JP2008501782A5 - - Google Patents
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- Publication number
- JP2008501782A5 JP2008501782A5 JP2007526704A JP2007526704A JP2008501782A5 JP 2008501782 A5 JP2008501782 A5 JP 2008501782A5 JP 2007526704 A JP2007526704 A JP 2007526704A JP 2007526704 A JP2007526704 A JP 2007526704A JP 2008501782 A5 JP2008501782 A5 JP 2008501782A5
- Authority
- JP
- Japan
- Prior art keywords
- amphotericin
- sterol
- mixed layered
- enriched mixed
- liposome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims description 23
- 239000002502 liposome Substances 0.000 claims description 19
- 229930182558 Sterol Natural products 0.000 claims description 17
- 235000003702 sterols Nutrition 0.000 claims description 17
- 150000003432 sterols Chemical class 0.000 claims description 16
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 claims description 12
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 claims description 12
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 claims description 12
- 229930183010 Amphotericin Natural products 0.000 claims description 12
- QGGFZZLFKABGNL-UHFFFAOYSA-N Amphotericin A Natural products OC1C(N)C(O)C(C)OC1OC1C=CC=CC=CC=CCCC=CC=CC(C)C(O)C(C)C(C)OC(=O)CC(O)CC(O)CCC(O)C(O)CC(O)CC(O)(CC(O)C2C(O)=O)OC2C1 QGGFZZLFKABGNL-UHFFFAOYSA-N 0.000 claims description 12
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 claims description 12
- 229940009444 amphotericin Drugs 0.000 claims description 12
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 claims description 11
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims description 9
- 229960003942 amphotericin b Drugs 0.000 claims description 9
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 8
- 150000003904 phospholipids Chemical group 0.000 claims description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 6
- 239000000725 suspension Substances 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 150000002632 lipids Chemical class 0.000 claims description 4
- 235000012000 cholesterol Nutrition 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 208000035473 Communicable disease Diseases 0.000 claims description 2
- 241000222722 Leishmania <genus> Species 0.000 claims description 2
- 239000000872 buffer Substances 0.000 claims description 2
- -1 ergosterol sterol Chemical class 0.000 claims description 2
- 230000037431 insertion Effects 0.000 claims 3
- 238000003780 insertion Methods 0.000 claims 3
- 210000000805 cytoplasm Anatomy 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 244000000040 protozoan parasite Species 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000009210 therapy by ultrasound Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000013020 final formulation Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1113/DEL/2004 | 2004-06-11 | ||
| IN1113DE2004 | 2004-06-11 | ||
| PCT/IN2005/000193 WO2005120460A1 (en) | 2004-06-11 | 2005-06-13 | Sterol enriched mixed lammelarity amphotericin intercalating liposomes in saline and the process for their preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008501782A JP2008501782A (ja) | 2008-01-24 |
| JP2008501782A5 true JP2008501782A5 (enExample) | 2012-02-16 |
| JP4966855B2 JP4966855B2 (ja) | 2012-07-04 |
Family
ID=34972096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007526704A Expired - Fee Related JP4966855B2 (ja) | 2004-06-11 | 2005-06-13 | 塩水中のステロール濃縮混合層状アンフォテリシン（Ａｍｐｈｏｔｅｒｉｃｉｎ）挿入リポソーム及びその調製方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20070218119A1 (enExample) |
| EP (1) | EP1771156B8 (enExample) |
| JP (1) | JP4966855B2 (enExample) |
| CN (1) | CN101014322A (enExample) |
| AT (1) | ATE476965T1 (enExample) |
| AU (1) | AU2005251572B2 (enExample) |
| BR (1) | BRPI0511371A (enExample) |
| DE (1) | DE602005022876D1 (enExample) |
| WO (1) | WO2005120460A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2481100C2 (ru) * | 2009-10-16 | 2013-05-10 | Лайфкеа Инновейшнз Пвт. Лтд. | Новая лекарственная форма для лечения грибковой инфекции |
| WO2017150705A1 (ja) * | 2016-03-04 | 2017-09-08 | 栗田工業株式会社 | 選択性透過膜及びその製造方法、該選択性透過膜を用いる水処理方法 |
| JP7355335B2 (ja) * | 2017-10-11 | 2023-10-03 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ | 小分子重炭酸イオンチャネルを用いた嚢胞性線維症の遺伝子型非依存性救済 |
| KR20240164801A (ko) | 2022-03-21 | 2024-11-20 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 암포테리신 b의 지질-코팅된 결정을 포함하는 이온 채널 보형 조성물 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2134869A (en) * | 1983-02-15 | 1984-08-22 | Squibb & Sons Inc | Method of preparing liposomes and products produced thereby |
| US4744989A (en) * | 1984-02-08 | 1988-05-17 | E. R. Squibb & Sons, Inc. | Method of preparing liposomes and products produced thereby |
| US4766046A (en) * | 1985-09-27 | 1988-08-23 | Liposome Technology, Inc. | Stabilized liposome/amphotericin composition and method |
-
2005
- 2005-06-13 AT AT05759293T patent/ATE476965T1/de not_active IP Right Cessation
- 2005-06-13 BR BRPI0511371-7A patent/BRPI0511371A/pt active Search and Examination
- 2005-06-13 CN CNA200580023366XA patent/CN101014322A/zh active Pending
- 2005-06-13 JP JP2007526704A patent/JP4966855B2/ja not_active Expired - Fee Related
- 2005-06-13 WO PCT/IN2005/000193 patent/WO2005120460A1/en not_active Ceased
- 2005-06-13 US US11/570,379 patent/US20070218119A1/en not_active Abandoned
- 2005-06-13 DE DE602005022876T patent/DE602005022876D1/de not_active Expired - Lifetime
- 2005-06-13 AU AU2005251572A patent/AU2005251572B2/en not_active Ceased
- 2005-06-13 EP EP05759293A patent/EP1771156B8/en not_active Expired - Lifetime
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