CN116135177A - Degradable self-fixing preperitoneal patch - Google Patents
Degradable self-fixing preperitoneal patch Download PDFInfo
- Publication number
- CN116135177A CN116135177A CN202310155156.6A CN202310155156A CN116135177A CN 116135177 A CN116135177 A CN 116135177A CN 202310155156 A CN202310155156 A CN 202310155156A CN 116135177 A CN116135177 A CN 116135177A
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- Prior art keywords
- patch
- self
- fixating
- preperitoneal
- shape
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 229920002101 Chitin Polymers 0.000 claims abstract description 25
- 239000000835 fiber Substances 0.000 claims abstract description 24
- 239000002121 nanofiber Substances 0.000 claims abstract description 18
- 102000008186 Collagen Human genes 0.000 claims abstract description 16
- 108010035532 Collagen Proteins 0.000 claims abstract description 16
- 229920001436 collagen Polymers 0.000 claims abstract description 16
- 239000002131 composite material Substances 0.000 claims abstract description 16
- 229920001661 Chitosan Polymers 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims description 8
- 238000009954 braiding Methods 0.000 claims description 5
- 238000009940 knitting Methods 0.000 claims description 3
- 210000004303 peritoneum Anatomy 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 238000009941 weaving Methods 0.000 claims description 3
- 238000009945 crocheting Methods 0.000 claims description 2
- 238000004026 adhesive bonding Methods 0.000 claims 1
- 238000007493 shaping process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 14
- 230000035807 sensation Effects 0.000 abstract description 9
- 210000001835 viscera Anatomy 0.000 abstract description 4
- 208000015181 infectious disease Diseases 0.000 abstract description 3
- 230000006872 improvement Effects 0.000 description 10
- 239000010410 layer Substances 0.000 description 10
- 230000015556 catabolic process Effects 0.000 description 5
- 238000006731 degradation reaction Methods 0.000 description 5
- 210000004379 membrane Anatomy 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- -1 polypropylene Polymers 0.000 description 5
- 239000004743 Polypropylene Substances 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 4
- 230000001070 adhesive effect Effects 0.000 description 4
- 238000004873 anchoring Methods 0.000 description 4
- 229920001155 polypropylene Polymers 0.000 description 4
- 239000002344 surface layer Substances 0.000 description 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- 206010019909 Hernia Diseases 0.000 description 2
- 208000004550 Postoperative Pain Diseases 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- PTHLSIBOMNYSIS-UHFFFAOYSA-N 5-(4-aminophenyl)-8-chloro-3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol Chemical compound C1N(C)CCC2=CC(Cl)=C(O)C=C2C1C1=CC=C(N)C=C1 PTHLSIBOMNYSIS-UHFFFAOYSA-N 0.000 description 1
- 206010060954 Abdominal Hernia Diseases 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001523 electrospinning Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003195 fascia Anatomy 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000004633 polyglycolic acid Substances 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000009958 sewing Methods 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
- A61F2002/0068—Implantable repair or support meshes, e.g. hernia meshes having a special mesh pattern
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to a decomposable self-fixing prepupum patch which comprises a mesh structure and a fixing structure arranged on the lower surface of the mesh structure, and is characterized in that the mesh structure is made of a slow release wire, the slow release wire comprises a chitin-based fiber shell and a chitosan collagen composite nanofiber inner core, a plurality of slow release cavities are arranged on the chitin-based fiber shell and penetrate through the chitin-based fiber shell, the whole patch is degradable and foreign body sensation is reduced by selecting the material of the patch, and the patch structure is designed to prevent the patch from moving or adhering with viscera, avoid infection and secondary operation and further reduce foreign body sensation of a patient.
Description
The invention relates to the technical field of medical materials, in particular to a decomposable self-fixing preperitoneal patch.
Background
The traditional treatment method for hernia is suture operation, namely surrounding tissues, muscles, aponeurosis and fascia are forced to be drawn together, and the defect is sutured, but the method has serious postoperative pain and slow recovery.
The treatment method is developed to the current state that the patch is usually adopted for repairing, namely tension-free repairing, the method can relieve postoperative pain and has the advantages of quick recovery and low recurrence rate, the patch is usually prepared from artificially synthesized high polymer materials, and the current repairing materials used in medicine can be divided into four main types: the first type is a non-absorbable polyester patch, a polypropylene patch and a puffed polytetrafluoroethylene patch; the second type is absorbable polyglycolic acid patch, polylactic acid glycolic acid patch and novel decellularized cell matrix (acel lulart i ssuematrix, ACTM) biological materials which can be degraded in human body, but the degradation time cannot be controlled, and the biological materials cannot be independently used as permanent repair materials for abdominal hernia; the third class is composite patches.
The existing patch is not placed in the abdominal cavity but placed on the peritoneum during operation, and the patch is unreasonable in structure, so that foreign body sensation can be brought to a human body, the patch moves or is adhered with viscera, a patient needs to take out the patch through secondary operation, secondary injury is brought to the patient, and meanwhile, most of patches made of common materials are not taken out and left in the body normally and cannot be decomposed.
The multilayer composite tissue repair patch of CN111840648A and a preparation method thereof comprise a nanofiber membrane, a woven mesh and an adhesive material, wherein the adhesive material is positioned between the nanofiber membrane and the woven mesh and is embedded into pores of the nanofiber membrane and the woven mesh; the adhesive material comprises hydrophilic natural substances and/or derivatives thereof which are modified by a cross-linking agent; the nanofiber membrane is combined with the woven mesh through the adhesive material, the peeling strength between the nanofiber membrane and the woven mesh is 20-75cN/mm, but the problems that the patch is not firmly placed, is easy to fall off, has foreign body sensation after operation and the like exist in use.
As in CN106923930B, a patch based on novel braiding technology and shape and its braiding method, the patch comprises at least two layers; at least two layers are a net surface layer woven by wires made of polypropylene material and a first degradation layer made of degradable material; the wire is provided with an anchoring structure for anchoring in biological tissues, and the anchoring structure is formed on the wire through an incision and is arranged on the lower surface of the net surface layer; the degradation layer is fixed on the lower surface of the net surface layer. Although the self-fixing effect is considered, the anchoring structure is made of polypropylene and is not degradable, and a strong foreign body sensation exists after operation.
Disclosure of Invention
The invention aims to design a decomposable self-fixing preperitoneal patch so as to solve the technical problems.
The specific technical scheme of the invention is as follows: the utility model provides a patch before degradable self-fixation's peritoneum, includes net piece structure and sets up the fixed knot who is in net piece structure lower surface constructs, its characterized in that, net piece structure is made by the slow-release line, the slow-release line includes chitin-based fiber shell and chitosan/collagen composite nanofiber inner core, be equipped with a plurality of slow-release chamber on the chitin-based fiber shell, the slow-release chamber run through in chitin-based fiber shell, and make with the chitosan/collagen composite nanofiber inner core part that the chitin-based fiber shell that runs through the position exposes.
As an improvement, the chitin-based fiber outer shell 6 is closely attached to the chitosan collagen composite nanofiber inner core 7.
As a further improvement, the mesh structure is made of slow release threads through braiding, weaving, knitting or crocheting processes.
As a further improvement, the shape of the slow release cavity comprises a cylinder, a cone, a round table, a cube and a torus.
As a further improvement, the fixing structure is fixedly connected with the net sheet structure, and the fixing connection comprises bonding and sewing.
As a further improvement, the fixing structure 2 comprises a plurality of inserts 3, the inserts 3 are made of collagen through molding, the inserts 3 are uniformly distributed on the lower surface of the net structure 1, and the inserts 3 have the same length.
As a further improvement, the shape of the insert includes barb-shape, wedge-shape, hook-shape, thorn-shape, etc.
As a further improvement, the insert is barb-shaped in shape.
As a further improvement, the tip portions of the barb-shaped inserts are aligned in the same direction.
As a further improvement, the shape of the mesh structure comprises rectangular, circular and elliptical.
The degradable self-fixing preperitoneal patch has the beneficial effects that the patch is wholly degradable and reduces foreign body sensation by selecting the material of the patch, and the patch structure is designed to prevent the patch from moving or adhering to viscera, avoid infection and secondary operation and further reduce foreign body sensation of patients.
Drawings
FIG. 1 is a top view of a detachable self-fixating preperitoneal patch of the present invention;
FIG. 2 is a perspective view of a detachable self-fixating preperitoneal patch of the present invention;
FIG. 3 is a cross-sectional view of a sustained release line of a self-fixating preperitoneal patch of the present invention;
FIG. 4 is a front view of a sustained release line of a self-fixating, dissolvable, preperitoneal patch of the present invention;
FIG. 5 is a cross-sectional view of a slow release line in some embodiments of a self-fixating, dissolvable, preperitoneal patch of the present invention;
reference numerals illustrate:
1. the novel chitosan/collagen composite nanofiber comprises a net piece structure 2, a fixing structure 3, an insert 4, a slow release wire 5, a slow release cavity 6, a chitin-based fiber shell 7 and a chitosan/collagen composite nanofiber inner core.
Detailed Description
Embodiments of the present invention will be described in detail with reference to examples.
Materials that may be used in the present application include: for example, the application number is CN107029285B, the name is an absorbable chitin-based composite patch and application thereof, the selected chitin-based fiber is produced by Qingdao institute of biotechnology, wherein the molar percentage of acyl groups in the chitin-based fiber is more than or equal to 70%, the molar percentage of hydrophilic groups in the chitin-based fiber is less than 30%, the degradation time of the chitin-based fiber is more than 36 weeks, the application number is CN200610116988, the name is collagen and chitosan composite nanofiber electrospinning preparation method is suitable for the field of drug slow release, and a slow release cavity is designed by designing the structures of the two materials so as to further control the degradation time.
As shown in fig. 1, the decomposable self-fixing preplan patch comprises a mesh structure and a fixing structure arranged on the lower surface of the mesh structure 1, wherein the mesh structure 1 is made of a slow release wire 4, the slow release wire 4 is required to be made through a braiding, weaving, knitting or hooking process, preferably, the mesh structure 1 is made of the slow release wire 4 in the embodiment, the mesh structure 1 is in a rectangular shape, a round shape and an elliptic shape, preferably, the mesh structure 1 is in a rectangular shape, as shown in fig. 3 and 4, the slow release wire 4 comprises a chitin-based fiber shell 6 and a chitosan collagen composite nanofiber inner core 7, the chitin-based fiber shell 6 is tightly attached to the chitosan collagen composite nanofiber inner core 7, a plurality of slow release cavities 5 are arranged on the chitin-based fiber shell 6, the slow release cavities 5 penetrate through the chitin-based fiber shell 6, the slow release cavities 5 enable the chitosan collagen composite nanofiber inner core 7 connected with the chitin-shell 6 at the penetrating position to be exposed, and the slow release cavities are in a cylindrical shape, and comprise circular cone-shaped slow release cavities, and preferably have a circular cone shape;
as shown in fig. 2, the fixing structure 2 is further disposed on the lower surface of the mesh structure 1, the fixing connection includes bonding and stitching, preferably, in this embodiment, the fixing structure 2 includes a plurality of inserts 3, the inserts 3 are made of collagen by molding, the inserts 3 are uniformly distributed on the lower surface of the mesh structure 1, the lengths of the inserts 3 are the same, the shapes of the inserts 3 include barb shapes, wedge shapes, hook shapes, thorn shapes, and the like, preferably, the shapes of the inserts 3 in this embodiment are barb shapes, and the tip portions of the barb-shaped inserts 3 are arranged in the same direction (the inserts 3 of the covered portion are not shown in the figure).
In some specific embodiments, referring to fig. 5, another slow release wire is provided, where the slow release cavity of the slow release wire is in the shape of a torus, and is disposed in the shell 6 of the chitin-based fiber layer, and holes are uniformly formed at the connection between the surface of the shell 6 of the chitin-based fiber layer and the slow release cavity, and it is noted that the holes include a circle, a rectangle, and an ellipse.
It should be noted that the self-fixating, decomposable pre-peritoneal patch of the present invention is useful for the repair of clinical hernia patches.
The invention adopts the slow release line comprising the chitin-based fiber layer of the outer layer and the chitosan/collagen composite nanofiber layer of the inner layer as the material of the net piece structure part of the patch, so that the whole degradable patch is degradable, thereby eliminating the foreign body sensation caused by incapability of decomposing by polypropylene in the prior art, preventing the patch from moving or adhering to viscera by redesigning the structure, avoiding infection and secondary operation, and further reducing the foreign body sensation of a patient.
The above examples are merely illustrative of the preferred embodiments of the present invention and are not intended to limit the scope of the present invention, and various modifications and improvements made by those skilled in the art to the technical solution of the present invention should fall within the scope of protection defined by the claims of the present invention without departing from the spirit of the present invention.
Claims (10)
1. The utility model provides a patch before degradable self-fixing's peritoneum, includes net piece structure (1) and sets up fixed knot constructs (2) of net piece structure (1) lower surface, a serial communication port, net piece structure (1) are made by slow-release line (4), slow-release line (4) include chitin-based fiber shell (6) and chitosan collagen composite nanofiber inner core (7), be equipped with a plurality of slow-release chamber (5) on chitin-based fiber shell (6), slow-release chamber (5) run through in chitin-based fiber shell (6).
2. A decomposable self-fixating preperitoneal patch according to claim 1, wherein the chitin-based fiber shell (6) is in close fit with the chitosan collagen composite nanofiber core (7).
3. A decomposable self-fixating preperitoneal patch according to claim 1, wherein the mesh structure (1) is made of slow release wire (4) by braiding, weaving, knitting or crocheting process.
4. The self-fixating, decomposable pre-peritoneal patch of claim 1, wherein the slow release lumen comprises a cylinder, cone, truncated cone, cube, torus shape.
5. A detachable self-fastening prepuppatch according to claim 1, wherein the fastening structure (2) is fixedly connected to the mesh structure, the fastening connection comprising adhesive bonding, suturing.
6. A decomposable self-fixating preperitoneal patch according to claim 1, wherein the fixating structure (2) comprises a number of inserts (3), the inserts (3) being made of collagen by a shaping process, the inserts (3) being evenly distributed on the lower surface of the mesh structure (1), the inserts (3) being of equal length.
7. A split self-fixating preperitoneal patch according to claim 6, characterized in that the shape of the insert (3) comprises a barb shape, a wedge shape, a hook shape, a thorn shape.
8. A split self-fixating preperitoneal patch according to claim 7, characterized in that the shape of the insert (3) is barb-shaped.
9. A split self-fixating preperitoneal patch according to claim 8, characterized in that the tip parts of the barb-shaped inserts (3) are co-aligned.
10. A detachable self-fixating preperitoneal patch according to claim 1, characterized in that the shape of the mesh structure (1) comprises rectangular, circular, oval.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310155156.6A CN116135177A (en) | 2023-02-23 | 2023-02-23 | Degradable self-fixing preperitoneal patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310155156.6A CN116135177A (en) | 2023-02-23 | 2023-02-23 | Degradable self-fixing preperitoneal patch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116135177A true CN116135177A (en) | 2023-05-19 |
Family
ID=86334549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310155156.6A Pending CN116135177A (en) | 2023-02-23 | 2023-02-23 | Degradable self-fixing preperitoneal patch |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116135177A (en) |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101014300A (en) * | 2004-07-29 | 2007-08-08 | 先进生物假体表面有限公司 | Metallic drug-releasing medical devices and method of making same |
| CN101348972A (en) * | 2007-07-17 | 2009-01-21 | 聚合-医药有限公司 | Absorbable / biodegradable composite yarn constructs and applications thereof |
| CN103966680A (en) * | 2014-05-04 | 2014-08-06 | 东华大学 | Method for preparing drug sustained release nanofibers |
| CN104491932A (en) * | 2014-12-04 | 2015-04-08 | 上海工程技术大学 | Drug-loaded nanometer anti-adhesion membrane having core/shell structure and preparation method thereof |
| CN104667340A (en) * | 2013-11-26 | 2015-06-03 | 沈攀攀 | A biodegradable suture with bioactivity |
| CN106390208A (en) * | 2016-10-09 | 2017-02-15 | 华南理工大学 | Three-dimensional support material containing hierarchical porous structures and preparation and application |
| CN111481731A (en) * | 2019-01-29 | 2020-08-04 | 中国人民解放军海军特色医学中心 | Collagen-chitosan electrostatic spinning membrane composite alginate anti-seawater soaking application and preparation method thereof |
| US20200315773A1 (en) * | 2019-02-07 | 2020-10-08 | Biorez, Inc. | Composite scaffold for the repair, reconstruction, and regeneration of soft tissues |
| CN213250042U (en) * | 2020-06-17 | 2021-05-25 | 江苏百纳医疗科技有限公司 | Hernia repair patch with degradable self-fixing function |
| CN217430252U (en) * | 2022-05-23 | 2022-09-16 | 东晟(广东)科技开发有限公司 | Hernia repair patch with degradable self-fixing function |
-
2023
- 2023-02-23 CN CN202310155156.6A patent/CN116135177A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101014300A (en) * | 2004-07-29 | 2007-08-08 | 先进生物假体表面有限公司 | Metallic drug-releasing medical devices and method of making same |
| CN101348972A (en) * | 2007-07-17 | 2009-01-21 | 聚合-医药有限公司 | Absorbable / biodegradable composite yarn constructs and applications thereof |
| CN104667340A (en) * | 2013-11-26 | 2015-06-03 | 沈攀攀 | A biodegradable suture with bioactivity |
| CN103966680A (en) * | 2014-05-04 | 2014-08-06 | 东华大学 | Method for preparing drug sustained release nanofibers |
| CN104491932A (en) * | 2014-12-04 | 2015-04-08 | 上海工程技术大学 | Drug-loaded nanometer anti-adhesion membrane having core/shell structure and preparation method thereof |
| CN106390208A (en) * | 2016-10-09 | 2017-02-15 | 华南理工大学 | Three-dimensional support material containing hierarchical porous structures and preparation and application |
| CN111481731A (en) * | 2019-01-29 | 2020-08-04 | 中国人民解放军海军特色医学中心 | Collagen-chitosan electrostatic spinning membrane composite alginate anti-seawater soaking application and preparation method thereof |
| US20200315773A1 (en) * | 2019-02-07 | 2020-10-08 | Biorez, Inc. | Composite scaffold for the repair, reconstruction, and regeneration of soft tissues |
| CN113727672A (en) * | 2019-02-07 | 2021-11-30 | 拜欧雷兹有限公司 | Composite scaffold for soft tissue repair, reconstruction and regeneration |
| CN213250042U (en) * | 2020-06-17 | 2021-05-25 | 江苏百纳医疗科技有限公司 | Hernia repair patch with degradable self-fixing function |
| CN217430252U (en) * | 2022-05-23 | 2022-09-16 | 东晟(广东)科技开发有限公司 | Hernia repair patch with degradable self-fixing function |
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