JP2008500317A5 - - Google Patents
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- Publication number
- JP2008500317A5 JP2008500317A5 JP2007514087A JP2007514087A JP2008500317A5 JP 2008500317 A5 JP2008500317 A5 JP 2008500317A5 JP 2007514087 A JP2007514087 A JP 2007514087A JP 2007514087 A JP2007514087 A JP 2007514087A JP 2008500317 A5 JP2008500317 A5 JP 2008500317A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- reaction
- compound
- pyridyl
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000006243 chemical reaction Methods 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical group O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 claims 1
- NVZIFMAZKAYQJR-UHFFFAOYSA-N 3-(aminomethyl)-1,3-oxazolidin-2-one Chemical compound NCN1CCOC1=O NVZIFMAZKAYQJR-UHFFFAOYSA-N 0.000 claims 1
- DVSMAFFYUWLENL-UHFFFAOYSA-N 3-(azidomethyl)-1,3-oxazolidin-2-one Chemical compound [N-]=[N+]=NCN1CCOC1=O DVSMAFFYUWLENL-UHFFFAOYSA-N 0.000 claims 1
- -1 4 -pyridyl-phenyl ring Chemical group 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- 239000007818 Grignard reagent Substances 0.000 claims 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 150000001299 aldehydes Chemical class 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 150000007942 carboxylates Chemical class 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 238000006352 cycloaddition reaction Methods 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 150000004795 grignard reagents Chemical class 0.000 claims 1
- 125000005283 haloketone group Chemical group 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 150000002443 hydroxylamines Chemical class 0.000 claims 1
- 239000012948 isocyanate Substances 0.000 claims 1
- 150000002513 isocyanates Chemical class 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000012038 nucleophile Substances 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 150000002923 oximes Chemical class 0.000 claims 1
- 150000002924 oxiranes Chemical class 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
- 0 CC(c(cc1)ncc1-c1c(*)cc(*)cc1*)=O Chemical compound CC(c(cc1)ncc1-c1c(*)cc(*)cc1*)=O 0.000 description 8
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0411593A GB0411593D0 (en) | 2004-05-25 | 2004-05-25 | Chemical compounds |
| GB0500054A GB0500054D0 (en) | 2005-01-05 | 2005-01-05 | Chemical compounds |
| PCT/GB2005/002051 WO2005116022A1 (en) | 2004-05-25 | 2005-05-24 | 3- `4- {6-substituted alkanoyl) pyridin-3-yl} -3-phenyl! -5- (1h-1, 2, 3-triazol-1-ylmethyl) -1, 3-oxazolidin-2-ones as antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008500317A JP2008500317A (ja) | 2008-01-10 |
| JP2008500317A5 true JP2008500317A5 (https=) | 2008-06-26 |
Family
ID=34968778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007514087A Pending JP2008500317A (ja) | 2004-05-25 | 2005-05-24 | 抗菌剤としての３−’４−｛６−置換アルカノイル）ピリジン−３−イル｝−３−フェニル−５−（１ｈ−１，２，３−トリアゾール−１−イルメチル）−１，３−オキサゾリジン−２−オン |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20080021012A1 (https=) |
| EP (1) | EP1753754A1 (https=) |
| JP (1) | JP2008500317A (https=) |
| AU (1) | AU2005247668A1 (https=) |
| BR (1) | BRPI0511526A (https=) |
| CA (1) | CA2566963A1 (https=) |
| IL (1) | IL179349A0 (https=) |
| MX (1) | MXPA06013537A (https=) |
| NO (1) | NO20065889L (https=) |
| WO (1) | WO2005116022A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100854211B1 (ko) * | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
| WO2010042887A2 (en) * | 2008-10-10 | 2010-04-15 | Trius Therapeutics | Methods for preparing oxazolidinones and compositions containing them |
| KR101918678B1 (ko) | 2009-02-03 | 2018-11-14 | 머크 샤프 앤드 돔 코포레이션 | Ｒ)-3-(4-(2-(2-메틸테트라졸-5-일)피리딘-5-일)-3-플루오로페닐)-5-히드록시메틸 옥사졸리딘-2-온 디히드로겐 포스페이트의 결정형 |
| US8580767B2 (en) * | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
| KR101561964B1 (ko) | 2013-11-15 | 2015-10-20 | 한국과학기술연구원 | 옥사졸리디논 화합물 및 이를 포함하는 c형 간염 예방 또는 치료용 약학 조성물 |
| EP3795563B1 (en) | 2016-03-31 | 2024-07-17 | Oncternal Therapeutics, Inc. | Indoline analogs and uses thereof |
| WO2021258013A1 (en) | 2020-06-18 | 2021-12-23 | Akagera Medicines, Inc. | Oxazolidinone compounds, liposome compositions comprising oxazolidinone compounds and methods of use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| BR0111280A (pt) * | 2000-06-05 | 2003-06-10 | Dong A Pharm Co Ltd | Novos derivados de oxazolidinona e um processo para a preparação dos mesmos |
| JP2005524661A (ja) * | 2002-02-28 | 2005-08-18 | アストラゼネカ アクチボラグ | ３−シクリル−５−（窒素含有５員環）メチル−オキサゾリジノン誘導体と抗菌剤としてのその使用 |
-
2005
- 2005-05-24 EP EP05746537A patent/EP1753754A1/en not_active Withdrawn
- 2005-05-24 CA CA002566963A patent/CA2566963A1/en not_active Abandoned
- 2005-05-24 BR BRPI0511526-4A patent/BRPI0511526A/pt not_active Application Discontinuation
- 2005-05-24 AU AU2005247668A patent/AU2005247668A1/en not_active Abandoned
- 2005-05-24 JP JP2007514087A patent/JP2008500317A/ja active Pending
- 2005-05-24 WO PCT/GB2005/002051 patent/WO2005116022A1/en not_active Ceased
- 2005-05-24 US US11/569,408 patent/US20080021012A1/en not_active Abandoned
- 2005-05-24 MX MXPA06013537A patent/MXPA06013537A/es not_active Application Discontinuation
-
2006
- 2006-11-16 IL IL179349A patent/IL179349A0/en unknown
- 2006-12-19 NO NO20065889A patent/NO20065889L/no not_active Application Discontinuation
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