AU2005222909B2 - Enhanced activity of HIV vaccine using a second generation immunomodulatory oligonucleotide - Google Patents
Enhanced activity of HIV vaccine using a second generation immunomodulatory oligonucleotide Download PDFInfo
- Publication number
- AU2005222909B2 AU2005222909B2 AU2005222909A AU2005222909A AU2005222909B2 AU 2005222909 B2 AU2005222909 B2 AU 2005222909B2 AU 2005222909 A AU2005222909 A AU 2005222909A AU 2005222909 A AU2005222909 A AU 2005222909A AU 2005222909 B2 AU2005222909 B2 AU 2005222909B2
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- Australia
- Prior art keywords
- hiv
- antigen
- immunomodulatory oligonucleotide
- immunogen
- depleted
- Prior art date
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Public Health (AREA)
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- Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Molecular Biology (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55287104P | 2004-03-12 | 2004-03-12 | |
| US60/552,871 | 2004-03-12 | ||
| PCT/US2005/008238 WO2005089231A2 (en) | 2004-03-12 | 2005-03-11 | Enhanced activity of hiv vaccine using a second generation immunomodulatory oligonucleotide |
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| AU2005222909B2 true AU2005222909B2 (en) | 2010-03-11 |
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| AU (1) | AU2005222909B2 (enExample) |
| CA (1) | CA2557443A1 (enExample) |
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| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US20030022854A1 (en) | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
| AR040996A1 (es) | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
| CN1753687A (zh) | 2002-10-29 | 2006-03-29 | 科勒制药集团股份有限公司 | Cpg寡核苷酸在治疗丙型肝炎病毒感染中的应用 |
| MY159370A (en) | 2004-10-20 | 2016-12-30 | Coley Pharm Group Inc | Semi-soft-class immunostimulatory oligonucleotides |
| US7470674B2 (en) * | 2005-11-07 | 2008-12-30 | Idera Pharmaceuticals, Inc. | Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides |
| KR101251707B1 (ko) | 2006-09-27 | 2013-04-11 | 콜리 파마슈티칼 게엠베하 | 면역 자극 활성이 증강된 소수성 Ｔ 유사체를 함유하는 ＣｐＧ 올리고뉴클레오티드 유사체 |
| BR112012030337B1 (pt) * | 2010-05-28 | 2021-04-27 | Coley Pharmaceutical Group, Inc | Vacina compreendendo um ou mais oligonucleotídeo(s) de cpg isolado(s) ou um agonista de tlr e colesterol, e uso da mesma |
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| US20040198685A1 (en) * | 2003-01-16 | 2004-10-07 | Hybridon, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides |
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| US5912332A (en) * | 1996-07-26 | 1999-06-15 | Hybridon, Inc. | Affinity-based purification of oligonucleotides using soluble multimeric oligonucleotides |
| CN101291691A (zh) * | 2003-08-28 | 2008-10-22 | 免疫反应公司 | 免疫原性hiv组合物和相关方法 |
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- 2005-03-11 WO PCT/US2005/008238 patent/WO2005089231A2/en not_active Ceased
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| US20040198685A1 (en) * | 2003-01-16 | 2004-10-07 | Hybridon, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides |
Non-Patent Citations (2)
| Title |
|---|
| Horner, A.A. The Journal of Immunology, 2001, Vol.167, pages 1584-1591 * |
| Lisawan, A., Vaccine, 1996, Vol.16, No.213, pages 142-149 * |
Also Published As
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| US20050266015A1 (en) | 2005-12-01 |
| EP1729802A4 (en) | 2009-12-16 |
| CA2557443A1 (en) | 2005-09-29 |
| WO2005089231A3 (en) | 2007-12-06 |
| WO2005089231A2 (en) | 2005-09-29 |
| CN101217973A (zh) | 2008-07-09 |
| JP2008500963A (ja) | 2008-01-17 |
| AU2005222909A1 (en) | 2005-09-29 |
| EP1729802A2 (en) | 2006-12-13 |
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Owner name: THE IMMUNE RESPONSE CORPORATION; IDERA PHARMACEUTI Free format text: FORMER APPLICANT(S): THE IMMUNE RESPONSE CORPORATION; HYBRIDON, INC. |
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