JP2008512457A - Ａ３及びａ１アデノシン受容体作用薬としてのプリン誘導体 - Google Patents

Ａ３及びａ１アデノシン受容体作用薬としてのプリン誘導体 Download PDF

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JP2008512457A
JP2008512457A JP2007531262A JP2007531262A JP2008512457A JP 2008512457 A JP2008512457 A JP 2008512457A JP 2007531262 A JP2007531262 A JP 2007531262A JP 2007531262 A JP2007531262 A JP 2007531262A JP 2008512457 A JP2008512457 A JP 2008512457A
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hydroxy
alkyl
chloro
hydrogen
compound
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JP2008512457A5 (enExample
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エイ． ジェイコブソン、ケネス
ヴィ−． ジョシ、バルチャンドラ
チリボン、スザンナ
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    • C07—ORGANIC CHEMISTRY
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    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

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  • Diabetes (AREA)
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  • Hematology (AREA)
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JP2007531262A 2004-09-09 2005-09-02 Ａ３及びａ１アデノシン受容体作用薬としてのプリン誘導体 Ceased JP2008512457A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60882304P 2004-09-09 2004-09-09
PCT/US2005/031678 WO2006031505A1 (en) 2004-09-09 2005-09-02 Purine derivatives as a3 and a1 adenosine receptor agonists

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JP2012128779A Division JP2012229215A (ja) 2004-09-09 2012-06-06 Ａ３及びａ１アデノシン受容体作用薬としてのプリン誘導体

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JP2008512457A true JP2008512457A (ja) 2008-04-24
JP2008512457A5 JP2008512457A5 (enExample) 2008-08-28

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JP2007531262A Ceased JP2008512457A (ja) 2004-09-09 2005-09-02 Ａ３及びａ１アデノシン受容体作用薬としてのプリン誘導体
JP2012128779A Withdrawn JP2012229215A (ja) 2004-09-09 2012-06-06 Ａ３及びａ１アデノシン受容体作用薬としてのプリン誘導体

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US (1) US7825126B2 (enExample)
EP (1) EP1794162A1 (enExample)
JP (2) JP2008512457A (enExample)
KR (1) KR20070050484A (enExample)
CN (1) CN101056879B (enExample)
AU (1) AU2005285284B2 (enExample)
BR (1) BRPI0515030A (enExample)
CA (1) CA2601996A1 (enExample)
IL (1) IL181716A0 (enExample)
WO (1) WO2006031505A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011529917A (ja) * 2008-08-01 2011-12-15 アメリカ合衆国 Ａ３アデノシン受容体アンタゴニストおよびａ３アデノシン受容体部分アゴニスト
JP2014503561A (ja) * 2011-01-26 2014-02-13 北京化工大学 リボフラノシルプリン化合物、その調製方法、およびその使用
JP2024515786A (ja) * 2021-04-28 2024-04-10 アストロサイト ファーマシューティカルズ， インコーポレイテッド プリンヌクレオシド、それらの中間体、およびそれらの調製方法

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GB0500785D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
GB0607944D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607953D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
PE20080361A1 (es) * 2006-04-21 2008-06-03 Novartis Ag Compuestos derivados de purina como activadores del receptor de adenosina a2a
GB0607950D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
DK2049127T3 (en) 2006-05-23 2015-01-05 Univ Connecticut N-METHANOCARBA DERIVATIVES FOR TREATMENT OF HEART DISEASES
CA2657973A1 (en) * 2006-06-27 2008-01-03 Biovitrum Ab (Publ) Therapeutic compounds
EP1889846A1 (en) 2006-07-13 2008-02-20 Novartis AG Purine derivatives as A2a agonists
WO2008023362A2 (en) * 2006-08-21 2008-02-28 Can-Fite Biopharma Ltd. Use of a combination of methotrexate and an a3ar agonist for the treatment of cancer
EP1903044A1 (en) * 2006-09-14 2008-03-26 Novartis AG Adenosine Derivatives as A2A Receptor Agonists
MX2009004991A (es) * 2006-11-10 2009-05-20 Novartis Ag Derivados de monoacetato de ciclopenteno-diol.
RU2470910C9 (ru) 2007-06-29 2013-05-20 Акьюсела, Инк. Соединения, представляющие собой алкинилфенильные производные, для лечения офтальмических заболеваний и расстройств
EP2170401A1 (en) 2007-06-29 2010-04-07 Government of the United States of America, Represented by the Secretary, Department of Health and Human Services Dendrimer conjugates of agonists and antagonists of the gpcr superfamily
CN101820883B (zh) 2007-10-15 2013-03-20 坎-菲特生物药物有限公司 A3ar激动剂在用于制备刺激肝细胞增殖的药物中的应用
US8916570B2 (en) 2008-03-31 2014-12-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services A3 adenosine receptor agonists and antagonists
US8735407B2 (en) * 2008-03-31 2014-05-27 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Purine derivatives as A3 adenosine receptor-selective agonists
US9181253B2 (en) 2008-08-01 2015-11-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adenosine receptor agonists, partial agonists, and antagonists
EP2507241A1 (en) 2009-12-02 2012-10-10 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Methanocarba adenosine derivatives and dendrimer conjugates thereof
US8822434B2 (en) 2010-02-22 2014-09-02 The University Of Connecticut Compositions and methods to treat cardiac diseases
US20130109645A1 (en) 2010-03-31 2013-05-02 The united States of America,as represented by Secretary,Dept.,of Health and Human Services Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders
SG10201902074UA (en) 2013-10-04 2019-04-29 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof
CN110003212B (zh) * 2013-11-27 2022-12-06 美国卫生和人力服务部 A3腺苷受体激动剂
CN113616656B (zh) 2014-03-19 2023-02-17 无限药品股份有限公司 用于治疗PI3K-γ介导的障碍的杂环化合物
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
AU2016322552B2 (en) 2015-09-14 2021-03-25 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
ES2989621T3 (es) 2016-04-21 2024-11-27 Astrocyte Pharmaceuticals Inc Compuestos y métodos para el tratamiento de afecciones neurológicas y cardiovasculares
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
KR101820909B1 (ko) * 2017-07-07 2018-01-23 퓨쳐메디신 주식회사 아데노신 유도체를 포함하는 만성신장질환 예방 및 치료용 약학적 조성물
JP7311855B2 (ja) 2018-02-09 2023-07-20 アストロサイト ファーマシューティカルズ， インコーポレイテッド 嗜癖および関連する障害を処置するための化合物および方法
AU2019346585B2 (en) 2018-09-26 2025-02-27 Astrocyte Pharmaceuticals, Inc. Polymorphic compounds and uses thereof
US20220396830A1 (en) * 2021-05-13 2022-12-15 Promega Corporation Bioluminescent detection of dna synthesis
WO2025019529A1 (en) * 2023-07-17 2025-01-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services 5-ht 2b serotonin receptor antagonists, pharmaceutical compositions thereof, and methods of use thereof
CN117503766B (zh) * 2024-01-04 2024-04-26 中国康复研究中心 Pld抑制剂在制备治疗脊髓损伤的药物中的用途

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WO2001051490A1 (en) * 2000-01-14 2001-07-19 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methanocarba cycloalkyl nucleoside analogues
JP2001522857A (ja) * 1997-11-08 2001-11-20 グラクソ グループ リミテッド 化合物
JP2002322193A (ja) * 2001-03-16 2002-11-08 Pfizer Prod Inc 虚血の治療のための化合物

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WO2006113204A2 (en) * 2005-04-15 2006-10-26 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thymidine derivatives for treatmemt of kaposi's sarcoma
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JP2001522857A (ja) * 1997-11-08 2001-11-20 グラクソ グループ リミテッド 化合物
WO2001051490A1 (en) * 2000-01-14 2001-07-19 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methanocarba cycloalkyl nucleoside analogues
JP2002322193A (ja) * 2001-03-16 2002-11-08 Pfizer Prod Inc 虚血の治療のための化合物

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011529917A (ja) * 2008-08-01 2011-12-15 アメリカ合衆国 Ａ３アデノシン受容体アンタゴニストおよびａ３アデノシン受容体部分アゴニスト
JP2014503561A (ja) * 2011-01-26 2014-02-13 北京化工大学 リボフラノシルプリン化合物、その調製方法、およびその使用
US9493502B2 (en) 2011-01-26 2016-11-15 Beijing Kbd Pharmaceuticals Co., Ltd. Ribofuranosyl purine compounds, methods for preparing the same and use thereof
JP2018087236A (ja) * 2011-01-26 2018-06-07 北京康倍得医▲藥▼技▲術▼▲開▼▲發▼有限公司 リボフラノシルプリン化合物、その調製方法、およびその使用
JP2024515786A (ja) * 2021-04-28 2024-04-10 アストロサイト ファーマシューティカルズ， インコーポレイテッド プリンヌクレオシド、それらの中間体、およびそれらの調製方法

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CN101056879A (zh) 2007-10-17
US7825126B2 (en) 2010-11-02
WO2006031505A1 (en) 2006-03-23
IL181716A0 (en) 2007-07-04
BRPI0515030A (pt) 2008-07-01
AU2005285284B2 (en) 2011-06-02
AU2005285284A1 (en) 2006-03-23
KR20070050484A (ko) 2007-05-15
US20070232626A1 (en) 2007-10-04
EP1794162A1 (en) 2007-06-13
JP2012229215A (ja) 2012-11-22
CA2601996A1 (en) 2006-03-23

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