JP2008501782A5 - - Google Patents
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- Publication number
- JP2008501782A5 JP2008501782A5 JP2007526704A JP2007526704A JP2008501782A5 JP 2008501782 A5 JP2008501782 A5 JP 2008501782A5 JP 2007526704 A JP2007526704 A JP 2007526704A JP 2007526704 A JP2007526704 A JP 2007526704A JP 2008501782 A5 JP2008501782 A5 JP 2008501782A5
- Authority
- JP
- Japan
- Prior art keywords
- amphotericin
- sterol
- mixed layered
- enriched mixed
- liposome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims description 23
- 239000002502 liposome Substances 0.000 claims description 19
- 229930182558 Sterol Natural products 0.000 claims description 17
- 235000003702 sterols Nutrition 0.000 claims description 17
- 150000003432 sterols Chemical class 0.000 claims description 16
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 claims description 12
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 claims description 12
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 claims description 12
- 229930183010 Amphotericin Natural products 0.000 claims description 12
- QGGFZZLFKABGNL-UHFFFAOYSA-N Amphotericin A Natural products OC1C(N)C(O)C(C)OC1OC1C=CC=CC=CC=CCCC=CC=CC(C)C(O)C(C)C(C)OC(=O)CC(O)CC(O)CCC(O)C(O)CC(O)CC(O)(CC(O)C2C(O)=O)OC2C1 QGGFZZLFKABGNL-UHFFFAOYSA-N 0.000 claims description 12
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 claims description 12
- 229940009444 amphotericin Drugs 0.000 claims description 12
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 claims description 11
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims description 9
- 229960003942 amphotericin b Drugs 0.000 claims description 9
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 8
- 150000003904 phospholipids Chemical group 0.000 claims description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 6
- 239000000725 suspension Substances 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 150000002632 lipids Chemical class 0.000 claims description 4
- 235000012000 cholesterol Nutrition 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 208000035473 Communicable disease Diseases 0.000 claims description 2
- 241000222722 Leishmania <genus> Species 0.000 claims description 2
- 239000000872 buffer Substances 0.000 claims description 2
- -1 ergosterol sterol Chemical class 0.000 claims description 2
- 230000037431 insertion Effects 0.000 claims 3
- 238000003780 insertion Methods 0.000 claims 3
- 210000000805 cytoplasm Anatomy 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 244000000040 protozoan parasite Species 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000009210 therapy by ultrasound Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000013020 final formulation Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1113DE2004 | 2004-06-11 | ||
| IN1113/DEL/2004 | 2004-06-11 | ||
| PCT/IN2005/000193 WO2005120460A1 (en) | 2004-06-11 | 2005-06-13 | Sterol enriched mixed lammelarity amphotericin intercalating liposomes in saline and the process for their preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008501782A JP2008501782A (ja) | 2008-01-24 |
| JP2008501782A5 true JP2008501782A5 (enExample) | 2012-02-16 |
| JP4966855B2 JP4966855B2 (ja) | 2012-07-04 |
Family
ID=34972096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007526704A Expired - Fee Related JP4966855B2 (ja) | 2004-06-11 | 2005-06-13 | 塩水中のステロール濃縮混合層状アンフォテリシン（Ａｍｐｈｏｔｅｒｉｃｉｎ）挿入リポソーム及びその調製方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20070218119A1 (enExample) |
| EP (1) | EP1771156B8 (enExample) |
| JP (1) | JP4966855B2 (enExample) |
| CN (1) | CN101014322A (enExample) |
| AT (1) | ATE476965T1 (enExample) |
| AU (1) | AU2005251572B2 (enExample) |
| BR (1) | BRPI0511371A (enExample) |
| DE (1) | DE602005022876D1 (enExample) |
| WO (1) | WO2005120460A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI1003990B1 (pt) * | 2009-10-16 | 2021-09-14 | Lifecare Innovations Pvt. Ltd | Formulação para o tratamento de infecções fúngicas |
| CN108602025B (zh) | 2016-03-04 | 2021-02-26 | 栗田工业株式会社 | 选择性透过膜及其制造方法、使用该选择性透过膜的水处理方法 |
| PT3694526T (pt) | 2017-10-11 | 2025-01-20 | Univ Illinois | Resgate independente do genótipo da fibrose quística com canais de bicarbonato de moléculas pequenas |
| IL315719A (en) | 2022-03-21 | 2024-11-01 | Univ Illinois | Prosthetic assemblies of ion channels containing lipid-coated amphotericin B crystals |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2134869A (en) * | 1983-02-15 | 1984-08-22 | Squibb & Sons Inc | Method of preparing liposomes and products produced thereby |
| US4744989A (en) * | 1984-02-08 | 1988-05-17 | E. R. Squibb & Sons, Inc. | Method of preparing liposomes and products produced thereby |
| US4766046A (en) * | 1985-09-27 | 1988-08-23 | Liposome Technology, Inc. | Stabilized liposome/amphotericin composition and method |
-
2005
- 2005-06-13 CN CNA200580023366XA patent/CN101014322A/zh active Pending
- 2005-06-13 EP EP05759293A patent/EP1771156B8/en not_active Expired - Lifetime
- 2005-06-13 AT AT05759293T patent/ATE476965T1/de not_active IP Right Cessation
- 2005-06-13 JP JP2007526704A patent/JP4966855B2/ja not_active Expired - Fee Related
- 2005-06-13 BR BRPI0511371-7A patent/BRPI0511371A/pt active Search and Examination
- 2005-06-13 US US11/570,379 patent/US20070218119A1/en not_active Abandoned
- 2005-06-13 WO PCT/IN2005/000193 patent/WO2005120460A1/en not_active Ceased
- 2005-06-13 AU AU2005251572A patent/AU2005251572B2/en not_active Ceased
- 2005-06-13 DE DE602005022876T patent/DE602005022876D1/de not_active Expired - Lifetime
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