JP2008512457A - Ａ３及びａ１アデノシン受容体作用薬としてのプリン誘導体 - Google Patents

Ａ３及びａ１アデノシン受容体作用薬としてのプリン誘導体 Download PDF

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JP2008512457A
JP2008512457A JP2007531262A JP2007531262A JP2008512457A JP 2008512457 A JP2008512457 A JP 2008512457A JP 2007531262 A JP2007531262 A JP 2007531262A JP 2007531262 A JP2007531262 A JP 2007531262A JP 2008512457 A JP2008512457 A JP 2008512457A
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hydroxy
alkyl
chloro
hydrogen
compound
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JP2008512457A5 (enExample
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エイ． ジェイコブソン、ケネス
ヴィ−． ジョシ、バルチャンドラ
チリボン、スザンナ
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    • C07—ORGANIC CHEMISTRY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

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  • Heart & Thoracic Surgery (AREA)
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  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
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  • Urology & Nephrology (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Obesity (AREA)
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JP2007531262A 2004-09-09 2005-09-02 Ａ３及びａ１アデノシン受容体作用薬としてのプリン誘導体 Ceased JP2008512457A (ja)

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Application Number Priority Date Filing Date Title
US60882304P 2004-09-09 2004-09-09
PCT/US2005/031678 WO2006031505A1 (en) 2004-09-09 2005-09-02 Purine derivatives as a3 and a1 adenosine receptor agonists

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JP2012128779A Division JP2012229215A (ja) 2004-09-09 2012-06-06 Ａ３及びａ１アデノシン受容体作用薬としてのプリン誘導体

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JP2008512457A true JP2008512457A (ja) 2008-04-24
JP2008512457A5 JP2008512457A5 (enExample) 2008-08-28

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JP2012128779A Withdrawn JP2012229215A (ja) 2004-09-09 2012-06-06 Ａ３及びａ１アデノシン受容体作用薬としてのプリン誘導体

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US (1) US7825126B2 (enExample)
EP (1) EP1794162A1 (enExample)
JP (2) JP2008512457A (enExample)
KR (1) KR20070050484A (enExample)
CN (1) CN101056879B (enExample)
AU (1) AU2005285284B2 (enExample)
BR (1) BRPI0515030A (enExample)
CA (1) CA2601996A1 (enExample)
IL (1) IL181716A0 (enExample)
WO (1) WO2006031505A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011529917A (ja) * 2008-08-01 2011-12-15 アメリカ合衆国 Ａ３アデノシン受容体アンタゴニストおよびａ３アデノシン受容体部分アゴニスト
JP2014503561A (ja) * 2011-01-26 2014-02-13 北京化工大学 リボフラノシルプリン化合物、その調製方法、およびその使用
JP2024515786A (ja) * 2021-04-28 2024-04-10 アストロサイト ファーマシューティカルズ， インコーポレイテッド プリンヌクレオシド、それらの中間体、およびそれらの調製方法

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GB0500785D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
HRP20120494T1 (hr) 2006-04-21 2012-08-31 Novartis Ag Derivati purina za uporabu kao agonista adenozin a2a receptora
GB0607950D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607944D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607953D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
ES2526713T3 (es) 2006-05-23 2015-01-14 University Of Connecticut Derivados de N-metanocarba para tratar enfermedades cardiacas
US7906518B2 (en) * 2006-06-27 2011-03-15 Cbt Development Limited Therapeutic compounds
EP1889846A1 (en) 2006-07-13 2008-02-20 Novartis AG Purine derivatives as A2a agonists
WO2008023362A2 (en) * 2006-08-21 2008-02-28 Can-Fite Biopharma Ltd. Use of a combination of methotrexate and an a3ar agonist for the treatment of cancer
EP1903044A1 (en) * 2006-09-14 2008-03-26 Novartis AG Adenosine Derivatives as A2A Receptor Agonists
JP2010508835A (ja) * 2006-11-10 2010-03-25 ノバルティス アーゲー シクロペンテンジオールモノアセテート誘導体
WO2009006046A1 (en) 2007-06-29 2009-01-08 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Dendrimer conjugates of agonists and antagonists of the gpcr superfamily
NZ601866A (en) 2007-06-29 2013-12-20 Acucela Inc Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders
EP2227234B1 (en) 2007-10-15 2014-05-07 Can-Fite Biopharma Ltd. Method for inducing hepatocyte proliferation and uses thereof
AU2009231978C1 (en) 2008-03-31 2014-01-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Purine derivatives as A3 adenosine receptor- selective agonists
US8916570B2 (en) 2008-03-31 2014-12-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services A3 adenosine receptor agonists and antagonists
US9181253B2 (en) 2008-08-01 2015-11-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adenosine receptor agonists, partial agonists, and antagonists
EP2507241A1 (en) 2009-12-02 2012-10-10 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Methanocarba adenosine derivatives and dendrimer conjugates thereof
PT2539352T (pt) 2010-02-22 2018-01-03 Univ Connecticut Composições e métodos para tratar doenças cardíacas
WO2011123518A1 (en) 2010-03-31 2011-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders
EP3964507A1 (en) 2013-10-04 2022-03-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2015080940A1 (en) * 2013-11-27 2015-06-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services A3 adenosine receptor agonists
CN106456628A (zh) 2014-03-19 2017-02-22 无限药品股份有限公司 用于治疗PI3K‑γ介导的障碍的杂环化合物
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN114230571B (zh) 2015-09-14 2025-07-08 无限药品股份有限公司 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
CN109310695B (zh) * 2016-04-21 2022-04-01 阿斯特罗赛特制药公司 治疗神经和心血管病况的化合物和方法
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
KR101820909B1 (ko) * 2017-07-07 2018-01-23 퓨쳐메디신 주식회사 아데노신 유도체를 포함하는 만성신장질환 예방 및 치료용 약학적 조성물
US11839615B2 (en) 2018-02-09 2023-12-12 Astrocyte Pharmaceuticals, Inc. Compounds and methods for treating addiction and related disorders
EP3856741A4 (en) 2018-09-26 2022-06-22 Astrocyte Pharmaceuticals, Inc. POLYMORPHOUS COMPOUNDS AND USES THEREOF
EP4337646A4 (en) 2021-05-13 2025-05-21 Promega Corporation BIOLUMINESCENT DETECTION OF DNA SYNTHESIS
EP4747254A1 (en) * 2023-07-17 2026-05-27 The United States of America, as represented by the Secretary, Department of Health and Human Services <sup2/>? <sub2/>?2b?5-htserotonin receptor antagonists, pharmaceutical compositions thereof, and methods of use thereof
CN117503766B (zh) * 2024-01-04 2024-04-26 中国康复研究中心 Pld抑制剂在制备治疗脊髓损伤的药物中的用途

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WO2001051490A1 (en) * 2000-01-14 2001-07-19 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methanocarba cycloalkyl nucleoside analogues
JP2001522857A (ja) * 1997-11-08 2001-11-20 グラクソ グループ リミテッド 化合物
JP2002322193A (ja) * 2001-03-16 2002-11-08 Pfizer Prod Inc 虚血の治療のための化合物

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US6586413B2 (en) * 1999-11-05 2003-07-01 The United States Of America As Represented By The Department Of Health And Human Services Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists
US20050261237A1 (en) * 2003-04-25 2005-11-24 Boojamra Constantine G Nucleoside phosphonate analogs
US20090192077A1 (en) * 2005-04-15 2009-07-30 Shizuko Sei North-2'deoxy -methanocarbathymidines as antiviral agents for treatment of kaposi's sarcoma-associated herpes virus
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US5773423A (en) * 1993-07-13 1998-06-30 The United States Of America As Represented By The Department Of Health And Human Services A3 adenosine receptor agonists
JP2001522857A (ja) * 1997-11-08 2001-11-20 グラクソ グループ リミテッド 化合物
WO2001051490A1 (en) * 2000-01-14 2001-07-19 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methanocarba cycloalkyl nucleoside analogues
JP2002322193A (ja) * 2001-03-16 2002-11-08 Pfizer Prod Inc 虚血の治療のための化合物

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011529917A (ja) * 2008-08-01 2011-12-15 アメリカ合衆国 Ａ３アデノシン受容体アンタゴニストおよびａ３アデノシン受容体部分アゴニスト
JP2014503561A (ja) * 2011-01-26 2014-02-13 北京化工大学 リボフラノシルプリン化合物、その調製方法、およびその使用
US9493502B2 (en) 2011-01-26 2016-11-15 Beijing Kbd Pharmaceuticals Co., Ltd. Ribofuranosyl purine compounds, methods for preparing the same and use thereof
JP2018087236A (ja) * 2011-01-26 2018-06-07 北京康倍得医▲藥▼技▲術▼▲開▼▲發▼有限公司 リボフラノシルプリン化合物、その調製方法、およびその使用
JP2024515786A (ja) * 2021-04-28 2024-04-10 アストロサイト ファーマシューティカルズ， インコーポレイテッド プリンヌクレオシド、それらの中間体、およびそれらの調製方法

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CN101056879B (zh) 2011-10-05
WO2006031505A1 (en) 2006-03-23
JP2012229215A (ja) 2012-11-22
BRPI0515030A (pt) 2008-07-01
EP1794162A1 (en) 2007-06-13
US7825126B2 (en) 2010-11-02
CA2601996A1 (en) 2006-03-23
KR20070050484A (ko) 2007-05-15
AU2005285284A1 (en) 2006-03-23
CN101056879A (zh) 2007-10-17
AU2005285284B2 (en) 2011-06-02
IL181716A0 (en) 2007-07-04

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