JP2008501771A - ヒストン脱アセチル化酵素阻害剤 - Google Patents
ヒストン脱アセチル化酵素阻害剤 Download PDFInfo
- Publication number
- JP2008501771A JP2008501771A JP2007526538A JP2007526538A JP2008501771A JP 2008501771 A JP2008501771 A JP 2008501771A JP 2007526538 A JP2007526538 A JP 2007526538A JP 2007526538 A JP2007526538 A JP 2007526538A JP 2008501771 A JP2008501771 A JP 2008501771A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino
- benzamide
- vinyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 C*c1ncccc1*C(c(cc1)ccc1C(CNCc1cnccc1)=C)=O Chemical compound C*c1ncccc1*C(c(cc1)ccc1C(CNCc1cnccc1)=C)=O 0.000 description 6
- CIXROPWNAJKHLB-UHFFFAOYSA-N C=C(CN(CC1)Cc2c1[nH]c(cc1)c2cc1F)c(cc1)ccc1C(Nc1ccccc1N)=O Chemical compound C=C(CN(CC1)Cc2c1[nH]c(cc1)c2cc1F)c(cc1)ccc1C(Nc1ccccc1N)=O CIXROPWNAJKHLB-UHFFFAOYSA-N 0.000 description 1
- OZFLLPPUUDUIDP-UHFFFAOYSA-N C=C(CN1CCOCC1)c1ccc(CCC(Nc2ccccc2N)=O)cc1 Chemical compound C=C(CN1CCOCC1)c1ccc(CCC(Nc2ccccc2N)=O)cc1 OZFLLPPUUDUIDP-UHFFFAOYSA-N 0.000 description 1
- DKSOUGZOBBNBJL-UHFFFAOYSA-N CC(CN(CC1)CCN1c1cc(F)ccc1)c(cc1)ccc1C(Nc(cccc1)c1N)=O Chemical compound CC(CN(CC1)CCN1c1cc(F)ccc1)c(cc1)ccc1C(Nc(cccc1)c1N)=O DKSOUGZOBBNBJL-UHFFFAOYSA-N 0.000 description 1
- USRKLNMBGODGNX-UHFFFAOYSA-N CC1C(CNCC(c(cc2)ccc2C(Nc(cccc2)c2N)=O)=C)=CC=CC1 Chemical compound CC1C(CNCC(c(cc2)ccc2C(Nc(cccc2)c2N)=O)=C)=CC=CC1 USRKLNMBGODGNX-UHFFFAOYSA-N 0.000 description 1
- VONAEAJVUUESQA-IBGZPJMESA-N C[C@@H](CN(CC1)CCN1c(cccc1)c1F)c(cc1)ccc1C(NC(C=CCC1)=C1N)=O Chemical compound C[C@@H](CN(CC1)CCN1c(cccc1)c1F)c(cc1)ccc1C(NC(C=CCC1)=C1N)=O VONAEAJVUUESQA-IBGZPJMESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57891504P | 2004-06-10 | 2004-06-10 | |
| GB0412964A GB0412964D0 (en) | 2004-06-10 | 2004-06-10 | Inhibitors of histone deacetylase |
| PCT/GB2005/002234 WO2005121073A1 (en) | 2004-06-10 | 2005-06-07 | Inhibitors of histone deacetylase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008501771A true JP2008501771A (ja) | 2008-01-24 |
| JP2008501771A5 JP2008501771A5 (enExample) | 2008-07-17 |
Family
ID=34970964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007526538A Withdrawn JP2008501771A (ja) | 2004-06-10 | 2005-06-07 | ヒストン脱アセチル化酵素阻害剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20080234254A1 (enExample) |
| EP (1) | EP1758847A1 (enExample) |
| JP (1) | JP2008501771A (enExample) |
| WO (1) | WO2005121073A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2642813A1 (en) | 2006-02-28 | 2007-09-07 | Merck & Co., Inc. | Inhibitors of histone deacetylase |
| KR20100074288A (ko) * | 2007-10-22 | 2010-07-01 | 오키드 리서치 레버라토리즈 리미티드 | 히스톤 디아세틸라제 억제제 |
| AU2009289649B2 (en) | 2008-09-03 | 2016-05-05 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
| CN102249958B (zh) * | 2010-11-29 | 2014-06-04 | 江苏先声药物研究有限公司 | 苯甲酰氨类组蛋白去乙酰化酶抑制剂 |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| JP6250403B2 (ja) | 2011-02-28 | 2017-12-20 | バイオマリン ファーマシューティカル インク | ヒストン脱アセチル化酵素阻害剤 |
| CN102807526B (zh) * | 2011-06-21 | 2015-12-02 | 寿光富康制药有限公司 | 组蛋白去乙酰化酶抑制剂ZYJ-D08a及其差向异构体的制备方法与应用 |
| GB201111630D0 (en) | 2011-07-07 | 2011-08-24 | Cancer Rec Tech Ltd | Novel compounds and their use |
| WO2013169858A1 (en) | 2012-05-08 | 2013-11-14 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
| PT2970139T (pt) | 2013-03-15 | 2018-08-01 | Biomarin Pharm Inc | Inibidores de hdac |
| EP3062783B1 (en) | 2013-10-18 | 2020-08-12 | The General Hospital Corporation | Imaging histone deacetylases with a radiotracer using positron emission tomography |
| EP3237390B1 (en) | 2014-12-23 | 2019-05-08 | Crossing S.r.l. | Method for the industrial production of 2-halo-4,6-dialkoxy-1,3,5-triazine and their use in the presence of amines |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6174905B1 (en) * | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
| EP1551795A1 (en) * | 2002-10-17 | 2005-07-13 | Methylgene, Inc. | Inhibitors of histone deacetylase |
-
2005
- 2005-06-07 US US11/628,992 patent/US20080234254A1/en not_active Abandoned
- 2005-06-07 JP JP2007526538A patent/JP2008501771A/ja not_active Withdrawn
- 2005-06-07 EP EP05754307A patent/EP1758847A1/en not_active Withdrawn
- 2005-06-07 WO PCT/GB2005/002234 patent/WO2005121073A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005121073A1 (en) | 2005-12-22 |
| US20080234254A1 (en) | 2008-09-25 |
| EP1758847A1 (en) | 2007-03-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100863924B1 (ko) | 헤테로아릴설포닐 측쇄를 갖는 안트라닐산 아미드 및 당해 화합물을 함유하는 약제학적 제제 | |
| US8119627B2 (en) | Heterocyclic compounds as inhibitors of 17beta-HSD3 | |
| US20050250707A1 (en) | HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis | |
| KR102574135B1 (ko) | 히스톤 데아세틸라제 1 및 2 (hdac1-2)의 선택적인 저해제로서 새로운 헤테로아릴 아미드 유도체 | |
| AU2002345644A1 (en) | HV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis | |
| JP2003509410A (ja) | カテプシンインヒビターとしての化合物および薬学的組成物 | |
| JP2009501236A (ja) | ヒストンデアセチラーゼ阻害剤 | |
| WO2011145669A1 (ja) | アミド誘導体 | |
| KR20150022789A (ko) | 포스포디에스테라제 억제제로서 1-페닐-2-피리디닐 알킬 알코올의 유도체 | |
| KR20070070179A (ko) | 신규 히스톤 탈아세틸효소 억제제 | |
| US20080234254A1 (en) | Inhibitors of Histone Deacetylase | |
| US8558028B2 (en) | Compound capable of inhibiting 17-beta hydroxysteriod dehydrogenase | |
| CN109232358A (zh) | 吲哚类衍生物或其盐及其制备方法和用途 | |
| CN103992311B (zh) | Hedgehog信号通路抑制剂 | |
| JP2002537285A (ja) | システインプロテアーゼ阻害薬としてのアシル化アミノアセトニトリル類 | |
| US20110077305A1 (en) | 5-lipoxygenase inhibitors | |
| WO2005085201A1 (ja) | 置換又は無置換アミノ基を導入した４－ピリジルアルキルチオ基を有する新規環式化合物 | |
| CN101272774B (zh) | 取代的丙烯酰胺衍生物和包含其的药物组合物 | |
| CN119176770A (zh) | Hdac抑制剂、组合物及其用途 | |
| ES2396557T3 (es) | Derivado de benciloxipropilamina | |
| JPS60142959A (ja) | キノリン誘導体 | |
| CN103058959B (zh) | 一种n-(2-(4-甲基哌嗪-1-基)-5-甲酰苯基)酰胺类化合物及其应用 | |
| CN120923445A (zh) | 作为nlrp3炎性小体抑制剂的酰胺类化合物 | |
| CA3220193A1 (en) | Novel oxazole derivative and pharmaceutical composition for preventing or treating allergic diseases comprising the same | |
| CN115677703A (zh) | 吡啶酮类化合物及其用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080529 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080529 |
|
| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20100722 |