JP2008506750A - チオール基を含む化合物の排出ポンプ抑制剤としての使用 - Google Patents
チオール基を含む化合物の排出ポンプ抑制剤としての使用 Download PDFInfo
- Publication number
- JP2008506750A JP2008506750A JP2007521944A JP2007521944A JP2008506750A JP 2008506750 A JP2008506750 A JP 2008506750A JP 2007521944 A JP2007521944 A JP 2007521944A JP 2007521944 A JP2007521944 A JP 2007521944A JP 2008506750 A JP2008506750 A JP 2008506750A
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- JP
- Japan
- Prior art keywords
- drug
- use according
- thiol groups
- glutathione
- thiolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000003396 thiol group Chemical group [H]S* 0.000 title claims abstract description 40
- 150000001875 compounds Chemical class 0.000 title claims description 58
- 239000003112 inhibitor Substances 0.000 title description 8
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims abstract description 74
- 239000003814 drug Substances 0.000 claims abstract description 53
- 229940079593 drug Drugs 0.000 claims abstract description 42
- 108010024636 Glutathione Proteins 0.000 claims abstract description 37
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- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 3
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- PRDFBSVERLRRMY-UHFFFAOYSA-N 2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole Chemical compound C1=CC(OCC)=CC=C1C1=NC2=CC=C(C=3NC4=CC(=CC=C4N=3)N3CCN(C)CC3)C=C2N1 PRDFBSVERLRRMY-UHFFFAOYSA-N 0.000 description 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/795—Polymers containing sulfur
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT12502004 | 2004-07-22 | ||
| PCT/EP2005/053395 WO2006008270A1 (de) | 2004-07-22 | 2005-07-14 | Verwendung von thiolgruppen-hältigen verbindungen als efflux-pumpen-hemmer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008506750A true JP2008506750A (ja) | 2008-03-06 |
| JP2008506750A5 JP2008506750A5 (OSRAM) | 2008-08-14 |
Family
ID=34981500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007521944A Pending JP2008506750A (ja) | 2004-07-22 | 2005-07-14 | チオール基を含む化合物の排出ポンプ抑制剤としての使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20080200563A1 (OSRAM) |
| EP (1) | EP1768676A1 (OSRAM) |
| JP (1) | JP2008506750A (OSRAM) |
| CN (1) | CN101035547A (OSRAM) |
| AU (1) | AU2005263729B2 (OSRAM) |
| CA (1) | CA2574232A1 (OSRAM) |
| WO (1) | WO2006008270A1 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2107913T1 (sl) | 2006-12-22 | 2012-05-31 | Croma Pharma Ges M B H | Uporaba tioliranih polisaharidov za tkivno avgmentacijo |
| EP2291524A2 (en) | 2008-04-24 | 2011-03-09 | Medtronic, Inc | Rehydratable thiolated polysaccharide particles and sponge |
| EP2291448B1 (en) | 2008-04-24 | 2017-01-04 | Medtronic, Inc | Rehydratable polysaccharide particles and sponge |
| JP5833919B2 (ja) | 2008-04-24 | 2015-12-16 | メドトロニック，インコーポレイテッド | キトサンと酸化多糖とに基づく保護用ゲル |
| US8530632B2 (en) | 2008-04-24 | 2013-09-10 | Medtronic Xomed, Inc. | Chitosan-containing protective composition |
| KR101673042B1 (ko) | 2009-03-12 | 2016-11-04 | 키바이오사이언스 아게 | 당뇨병 및 대사 증후군의 치료 |
| RS57519B1 (sr) | 2011-11-02 | 2018-10-31 | Keybioscience Ag | Mimetici kalcitonina za lečenje bolesti i poremećaja |
| KR102019911B1 (ko) | 2011-11-02 | 2019-09-09 | 키바이오사이언스 아게 | 질병 및 장애 치료용 펩타이드 유사체 |
| HRP20180337T1 (hr) | 2013-11-14 | 2018-05-18 | Keybioscience Ag | Kalcitonin mimetika za liječenje bolesti i poremećaja |
| GB201500263D0 (en) | 2015-01-08 | 2015-02-25 | Keybioscience Ag | Calcitonin analogues for treating diseases and disorders |
| GB201704429D0 (en) | 2017-03-21 | 2017-05-03 | Keybioscience Ag | Calcitonin mimetics for treating diseases and disorders |
| GB201707955D0 (en) | 2017-05-18 | 2017-07-05 | Keybioscience Ag | Dual amylin and calcitonin receptor agonists for treating diseases and disorders |
| GB201813677D0 (en) | 2018-08-22 | 2018-10-03 | Keybioscience Ag | Calcitonin mimetics for treating diseases and disorders |
| GB201813678D0 (en) | 2018-08-22 | 2018-10-03 | Keybioscience Ag | Acylated calcitonin mimetics |
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| JPH07507325A (ja) * | 1992-06-24 | 1995-08-10 | ベーリンガー マンハイム イタリア エス．ピー．エイ． | 化学保護剤としてのグルタチオン |
| JPH1045502A (ja) * | 1996-05-07 | 1998-02-17 | Wisconsin Alumni Res Found | 臓器保存及び心臓麻痺性の薬としての使用のためのタキソール合成物 |
| JPH10502085A (ja) * | 1994-06-23 | 1998-02-24 | アルコン・ラボラトリーズ・インコーポレーテッド | Ｉｏｐを制御するための医薬を含有する眼内潅注溶液 |
| JP2004502728A (ja) * | 2000-07-11 | 2004-01-29 | ハンター−フレミング・リミテッド | 薬学的化合物の還元体の治療的および予防的使用 |
| JP2005298364A (ja) * | 2004-04-07 | 2005-10-27 | Rohto Pharmaceut Co Ltd | アズレン含有水性液剤 |
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| SE420733B (sv) * | 1974-05-30 | 1981-10-26 | Exploaterings Ab Tbf | Gelprodukt, innehallande tiosulfatgrupper samt sett for framstellning derav |
| IT1282625B1 (it) * | 1996-02-14 | 1998-03-31 | Zambon Spa | Composizione farmaceutica atta ad inibire la formazione di metastasi tumorali |
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2005
- 2005-07-14 CA CA002574232A patent/CA2574232A1/en not_active Abandoned
- 2005-07-14 US US11/632,868 patent/US20080200563A1/en not_active Abandoned
- 2005-07-14 WO PCT/EP2005/053395 patent/WO2006008270A1/de not_active Ceased
- 2005-07-14 EP EP05771836A patent/EP1768676A1/de not_active Withdrawn
- 2005-07-14 AU AU2005263729A patent/AU2005263729B2/en not_active Ceased
- 2005-07-14 JP JP2007521944A patent/JP2008506750A/ja active Pending
- 2005-07-14 CN CNA2005800242315A patent/CN101035547A/zh active Pending
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|---|---|---|---|---|
| JPH07507325A (ja) * | 1992-06-24 | 1995-08-10 | ベーリンガー マンハイム イタリア エス．ピー．エイ． | 化学保護剤としてのグルタチオン |
| JPH10502085A (ja) * | 1994-06-23 | 1998-02-24 | アルコン・ラボラトリーズ・インコーポレーテッド | Ｉｏｐを制御するための医薬を含有する眼内潅注溶液 |
| JPH1045502A (ja) * | 1996-05-07 | 1998-02-17 | Wisconsin Alumni Res Found | 臓器保存及び心臓麻痺性の薬としての使用のためのタキソール合成物 |
| JP2004502728A (ja) * | 2000-07-11 | 2004-01-29 | ハンター−フレミング・リミテッド | 薬学的化合物の還元体の治療的および予防的使用 |
| JP2005298364A (ja) * | 2004-04-07 | 2005-10-27 | Rohto Pharmaceut Co Ltd | アズレン含有水性液剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20080200563A1 (en) | 2008-08-21 |
| AU2005263729A1 (en) | 2006-01-26 |
| EP1768676A1 (de) | 2007-04-04 |
| AU2005263729B2 (en) | 2011-01-06 |
| CA2574232A1 (en) | 2006-01-26 |
| WO2006008270A1 (de) | 2006-01-26 |
| CN101035547A (zh) | 2007-09-12 |
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