JP2008500963A - 第二世代免疫調節性オリゴヌクレオチドを用いて増幅されたhivワクチン活性 - Google Patents

第二世代免疫調節性オリゴヌクレオチドを用いて増幅されたhivワクチン活性 Download PDF

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Publication number
JP2008500963A
JP2008500963A JP2007503063A JP2007503063A JP2008500963A JP 2008500963 A JP2008500963 A JP 2008500963A JP 2007503063 A JP2007503063 A JP 2007503063A JP 2007503063 A JP2007503063 A JP 2007503063A JP 2008500963 A JP2008500963 A JP 2008500963A
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JP
Japan
Prior art keywords
hiv
antigen
immunogen
immunomodulatory oligonucleotide
mixed
Prior art date
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Pending
Application number
JP2007503063A
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English (en)
Japanese (ja)
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JP2008500963A5 (enExample
Inventor
クレリーチ,マリオ
バーソロミュー,リチャード
ブレイ,ドロシー
カンディマラ,エカンバー
アグラワル,サディール
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aceragen Inc
Original Assignee
Idera Pharmaceuticals Inc
Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idera Pharmaceuticals Inc, Hybridon Inc filed Critical Idera Pharmaceuticals Inc
Publication of JP2008500963A publication Critical patent/JP2008500963A/ja
Publication of JP2008500963A5 publication Critical patent/JP2008500963A5/ja
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/21Retroviridae, e.g. equine infectious anemia virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5252Virus inactivated (killed)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16111Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007503063A 2004-03-12 2005-03-11 第二世代免疫調節性オリゴヌクレオチドを用いて増幅されたhivワクチン活性 Pending JP2008500963A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55287104P 2004-03-12 2004-03-12
PCT/US2005/008238 WO2005089231A2 (en) 2004-03-12 2005-03-11 Enhanced activity of hiv vaccine using a second generation immunomodulatory oligonucleotide

Publications (2)

Publication Number Publication Date
JP2008500963A true JP2008500963A (ja) 2008-01-17
JP2008500963A5 JP2008500963A5 (enExample) 2008-05-15

Family

ID=34994209

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007503063A Pending JP2008500963A (ja) 2004-03-12 2005-03-11 第二世代免疫調節性オリゴヌクレオチドを用いて増幅されたhivワクチン活性

Country Status (7)

Country Link
US (1) US20050266015A1 (enExample)
EP (1) EP1729802A4 (enExample)
JP (1) JP2008500963A (enExample)
CN (1) CN101217973A (enExample)
AU (1) AU2005222909B2 (enExample)
CA (1) CA2557443A1 (enExample)
WO (1) WO2005089231A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US20030022854A1 (en) 1998-06-25 2003-01-30 Dow Steven W. Vaccines using nucleic acid-lipid complexes
AR040996A1 (es) 2002-08-19 2005-04-27 Coley Pharm Group Inc Acidos nucleicos inmunoestimuladores
CN1753687A (zh) 2002-10-29 2006-03-29 科勒制药集团股份有限公司 Cpg寡核苷酸在治疗丙型肝炎病毒感染中的应用
MY159370A (en) 2004-10-20 2016-12-30 Coley Pharm Group Inc Semi-soft-class immunostimulatory oligonucleotides
US7470674B2 (en) * 2005-11-07 2008-12-30 Idera Pharmaceuticals, Inc. Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
KR101251707B1 (ko) 2006-09-27 2013-04-11 콜리 파마슈티칼 게엠베하 면역 자극 활성이 증강된 소수성 T 유사체를 함유하는 CpG 올리고뉴클레오티드 유사체
BR112012030337B1 (pt) * 2010-05-28 2021-04-27 Coley Pharmaceutical Group, Inc Vacina compreendendo um ou mais oligonucleotídeo(s) de cpg isolado(s) ou um agonista de tlr e colesterol, e uso da mesma

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912332A (en) * 1996-07-26 1999-06-15 Hybridon, Inc. Affinity-based purification of oligonucleotides using soluble multimeric oligonucleotides
KR101123489B1 (ko) * 2003-01-16 2012-03-28 이데라 파마슈티칼즈, 인코포레이티드 개질된 면역자극성 디뉴클레오티드를 이용한 올리고뉴클레오티드-기재 화합물의 면역자극 특성의 조절
CN101291691A (zh) * 2003-08-28 2008-10-22 免疫反应公司 免疫原性hiv组合物和相关方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN6010068912, "Immune Response Licenses Hybridon’s AMPLIVAX vaccine adjuvant", BIOTECH Patent News, 200310, Vol.17, No.10, p.14−15 *
JPN6010068913, KANDIMALLA, E.R., et al., "Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomod", Nucleic Acids Research, 2003, Vol.31, No.9, p.2393−2400 *
JPN6010068914, HORNER, A.A., et al., "Immunostimulatory DNA−Based Vaccines Elicit Multifaceted Immune Responses Against HIV at Systemic an", The Journal of Immunology, 2001, Vol.167, p.1584−1591 *
JPN6010068915, LIMSUWAN, A., et al., "Safety and immunogenicity of REMUNE TM in HIV−infected Thai subjects", Vaccine, 1998, Vol.16, No.2/3, p.142−149 *

Also Published As

Publication number Publication date
US20050266015A1 (en) 2005-12-01
EP1729802A4 (en) 2009-12-16
CA2557443A1 (en) 2005-09-29
AU2005222909B2 (en) 2010-03-11
WO2005089231A3 (en) 2007-12-06
WO2005089231A2 (en) 2005-09-29
CN101217973A (zh) 2008-07-09
AU2005222909A1 (en) 2005-09-29
EP1729802A2 (en) 2006-12-13

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