JP2008508054A5 - - Google Patents

Claims (25)

a. A body member comprising a material selected from the group consisting of a metallic material and a pseudo-metallic material and having a first surface, a second surface, and a thickness intermediate between the first surface and the second surface;
b. A plurality of enclosures disposed completely within the thickness of the body member;
c. At least one opening passing through at least one of the first surface and the second surface and communicating with one of the plurality of enclosure chambers;
d. A drug-releasing medical device, comprising: at least one pharmacologically active agent disposed inside the plurality of enclosure chambers and releasable through the at least one opening.   The medical device according to claim 1, wherein the main body member further includes a thin metallic film.   The material of the main body member is titanium, vanadium, aluminum, nickel, tantalum, zirconium, chromium, silver, gold, silicon, magnesium, niobium, scandium, platinum, cobalt, palladium, manganese, molybdenum, and alloys thereof, cobalt chromium 2. The drug release medical device according to claim 1, wherein the device is made of a metal material selected from the group consisting of an alloy, stainless steel, and nickel titanium alloy.   The drug release medical device according to claim 1, further comprising a biocompatible polymer covering the at least one opening of a plurality of openings.   The apparatus of claim 1, further comprising a plurality of openings patterned in the body member for directional release of the at least one pharmacologically active agent from a proximal end and a distal end of the body member. 2. A medical release medical device according to 2.   The plurality of openings around the at least one of the longitudinal axis and the circumferential axis of the device, such that the plurality of openings provide different drug releases along at least one of the longitudinal axis and the circumferential axis of the body member. The medical-release medical device according to claim 1, wherein the medical-release medical device is disposed on the medical device.   7. The drug release medical device of claim 6, wherein the plurality of openings have different opening sizes sufficient to provide different drug release rates. The body member further comprises a tubular member, the first surface further comprises a luminal surface of the tubular member, the second surface further comprises an antiluminal surface of the tubular member, and the at least one of a plurality of openings. The medical-release medical device according to claim 1, wherein one opening passes through at least one of the luminal surface and the anti-luminal surface of the tubular member.
Medical device.   The plurality of containment chambers are substantially uniformly distributed about a circumferential axis and a longitudinal axis of the tubular member, and the at least one opening is formed on the anti-luminal surface and the luminal surface of the tubular member The drug release medical device according to claim 1, wherein the device is in communication with at least one.   The drug release medical device according to claim 1, further comprising a polymer carrier of the at least one pharmacologically active agent.   The pharmaceutical release medical device of claim 1, further comprising a polymeric material that at least partially occludes the at least one opening.   The body member further comprises at least two material layers, a first layer forming the first surface and a second layer forming the second surface, the at least two material layers being associated with each other at an interval. The medical device according to claim 1, wherein the plurality of enclosing chambers are formed between the associated regions of the at least two material layers.   The plurality of containment chambers have at least a lateral surface and a top or bottom surface of each containment chamber by a recess in the first layer of material and a second layer of material associated over the first material layer. 13. The pharmaceutical release medical device according to claim 12, defined on one side, thereby enclosing each of the plurality of enclosure chambers. A method of making a drug release device comprising:
a. Providing a first layer and a second layer of biocompatible material;
b. Associating the first layer and the second layer to define a plurality of internal chambers intermediate the first layer and the second layer;
c. Providing at least one opening that passes through at least one of the first layer and the second layer and communicates with at least one of the plurality of internal chambers;
d. Loading at least one pharmacologically active agent into at least one of the plurality of internal chambers in sufficient form to be eluteable through the at least one opening.   The method of claim 14, wherein step (a) further comprises forming the first layer and the second layer of biocompatible material by a vacuum deposition process.   The first layer and the second layer of biocompatible material are titanium, vanadium, aluminum, nickel, tantalum, zirconium, chromium, silver, gold, silicon, magnesium, niobium, scandium, platinum, cobalt, palladium, manganese, 16. A metal or pseudometal selected from the group consisting of molybdenum and its alloys, cobalt chrome alloys, stainless steel, and nickel titanium alloys, ceramics, biocompatible polymers, and carbon fiber matrices. The method described in 1.   The plurality of internal chambers are partially defined in the first layer of vacuum deposition material, and the second layer of vacuum deposition material is associated with the first layer of vacuum deposition material. The method according to claim 14.   The method of claim 14, further comprising providing a sacrificial material between the first layer and the second layer of biocompatible material.   19. The method of claim 18, further comprising patterning a vacuum deposited sacrificial material prior to depositing the second layer of biocompatible material thereon.   The method further comprises adding a diffusion barrier between the first layer of biocompatible material and patterning the sacrificial material prior to depositing the second layer of biocompatible material thereon. 18. The method according to 18.   21. The method of claim 20, further comprising adding a diffusion barrier between the sacrificial material and the second layer of biocompatible material.   Removing the sacrificial material through the at least one opening passing through at least one of the first layer and the second layer and communicating with at least one of the plurality of internal chambers of biocompatible material. The method according to claim 18, wherein:   The method further comprises removing the sacrificial material through the at least one opening that passes through at least one of the first layer and the second layer and communicates with at least one of the plurality of internal chambers. The method of claim 21.   The method further comprises removing the diffusion barrier through the at least one opening that passes through at least one of the first layer and the second layer and communicates with at least one of the plurality of internal chambers. The method of claim 22.   24. The method of claim 23, wherein the step of removing the diffusion barrier further comprises etching the diffusion barrier.