JP2008508287A - ５’−メチルチオアデノシンホスホリラーゼ及び５’メチルチオアデノシン／ｓ−アデノシルホモシステインヌクレオシダーゼの阻害剤 - Google Patents
５’−メチルチオアデノシンホスホリラーゼ及び５’メチルチオアデノシン／ｓ−アデノシルホモシステインヌクレオシダーゼの阻害剤 Download PDFInfo
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- JP2008508287A JP2008508287A JP2007523709A JP2007523709A JP2008508287A JP 2008508287 A JP2008508287 A JP 2008508287A JP 2007523709 A JP2007523709 A JP 2007523709A JP 2007523709 A JP2007523709 A JP 2007523709A JP 2008508287 A JP2008508287 A JP 2008508287A
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Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US59144204P | 2004-07-27 | 2004-07-27 | |
| US61912604P | 2004-10-15 | 2004-10-15 | |
| PCT/US2005/026419 WO2006014913A2 (en) | 2004-07-27 | 2005-07-26 | Inhibitors of 5'-methylthioadenosine phosphorylase and 5'methylthioadenosine/s-adenosylhomocysteine nucleosidase |
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| JP2008508287A true JP2008508287A (ja) | 2008-03-21 |
| JP2008508287A5 JP2008508287A5 (enExample) | 2008-07-31 |
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| EP (1) | EP1771452A4 (enExample) |
| JP (1) | JP2008508287A (enExample) |
| AU (1) | AU2005269541A1 (enExample) |
| WO (1) | WO2006014913A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2012533538A (ja) * | 2009-07-17 | 2012-12-27 | アルバート・アインシュタイン・カレッジ・オブ・メディシン・オブ・イエシヴァ・ユニバーシティー | ５’−メチルチオアデノシンホスホリラーゼ及びヌクレオシダーゼの３−ヒドロキシピロリジン阻害剤 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5985848A (en) | 1997-10-14 | 1999-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of nucleoside metabolism |
| ES2625636T3 (es) | 1999-04-08 | 2017-07-20 | Victoria Link Limited | Proceso para preparar inhibidores del metabolismo de nucleósidos |
| CN100379750C (zh) | 2002-08-21 | 2008-04-09 | 阿尔伯爱因斯坦医科叶希瓦大学 | 核苷磷酸化酶和核苷酶抑制剂 |
| NZ523970A (en) | 2003-02-04 | 2005-02-25 | Ind Res Ltd | Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases |
| NZ533360A (en) | 2004-06-04 | 2007-02-23 | Ind Res Ltd | Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds |
| WO2007016291A2 (en) * | 2005-07-27 | 2007-02-08 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases |
| CA2643056A1 (en) * | 2006-02-24 | 2007-08-30 | Industrial Research Limited | Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases |
| JP2009527550A (ja) * | 2006-02-24 | 2009-07-30 | アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ | 癌を処置する方法 |
| WO2008030118A1 (en) | 2006-09-07 | 2008-03-13 | Industrial Research Limited | Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase |
| US8853224B2 (en) | 2006-09-07 | 2014-10-07 | Industrial Research Limited | Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases |
| AU2007300624A1 (en) * | 2006-09-26 | 2008-04-03 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state structure of human 5'-methylthioadenosine phosphorylase |
| KR20090101278A (ko) | 2006-12-22 | 2009-09-24 | 인더스트리얼 리서치 리미티드 | 누클레오시다제 및 포스포릴라제 억제제의 아제티딘 유사체 |
| US20110190265A1 (en) * | 2008-09-22 | 2011-08-04 | Schramm Vern L | Methods and compositions for treating bacterial infections by inhibiting quorum sensing |
| US9102974B2 (en) * | 2010-09-29 | 2015-08-11 | Florida State University Research Foundation, Inc. | Semi-synthetic quorum sensors |
| CN103193781B (zh) * | 2013-04-01 | 2015-12-23 | 济南大学 | 一种sahn酶蛋白的特异性抑制化合物及其合成方法 |
| WO2017062421A1 (en) | 2015-10-05 | 2017-04-13 | The University Of North Carolina At Chapel Hill | Use of mtap inhibitors for the treatment of lung disease |
| CN116478172B (zh) * | 2023-06-20 | 2023-09-05 | 英矽智能科技(上海)有限公司 | 吡咯并[3,2-d]嘧啶类化合物及其应用 |
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|---|---|---|---|---|
| WO2003080620A1 (en) * | 2002-03-25 | 2003-10-02 | Industrial Research Limited | Inhibitors of nucleoside phosphorylases and nucleosidases |
| WO2004018496A1 (en) * | 2002-08-21 | 2004-03-04 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of nucleoside phosphorylases and nucleosidases |
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| US6458799B1 (en) * | 2000-08-31 | 2002-10-01 | Biocryst Pharmaceuticals, Inc. | Deazaguanine analog, preparation thereof and use thereof |
| US7572799B2 (en) * | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
| US20090227562A1 (en) * | 2004-08-10 | 2009-09-10 | Pfizer Inc. | Combination of a Selective Noradrenaline Reuptake Unhibitor and a PDEV Inhibitor |
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2005
- 2005-07-26 WO PCT/US2005/026419 patent/WO2006014913A2/en not_active Ceased
- 2005-07-26 AU AU2005269541A patent/AU2005269541A1/en not_active Abandoned
- 2005-07-26 JP JP2007523709A patent/JP2008508287A/ja active Pending
- 2005-07-26 EP EP05775512A patent/EP1771452A4/en not_active Withdrawn
- 2005-07-26 US US11/658,794 patent/US20090012104A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2003080620A1 (en) * | 2002-03-25 | 2003-10-02 | Industrial Research Limited | Inhibitors of nucleoside phosphorylases and nucleosidases |
| WO2004018496A1 (en) * | 2002-08-21 | 2004-03-04 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of nucleoside phosphorylases and nucleosidases |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012533538A (ja) * | 2009-07-17 | 2012-12-27 | アルバート・アインシュタイン・カレッジ・オブ・メディシン・オブ・イエシヴァ・ユニバーシティー | ５’−メチルチオアデノシンホスホリラーゼ及びヌクレオシダーゼの３−ヒドロキシピロリジン阻害剤 |
Also Published As
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| AU2005269541A2 (en) | 2006-02-09 |
| WO2006014913A3 (en) | 2006-12-14 |
| AU2005269541A1 (en) | 2006-02-09 |
| EP1771452A4 (en) | 2009-07-15 |
| WO2006014913A2 (en) | 2006-02-09 |
| US20090012104A1 (en) | 2009-01-08 |
| EP1771452A2 (en) | 2007-04-11 |
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