JP2008514650A5 - - Google Patents
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- Publication number
- JP2008514650A5 JP2008514650A5 JP2007533838A JP2007533838A JP2008514650A5 JP 2008514650 A5 JP2008514650 A5 JP 2008514650A5 JP 2007533838 A JP2007533838 A JP 2007533838A JP 2007533838 A JP2007533838 A JP 2007533838A JP 2008514650 A5 JP2008514650 A5 JP 2008514650A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally
- het
- cooh
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 39
- 150000001875 compounds Chemical class 0.000 claims 17
- 125000005842 heteroatom Chemical group 0.000 claims 17
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 13
- 125000000623 heterocyclic group Chemical group 0.000 claims 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 150000002148 esters Chemical class 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- 208000031886 HIV Infections Diseases 0.000 claims 5
- 208000037357 HIV infectious disease Diseases 0.000 claims 5
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 125000004430 oxygen atom Chemical group O* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 2
- 125000000815 N-oxide group Chemical group 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- -1 -CONHSO 2 R 9 Chemical group 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 230000000798 anti-retroviral effect Effects 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 1
- 239000005022 packaging material Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61457604P | 2004-09-30 | 2004-09-30 | |
| US60/614,576 | 2004-09-30 | ||
| PCT/CA2005/001480 WO2006034583A1 (en) | 2004-09-30 | 2005-09-27 | Alkynyl based dervatives of benzophenone as non-nucleoside reverse transcriptase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008514650A JP2008514650A (ja) | 2008-05-08 |
| JP2008514650A5 true JP2008514650A5 (https=) | 2008-11-13 |
| JP5036543B2 JP5036543B2 (ja) | 2012-09-26 |
Family
ID=36118542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007533838A Expired - Fee Related JP5036543B2 (ja) | 2004-09-30 | 2005-09-27 | 非ヌクレオシド逆転写酵素インヒビターとしてのベンゾフェノンのアルキニル誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7300948B2 (https=) |
| EP (1) | EP1797062B8 (https=) |
| JP (1) | JP5036543B2 (https=) |
| AT (1) | ATE495165T1 (https=) |
| CA (1) | CA2577144C (https=) |
| DE (1) | DE602005025900D1 (https=) |
| ES (1) | ES2357391T3 (https=) |
| WO (1) | WO2006034583A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2339533A (en) * | 1998-07-14 | 2000-02-02 | James Martin Biggs | Topical pharmaceutical preparations |
| WO2005089241A2 (en) | 2004-03-13 | 2005-09-29 | Cluster Resources, Inc. | System and method for providing object triggers |
| US20070266388A1 (en) | 2004-06-18 | 2007-11-15 | Cluster Resources, Inc. | System and method for providing advanced reservations in a compute environment |
| US8176490B1 (en) | 2004-08-20 | 2012-05-08 | Adaptive Computing Enterprises, Inc. | System and method of interfacing a workload manager and scheduler with an identity manager |
| CA2586763C (en) | 2004-11-08 | 2013-12-17 | Cluster Resources, Inc. | System and method of providing system jobs within a compute environment |
| US8863143B2 (en) | 2006-03-16 | 2014-10-14 | Adaptive Computing Enterprises, Inc. | System and method for managing a hybrid compute environment |
| US8782231B2 (en) | 2005-03-16 | 2014-07-15 | Adaptive Computing Enterprises, Inc. | Simple integration of on-demand compute environment |
| US9231886B2 (en) | 2005-03-16 | 2016-01-05 | Adaptive Computing Enterprises, Inc. | Simple integration of an on-demand compute environment |
| WO2006108187A2 (en) | 2005-04-07 | 2006-10-12 | Cluster Resources, Inc. | On-demand access to compute resources |
| AR060492A1 (es) * | 2006-04-17 | 2008-06-18 | Smithkline Beecham Corp | Compuestos quimicos |
| CL2007002105A1 (es) * | 2006-07-21 | 2008-02-22 | Hoffmann La Roche | Compuestos derivados de 2-[3-(3-cianofenoxi)(fenoxi o fenilsulfanil)]-n-fenil acetamida, inhibidores de la transcriptasa inversa del vih; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar u |
| CA2658984C (en) * | 2006-08-16 | 2014-12-02 | Joshua Kennedy-Smith | Non-nucleoside reverse transcriptase inhibitors |
| BRPI0811645A2 (pt) | 2007-05-30 | 2014-11-11 | Hoffmann La Roche | Inibidores de transcriptase reversa de não-nucleosídeo |
| EP2170836A1 (en) * | 2007-06-22 | 2010-04-07 | F. Hoffmann-Roche AG | Urea and carbamate derivatives as non-nucleoside reverse transcriptase inhibitors |
| RU2495878C2 (ru) * | 2007-12-21 | 2013-10-20 | Ф.Хоффманн-Ля Рош Аг | Гетероциклические антивирусные соединения |
| CA2758149A1 (en) | 2009-04-09 | 2010-10-14 | Boehringer Ingelheim International Gmbh | Inhibitors of hiv replication |
| US11720290B2 (en) | 2009-10-30 | 2023-08-08 | Iii Holdings 2, Llc | Memcached server functionality in a cluster of data processing nodes |
| HUE040156T2 (hu) * | 2010-11-05 | 2019-02-28 | Oat Agrio Co Ltd | Etinilfenilamidinvegyület vagy sója, eljárás azok elõállítására, és fungicid mezõgazdasági és kertészeti alkalmazásra |
| US11132277B2 (en) * | 2012-12-28 | 2021-09-28 | Iii Holdings 2, Llc | System and method for continuous low-overhead monitoring of distributed applications running on a cluster of data processing nodes |
| EP3455203B1 (en) * | 2016-05-12 | 2021-09-22 | Research Triangle Institute | Vinylogous phenethylamines as neurotransmitter releasers |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9920872D0 (en) * | 1999-09-04 | 1999-11-10 | Glaxo Group Ltd | Benzophenones as inhibitors of reverse transcriptase |
| JP2004525914A (ja) | 2001-03-02 | 2004-08-26 | スミスクライン ビーチャム コーポレーション | 逆転写酵素阻害剤としてのベンゾフェノン類 |
| US7642277B2 (en) | 2002-12-04 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
| US20060025480A1 (en) * | 2004-08-02 | 2006-02-02 | Boehringer Ingelheim International Gmbh | Benzoic acid derivatives as non nucleoside reverse transcriptase inhibitors |
-
2005
- 2005-09-27 JP JP2007533838A patent/JP5036543B2/ja not_active Expired - Fee Related
- 2005-09-27 WO PCT/CA2005/001480 patent/WO2006034583A1/en not_active Ceased
- 2005-09-27 EP EP05792224A patent/EP1797062B8/en not_active Not-in-force
- 2005-09-27 DE DE602005025900T patent/DE602005025900D1/de active Active
- 2005-09-27 CA CA2577144A patent/CA2577144C/en not_active Expired - Fee Related
- 2005-09-27 AT AT05792224T patent/ATE495165T1/de active
- 2005-09-27 ES ES05792224T patent/ES2357391T3/es active Active
- 2005-09-29 US US11/238,732 patent/US7300948B2/en not_active Expired - Lifetime
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