CN107802377A - A kind of titanium alloy film-coated vascular support - Google Patents
A kind of titanium alloy film-coated vascular support Download PDFInfo
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- CN107802377A CN107802377A CN201711222449.2A CN201711222449A CN107802377A CN 107802377 A CN107802377 A CN 107802377A CN 201711222449 A CN201711222449 A CN 201711222449A CN 107802377 A CN107802377 A CN 107802377A
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- Prior art keywords
- titanium alloy
- tube wall
- rack body
- alloy film
- vascular support
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- 229910001069 Ti alloy Inorganic materials 0.000 title claims abstract description 51
- 230000002792 vascular Effects 0.000 title claims abstract description 32
- 239000012528 membrane Substances 0.000 claims abstract description 20
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 10
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 10
- 239000010936 titanium Substances 0.000 claims description 10
- 229910052719 titanium Inorganic materials 0.000 claims description 10
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims description 6
- 229910052802 copper Inorganic materials 0.000 claims description 6
- 239000010949 copper Substances 0.000 claims description 6
- 229910052750 molybdenum Inorganic materials 0.000 claims description 6
- 239000011733 molybdenum Substances 0.000 claims description 6
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 claims description 5
- 229910052758 niobium Inorganic materials 0.000 claims description 5
- 239000010955 niobium Substances 0.000 claims description 5
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 claims description 5
- 229910052763 palladium Inorganic materials 0.000 claims description 5
- 229910052726 zirconium Inorganic materials 0.000 claims description 5
- 229910052786 argon Inorganic materials 0.000 claims description 4
- 239000007789 gas Substances 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000005245 sintering Methods 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 238000005275 alloying Methods 0.000 claims description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
- 238000000498 ball milling Methods 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 239000001301 oxygen Substances 0.000 claims description 3
- 229910052760 oxygen Inorganic materials 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 238000004663 powder metallurgy Methods 0.000 claims description 3
- MEYZYGMYMLNUHJ-UHFFFAOYSA-N tunicamycin Natural products CC(C)CCCCCCCCCC=CC(=O)NC1C(O)C(O)C(CC(O)C2OC(C(O)C2O)N3C=CC(=O)NC3=O)OC1OC4OC(CO)C(O)C(O)C4NC(=O)C MEYZYGMYMLNUHJ-UHFFFAOYSA-N 0.000 claims description 2
- 210000004204 blood vessel Anatomy 0.000 abstract description 19
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 abstract description 16
- 229910052759 nickel Inorganic materials 0.000 abstract description 8
- 239000000463 material Substances 0.000 abstract description 7
- 238000006073 displacement reaction Methods 0.000 abstract description 5
- 206010067484 Adverse reaction Diseases 0.000 abstract description 4
- 230000006838 adverse reaction Effects 0.000 abstract description 4
- 229910001220 stainless steel Inorganic materials 0.000 abstract description 3
- 239000010935 stainless steel Substances 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 13
- 239000000956 alloy Substances 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 4
- 229910045601 alloy Inorganic materials 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 208000031481 Pathologic Constriction Diseases 0.000 description 2
- 208000030961 allergic reaction Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000009172 bursting Effects 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- IUYOGGFTLHZHEG-UHFFFAOYSA-N copper titanium Chemical compound [Ti].[Cu] IUYOGGFTLHZHEG-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 206010020718 hyperplasia Diseases 0.000 description 2
- 230000002390 hyperplastic effect Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000036262 stenosis Effects 0.000 description 2
- 208000037804 stenosis Diseases 0.000 description 2
- 206010002329 Aneurysm Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 208000031320 Teratogenesis Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 238000010420 art technique Methods 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- -1 polytetrafluoroethylene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229910001285 shape-memory alloy Inorganic materials 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
- B22F3/10—Sintering only
- B22F3/105—Sintering only by using electric current other than for infrared radiant energy, laser radiation or plasma ; by ultrasonic bonding
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C1/00—Making non-ferrous alloys
- C22C1/04—Making non-ferrous alloys by powder metallurgy
- C22C1/045—Alloys based on refractory metals
- C22C1/0458—Alloys based on titanium, zirconium or hafnium
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C14/00—Alloys based on titanium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
- B22F3/10—Sintering only
- B22F3/105—Sintering only by using electric current other than for infrared radiant energy, laser radiation or plasma ; by ultrasonic bonding
- B22F2003/1054—Sintering only by using electric current other than for infrared radiant energy, laser radiation or plasma ; by ultrasonic bonding by microwave
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F2998/00—Supplementary information concerning processes or compositions relating to powder metallurgy
- B22F2998/10—Processes characterised by the sequence of their steps
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Mechanical Engineering (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Gastroenterology & Hepatology (AREA)
- Optics & Photonics (AREA)
- Manufacturing & Machinery (AREA)
- Inorganic Chemistry (AREA)
- Prostheses (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Materials For Medical Uses (AREA)
- Physics & Mathematics (AREA)
Abstract
The invention discloses a kind of titanium alloy film-coated vascular support, it is related to medical instruments field.A kind of titanium alloy film-coated vascular support of the present invention includes rack body and outer membrane；Rack body is made up of titanium alloy；Rack body is in hollow tubular, tube wall reticulates structure, tube wall is divided into symmetrical upper tube wall and lower tube wall by the plane where the axis of hollow tubular structure, upper tube wall and lower tube wall are respectively arranged with projection, and the line of the geometric center of adjacent upper tube wall projection and lower tube wall projection is not orthogonal to the axis of hollow tubular structure；Outer membrane is set in rack body outer wall and wraps up at least part rack body outer wall.The titanium alloy film-coated vascular support of the present invention is on the one hand by setting anti-skid bulge to prevent the relative displacement between support and blood vessel；On the other hand the material of rack body is improved, replaces containing nickel and stainless steel using titanium alloy, avoids nickel to adverse reaction caused by human body, it is common to improve clinical practice security；In addition, its outer wall overlay film, improves Clinical practicability.
Description
Technical field
The present invention relates to medical instruments field, especially a kind of titanium alloy film-coated vascular support.
Background technology
Puncture shaping surgery, abbreviation PTA arts, it is under the guiding of medical imaging device, utilizes puncture needle, seal wire
The foley's tube for the support for being cased with tightening is injected human vas with guide sheath, and is transported at hemadostewnosis, with the expansion of sacculus
, support is also softened, and after sacculus contraction is withdrawn, the metallic support for producing plastic deformation then stays in original place, and embedded in blood vessel,
Play a part of expanding blood vessel.This method is widely used in treating angiocardiopathy at present.
The intravascular stent form of prior art have it is a variety of, most commonly rest body using shape-memory alloy wire weave
Form or be welded after being cut using marmem thin plate, through axial tension, make its axial elongation, radially shorten.
Its purpose is all the functions such as the radial support intensity of support to be improved and axially soft property.Its major defect is, on the one hand, branch
Frame is integrally in the flat segments of cylinder, and after implantable intravascular, with angiogenesis relative displacement, potential prestige is easily caused to patient for support
The side of body.On the other hand, the main material of intravascular stent is the medical embedded stainless steels of 316L at present, although its function admirable, contains
The mass percent of nickel element be 13-15%, allergic reaction is produced to human body, contact dermatitis occurs, teratogenesis, carcinogenic be present
Harmfulness.German scholar thinks：" it is probably to trigger in-stent restenosis mechanism to discharging nickel and molybdenum allergic reaction on support
One of ".Therefore further improving the structure and material of intravascular stent turns into the main development and application trend of intravascular stent.
The content of the invention
The goal of the invention of the present invention is：For above-mentioned problem, there is provided a kind of titanium alloy film-coated vascular support, should
Intravascular stent prevents the relative displacement between support and blood vessel on the one hand by setting anti-skid bulge；On the other hand, support is improved
The material of body, replace containing nickel and stainless steel using titanium alloy, avoid nickel to adverse reaction caused by human body, it is common to improve clinical answer
Use security；In addition, its outer wall overlay film, improves Clinical practicability.
The technical solution adopted by the present invention is as follows：
A kind of titanium alloy film-coated vascular support, it includes rack body and outer membrane；The rack body is made up of titanium alloy；Support
Body is in hollow tubular structure, and tube wall reticulates structure, and tube wall is divided into pair by the plane where the axis of hollow tubular structure
Tube wall and lower tube wall are much of, projection is respectively arranged with upper tube wall and lower tube wall, adjacent upper tube wall projection and lower tube wall are dashed forward
The line of the geometric center risen is not orthogonal to the axis of hollow tubular structure；The outer membrane is set in the rack body outer wall
Wrap up at least part rack body outer wall.
By adopting the above-described technical solution, by adopting the above-described technical solution, the upper tube wall and down tube of rack body
Wall is provided with projection, projection extruding blood vessel, increases the frictional force between blood vessel and rack body, prevents support sheet
Relative displacement occurs between body and blood vessel, it is safe.Due to the geometric center that adjacent upper tube wall is raised and lower tube wall is raised
Line be not orthogonal to the axis of hollow tubular structure, same section of blood vessel be solely subjected to that upper tube wall is raised or lower tube wall projection wherein
The extruding of one, i.e. one-sided compression, can effectively reduce the probability that blood vessel is bursting at the collision, and what is used is safe.Outside rack body
Wall is provided with outer membrane, prevents growing into for the outer hyperplastic tissue of blood vessel, reduces the generation of postoperative stenosis, can improve Clinical practicability.
In addition, rack body is made of titanium alloy material, avoid causing adverse reaction to human body using nickel-containing material, further improve
Clinical practice security.
The geometric center of a kind of titanium alloy film-coated vascular support of the present invention, adjacent upper tube wall projection and lower tube wall projection
Line and hollow tubular structure axis between angle be in 30 ° -75 ° or 105 ° -150 °.
By adopting the above-described technical solution, by adopting the above-described technical solution, upper tube wall is raised raised with lower tube wall
Asymmetry is set, and distance is suitable between the raised and lower tube wall projection of adjacent upper tube wall, ensures its skidproof effect.
A kind of titanium alloy film-coated vascular support of the present invention, projection are in arc-shaped, and the central angle of circular arc is 135 °-
180°。
By adopting the above-described technical solution, arc-shaped projection avoids contacting the wind that blood vessel is broken up in increase with vascularization point
Danger.Central angle is too small, and raised squeezing action is too small, and skidproof effect is weak；Central angle is excessive, and it is difficult to paste completely with blood vessel
Close, it is also difficult to reach satisfied skidproof effect, or even play reverse effect.
A kind of titanium alloy film-coated vascular support of the present invention, the diameter of the rack body gradually subtract from centre to both ends
It is small, the 75%-80% of a diameter of middle part diameter in both ends.
By adopting the above-described technical solution, middle part diameter is slightly larger, have using therapeutic purposes are reached, both ends diameter is slightly
It is small, there is the injury for using transition bonding is formed between support and blood vessel, preventing edge to blood vessel.
A kind of titanium alloy film-coated vascular support of the present invention, the outer membrane are provided with layer 2-4.
By adopting the above-described technical solution, multilayer coating film can preferably improve the biocompatibility of overlay film frame and same
Shi Zengjia covers film strength, prevents the breakage of the overlay film during overlay film frame pressure is held, discharges and bent etc..
A kind of titanium alloy film-coated vascular support of the present invention, in the outer membrane except most press close to the tunic of rack body outer wall one it
Through hole is provided with other outer outer membranes, and is gradually increased from every layer of aperture of core band outer layer.
A kind of titanium alloy film-coated vascular support of the present invention, the aperture of through hole is 0.1-100 μm.
By adopting the above-described technical solution, increase overlay film outer layer hole while overlay film frame channel of blood flow is ensured
Rate, promote cell differentiation to promote tissue to be grown into blood vessel effectively to stick endothelial cell, accelerate aneurysm diseased region endothelium
Change, to have the function that more effectively to treat aneurysmal disease.
It should be noted that overlay film can use the high scores such as polyurethane, polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylsealing in the present invention
Sub- synthetic material either biological tissue's derived material is made.
A kind of titanium alloy film-coated vascular support of the present invention, the length of the rack body is 0.5-20cm, a diameter of
1.0-8.0mm。
By adopting the above-described technical solution, by adopting the above-described technical solution, in Clinical practice, can be according to trouble
The difference of person or the different sizes to intravascular stent of disease location select.
A kind of titanium alloy film-coated vascular support of the present invention, the titanium alloy include niobium 14.3% by weight percentage,
Zirconium 5.2%, molybdenum 4.7%, copper 2.4%, palladium 0.18%, surplus are titanium and inevitable impurity, wherein oxygen≤0.1%, carbon≤0.04%,
Nitrogen≤0.03, hydrogen≤0.002%.
A kind of titanium alloy film-coated vascular support of the present invention, the titanium alloy are prepared with the following method：By titanium valve
And alloying element powder dispensing in proportion, ball milling mixing is carried out by powder metallurgy blank-making technology, is mechanically pressed into base, then by base
Material, which is placed in heat-preserving container, is put into microwave agglomerating furnace, and vacuum keeps vacuum to be less than 0.1Pa in furnace chamber, and being filled with purity is
99.999% argon gas forms recycling-guard, is heated to 900 DEG C of sintering temperature with 22 DEG C/min heating rate, is incubated 15min,
Microwave source is closed, furnace cooling produces.
It is anticorrosive, intensity is high, extensibility is strong, its alloy material by adopting the above-described technical solution, titanium nature is excellent
Expect that niobium, zirconium, molybdenum, palladium, the biocompatibility of copper are excellent.Wherein, niobium, zirconium, molybdenum are beneficial to alloy strengthening, drop low-alloyed springform
Amount, improves its plasticity；Palladium is cathode active metallic element, has excellent corrosion resistance, improves alloy in physiological saline
Stability；Copper forms titanium copper under heat treatment condition with titanium, and mutually even dispersion separates out from titanium alloy.Titanium copper is mainly mutually
CuTi2, when in the environment or liquid that titanium alloy is in moist, Cu2+From titanium alloy surface dissolution so as to playing antibacterium sense
Function is contaminated, if copper content is relatively too high, can cause to separate out titanium copper phase too much in titanium alloy, titanium can be seriously affected
The mechanical property and process industrial art performance of alloy.
In summary, by adopting the above-described technical solution, the beneficial effects of the invention are as follows：
1. being provided with projection on the relative upper tube wall with contacts blood and lower tube wall, this projects through extruding vascular wall to increase
The frictional force between pipe holder and vascular wall is healed, so as to prevent the relative displacement between support and blood vessel；Adjacent upper tube wall
It is asymmetric between raised and lower tube wall projection to set, ensure same section of blood vessel be solely subjected to that upper tube wall is raised or lower tube wall projection wherein
The extruding of one, i.e. one-sided compression, the probability that blood vessel is bursting at the collision can be effectively reduced, improve the security of Clinical practice.
2. rack body is made up of titanium alloy material, the titanium alloy not only has good biocompatibility, is avoided that nickel
The adverse reaction to caused by human body, and property is stable in body fluid, the function with bacterial-infection resisting, improves clinical practice
Property.
3. rack body outer wall overlay film, growing into for the outer hyperplastic tissue of blood vessel can be prevented, reduces the generation of postoperative stenosis, outer membrane
It is divided into multilayer and there is space, film strength is covered in increase, prevents the overlay film during overlay film frame pressure is held, discharges and bent etc.
Breakage, improve Clinical practicability.
Brief description of the drawings
Examples of the present invention will be described by way of reference to the accompanying drawings, wherein：
The planar structure schematic diagram of the rack body for the titanium alloy film-coated vascular support that Fig. 1 the present embodiment provides；
The dimensional structure diagram of the rack body for the titanium alloy film-coated vascular support that Fig. 2 the present embodiment provides.
In figure, 1 is rack body, and 12 be upper tube wall, and 13 be lower tube wall, and 21 be raised, and 22 be raised.
Embodiment
All features disclosed in this specification, or disclosed all methods or during the step of, except mutually exclusive
Feature and/or step beyond, can combine in any way.
This specification（Including any accessory claim, summary）Disclosed in any feature, unless specifically stated otherwise,
Replaced by other equivalent or with similar purpose alternative features.I.e., unless specifically stated otherwise, each feature is a series of
An example in equivalent or similar characteristics.
Embodiment 1
The present embodiment provides a kind of titanium alloy film-coated vascular support, and it includes rack body 1, and rack body 1 is in hollow tubular knot
Structure, tube wall is into hollow mesh structure.Rack body 1 in the present embodiment is made of titanium alloy.The diameter of rack body 1 is in
Between be gradually reduced to both ends, the 75%-80% of a diameter of middle part diameter in both ends.Anti-skidding intravascular stent provided by the invention, branch
The length of frame body 1 is 0.5-20cm, a diameter of 1.0-8.0cm of rack body 1.
Rack body 1 is divided into symmetrical upper tube wall 12 and lower tube wall by the plane where the axis of hollow tubular structure
13, projection 21 is provided with upper tube wall 12, projection 22, adjacent projection 21 of any two and raised 22 are provided with lower tube wall 13
The line of geometric center be not orthogonal to the axis of hollow tubular structure, the i.e. adjacent projection 21 of any two and projection 22 not
It is symmetrical arranged.Preferably, the line of geometric center and the axis of hollow tubular structure of two adjacent projections 21 and projection 22
Angle between line is in 30 ° -75 ° or 105 ° -150 °.Projection 21 and projection 22 are in arc-shaped, it is preferable that the central angle of circular arc
For 135 ° -180 °.
The outer wall of rack body 1 is set with outer membrane（It is not shown）, the outer membrane of outer membrane at least part coated stent body.Outer membrane can
To be arranged as required to layer 2-4.Preferably, the thickness of outer membrane is between 0.01-0.1mm.Wherein, except most pressing close to rack body 1
Outside one layer of outer membrane of outer wall, through hole is respectively provided with other films, and the aperture of through hole every layer of aperture from internal layer to outer layer is gradual
Increase.Preferably, the aperture of through hole is between 0.1-100 μm.
Embodiment 2
The present embodiment provides a kind of titanium alloy material, and the titanium alloy stability is high, and biocompatibility is good, can also be sent out in body
Wave anti-infective function.The titanium alloy includes the niobium 14.3% being calculated in mass percent, zirconium 5.2%, molybdenum 4.7%, copper 2.4%, palladium
0.18%, surplus is titanium and inevitable impurity, wherein oxygen≤0.1%, carbon≤0.04%, nitrogen≤0.03, hydrogen≤0.002%.
The titanium alloy is prepared via a method which to form：
Titanium valve and each alloying element powder are weighed by above-mentioned raw materials and mass ratio, according to powder metallurgy base of the prior art
Technique carries out ball milling mixing, is mechanically pressed into base.Blank is placed in heat-preserving container, and heat-preserving container then is put into microwave agglomerating furnace.It is micro-
The furnace chamber of ripple sintering furnace is evacuated to vacuum and is less than 0.1Pa, is filled with the argon gas that purity is 99.999% and forms recycling-guard.
Under conditions of argon gas protection, 900 DEG C of sintering temperature is heated to 22 DEG C/min heating rate, is then incubated at 900 DEG C
15min, closes microwave source, and furnace cooling produces.
The invention is not limited in foregoing embodiment.The present invention, which expands to, any in this manual to be disclosed
New feature or any new combination, and disclose any new method or process the step of or any new combination.
Claims (10)
1. a kind of titanium alloy film-coated vascular support, it is characterised in that it includes rack body and outer membrane；The rack body is by titanium
Alloy is made；Rack body is in hollow tubular structure, and tube wall reticulates structure, and tube wall is where the axis of hollow tubular structure
Plane be divided into symmetrical upper tube wall and lower tube wall, be respectively arranged with projection on upper tube wall and lower tube wall, adjacent upper tube wall is dashed forward
Rise and the line of the geometric center of lower tube wall projection is not orthogonal to the axis of hollow tubular structure；The outer membrane is set in described
Rack body outer wall wraps up at least part rack body outer wall.
2. titanium alloy film-coated vascular support according to claim 1, it is characterised in that adjacent upper tube wall projection and down tube
Angle between the line of the geometric center of wall projection and the axis of hollow tubular structure is in 30 ° -75 ° or 105 ° -150 °.
3. titanium alloy film-coated vascular support according to claim 2, it is characterised in that the projection is in arc-shaped, circular arc
Central angle be 135 ° -180 °.
4. titanium alloy film-coated vascular support according to claim 3, it is characterised in that the diameter of the rack body is in
Between be gradually reduced to both ends, the 75%-80% of a diameter of middle part diameter in both ends.
5. titanium alloy film-coated vascular support according to claim 1, it is characterised in that the outer membrane is provided with layer 2-4.
6. titanium alloy film-coated vascular support according to claim 5, it is characterised in that removed in the outer membrane and most press close to support
Through hole is provided with other outer membranes outside the tunic of body outer wall one.
7. titanium alloy film-coated vascular support according to claim 6, it is characterised in that the aperture of through hole is 0.1-100 μm.
8. described titanium alloy film-coated vascular support according to claim 7, it is characterised in that the length of the rack body
For 0.5-20cm, a diameter of 1.0-8.0mm.
9. the titanium alloy film-coated vascular support according to any one of claim 1-8, it is characterised in that the titanium alloy bag
Include niobium 14.3% by weight percentage, zirconium 5.2%, molybdenum 4.7%, copper 2.4%, palladium 0.18%, surplus is titanium and inevitably miscellaneous
Matter, wherein oxygen≤0.1%, carbon≤0.04%, nitrogen≤0.03, hydrogen≤0.002%.
10. titanium alloy film-coated vascular support according to claim 9, it is characterised in that the titanium alloy uses such as lower section
Method is prepared：By titanium valve and alloying element powder dispensing in proportion, ball milling mixing, machinery are carried out by powder metallurgy blank-making technology
Base is pressed into, then blank is placed in heat-preserving container and is put into microwave agglomerating furnace, vacuum keeps vacuum to be less than in furnace chamber
0.1Pa, it is filled with the argon gas that purity is 99.999% and forms recycling-guard, sintering temperature is heated to 22 DEG C/min heating rate
900 DEG C, 15min is incubated, closes microwave source, furnace cooling produces.
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| CN201711222449.2A CN107802377A (en) | 2017-11-29 | 2017-11-29 | A kind of titanium alloy film-coated vascular support |
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| CN201711222449.2A CN107802377A (en) | 2017-11-29 | 2017-11-29 | A kind of titanium alloy film-coated vascular support |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109259910A (en) * | 2018-05-21 | 2019-01-25 | 广州医科大学 | A kind of multilayer coating film airway stent and preparation method thereof |
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