MX2012000752A - Profármarcos novedosos de péptidos y aminoácidos de carbamato de opioides y usos de los mismos. - Google Patents
Profármarcos novedosos de péptidos y aminoácidos de carbamato de opioides y usos de los mismos.Info
- Publication number
- MX2012000752A MX2012000752A MX2012000752A MX2012000752A MX2012000752A MX 2012000752 A MX2012000752 A MX 2012000752A MX 2012000752 A MX2012000752 A MX 2012000752A MX 2012000752 A MX2012000752 A MX 2012000752A MX 2012000752 A MX2012000752 A MX 2012000752A
- Authority
- MX
- Mexico
- Prior art keywords
- prodrug
- opioid
- amino acid
- gastrointestinal side
- opioids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Se proporcionan profármacos ligados a carbamato de meptazinol y otros analgésicos opioides. La porción de profármaco puede comprender un aminoácido sencillo o péptido corto. Adicionalmente, la presente invención se refiere a métodos para reducir efectos colaterales gastrointestinales en un sujeto, los efectos colaterales gastronintestinales se asocian con la administración de un analgésico opioide. Los métodos comprenden administrar oralmente un profármaco opiolde o sal farmacéuticamente aceptable del mismo a un sujeto, en donde el profármaco opioide comprende un analgésico covalentemente enlazado a través de una ligadura carbamato a una porción de profármaco, y en donde durante la administración oral, el profármaco o sal farmacéuticamente aceptable minimiza al menos un efecto colateral gastrointestinal asociado con administración oral del analgésico opioide solo. También se proporcionan composiciones para uso con el método.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27118509P | 2009-07-17 | 2009-07-17 | |
| PCT/IB2010/001747 WO2011007247A1 (en) | 2009-07-17 | 2010-07-16 | Novel carbamate amino acid and peptide prodrugs of opioids and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012000752A true MX2012000752A (es) | 2012-05-08 |
Family
ID=42768038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012000752A MX2012000752A (es) | 2009-07-17 | 2010-07-16 | Profármarcos novedosos de péptidos y aminoácidos de carbamato de opioides y usos de los mismos. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20120270847A1 (es) |
| EP (1) | EP2453900A1 (es) |
| JP (1) | JP2013527124A (es) |
| KR (1) | KR20120060203A (es) |
| AU (1) | AU2010272233A1 (es) |
| BR (1) | BR112012001164A2 (es) |
| CA (1) | CA2767987A1 (es) |
| MX (1) | MX2012000752A (es) |
| RU (1) | RU2012105460A (es) |
| WO (1) | WO2011007247A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102186467B (zh) | 2008-10-17 | 2014-06-04 | 特色疗法股份有限公司 | 具有减弱释放酚类阿片样物质的药用组合物 |
| JP2013503862A (ja) | 2009-09-08 | 2013-02-04 | シグネーチャー セラピューティクス，インク． | 酵素切断可能なケトン修飾オピオイドプロドラッグとその任意選択のインヒビターとを含んでなる組成物 |
| DK2560486T3 (en) | 2010-04-21 | 2019-02-04 | Signature Therapeutics Inc | COMPOSITIONS COMPREHENSIVE ENZYM-TENDABLE AMPHETAMINE PRODRUGS AND ITS INHIBITORS |
| US20110262355A1 (en) | 2010-04-21 | 2011-10-27 | Jenkins Thomas E | Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof |
| CA2814763C (en) | 2011-01-11 | 2019-05-28 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable oxycodone prodrug |
| CA2827662C (en) * | 2011-03-09 | 2020-07-14 | Signature Therapeutics, Inc. | Active agent prodrugs with heterocyclic linkers |
| HUE052542T2 (hu) | 2011-04-29 | 2021-05-28 | Univ Rutgers | Eljárás diszkinézia kezelésére |
| US9918980B2 (en) | 2011-04-29 | 2018-03-20 | Rutgers, The State University Of New Jersey | Method of treating dyskinesia |
| US10736889B2 (en) | 2011-04-29 | 2020-08-11 | Rutgers, The State University Of New Jersey | Method of treating dyskinesia |
| TW201341356A (zh) * | 2012-02-28 | 2013-10-16 | 皮拉馬爾企業有限公司 | 作為gpr促效劑之苯基烷酸衍生物 |
| ES2784690T3 (es) | 2013-12-05 | 2020-09-29 | Univ Bath | Nuevos compuestos opioides y sus usos |
| US11634384B2 (en) | 2014-11-25 | 2023-04-25 | Concentric Analgesics, Inc. | Prodrugs of phenolic TRPV1 agonists |
| US10821105B2 (en) | 2016-05-25 | 2020-11-03 | Concentric Analgesics, Inc. | Prodrugs of phenolic TRPV1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia |
| US10577346B2 (en) | 2016-11-17 | 2020-03-03 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | Benzobicycloalkane derivatives, their preparation and pharmaceutical use thereof |
| US10799496B2 (en) | 2018-07-13 | 2020-10-13 | Alkermes Pharma Ireland Limited | Naphthylenyl compounds for long-acting injectable compositions and related methods |
| US10807995B2 (en) | 2018-07-13 | 2020-10-20 | Alkermes Pharma Ireland Limited | Thienothiophene compounds for long-acting injectable compositions and related methods |
| CA3107433A1 (en) | 2018-07-27 | 2020-01-30 | Concentric Analgesics, Inc. | Pegylated prodrugs of phenolic trpv1 agonists |
| US11186585B2 (en) | 2018-08-17 | 2021-11-30 | Kappa-Pharma LLC | Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates |
| WO2020094634A1 (en) | 2018-11-05 | 2020-05-14 | Alkermes Pharma Ireland Limited | Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods |
| MX2022001520A (es) | 2019-08-11 | 2022-07-21 | Kappa Pharma Llc | Composiciones y metodos para mejorar activacion de receptor de opioide por hexadienoatos opioides y hexadienoatos opcionalmente sustituidos. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19602971A1 (de) * | 1995-12-20 | 1997-07-31 | Nycomed Arzneimittel Gmbh | Neue 7,8-Dihydromorphinderivate, Verfahren zu deren Herstellung und deren Verwendung |
| US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| JP4188078B2 (ja) | 2000-06-28 | 2008-11-26 | スミスクライン ビーチャム ピー エル シー | 湿式粉砕法 |
| WO2003020200A2 (en) | 2000-11-16 | 2003-03-13 | New River Pharmaceuticals Inc. | A novel pharmaceutical compound and methods of making and using same |
| US20070060500A1 (en) | 2000-08-22 | 2007-03-15 | New River Pharmaceuticals Inc. | Pharmaceutical compositions for prevention of overdose or abuse |
| ES2500117T3 (es) | 2002-02-22 | 2014-09-30 | Shire Llc | Novedosos compuestos farmacéuticos de liberación sostenida para prevenir el abuso de sustancias controladas |
| NZ546226A (en) | 2003-09-30 | 2009-03-31 | Shire Llc | Oxycodone conjugates for prevention of overdose or abuse |
| CA2621847A1 (en) | 2005-09-08 | 2007-03-15 | Shire Llc | Prodrugs of t3 and t4 with enhanced bioavailability |
| CA2649360A1 (en) | 2006-04-10 | 2007-10-25 | Shire Llc | Mono and di-substituted oxycodone compounds and compositions |
| WO2009092071A2 (en) * | 2008-01-18 | 2009-07-23 | Shire Llc | Amino acid and peptide pro-drugs of phenolic analgesics and uses thereof |
-
2010
- 2010-07-16 JP JP2012520120A patent/JP2013527124A/ja active Pending
- 2010-07-16 MX MX2012000752A patent/MX2012000752A/es not_active Application Discontinuation
- 2010-07-16 AU AU2010272233A patent/AU2010272233A1/en not_active Abandoned
- 2010-07-16 WO PCT/IB2010/001747 patent/WO2011007247A1/en active Application Filing
- 2010-07-16 US US13/383,831 patent/US20120270847A1/en not_active Abandoned
- 2010-07-16 KR KR1020127003869A patent/KR20120060203A/ko not_active Application Discontinuation
- 2010-07-16 RU RU2012105460/04A patent/RU2012105460A/ru unknown
- 2010-07-16 CA CA2767987A patent/CA2767987A1/en not_active Abandoned
- 2010-07-16 US US12/837,788 patent/US20110015182A1/en not_active Abandoned
- 2010-07-16 EP EP10743230A patent/EP2453900A1/en not_active Withdrawn
- 2010-07-16 BR BR112012001164A patent/BR112012001164A2/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011007247A8 (en) | 2012-07-19 |
| BR112012001164A2 (pt) | 2016-03-01 |
| KR20120060203A (ko) | 2012-06-11 |
| EP2453900A1 (en) | 2012-05-23 |
| AU2010272233A1 (en) | 2012-02-09 |
| US20120270847A1 (en) | 2012-10-25 |
| WO2011007247A1 (en) | 2011-01-20 |
| JP2013527124A (ja) | 2013-06-27 |
| CA2767987A1 (en) | 2011-01-20 |
| US20110015182A1 (en) | 2011-01-20 |
| RU2012105460A (ru) | 2013-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |