JP2008513479A5 - - Google Patents
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- JP2008513479A5 JP2008513479A5 JP2007532511A JP2007532511A JP2008513479A5 JP 2008513479 A5 JP2008513479 A5 JP 2008513479A5 JP 2007532511 A JP2007532511 A JP 2007532511A JP 2007532511 A JP2007532511 A JP 2007532511A JP 2008513479 A5 JP2008513479 A5 JP 2008513479A5
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- Japan
- Prior art keywords
- peptide
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- stent
- mammal
- lys
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 65
- -1 9-fluoreneacetyl group Chemical group 0.000 claims 44
- 238000000034 method Methods 0.000 claims 42
- 241000124008 Mammalia Species 0.000 claims 24
- 150000001413 amino acids Chemical class 0.000 claims 20
- 125000006239 protecting group Chemical group 0.000 claims 19
- 201000001320 Atherosclerosis Diseases 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 229920000642 polymer Polymers 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims 9
- WTKQMHWYSBWUBE-UHFFFAOYSA-N (3-nitropyridin-2-yl) thiohypochlorite Chemical group [O-][N+](=O)C1=CC=CN=C1SCl WTKQMHWYSBWUBE-UHFFFAOYSA-N 0.000 claims 6
- 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 claims 6
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 6
- 125000002933 cyclohexyloxy group Chemical group C1(CCCCC1)O* 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 238000009472 formulation Methods 0.000 claims 6
- 208000024891 symptom Diseases 0.000 claims 6
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 6
- 239000013543 active substance Substances 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- 230000004968 inflammatory condition Effects 0.000 claims 5
- 238000010255 intramuscular injection Methods 0.000 claims 5
- 239000007927 intramuscular injection Substances 0.000 claims 5
- 239000007928 intraperitoneal injection Substances 0.000 claims 5
- 238000010253 intravenous injection Methods 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 238000010254 subcutaneous injection Methods 0.000 claims 5
- 239000007929 subcutaneous injection Substances 0.000 claims 5
- 150000008574 D-amino acids Chemical class 0.000 claims 4
- 102000007079 Peptide Fragments Human genes 0.000 claims 4
- 108010033276 Peptide Fragments Proteins 0.000 claims 4
- 208000006011 Stroke Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims 3
- WSNDAYQNZRJGMJ-UHFFFAOYSA-N 2,2,2-trifluoroethanone Chemical compound FC(F)(F)[C]=O WSNDAYQNZRJGMJ-UHFFFAOYSA-N 0.000 claims 3
- 125000006181 4-methyl benzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])* 0.000 claims 3
- HTPXFGUCAUTOEL-UHFFFAOYSA-N 9h-fluorene-1-carboxylic acid Chemical group C1C2=CC=CC=C2C2=C1C(C(=O)O)=CC=C2 HTPXFGUCAUTOEL-UHFFFAOYSA-N 0.000 claims 3
- DNVJGJUGFFYUPT-UHFFFAOYSA-N 9h-fluorene-9-carboxylic acid Chemical group C1=CC=C2C(C(=O)O)C3=CC=CC=C3C2=C1 DNVJGJUGFFYUPT-UHFFFAOYSA-N 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000001408 amides Chemical group 0.000 claims 3
- 230000003110 anti-inflammatory effect Effects 0.000 claims 3
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 3
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 3
- 230000002209 hydrophobic effect Effects 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 125000006178 methyl benzyl group Chemical group 0.000 claims 3
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 3
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- 230000004044 response Effects 0.000 claims 3
- 208000037803 restenosis Diseases 0.000 claims 3
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims 3
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims 3
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- 206010048998 Acute phase reaction Diseases 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 230000004658 acute-phase response Effects 0.000 claims 2
- 229910045601 alloy Inorganic materials 0.000 claims 2
- 239000000956 alloy Substances 0.000 claims 2
- 230000004888 barrier function Effects 0.000 claims 2
- 210000004204 blood vessel Anatomy 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- WJJGAKCAAJOICV-JTQLQIEISA-N (2s)-2-(dimethylamino)-3-(4-hydroxyphenyl)propanoic acid Chemical group CN(C)[C@H](C(O)=O)CC1=CC=C(O)C=C1 WJJGAKCAAJOICV-JTQLQIEISA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 108091028732 Concatemer Proteins 0.000 claims 1
- 150000008575 L-amino acids Chemical class 0.000 claims 1
- QCZYYEFXOBKCNQ-STQMWFEESA-N Lys-Phe Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 QCZYYEFXOBKCNQ-STQMWFEESA-N 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 229920000249 biocompatible polymer Polymers 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000005520 cutting process Methods 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000007791 liquid phase Substances 0.000 claims 1
- 108010038320 lysylphenylalanine Proteins 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 claims 1
- 229910001000 nickel titanium Inorganic materials 0.000 claims 1
- 230000000149 penetrating effect Effects 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920000307 polymer substrate Polymers 0.000 claims 1
- 230000000770 proinflammatory effect Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 239000010935 stainless steel Substances 0.000 claims 1
- 229910001220 stainless steel Inorganic materials 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 229910052715 tantalum Inorganic materials 0.000 claims 1
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 229910052719 titanium Inorganic materials 0.000 claims 1
- 239000010936 titanium Substances 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61071104P | 2004-09-16 | 2004-09-16 | |
| PCT/US2005/033205 WO2006034056A2 (en) | 2004-09-16 | 2005-09-16 | G-type peptides and other agents to ameliorate atherosclerosis and other pathologies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008513479A JP2008513479A (ja) | 2008-05-01 |
| JP2008513479A5 true JP2008513479A5 (enExample) | 2008-11-06 |
Family
ID=36090532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007532511A Pending JP2008513479A (ja) | 2004-09-16 | 2005-09-16 | アテローム性動脈硬化症および他の病理を改善するためのｇ型ペプチドおよび他の薬剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20060205669A1 (enExample) |
| EP (1) | EP1799242A4 (enExample) |
| JP (1) | JP2008513479A (enExample) |
| CN (1) | CN101065137A (enExample) |
| AU (1) | AU2005287004B2 (enExample) |
| CA (1) | CA2580501A1 (enExample) |
| RU (1) | RU2448977C2 (enExample) |
| WO (1) | WO2006034056A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8568766B2 (en) | 2000-08-24 | 2013-10-29 | Gattadahalli M. Anantharamaiah | Peptides and peptide mimetics to treat pathologies associated with eye disease |
| US7723303B2 (en) | 2000-08-24 | 2010-05-25 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| US7199102B2 (en) | 2000-08-24 | 2007-04-03 | The Regents Of The University Of California | Orally administered peptides synergize statin activity |
| US7148197B2 (en) * | 2000-08-24 | 2006-12-12 | The Regents Of The University Of California | Orally administered small peptides synergize statin activity |
| BRPI0513402A (pt) * | 2004-07-16 | 2008-05-06 | Tufts College | miméticos de apolipoproteìna a1 e usos dos mesmos |
| RU2414236C2 (ru) | 2004-12-06 | 2011-03-20 | Зе Риджентс Оф Зи Юнивесити Оф Кэлифонье | Способ улучшения структуры и/или функций артериол |
| US20080293639A1 (en) * | 2005-04-29 | 2008-11-27 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| EA200900786A1 (ru) * | 2005-04-29 | 2009-10-30 | Зе Риджентс Оф Зи Юнивесити Оф Кэлифонье | Пептид в качестве лекарственного средства и способ лечения патологий, связанных с воспалительными процессами, посредством пептида |
| EP2049137A4 (en) * | 2006-08-08 | 2013-05-01 | Univ California | SALICYLANILIDES AS AMPLIFIERS OF THE ORAL RELEASE OF THERAPEUTIC PEPTIDES |
| AU2008296478B9 (en) | 2007-08-28 | 2015-03-19 | The Uab Research Foundation | Synthetic apolipoprotein E mimicking polypeptides and methods of use |
| JP2010537638A (ja) | 2007-08-28 | 2010-12-09 | ユーエービー リサーチ ファウンデーション | 合成アポリポ蛋白質ｅ模倣ポリペプチドおよび使用方法 |
| US9173890B2 (en) * | 2007-09-20 | 2015-11-03 | Abbott Cardiovascular Systems Inc. | Sustained release of Apo A-I mimetic peptides and methods of treatment |
| US9051349B2 (en) | 2007-11-21 | 2015-06-09 | Alba Therapeutics Corporation | Larazotide acetate compositions |
| EP2062909A1 (en) * | 2007-11-21 | 2009-05-27 | SOLVAY (Société Anonyme) | Peptide production and purification process |
| EP2240196A2 (en) | 2008-01-22 | 2010-10-20 | Compugen Ltd. | Clusterin derived peptide |
| US20110206679A1 (en) * | 2008-07-07 | 2011-08-25 | Athera Biotechnologies Ab | New Therapeutic and Diagnostic Methods for Alzheimer's Disease |
| WO2013063160A1 (en) * | 2011-10-24 | 2013-05-02 | Mannkind Corporation | Methods and compositions for treating pain |
| WO2013126775A1 (en) * | 2012-02-23 | 2013-08-29 | Cornell University | Aromatic-cationic peptides and uses of same |
| US9539300B2 (en) | 2012-03-31 | 2017-01-10 | The Regents Of The University Of California | Modulating disease through genetic engineering of plants |
| CA2954475C (en) | 2014-07-31 | 2023-05-16 | Uab Research Foundation | Apoe mimetic peptides and higher potency to clear plasma cholesterol |
| US10905736B2 (en) | 2016-09-28 | 2021-02-02 | The Regents Of The University Of California | Ezetimibe-associated ApoA-I mimetic peptides showing enhanced synergism |
| EP3837549A1 (en) * | 2018-08-16 | 2021-06-23 | Roche Diagnostics GmbH | Circulating tfpi-2 (tissue factor pathway inhibitor 2) in the assessment of atrial fibrillation and anticoagulation therapy |
| US12036286B2 (en) | 2021-03-18 | 2024-07-16 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
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| US7166578B2 (en) * | 2000-08-24 | 2007-01-23 | The Regents Of The University Of California | Orally administered peptides synergize statin activity |
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| US7217785B2 (en) * | 2001-05-09 | 2007-05-15 | The Regents Of The University Of California | Cysteine-containing peptides having antioxidant properties |
| US20030125260A1 (en) * | 2001-10-31 | 2003-07-03 | Fortuna Haviv | Tetra-and pentapeptides having antiangiogenic activity |
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| JP4032857B2 (ja) * | 2002-07-24 | 2008-01-16 | ソニー株式会社 | タッチパネル用のガラス基板、タッチパネル及び携帯端末 |
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| WO2004069206A2 (en) * | 2003-02-04 | 2004-08-19 | University Of Connecticut Health Center | Immunogenic cd91 ligand-antigenic molecule complexes and fusion proteins |
| US20050070996A1 (en) * | 2003-04-08 | 2005-03-31 | Dinh Thomas Q. | Drug-eluting stent for controlled drug delivery |
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| BRPI0513402A (pt) * | 2004-07-16 | 2008-05-06 | Tufts College | miméticos de apolipoproteìna a1 e usos dos mesmos |
| RU2414236C2 (ru) * | 2004-12-06 | 2011-03-20 | Зе Риджентс Оф Зи Юнивесити Оф Кэлифонье | Способ улучшения структуры и/или функций артериол |
| US20080293639A1 (en) * | 2005-04-29 | 2008-11-27 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| RU2007148927A (ru) * | 2005-05-26 | 2009-07-10 | Метабэйзис Терапьютикс, Инк. (Us) | Новые тиреомиметики, содержащие фосфиновую кислоту |
-
2005
- 2005-09-16 US US11/229,042 patent/US20060205669A1/en not_active Abandoned
- 2005-09-16 RU RU2007114144/04A patent/RU2448977C2/ru not_active IP Right Cessation
- 2005-09-16 CN CNA2005800392242A patent/CN101065137A/zh active Pending
- 2005-09-16 JP JP2007532511A patent/JP2008513479A/ja active Pending
- 2005-09-16 WO PCT/US2005/033205 patent/WO2006034056A2/en not_active Ceased
- 2005-09-16 CA CA002580501A patent/CA2580501A1/en not_active Abandoned
- 2005-09-16 AU AU2005287004A patent/AU2005287004B2/en not_active Ceased
- 2005-09-16 EP EP05803724A patent/EP1799242A4/en not_active Withdrawn
-
2011
- 2011-06-08 US US13/156,269 patent/US20120004720A1/en not_active Abandoned
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