CA2580203A1 - Tricycles, their manufacture and use as pharmaceutical agents - Google Patents

Tricycles, their manufacture and use as pharmaceutical agents Download PDF

Info

Publication number
CA2580203A1
CA2580203A1 CA002580203A CA2580203A CA2580203A1 CA 2580203 A1 CA2580203 A1 CA 2580203A1 CA 002580203 A CA002580203 A CA 002580203A CA 2580203 A CA2580203 A CA 2580203A CA 2580203 A1 CA2580203 A1 CA 2580203A1
Authority
CA
Canada
Prior art keywords
pyrazol
dihydro
imidazo
indol
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002580203A
Other languages
English (en)
French (fr)
Inventor
Guy Georges
Bernhard Goller
Hans-Willi Krell
Klaus-Peter Kuenkele
Anja Limberg
Petra Rueger
Matthias Rueth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
Guy Georges
Bernhard Goller
Hans-Willi Krell
Klaus-Peter Kuenkele
Anja Limberg
Petra Rueger
Matthias Rueth
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guy Georges, Bernhard Goller, Hans-Willi Krell, Klaus-Peter Kuenkele, Anja Limberg, Petra Rueger, Matthias Rueth, F. Hoffmann-La Roche Ag filed Critical Guy Georges
Publication of CA2580203A1 publication Critical patent/CA2580203A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002580203A 2004-09-24 2005-09-23 Tricycles, their manufacture and use as pharmaceutical agents Abandoned CA2580203A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP04022753.0 2004-09-24
EP04022753 2004-09-24
EP05010528.7 2005-05-13
EP05010528 2005-05-13
PCT/EP2005/010312 WO2006032519A1 (en) 2004-09-24 2005-09-23 Tricycles, their manufacture and use as pharmaceutical agents

Publications (1)

Publication Number Publication Date
CA2580203A1 true CA2580203A1 (en) 2006-03-30

Family

ID=35429559

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002580203A Abandoned CA2580203A1 (en) 2004-09-24 2005-09-23 Tricycles, their manufacture and use as pharmaceutical agents

Country Status (10)

Country Link
EP (1) EP1793822A1 (ko)
JP (1) JP2008514565A (ko)
KR (1) KR100845749B1 (ko)
AR (1) AR050949A1 (ko)
AU (1) AU2005287459A1 (ko)
CA (1) CA2580203A1 (ko)
MX (1) MX2007003463A (ko)
RU (1) RU2007115159A (ko)
TW (1) TW200626149A (ko)
WO (1) WO2006032519A1 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006108489A1 (en) * 2005-04-14 2006-10-19 F. Hoffmann-La Roche Ag Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents
JP2009519279A (ja) * 2005-12-15 2009-05-14 エフ．ホフマン−ラ ロシュ アーゲー 三員環ラクタム誘導体、それらの製造方法、及び医薬剤としての使用
US20090291968A1 (en) * 2006-03-23 2009-11-26 Guy Georges Substituted indazole derivatives, their manufacture and use as pharmaceutical agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
US4835280A (en) * 1985-01-18 1989-05-30 Boehringer Mannheim Gmbh Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles
DE3740985A1 (de) * 1987-12-03 1989-06-15 Boehringer Mannheim Gmbh Verwendung linear anellierter tricyclen als hemmer der erythrozytenaggregation

Also Published As

Publication number Publication date
KR20070045339A (ko) 2007-05-02
MX2007003463A (es) 2007-05-23
JP2008514565A (ja) 2008-05-08
RU2007115159A (ru) 2008-11-10
AR050949A1 (es) 2006-12-06
TW200626149A (en) 2006-08-01
EP1793822A1 (en) 2007-06-13
WO2006032519A1 (en) 2006-03-30
KR100845749B1 (ko) 2008-07-11
AU2005287459A1 (en) 2006-03-30

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Legal Events

Date Code Title Description
FZDE Discontinued