JP2008512984A5 - - Google Patents
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- JP2008512984A5 JP2008512984A5 JP2007515423A JP2007515423A JP2008512984A5 JP 2008512984 A5 JP2008512984 A5 JP 2008512984A5 JP 2007515423 A JP2007515423 A JP 2007515423A JP 2007515423 A JP2007515423 A JP 2007515423A JP 2008512984 A5 JP2008512984 A5 JP 2008512984A5
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- JP
- Japan
- Prior art keywords
- marker
- cancer
- sample
- activity
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000003550 marker Substances 0.000 claims 80
- 206010028980 Neoplasm Diseases 0.000 claims 52
- 201000011510 cancer Diseases 0.000 claims 51
- 238000000034 method Methods 0.000 claims 44
- 239000000523 sample Substances 0.000 claims 41
- 230000000694 effects Effects 0.000 claims 29
- 102000003979 Mineralocorticoid Receptors Human genes 0.000 claims 28
- 108090000375 Mineralocorticoid Receptors Proteins 0.000 claims 28
- 238000006452 multicomponent reaction Methods 0.000 claims 28
- 108090000623 proteins and genes Proteins 0.000 claims 28
- 102000004169 proteins and genes Human genes 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 18
- 102000040430 polynucleotide Human genes 0.000 claims 18
- 108091033319 polynucleotide Proteins 0.000 claims 18
- 239000002157 polynucleotide Substances 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 16
- 230000014509 gene expression Effects 0.000 claims 11
- 239000012634 fragment Substances 0.000 claims 8
- 239000003153 chemical reaction reagent Substances 0.000 claims 7
- 238000000338 in vitro Methods 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 238000009396 hybridization Methods 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 238000010171 animal model Methods 0.000 claims 2
- 238000000137 annealing Methods 0.000 claims 2
- 210000000941 bile Anatomy 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 230000000052 comparative effect Effects 0.000 claims 2
- 239000002299 complementary DNA Substances 0.000 claims 2
- 239000013068 control sample Substances 0.000 claims 2
- 210000003608 fece Anatomy 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 239000002853 nucleic acid probe Substances 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 210000001819 pancreatic juice Anatomy 0.000 claims 2
- 210000004923 pancreatic tissue Anatomy 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 238000003753 real-time PCR Methods 0.000 claims 2
- 210000003296 saliva Anatomy 0.000 claims 2
- 230000011218 segmentation Effects 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 230000004075 alteration Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000000074 antisense oligonucleotide Substances 0.000 claims 1
- 238000012230 antisense oligonucleotides Methods 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 230000009368 gene silencing by RNA Effects 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 238000007901 in situ hybridization Methods 0.000 claims 1
- 230000002452 interceptive effect Effects 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000816 peptidomimetic Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 239000012474 protein marker Substances 0.000 claims 1
- 230000004850 protein–protein interaction Effects 0.000 claims 1
- 238000007423 screening assay Methods 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57579504P | 2004-05-28 | 2004-05-28 | |
| US58033704P | 2004-06-15 | 2004-06-15 | |
| PCT/US2005/018850 WO2005118869A2 (en) | 2004-05-28 | 2005-05-27 | Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008512984A JP2008512984A (ja) | 2008-05-01 |
| JP2008512984A5 true JP2008512984A5 (https=) | 2008-07-17 |
Family
ID=35463470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007515423A Pending JP2008512984A (ja) | 2004-05-28 | 2005-05-27 | 癌の同定、評価、予防および治療のための組成物、キットおよび方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8999633B2 (https=) |
| EP (1) | EP1774043A4 (https=) |
| JP (1) | JP2008512984A (https=) |
| CA (1) | CA2568413A1 (https=) |
| WO (1) | WO2005118869A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008536480A (ja) * | 2005-02-17 | 2008-09-11 | ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド | 癌の同定、評価、予防、および治療用組成物、キット、および方法、ならびに癌の治療法 |
| WO2006092714A2 (en) * | 2005-03-02 | 2006-09-08 | National Institute Of Immunology | Inhibition of spag9 expression with sirnas |
| WO2007037550A1 (ja) * | 2005-09-30 | 2007-04-05 | Link Genomics, Inc. | Ｔｓｔａ３遺伝子の治療的又は診断的用途 |
| JPWO2007037533A1 (ja) * | 2005-09-30 | 2009-04-16 | リンク・ジェノミクス株式会社 | Ｐｐｐ１ｒ３ｄ遺伝子の治療的又は診断的用途 |
| US20090035312A1 (en) * | 2005-09-30 | 2009-02-05 | Universiteit Maastricht | Tumor angiogenesis associated genes and a method for their identification |
| US8211634B2 (en) | 2006-02-14 | 2012-07-03 | Dana-Farber Cancer Institute, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer |
| JP4867018B2 (ja) | 2006-03-22 | 2012-02-01 | 富士フイルム株式会社 | 癌の検出方法および抑制方法 |
| PL2092081T3 (pl) | 2006-11-13 | 2013-07-31 | Valipharma | Sposoby i zastosowania obejmujące genetyczne nieprawidłowości w chromosomie 12 |
| US20100256610A1 (en) * | 2007-10-25 | 2010-10-07 | Basil Rigas | Apparatus and method of detection and localized treatment of abnormal conditions |
| US10611835B2 (en) | 2008-07-10 | 2020-04-07 | Toray Industries, Inc. | Pharmaceutical composition for treatment and prevention of cancer |
| EP2421991B1 (en) * | 2009-04-20 | 2015-11-11 | Lan Ko | Breast cancer susceptibility gene gt198 and uses thereof |
| US20120252028A1 (en) * | 2009-08-14 | 2012-10-04 | Michael Shtulman | Target genes for cancer therapy |
| US20120214679A1 (en) * | 2010-11-29 | 2012-08-23 | Precision Therapeutics, Inc. | Methods and systems for evaluating the sensitivity or resistance of tumor specimens to chemotherapeutic agents |
| US9233121B2 (en) | 2011-03-11 | 2016-01-12 | Board Of Regents Of The University Of Nebraska | Compositions and methods for the treatment of cancer |
| EP2852399B1 (en) * | 2012-05-21 | 2020-02-19 | The Regents of The University of Colorado, A Body Corporate | Ledgf peptides and formulations thereof for treatment of degenerative disorders |
| KR101535336B1 (ko) * | 2013-04-30 | 2015-07-09 | 고려대학교 산학협력단 | 골 형성 과정에서 인간 작은 류신 지퍼 단백질의 용도 |
| US10787711B2 (en) * | 2014-03-12 | 2020-09-29 | Juntendo Educational Foundation | Method for differentiating between lung squamous cell carcinoma and lung adenocarcinoma |
| CN103923212A (zh) | 2014-03-31 | 2014-07-16 | 天津市应世博科技发展有限公司 | Ehd2抗体及其在制备乳腺癌免疫组化检测试剂中的应用 |
| CN114582509B (zh) * | 2022-03-07 | 2025-04-25 | 温州医科大学附属眼视光医院 | 一种葡萄膜黑色素瘤预后风险评分模型及其应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5976790A (en) * | 1992-03-04 | 1999-11-02 | The Regents Of The University Of California | Comparative Genomic Hybridization (CGH) |
| US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
| US5569753A (en) | 1994-12-20 | 1996-10-29 | Cold Spring Harbor Laboratory | Cancer detection probes |
| US6350576B1 (en) | 1994-12-20 | 2002-02-26 | Cold Spring Harbor Laboratory | Cancer detection probes |
| US5690894A (en) | 1995-05-23 | 1997-11-25 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
| US5837196A (en) | 1996-01-26 | 1998-11-17 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
| US5982534A (en) | 1997-06-18 | 1999-11-09 | The Regents Of The University Of California | Specimen illumination apparatus with optical cavity for dark field illumination |
| US6210878B1 (en) | 1997-08-08 | 2001-04-03 | The Regents Of The University Of California | Array-based detection of genetic alterations associated with disease |
| AU3071399A (en) * | 1998-03-05 | 1999-09-20 | Penn State Research Foundation | Human homolog of a nuclear migration and its use |
| JP2002522097A (ja) | 1998-08-14 | 2002-07-23 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ヒト第２０染色体の２０ｑ１３領域における新規アンプリコンおよびその使用 |
| AU3395900A (en) * | 1999-03-12 | 2000-10-04 | Human Genome Sciences, Inc. | Human lung cancer associated gene sequences and polypeptides |
| US6261775B1 (en) | 1999-04-09 | 2001-07-17 | The Regents Of The University Of California | Detection of chromosome copy number changes to distinguish melanocytic nevi from malignant melanoma |
| US6613510B2 (en) | 1999-04-28 | 2003-09-02 | Mayo Foundation For Medical Education And Research | Methods and probe sets for determining prostate cancer prognosis |
| US6465182B1 (en) | 1999-04-29 | 2002-10-15 | The Regents Of The University Of California | Comparative fluorescence hybridization to oligonucleotide microarrays |
| US6326148B1 (en) | 1999-07-12 | 2001-12-04 | The Regents Of The University Of California | Detection of copy number changes in colon cancer |
| CA2411601A1 (en) * | 2000-06-05 | 2001-12-13 | Avalon Pharmaceuticals | Cancer gene determination and therapeutic screening using signature gene sets |
| US20020081301A1 (en) * | 2000-09-25 | 2002-06-27 | Daniel Soppet | Cancer gene determination and therapeutic screening using signature gene sets |
| US20030215936A1 (en) * | 2000-12-13 | 2003-11-20 | Olli Kallioniemi | High-throughput tissue microarray technology and applications |
| US20020142305A1 (en) | 2001-03-27 | 2002-10-03 | Koei Chin | Methods for diagnosing and monitoring ovarian cancer by screening gene copy numbers |
| JP4733644B2 (ja) * | 2003-11-26 | 2011-07-27 | ダナ−ファーバー キャンサー インスティテュート インク． | 膵臓腺癌の動物モデルおよびその使用 |
-
2005
- 2005-05-27 EP EP05804854A patent/EP1774043A4/en not_active Withdrawn
- 2005-05-27 JP JP2007515423A patent/JP2008512984A/ja active Pending
- 2005-05-27 US US11/597,825 patent/US8999633B2/en not_active Expired - Fee Related
- 2005-05-27 CA CA002568413A patent/CA2568413A1/en not_active Abandoned
- 2005-05-27 WO PCT/US2005/018850 patent/WO2005118869A2/en not_active Ceased
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