JP2008509889A5 - - Google Patents

Info

Publication number

JP2008509889A5

JP2008509889A5 JP2007519454A JP2007519454A JP2008509889A5 JP 2008509889 A5 JP2008509889 A5 JP 2008509889A5 JP 2007519454 A JP2007519454 A JP 2007519454A JP 2007519454 A JP2007519454 A JP 2007519454A JP 2008509889 A5 JP2008509889 A5 JP 2008509889A5

Authority

JP

Japan

Prior art keywords

interferon

polyol

conjugate

moiety

composition

Prior art date

2005-06-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 229940079322 interferon Drugs 0.000 claims 22
• 238000000034 method Methods 0.000 claims 22
• 150000003077 polyols Chemical group 0.000 claims 18
• 239000000203 mixture Substances 0.000 claims 15
• 102000014150 Interferons Human genes 0.000 claims 11
• 108010050904 Interferons Proteins 0.000 claims 11
• 108010047761 Interferon-alpha Proteins 0.000 claims 9
• 102000006992 Interferon-alpha Human genes 0.000 claims 9
• 101000959820 Homo sapiens Interferon alpha-1/13 Proteins 0.000 claims 8
• 102100040019 Interferon alpha-1/13 Human genes 0.000 claims 8
• 229920005862 polyol Polymers 0.000 claims 6
• 108010002492 human interferon alfa-1b Proteins 0.000 claims 5
• 102000000707 human interferon alfa-1b Human genes 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 4
• 210000004027 cell Anatomy 0.000 claims 4
• 239000012539 chromatography resin Substances 0.000 claims 4
• 239000012634 fragment Substances 0.000 claims 4
• 125000003827 glycol group Chemical group 0.000 claims 4
• 238000001542 size-exclusion chromatography Methods 0.000 claims 4
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 3
• 206010028980 Neoplasm Diseases 0.000 claims 3
• 208000036142 Viral infection Diseases 0.000 claims 3
• 201000011510 cancer Diseases 0.000 claims 3
• 238000004191 hydrophobic interaction chromatography Methods 0.000 claims 3
• 230000009385 viral infection Effects 0.000 claims 3
• 229920000936 Agarose Polymers 0.000 claims 2
• 208000035143 Bacterial infection Diseases 0.000 claims 2
• 239000002202 Polyethylene glycol Substances 0.000 claims 2
• 208000022362 bacterial infectious disease Diseases 0.000 claims 2
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
• 208000027866 inflammatory disease Diseases 0.000 claims 2
• -1 maleimide polyol Chemical class 0.000 claims 2
• 230000001404 mediated effect Effects 0.000 claims 2
• 230000035772 mutation Effects 0.000 claims 2
• 229920001515 polyalkylene glycol Polymers 0.000 claims 2
• 229920001223 polyethylene glycol Polymers 0.000 claims 2
• 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 201000003883 Cystic fibrosis Diseases 0.000 claims 1
• 229920002307 Dextran Polymers 0.000 claims 1
• 208000031886 HIV Infections Diseases 0.000 claims 1
• 208000037357 HIV infectious disease Diseases 0.000 claims 1
• 208000005176 Hepatitis C Diseases 0.000 claims 1
• 241000238631 Hexapoda Species 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
• 206010025323 Lymphomas Diseases 0.000 claims 1
• 241001465754 Metazoa Species 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 235000001014 amino acid Nutrition 0.000 claims 1
• 210000004102 animal cell Anatomy 0.000 claims 1
• 206010003246 arthritis Diseases 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 230000001580 bacterial effect Effects 0.000 claims 1
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 125000002228 disulfide group Chemical group 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 230000002538 fungal effect Effects 0.000 claims 1
• 201000009277 hairy cell leukemia Diseases 0.000 claims 1
• 208000006454 hepatitis Diseases 0.000 claims 1
• 231100000283 hepatitis Toxicity 0.000 claims 1
• 208000010710 hepatitis C virus infection Diseases 0.000 claims 1
• 210000005260 human cell Anatomy 0.000 claims 1
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 201000007270 liver cancer Diseases 0.000 claims 1
• 208000014018 liver neoplasm Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 201000000050 myeloid neoplasm Diseases 0.000 claims 1
• 239000008177 pharmaceutical agent Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 108091033319 polynucleotide Proteins 0.000 claims 1
• 102000040430 polynucleotide Human genes 0.000 claims 1
• 239000002157 polynucleotide Substances 0.000 claims 1
• 239000011347 resin Substances 0.000 claims 1
• 229920005989 resin Polymers 0.000 claims 1
• 230000009261 transgenic effect Effects 0.000 claims 1
• 238000013060 ultrafiltration and diafiltration Methods 0.000 claims 1
• 210000005253 yeast cell Anatomy 0.000 claims 1