JP2008514565A - 三環式化合物、それら製造方法、及び医薬剤としての使用 - Google Patents

三環式化合物、それら製造方法、及び医薬剤としての使用 Download PDF

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Publication number
JP2008514565A
JP2008514565A JP2007532844A JP2007532844A JP2008514565A JP 2008514565 A JP2008514565 A JP 2008514565A JP 2007532844 A JP2007532844 A JP 2007532844A JP 2007532844 A JP2007532844 A JP 2007532844A JP 2008514565 A JP2008514565 A JP 2008514565A
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JP
Japan
Prior art keywords
pyrazol
dihydro
imidazo
indol
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007532844A
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English (en)
Japanese (ja)
Inventor
ジョルジュ，ギイ
ゴーラー，ベルンハルト
クレル，ハンス−ウィリー
クエンケル，クラウス−ペーター
リンバーク，アンヤ
ルーガー，ペトラ
ルース，マシアス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2008514565A publication Critical patent/JP2008514565A/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2007532844A 2004-09-24 2005-09-23 三環式化合物、それら製造方法、及び医薬剤としての使用 Pending JP2008514565A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04022753 2004-09-24
EP05010528 2005-05-13
PCT/EP2005/010312 WO2006032519A1 (en) 2004-09-24 2005-09-23 Tricycles, their manufacture and use as pharmaceutical agents

Publications (1)

Publication Number Publication Date
JP2008514565A true JP2008514565A (ja) 2008-05-08

Family

ID=35429559

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007532844A Pending JP2008514565A (ja) 2004-09-24 2005-09-23 三環式化合物、それら製造方法、及び医薬剤としての使用

Country Status (10)

Country Link
EP (1) EP1793822A1 (ko)
JP (1) JP2008514565A (ko)
KR (1) KR100845749B1 (ko)
AR (1) AR050949A1 (ko)
AU (1) AU2005287459A1 (ko)
CA (1) CA2580203A1 (ko)
MX (1) MX2007003463A (ko)
RU (1) RU2007115159A (ko)
TW (1) TW200626149A (ko)
WO (1) WO2006032519A1 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006108489A1 (en) * 2005-04-14 2006-10-19 F. Hoffmann-La Roche Ag Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents
JP2009519279A (ja) * 2005-12-15 2009-05-14 エフ．ホフマン−ラ ロシュ アーゲー 三員環ラクタム誘導体、それらの製造方法、及び医薬剤としての使用
US20090291968A1 (en) * 2006-03-23 2009-11-26 Guy Georges Substituted indazole derivatives, their manufacture and use as pharmaceutical agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61167689A (ja) * 1985-01-18 1986-07-29 ベーリンガー・マンハイム・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 新規ピロロベンゾイミダゾール．その製法及び該化合物を含有する心臓‐及び循環器系疾患の予防‐及び治療剤
US4835280A (en) * 1985-01-18 1989-05-30 Boehringer Mannheim Gmbh Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3740985A1 (de) * 1987-12-03 1989-06-15 Boehringer Mannheim Gmbh Verwendung linear anellierter tricyclen als hemmer der erythrozytenaggregation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61167689A (ja) * 1985-01-18 1986-07-29 ベーリンガー・マンハイム・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 新規ピロロベンゾイミダゾール．その製法及び該化合物を含有する心臓‐及び循環器系疾患の予防‐及び治療剤
US4835280A (en) * 1985-01-18 1989-05-30 Boehringer Mannheim Gmbh Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles

Also Published As

Publication number Publication date
KR20070045339A (ko) 2007-05-02
MX2007003463A (es) 2007-05-23
RU2007115159A (ru) 2008-11-10
AR050949A1 (es) 2006-12-06
TW200626149A (en) 2006-08-01
EP1793822A1 (en) 2007-06-13
WO2006032519A1 (en) 2006-03-30
CA2580203A1 (en) 2006-03-30
KR100845749B1 (ko) 2008-07-11
AU2005287459A1 (en) 2006-03-30

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