JP2008510719A - Chk1の阻害に有用な化合物 - Google Patents
Chk1の阻害に有用な化合物 Download PDFInfo
- Publication number
- JP2008510719A JP2008510719A JP2007528037A JP2007528037A JP2008510719A JP 2008510719 A JP2008510719 A JP 2008510719A JP 2007528037 A JP2007528037 A JP 2007528037A JP 2007528037 A JP2007528037 A JP 2007528037A JP 2008510719 A JP2008510719 A JP 2008510719A
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- group
- alkylene
- heteroaryl
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *c1cc(N)c(*)c(*)c1* Chemical compound *c1cc(N)c(*)c(*)c1* 0.000 description 6
- ZXLYYQUMYFHCLQ-UHFFFAOYSA-N CN(C(c1ccccc11)=O)C1=O Chemical compound CN(C(c1ccccc11)=O)C1=O ZXLYYQUMYFHCLQ-UHFFFAOYSA-N 0.000 description 1
- CAWHJQAVHZEVTJ-UHFFFAOYSA-N Cc1nccnc1 Chemical compound Cc1nccnc1 CAWHJQAVHZEVTJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60296804P | 2004-08-19 | 2004-08-19 | |
PCT/US2005/029518 WO2006021002A2 (en) | 2004-08-19 | 2005-08-18 | Compounds useful for inhibiting chk1 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2008510719A true JP2008510719A (ja) | 2008-04-10 |
JP2008510719A5 JP2008510719A5 (pt-PT) | 2008-10-02 |
Family
ID=35744692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007528037A Pending JP2008510719A (ja) | 2004-08-19 | 2005-08-18 | Chk1の阻害に有用な化合物 |
Country Status (10)
Country | Link |
---|---|
US (1) | US20080318974A1 (pt-PT) |
EP (1) | EP1778648A2 (pt-PT) |
JP (1) | JP2008510719A (pt-PT) |
KR (1) | KR20070054205A (pt-PT) |
CN (1) | CN101115727A (pt-PT) |
AU (1) | AU2005272586A1 (pt-PT) |
BR (1) | BRPI0514466A (pt-PT) |
CA (1) | CA2577880A1 (pt-PT) |
MX (1) | MX2007002040A (pt-PT) |
WO (1) | WO2006021002A2 (pt-PT) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201008005D0 (en) | 2010-05-13 | 2010-06-30 | Sentinel Oncology Ltd | Pharmaceutical compounds |
GB201119799D0 (en) | 2011-11-16 | 2011-12-28 | Sentinel Oncology Ltd | Pharmaceutical compounds |
GB201402277D0 (en) | 2014-02-10 | 2014-03-26 | Sentinel Oncology Ltd | Pharmaceutical compounds |
AU2015277786B2 (en) | 2014-06-19 | 2019-04-18 | Takeda Pharmaceutical Company Limited | Heteroaryl compounds for kinase inhibition |
CN104628659A (zh) * | 2015-01-27 | 2015-05-20 | 广西师范大学 | 具有抗肿瘤作用的吡嗪-芳基脲衍生物及其制备方法与应用 |
EP3402532B1 (en) * | 2016-01-11 | 2022-04-13 | Celator Pharmaceuticals, Inc. | Inhibiting ataxia telangiectasia and rad3-related protein (atr) |
WO2017132928A1 (en) | 2016-02-04 | 2017-08-10 | Pharmaengine, Inc. | 3,5-disubstituted pyrazoles useful as checkpoint kinase 1 (chk1) inhibitors, and their preparations and applications |
US20200108074A1 (en) | 2017-03-31 | 2020-04-09 | Seattle Genetics, Inc. | Combinations of chk1- and wee1- inhibitors |
WO2021104461A1 (zh) * | 2019-11-29 | 2021-06-03 | 南京明德新药研发有限公司 | 二氮杂吲哚类衍生物及其作为Chk1抑制剂的应用 |
WO2021119236A1 (en) | 2019-12-10 | 2021-06-17 | Seagen Inc. | Preparation of a chk1 inhibitor compound |
GB202107924D0 (en) | 2021-06-03 | 2021-07-21 | Sentinel Oncology Ltd | A pharmaceutical salt |
GB202107932D0 (en) | 2021-06-03 | 2021-07-21 | Sentinel Oncology Ltd | Preparation of a CHK1 Inhibitor Compound |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB921682A (en) * | 1959-08-14 | 1963-03-20 | Geigy Ag J R | New diphenyl urea derivatives, processes for their production and compositions containing same |
JPS4828897B1 (pt-PT) * | 1969-01-31 | 1973-09-05 | ||
US4071524A (en) * | 1976-11-08 | 1978-01-31 | Riker Laboratories, Inc. | Derivatives of urea |
JP2001526258A (ja) * | 1997-12-22 | 2001-12-18 | バイエル コーポレイション | 対称および非対称置換ジフェニル尿素を用いるrafキナーゼの阻害 |
WO2003093297A2 (en) * | 2002-05-03 | 2003-11-13 | Exelixis, Inc. | Protein kinase modulators and methods of use |
JP2004523568A (ja) * | 2001-03-02 | 2004-08-05 | アイコス コーポレイション | 放射線増感剤および化学増感剤としてのアリールおよびヘテロアリール尿素Chk1阻害剤の使用 |
JP2007519609A (ja) * | 2003-09-17 | 2007-07-19 | アイコス コーポレイション | 細胞増殖を制御するためのchk1インヒビターの使用 |
JP2008504283A (ja) * | 2004-06-25 | 2008-02-14 | イコス・コーポレイション | Chk1の阻害に有用なビスアリール尿素誘導体 |
JP2008505112A (ja) * | 2004-07-02 | 2008-02-21 | イコス・コーポレイション | Chk1の阻害に有用な化合物 |
-
2005
- 2005-08-18 WO PCT/US2005/029518 patent/WO2006021002A2/en active Application Filing
- 2005-08-18 US US11/659,389 patent/US20080318974A1/en not_active Abandoned
- 2005-08-18 AU AU2005272586A patent/AU2005272586A1/en not_active Abandoned
- 2005-08-18 JP JP2007528037A patent/JP2008510719A/ja active Pending
- 2005-08-18 BR BRPI0514466-3A patent/BRPI0514466A/pt not_active IP Right Cessation
- 2005-08-18 KR KR1020077006216A patent/KR20070054205A/ko not_active Application Discontinuation
- 2005-08-18 CA CA002577880A patent/CA2577880A1/en not_active Abandoned
- 2005-08-18 CN CNA2005800353820A patent/CN101115727A/zh active Pending
- 2005-08-18 EP EP05810303A patent/EP1778648A2/en not_active Withdrawn
- 2005-08-18 MX MX2007002040A patent/MX2007002040A/es not_active Application Discontinuation
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB921682A (en) * | 1959-08-14 | 1963-03-20 | Geigy Ag J R | New diphenyl urea derivatives, processes for their production and compositions containing same |
JPS4828897B1 (pt-PT) * | 1969-01-31 | 1973-09-05 | ||
US4071524A (en) * | 1976-11-08 | 1978-01-31 | Riker Laboratories, Inc. | Derivatives of urea |
JP2001526258A (ja) * | 1997-12-22 | 2001-12-18 | バイエル コーポレイション | 対称および非対称置換ジフェニル尿素を用いるrafキナーゼの阻害 |
JP2004523568A (ja) * | 2001-03-02 | 2004-08-05 | アイコス コーポレイション | 放射線増感剤および化学増感剤としてのアリールおよびヘテロアリール尿素Chk1阻害剤の使用 |
WO2003093297A2 (en) * | 2002-05-03 | 2003-11-13 | Exelixis, Inc. | Protein kinase modulators and methods of use |
JP2007519609A (ja) * | 2003-09-17 | 2007-07-19 | アイコス コーポレイション | 細胞増殖を制御するためのchk1インヒビターの使用 |
JP2008504283A (ja) * | 2004-06-25 | 2008-02-14 | イコス・コーポレイション | Chk1の阻害に有用なビスアリール尿素誘導体 |
JP2008505112A (ja) * | 2004-07-02 | 2008-02-21 | イコス・コーポレイション | Chk1の阻害に有用な化合物 |
Also Published As
Publication number | Publication date |
---|---|
AU2005272586A1 (en) | 2006-02-23 |
BRPI0514466A (pt) | 2008-06-10 |
MX2007002040A (es) | 2008-01-11 |
US20080318974A1 (en) | 2008-12-25 |
CN101115727A (zh) | 2008-01-30 |
EP1778648A2 (en) | 2007-05-02 |
KR20070054205A (ko) | 2007-05-28 |
WO2006021002A3 (en) | 2006-04-20 |
CA2577880A1 (en) | 2006-02-23 |
WO2006021002A2 (en) | 2006-02-23 |
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JP5117374B2 (ja) | Chk1阻害に有用なヘテロアリール尿素誘導体 | |
JP4222833B2 (ja) | 放射線増感剤および化学増感剤としてのアリールおよびヘテロアリール尿素Chk1阻害剤の使用 | |
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