHFFFAOYSA-N reticulin Natural products COC1CC(OC2C(CO)OC(OC3C(O)CC(OC4C(C)OC(CC4OC)OC5CCC6(C)C7CCC8(C)C(CCC8(O)C7CC=C6C5)C(C)O)OC3C)C(O)C2OC)OC(C)C1O JTQHYPFKHZLTSH-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61504804P | 2004-10-01 | 2004-10-01 | |
| US71476905P | 2005-09-06 | 2005-09-06 | |
| PCT/US2005/035628 WO2006039691A2 (en) | 2004-10-01 | 2005-09-30 | Morphine and morphine precursors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008515801A JP2008515801A (ja) | 2008-05-15 |
| JP2008515801A5 true JP2008515801A5 (https=) | 2008-11-13 |
Family
ID=36143157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007534882A Pending JP2008515801A (ja) | 2004-10-01 | 2005-09-30 | モルヒネおよびモルヒネ前駆体 |
Country Status (6)
| Country | Link |
|---|---|
| US (6) | US20060088607A1 (https=) |
| EP (1) | EP1809283A2 (https=) |
| JP (1) | JP2008515801A (https=) |
| AU (1) | AU2005292184A1 (https=) |
| CA (1) | CA2582346A1 (https=) |
| WO (1) | WO2006039691A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060088607A1 (en) * | 2004-10-01 | 2006-04-27 | Stefano George B | Nutritional supplement compositions |
| US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| CN101766622A (zh) * | 2009-12-16 | 2010-07-07 | 昆明理工大学 | Morphine作为保护PC12细胞免于帕金森病毒性物损伤剂的应用 |
| PT2640358T (pt) * | 2010-11-15 | 2018-02-23 | Neuroderm Ltd | Administração contínua de l-dopa, inibidores de dopa descarboxilase, inibidores de catecol-o-metil transferase e composições para os mesmos |
| US10813901B2 (en) | 2013-10-22 | 2020-10-27 | Yamo Pharmaceuticals Llc | Compositions and methods for treating autism |
| US9326962B2 (en) | 2013-10-22 | 2016-05-03 | Steven Hoffman | Compositions and methods for treating intestinal hyperpermeability |
| US10751313B2 (en) | 2013-10-22 | 2020-08-25 | Yamo Pharmaceuticals Llc | Compositions and methods for treating autism |
| US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
| DK3116475T3 (da) | 2014-03-13 | 2020-12-07 | Neuroderm Ltd | Dopa-decarboxylasehæmmersammensætninger |
| MX2017013176A (es) * | 2015-04-14 | 2018-01-30 | Hoffman Steven | Composiciones y metodos para tratar autismo. |
| CN112789045A (zh) | 2018-07-19 | 2021-05-11 | 亚莫制药有限公司 | 用于治疗孤独症的组合物和方法 |
| CA3127824A1 (en) | 2019-01-25 | 2020-07-30 | Avedro, Inc. | Bis(diazirine) derivatives as photo-crossslinker for treating corneal ectatic disorders |
| US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
| US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
| US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
| US12161612B2 (en) | 2023-04-14 | 2024-12-10 | Neuroderm, Ltd. | Methods and compositions for reducing symptoms of Parkinson's disease |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3894027A (en) * | 1973-07-31 | 1975-07-08 | Merck & Co Inc | Resolution of racemic reticuline and racemization of its enantiomers |
| US4873191A (en) * | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US6451341B1 (en) * | 1990-02-05 | 2002-09-17 | Thomas J. Slaga | Time release formulation of vitamins, minerals and other beneficial supplements |
| US5116847A (en) * | 1991-01-25 | 1992-05-26 | The Procter & Gamble Company | Use of loperamide and related compounds for treatment of respiratory disease symptoms |
| US5225440A (en) * | 1991-09-13 | 1993-07-06 | The United States Of America As Represented By The Department Of Health And Human Services | Attenuation of the opioid withdrawal syndrome by inhibitors of nitric oxide synthase |
| US5879705A (en) * | 1993-07-27 | 1999-03-09 | Euro-Celtique S.A. | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions |
| US5672988A (en) * | 1994-04-15 | 1997-09-30 | Linear Technology Corporation | High-speed switching regulator drive circuit |
| US5849761A (en) * | 1995-09-12 | 1998-12-15 | Regents Of The University Of California | Peripherally active anti-hyperalgesic opiates |
| AU6494798A (en) | 1997-02-03 | 1998-08-25 | Max-Delbruck-Centrum Fur Molekulare Medizin | Genomic sequence of the human mu-opioid receptor gene and the variants, polymorphisms and mutations thereof |
| US6403602B1 (en) * | 1997-02-20 | 2002-06-11 | The University Of Kentucky Research Foundation | Morphine-6-sulfate analogues and their use for the treatment of pain |
| US5976568A (en) * | 1997-02-21 | 1999-11-02 | Medical Doctors' Research Institute, Inc. | Modular system of dietary supplement compositions for optimizing health benefits and methods |
| US6124282A (en) * | 1997-05-22 | 2000-09-26 | Sellers; Edward M. | Drug formulations |
| WO1999024471A1 (en) | 1997-11-10 | 1999-05-20 | The Research Foundation Of State University Of New York | Opiate, cannabinoid, and estrogen receptors |
| US6914073B2 (en) * | 1999-03-18 | 2005-07-05 | Bristol Myers Squibb Company | Vitamin formulation for cardiovascular health |
| WO2001008680A1 (de) * | 1999-07-28 | 2001-02-08 | Oswald Wiss | Präparate mit sauerstoffsparender wirkung bei körperlicher leistung |
| JP4426083B2 (ja) * | 2000-11-17 | 2010-03-03 | 日本碍子株式会社 | 炭化珪素質多孔体及びその製造方法 |
| US20020193323A1 (en) * | 2000-11-22 | 2002-12-19 | Inna Yegorova | Compositions and methods for promoting a healthy cardiovascular system and enhancing blood flow |
| US20030087896A1 (en) * | 2001-08-09 | 2003-05-08 | Hillel Glover | Treatment of refractory depression with an opiate antagonist and an antidepressant |
| JP2005524676A (ja) * | 2002-03-20 | 2005-08-18 | ザ・ユニバーシティ・オブ・クイーンズランド | 一酸化窒素供与体及びオピオイド鎮痛薬を含む方法及び組成物 |
| US7323402B2 (en) * | 2002-07-11 | 2008-01-29 | International Rectifier Corporation | Trench Schottky barrier diode with differential oxide thickness |
| US20060088607A1 (en) | 2004-10-01 | 2006-04-27 | Stefano George B | Nutritional supplement compositions |
-
2005
- 2005-09-30 US US11/241,248 patent/US20060088607A1/en not_active Abandoned
- 2005-09-30 US US11/576,448 patent/US20080221143A1/en not_active Abandoned
- 2005-09-30 WO PCT/US2005/035628 patent/WO2006039691A2/en not_active Ceased
- 2005-09-30 JP JP2007534882A patent/JP2008515801A/ja active Pending
- 2005-09-30 CA CA002582346A patent/CA2582346A1/en not_active Abandoned
- 2005-09-30 EP EP05810196A patent/EP1809283A2/en not_active Withdrawn
- 2005-09-30 AU AU2005292184A patent/AU2005292184A1/en not_active Abandoned
-
2010
- 2010-10-14 US US12/904,373 patent/US8481559B2/en not_active Expired - Fee Related
-
2013
- 2013-06-21 US US13/924,211 patent/US8865696B2/en not_active Expired - Fee Related
-
2014
- 2014-01-10 US US14/152,536 patent/US20140128420A1/en not_active Abandoned
- 2014-08-15 US US14/460,809 patent/US9474749B2/en not_active Expired - Fee Related
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