JP2008514639A - フラビウイルス、ペスチウイルス及びヘパシウイルスの感染症を治療するための方法及び組成物 - Google Patents
フラビウイルス、ペスチウイルス及びヘパシウイルスの感染症を治療するための方法及び組成物 Download PDFInfo
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- JP2008514639A JP2008514639A JP2007533754A JP2007533754A JP2008514639A JP 2008514639 A JP2008514639 A JP 2008514639A JP 2007533754 A JP2007533754 A JP 2007533754A JP 2007533754 A JP2007533754 A JP 2007533754A JP 2008514639 A JP2008514639 A JP 2008514639A
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- alkyl
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61308504P | 2004-09-24 | 2004-09-24 | |
| PCT/US2005/034786 WO2006037028A2 (en) | 2004-09-24 | 2005-09-26 | Methods and compositions for treating flaviviruses, pestiviruses and hepacivirus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008514639A true JP2008514639A (ja) | 2008-05-08 |
| JP2008514639A5 JP2008514639A5 (https=) | 2008-11-13 |
Family
ID=36119563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007533754A Pending JP2008514639A (ja) | 2004-09-24 | 2005-09-26 | フラビウイルス、ペスチウイルス及びヘパシウイルスの感染症を治療するための方法及び組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20080280850A1 (https=) |
| EP (1) | EP1804811A4 (https=) |
| JP (1) | JP2008514639A (https=) |
| KR (1) | KR20070073805A (https=) |
| CN (1) | CN101072570A (https=) |
| AU (1) | AU2005289517A1 (https=) |
| BR (1) | BRPI0515896A (https=) |
| CA (1) | CA2581523A1 (https=) |
| IL (1) | IL182061A0 (https=) |
| NO (1) | NO20072055L (https=) |
| RU (1) | RU2007115419A (https=) |
| WO (1) | WO2006037028A2 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| KR20080021797A (ko) | 2000-05-26 | 2008-03-07 | 이데닉스(케이만)리미티드 | 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물 |
| NZ537662A (en) | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| PL374781A1 (en) | 2002-06-28 | 2005-10-31 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| HUE033832T2 (en) | 2002-11-15 | 2018-01-29 | Idenix Pharmaceuticals Llc | 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation |
| RU2005121904A (ru) | 2002-12-12 | 2006-01-20 | Айденикс (Кайман) Лимитед (Ky) | Способ получения 2`-разветвленных нуклеозидов |
| EP2345657A1 (en) | 2003-05-30 | 2011-07-20 | Pharmasset, Inc. | Modified fluorinated nucleoside analogues |
| CN101023094B (zh) | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
| AU2005285045B2 (en) | 2004-09-14 | 2011-10-13 | Gilead Sciences, Inc. | Preparation of 2'fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| GB2471806B (en) * | 2008-04-03 | 2012-12-19 | Spring Bank Pharmaceuticals Inc | Compositions and methods for treating viral infections |
| PT2376088T (pt) | 2008-12-23 | 2017-05-02 | Gilead Pharmasset Llc | Fosforamidatos de nucleósidos de 2-amino-purina 6-osubstituída |
| KR20110098849A (ko) | 2008-12-23 | 2011-09-01 | 파마셋 인코포레이티드 | 뉴클레오시드 유사체 |
| SG194404A1 (en) | 2008-12-23 | 2013-11-29 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| TWI598358B (zh) | 2009-05-20 | 2017-09-11 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| PT2609923T (pt) | 2010-03-31 | 2017-08-30 | Gilead Pharmasset Llc | Processo para a cristalização de 2-(((s)- (perfluorofenoxi)(fenoxi)fosforil)amino)propanoato de (s)-isopropilo |
| PL3290428T3 (pl) | 2010-03-31 | 2022-02-07 | Gilead Pharmasset Llc | Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu |
| AU2011336632B2 (en) | 2010-11-30 | 2015-09-03 | Gilead Pharmasset Llc | Compounds |
| PL2709613T5 (pl) | 2011-09-16 | 2020-12-14 | Gilead Pharmasset Llc | Metody leczenia hcv |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| CN103833812A (zh) * | 2012-11-23 | 2014-06-04 | 中国人民解放军军事医学科学院毒物药物研究所 | 吡嗪衍生物及其医药用途 |
| PT2950786T (pt) | 2013-01-31 | 2020-03-03 | Gilead Pharmasset Llc | Formulação de combinação de dois compostos antivirais |
| ES2734209T3 (es) | 2013-08-06 | 2019-12-04 | Imago Biosciences Inc | Inhibidores de KDM1A para el tratamiento de enfermedades |
| EA201690473A1 (ru) | 2013-08-27 | 2017-03-31 | ГАЙЛИД ФАРМАССЕТ ЭлЭлСи | Комбинированный состав двух противовирусных соединений |
| CN105732748B (zh) * | 2014-12-12 | 2019-01-01 | 浙江医药股份有限公司新昌制药厂 | 一种核苷酸类似物及其制备方法、以及含有核苷酸类似物的药物组合物及其应用 |
| PL3256218T3 (pl) | 2015-02-12 | 2025-03-31 | Imago Biosciences Inc. | Inhibitor kdm1a i jego zastosowanie w terapii |
| WO2018035259A1 (en) | 2016-08-16 | 2018-02-22 | Imago Biosciences, Inc. | Methods and processes for the preparation of kdm1a inhibitors |
| BR112021001066A2 (pt) | 2018-05-11 | 2021-04-20 | Imago Biosciences, Inc. | composto, método de tratamento de uma doença mediada por kdm1a, método de tratamento de uma doença mediada por globina, composição farmacêutica; método de inibição de kdm1a, método para obter um efeito em um paciente, e método para inibir pelo menos uma função de kdm1a |
Citations (14)
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| JPH0398599A (ja) * | 1989-08-29 | 1991-04-24 | Monsanto Co | 改良プローブ |
| WO2001060834A1 (en) * | 2000-02-16 | 2001-08-23 | Toyama Chemical Co., Ltd. | Novel pyrazine derivatives or salts thereof, pharmaceutical compositions containing the derivatives or the salts and intermediates for the preparation of both |
| WO2003015798A1 (fr) * | 2001-08-14 | 2003-02-27 | Toyama Chemical Co., Ltd. | Nouvelle methode virocide/inhibitrice de la proliferation virale et nouvel analogue de pyradine nucleotide/pyradine nucleoside |
| WO2003068244A1 (en) * | 2002-02-13 | 2003-08-21 | Merck & Co., Inc. | Methods of inhibiting orthopoxvirus replication with nucleoside compounds |
| WO2003072757A2 (en) * | 2002-02-28 | 2003-09-04 | Biota, Inc. | Nucleotide mimics and their prodrugs |
| WO2003093290A2 (en) * | 2002-05-06 | 2003-11-13 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis c virus infection |
| WO2003105770A2 (en) * | 2002-06-17 | 2003-12-24 | Merck & Co., Inc. | Carbocyclic nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| WO2004002422A2 (en) * | 2002-06-28 | 2004-01-08 | Idenix (Cayman) Limited | 2’-c-methyl-3’-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| WO2004003138A2 (en) * | 2002-06-27 | 2004-01-08 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| WO2004002999A2 (en) * | 2002-06-28 | 2004-01-08 | Idenix (Cayman) Limited | Modified 2' and 3' -nucleoside produgs for treating flaviridae infections |
| WO2004007512A2 (en) * | 2002-07-16 | 2004-01-22 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| JP2004043371A (ja) * | 2002-07-12 | 2004-02-12 | Toyama Chem Co Ltd | 新規なピラジン誘導体またはその塩並びにそれらを含有する抗ウイルス剤 |
| WO2004028481A2 (en) * | 2002-09-30 | 2004-04-08 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis c virus infection |
| WO2004046331A2 (en) * | 2002-11-15 | 2004-06-03 | Idenix (Cayman) Limited | 2’-branched nucleosides and flaviviridae mutation |
-
2005
- 2005-09-26 BR BRPI0515896-6A patent/BRPI0515896A/pt not_active Application Discontinuation
- 2005-09-26 EP EP05813010A patent/EP1804811A4/en not_active Withdrawn
- 2005-09-26 RU RU2007115419/04A patent/RU2007115419A/ru not_active Application Discontinuation
- 2005-09-26 JP JP2007533754A patent/JP2008514639A/ja active Pending
- 2005-09-26 US US11/884,414 patent/US20080280850A1/en not_active Abandoned
- 2005-09-26 AU AU2005289517A patent/AU2005289517A1/en not_active Abandoned
- 2005-09-26 CN CNA2005800404057A patent/CN101072570A/zh active Pending
- 2005-09-26 WO PCT/US2005/034786 patent/WO2006037028A2/en not_active Ceased
- 2005-09-26 CA CA002581523A patent/CA2581523A1/en not_active Abandoned
- 2005-09-26 KR KR1020077009174A patent/KR20070073805A/ko not_active Withdrawn
-
2007
- 2007-03-20 IL IL182061A patent/IL182061A0/en unknown
- 2007-04-20 NO NO20072055A patent/NO20072055L/no not_active Application Discontinuation
Patent Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0398599A (ja) * | 1989-08-29 | 1991-04-24 | Monsanto Co | 改良プローブ |
| WO2001060834A1 (en) * | 2000-02-16 | 2001-08-23 | Toyama Chemical Co., Ltd. | Novel pyrazine derivatives or salts thereof, pharmaceutical compositions containing the derivatives or the salts and intermediates for the preparation of both |
| WO2003015798A1 (fr) * | 2001-08-14 | 2003-02-27 | Toyama Chemical Co., Ltd. | Nouvelle methode virocide/inhibitrice de la proliferation virale et nouvel analogue de pyradine nucleotide/pyradine nucleoside |
| WO2003068244A1 (en) * | 2002-02-13 | 2003-08-21 | Merck & Co., Inc. | Methods of inhibiting orthopoxvirus replication with nucleoside compounds |
| WO2003072757A2 (en) * | 2002-02-28 | 2003-09-04 | Biota, Inc. | Nucleotide mimics and their prodrugs |
| WO2003093290A2 (en) * | 2002-05-06 | 2003-11-13 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis c virus infection |
| WO2003105770A2 (en) * | 2002-06-17 | 2003-12-24 | Merck & Co., Inc. | Carbocyclic nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| WO2004003138A2 (en) * | 2002-06-27 | 2004-01-08 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| WO2004002422A2 (en) * | 2002-06-28 | 2004-01-08 | Idenix (Cayman) Limited | 2’-c-methyl-3’-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| WO2004002999A2 (en) * | 2002-06-28 | 2004-01-08 | Idenix (Cayman) Limited | Modified 2' and 3' -nucleoside produgs for treating flaviridae infections |
| JP2004043371A (ja) * | 2002-07-12 | 2004-02-12 | Toyama Chem Co Ltd | 新規なピラジン誘導体またはその塩並びにそれらを含有する抗ウイルス剤 |
| WO2004007512A2 (en) * | 2002-07-16 | 2004-01-22 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| WO2004028481A2 (en) * | 2002-09-30 | 2004-04-08 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis c virus infection |
| WO2004046331A2 (en) * | 2002-11-15 | 2004-06-03 | Idenix (Cayman) Limited | 2’-branched nucleosides and flaviviridae mutation |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006037028A2 (en) | 2006-04-06 |
| BRPI0515896A (pt) | 2008-08-12 |
| WO2006037028A3 (en) | 2006-07-13 |
| CN101072570A (zh) | 2007-11-14 |
| EP1804811A4 (en) | 2011-04-27 |
| KR20070073805A (ko) | 2007-07-10 |
| EP1804811A2 (en) | 2007-07-11 |
| US20080280850A1 (en) | 2008-11-13 |
| AU2005289517A1 (en) | 2006-04-06 |
| NO20072055L (no) | 2007-06-14 |
| RU2007115419A (ru) | 2008-10-27 |
| CA2581523A1 (en) | 2006-04-06 |
| IL182061A0 (en) | 2007-07-24 |
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