CA2557443A1 - Enhanced activity of hiv vaccine using a second generation immunomodulatory oligonucleotide - Google Patents
Enhanced activity of hiv vaccine using a second generation immunomodulatory oligonucleotide Download PDFInfo
- Publication number
- CA2557443A1 CA2557443A1 CA002557443A CA2557443A CA2557443A1 CA 2557443 A1 CA2557443 A1 CA 2557443A1 CA 002557443 A CA002557443 A CA 002557443A CA 2557443 A CA2557443 A CA 2557443A CA 2557443 A1 CA2557443 A1 CA 2557443A1
- Authority
- CA
- Canada
- Prior art keywords
- hiv
- antigen
- immunomodulatory oligonucleotide
- immunogen
- deazaguanosine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
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- Microbiology (AREA)
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- Communicable Diseases (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55287104P | 2004-03-12 | 2004-03-12 | |
| US60/552,871 | 2004-03-12 | ||
| PCT/US2005/008238 WO2005089231A2 (en) | 2004-03-12 | 2005-03-11 | Enhanced activity of hiv vaccine using a second generation immunomodulatory oligonucleotide |
Publications (1)
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| CA2557443A1 true CA2557443A1 (en) | 2005-09-29 |
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Family Applications (1)
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|---|---|---|---|
| CA002557443A Abandoned CA2557443A1 (en) | 2004-03-12 | 2005-03-11 | Enhanced activity of hiv vaccine using a second generation immunomodulatory oligonucleotide |
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| EP (1) | EP1729802A4 (enExample) |
| JP (1) | JP2008500963A (enExample) |
| CN (1) | CN101217973A (enExample) |
| AU (1) | AU2005222909B2 (enExample) |
| CA (1) | CA2557443A1 (enExample) |
| WO (1) | WO2005089231A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US20030022854A1 (en) | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
| AR040996A1 (es) | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
| CN1753687A (zh) | 2002-10-29 | 2006-03-29 | 科勒制药集团股份有限公司 | Cpg寡核苷酸在治疗丙型肝炎病毒感染中的应用 |
| MY159370A (en) | 2004-10-20 | 2016-12-30 | Coley Pharm Group Inc | Semi-soft-class immunostimulatory oligonucleotides |
| US7470674B2 (en) * | 2005-11-07 | 2008-12-30 | Idera Pharmaceuticals, Inc. | Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides |
| KR101251707B1 (ko) | 2006-09-27 | 2013-04-11 | 콜리 파마슈티칼 게엠베하 | 면역 자극 활성이 증강된 소수성 Ｔ 유사체를 함유하는 ＣｐＧ 올리고뉴클레오티드 유사체 |
| BR112012030337B1 (pt) * | 2010-05-28 | 2021-04-27 | Coley Pharmaceutical Group, Inc | Vacina compreendendo um ou mais oligonucleotídeo(s) de cpg isolado(s) ou um agonista de tlr e colesterol, e uso da mesma |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5912332A (en) * | 1996-07-26 | 1999-06-15 | Hybridon, Inc. | Affinity-based purification of oligonucleotides using soluble multimeric oligonucleotides |
| KR101123489B1 (ko) * | 2003-01-16 | 2012-03-28 | 이데라 파마슈티칼즈, 인코포레이티드 | 개질된 면역자극성 디뉴클레오티드를 이용한 올리고뉴클레오티드-기재 화합물의 면역자극 특성의 조절 |
| CN101291691A (zh) * | 2003-08-28 | 2008-10-22 | 免疫反应公司 | 免疫原性hiv组合物和相关方法 |
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2005
- 2005-03-11 AU AU2005222909A patent/AU2005222909B2/en not_active Ceased
- 2005-03-11 JP JP2007503063A patent/JP2008500963A/ja active Pending
- 2005-03-11 CA CA002557443A patent/CA2557443A1/en not_active Abandoned
- 2005-03-11 WO PCT/US2005/008238 patent/WO2005089231A2/en not_active Ceased
- 2005-03-11 CN CNA2005800079845A patent/CN101217973A/zh active Pending
- 2005-03-11 US US11/078,654 patent/US20050266015A1/en not_active Abandoned
- 2005-03-11 EP EP05725427A patent/EP1729802A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20050266015A1 (en) | 2005-12-01 |
| EP1729802A4 (en) | 2009-12-16 |
| AU2005222909B2 (en) | 2010-03-11 |
| WO2005089231A3 (en) | 2007-12-06 |
| WO2005089231A2 (en) | 2005-09-29 |
| CN101217973A (zh) | 2008-07-09 |
| JP2008500963A (ja) | 2008-01-17 |
| AU2005222909A1 (en) | 2005-09-29 |
| EP1729802A2 (en) | 2006-12-13 |
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