MX2012000752A - Profármarcos novedosos de péptidos y aminoácidos de carbamato de opioides y usos de los mismos. - Google Patents
Profármarcos novedosos de péptidos y aminoácidos de carbamato de opioides y usos de los mismos.Info
- Publication number
- MX2012000752A MX2012000752A MX2012000752A MX2012000752A MX2012000752A MX 2012000752 A MX2012000752 A MX 2012000752A MX 2012000752 A MX2012000752 A MX 2012000752A MX 2012000752 A MX2012000752 A MX 2012000752A MX 2012000752 A MX2012000752 A MX 2012000752A
- Authority
- MX
- Mexico
- Prior art keywords
- prodrug
- opioid
- amino acid
- gastrointestinal side
- opioids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Se proporcionan profármacos ligados a carbamato de meptazinol y otros analgésicos opioides. La porción de profármaco puede comprender un aminoácido sencillo o péptido corto. Adicionalmente, la presente invención se refiere a métodos para reducir efectos colaterales gastrointestinales en un sujeto, los efectos colaterales gastronintestinales se asocian con la administración de un analgésico opioide. Los métodos comprenden administrar oralmente un profármaco opiolde o sal farmacéuticamente aceptable del mismo a un sujeto, en donde el profármaco opioide comprende un analgésico covalentemente enlazado a través de una ligadura carbamato a una porción de profármaco, y en donde durante la administración oral, el profármaco o sal farmacéuticamente aceptable minimiza al menos un efecto colateral gastrointestinal asociado con administración oral del analgésico opioide solo. También se proporcionan composiciones para uso con el método.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27118509P | 2009-07-17 | 2009-07-17 | |
| PCT/IB2010/001747 WO2011007247A1 (en) | 2009-07-17 | 2010-07-16 | Novel carbamate amino acid and peptide prodrugs of opioids and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012000752A true MX2012000752A (es) | 2012-05-08 |
Family
ID=42768038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012000752A MX2012000752A (es) | 2009-07-17 | 2010-07-16 | Profármarcos novedosos de péptidos y aminoácidos de carbamato de opioides y usos de los mismos. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20110015182A1 (es) |
| EP (1) | EP2453900A1 (es) |
| JP (1) | JP2013527124A (es) |
| KR (1) | KR20120060203A (es) |
| AU (1) | AU2010272233A1 (es) |
| BR (1) | BR112012001164A2 (es) |
| CA (1) | CA2767987A1 (es) |
| MX (1) | MX2012000752A (es) |
| RU (1) | RU2012105460A (es) |
| WO (1) | WO2011007247A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8802681B2 (en) | 2008-10-17 | 2014-08-12 | Signature Therapeutics, Inc. | Pharmaceutical compositions with attenuated release of phenolic opioids |
| SG179026A1 (en) | 2009-09-08 | 2012-04-27 | Signature Therapeutics Inc | Compositions comprising enzyme-cleavable ketone-modified opioid prodrugs and optional inhibitors thereof |
| US20110262355A1 (en) | 2010-04-21 | 2011-10-27 | Jenkins Thomas E | Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof |
| DK2560486T3 (en) | 2010-04-21 | 2019-02-04 | Signature Therapeutics Inc | COMPOSITIONS COMPREHENSIVE ENZYM-TENDABLE AMPHETAMINE PRODRUGS AND ITS INHIBITORS |
| JP6016810B2 (ja) | 2011-01-11 | 2016-10-26 | シグネーチャー セラピューティクス, インク.Signature Therapeutics, Inc. | 酵素切断可能なオキシコドンプロドラッグを含んでなる組成物 |
| BR112013022946A2 (pt) * | 2011-03-09 | 2017-07-18 | Signature Therapeutics Inc | pró-fármacos de agentes ativos com ligantes heterocíclocos |
| US9918980B2 (en) | 2011-04-29 | 2018-03-20 | Rutgers, The State University Of New Jersey | Method of treating dyskinesia |
| US10736889B2 (en) | 2011-04-29 | 2020-08-11 | Rutgers, The State University Of New Jersey | Method of treating dyskinesia |
| CA2834735C (en) | 2011-04-29 | 2021-06-01 | University Of Medicine And Dentistry Of New Jersey | Use of nalbuphine for treating dyskinesia |
| TW201341356A (zh) * | 2012-02-28 | 2013-10-16 | 皮拉馬爾企業有限公司 | 作為gpr促效劑之苯基烷酸衍生物 |
| WO2015082932A1 (en) | 2013-12-05 | 2015-06-11 | The University Of Bath | Novel opioid compounds and their uses |
| US11634384B2 (en) | 2014-11-25 | 2023-04-25 | Concentric Analgesics, Inc. | Prodrugs of phenolic TRPV1 agonists |
| JP2019516773A (ja) | 2016-05-25 | 2019-06-20 | コンセントリック アナルジジックス，インク． | 改善された局所麻酔のための局所麻酔薬及び血管収縮薬と組み合わせたフェノールｔｒｐｖ１アゴニストのプロドラッグ |
| US10577346B2 (en) | 2016-11-17 | 2020-03-03 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | Benzobicycloalkane derivatives, their preparation and pharmaceutical use thereof |
| US10799496B2 (en) | 2018-07-13 | 2020-10-13 | Alkermes Pharma Ireland Limited | Naphthylenyl compounds for long-acting injectable compositions and related methods |
| US10807995B2 (en) | 2018-07-13 | 2020-10-20 | Alkermes Pharma Ireland Limited | Thienothiophene compounds for long-acting injectable compositions and related methods |
| CN113166051A (zh) | 2018-07-27 | 2021-07-23 | 同心镇痛药物公司 | 酚类trpv1激动剂的聚乙二醇化前药 |
| US11186585B2 (en) | 2018-08-17 | 2021-11-30 | Kappa-Pharma LLC | Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates |
| US10975099B2 (en) | 2018-11-05 | 2021-04-13 | Alkermes Pharma Ireland Limited | Thiophene compounds for long-acting injectable compositions and related methods |
| WO2021029914A1 (en) | 2019-08-11 | 2021-02-18 | Kappa-Pharma LLC | Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19602970A1 (de) * | 1995-12-20 | 1997-07-31 | Nycomed Arzneimittel Gmbh | Neue 7,8- Dihydromorphinderivate, Verfahren zu deren Herstellung und deren Verwendung |
| US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| PT1294358E (pt) | 2000-06-28 | 2004-12-31 | Smithkline Beecham Plc | Processo de moagem por via humida |
| US20070060500A1 (en) | 2000-08-22 | 2007-03-15 | New River Pharmaceuticals Inc. | Pharmaceutical compositions for prevention of overdose or abuse |
| WO2003020200A2 (en) | 2000-11-16 | 2003-03-13 | New River Pharmaceuticals Inc. | A novel pharmaceutical compound and methods of making and using same |
| IL163667A0 (en) | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Novel sustained release pharmaceutical compounds to preventabuse of controlled substances |
| SG147485A1 (en) | 2003-09-30 | 2008-11-28 | Shire Llc | Pharmaceutical compositions for prevention of overdose or abuse |
| EP1929030A2 (en) | 2005-09-08 | 2008-06-11 | Shire LLC | Prodrugs of t3 and t4 with enhanced bioavailability |
| AU2007238858A1 (en) | 2006-04-10 | 2007-10-25 | Shire Llc | Mono and di-substituted oxycodone compounds and compositions |
| US20090186832A1 (en) * | 2008-01-18 | 2009-07-23 | Shire Llc | Amino acid peptide pro-drugs of phenolic analgesics and uses thereof |
-
2010
- 2010-07-16 EP EP10743230A patent/EP2453900A1/en not_active Withdrawn
- 2010-07-16 WO PCT/IB2010/001747 patent/WO2011007247A1/en active Application Filing
- 2010-07-16 MX MX2012000752A patent/MX2012000752A/es not_active Application Discontinuation
- 2010-07-16 KR KR1020127003869A patent/KR20120060203A/ko not_active Application Discontinuation
- 2010-07-16 CA CA2767987A patent/CA2767987A1/en not_active Abandoned
- 2010-07-16 US US12/837,788 patent/US20110015182A1/en not_active Abandoned
- 2010-07-16 JP JP2012520120A patent/JP2013527124A/ja active Pending
- 2010-07-16 US US13/383,831 patent/US20120270847A1/en not_active Abandoned
- 2010-07-16 BR BR112012001164A patent/BR112012001164A2/pt not_active Application Discontinuation
- 2010-07-16 RU RU2012105460/04A patent/RU2012105460A/ru unknown
- 2010-07-16 AU AU2010272233A patent/AU2010272233A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011007247A8 (en) | 2012-07-19 |
| US20120270847A1 (en) | 2012-10-25 |
| WO2011007247A1 (en) | 2011-01-20 |
| EP2453900A1 (en) | 2012-05-23 |
| CA2767987A1 (en) | 2011-01-20 |
| JP2013527124A (ja) | 2013-06-27 |
| KR20120060203A (ko) | 2012-06-11 |
| AU2010272233A1 (en) | 2012-02-09 |
| RU2012105460A (ru) | 2013-08-27 |
| US20110015182A1 (en) | 2011-01-20 |
| BR112012001164A2 (pt) | 2016-03-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2012000752A (es) | Profármarcos novedosos de péptidos y aminoácidos de carbamato de opioides y usos de los mismos. | |
| WO2009092073A3 (en) | Amino acid and peptide prodrugs of opioid analgesics with reduced gi side-effects | |
| WO2008131056A3 (en) | Sustained release monoeximic formulations of opioid and nonopioid analgesics | |
| WO2008131057A3 (en) | Sustained release formulations of opioid and nonopioid analgesics | |
| MY149731A (en) | Compounds | |
| WO2010065709A3 (en) | Hydroxamic acid derivatives, preparation and therapeutic uses thereof | |
| WO2008024435A3 (en) | Dendritic molecular intracellular transporters and methods of making and using same | |
| MX2010006284A (es) | Formulaciones farmaceuticas de fenilefrina y composiciones para la absorcion transmucosal. | |
| NZ703564A (en) | Oral formulations and lipophilic salts of methylnaltrexone | |
| WO2010065950A3 (en) | Albumin binding peptide-mediated disease targeting | |
| WO2012054500A3 (en) | Compositions for drug administration | |
| UA93709C2 (ru) | 12-имидазолил-1-додеканол и его применение b изготовлении фармацевтических композиций | |
| WO2010150995A3 (en) | Compositions for treating drug addiction and improving addiction-related behavior | |
| HK1176318A1 (en) | Injection device | |
| MX347106B (es) | Coposiciones farmacéuticas de liberación inmediata que comprenden oxicodona y naloxona. | |
| WO2012007159A3 (en) | Novel gastro-retentive dosage forms | |
| WO2011060104A3 (en) | Compositions and methods for inhibiting cellular adhesion or directing diagnostic or therapeutic agents to rgd binding sites | |
| GB2501219A (en) | Orally bioavailable peptide drug compositions and methods thereof | |
| PT2205279E (pt) | Associação farmacêutica de aliscireno e valsartan | |
| ZA200807027B (en) | Peptides and peptide derivatives, the production thereof as well as their use for preparing a therapeutically and/or preventively active pharmaceutical composition | |
| WO2010012459A3 (en) | A process for the preparation of solifenacin salts and their inclusion into pharmaceutical dosage forms | |
| WO2007133796A3 (en) | Methods and compositions for treatment of sleep apnea comprising administration of an endothelin antagonist | |
| WO2012166891A3 (en) | Mu-opioid receptor binding compounds | |
| NZ600243A (en) | Combination of theobromine with a decongestant and its use for the treatment of cough | |
| MX2012001193A (es) | Compuesto peptidico similar a motilina con capacidad de absorcion transmucosa impartida al mismo. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |