JP2008500317A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008500317A5 JP2008500317A5 JP2007514087A JP2007514087A JP2008500317A5 JP 2008500317 A5 JP2008500317 A5 JP 2008500317A5 JP 2007514087 A JP2007514087 A JP 2007514087A JP 2007514087 A JP2007514087 A JP 2007514087A JP 2008500317 A5 JP2008500317 A5 JP 2008500317A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- reaction
- compound
- pyridyl
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000006243 chemical reaction Methods 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical group O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 claims 1
- NVZIFMAZKAYQJR-UHFFFAOYSA-N 3-(aminomethyl)-1,3-oxazolidin-2-one Chemical compound NCN1CCOC1=O NVZIFMAZKAYQJR-UHFFFAOYSA-N 0.000 claims 1
- DVSMAFFYUWLENL-UHFFFAOYSA-N 3-(azidomethyl)-1,3-oxazolidin-2-one Chemical compound [N-]=[N+]=NCN1CCOC1=O DVSMAFFYUWLENL-UHFFFAOYSA-N 0.000 claims 1
- -1 4 -pyridyl-phenyl ring Chemical group 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- 239000007818 Grignard reagent Substances 0.000 claims 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 150000001299 aldehydes Chemical class 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 150000007942 carboxylates Chemical class 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 238000006352 cycloaddition reaction Methods 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 150000004795 grignard reagents Chemical class 0.000 claims 1
- 125000005283 haloketone group Chemical group 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 150000002443 hydroxylamines Chemical class 0.000 claims 1
- 239000012948 isocyanate Substances 0.000 claims 1
- 150000002513 isocyanates Chemical class 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000012038 nucleophile Substances 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 150000002923 oximes Chemical class 0.000 claims 1
- 150000002924 oxiranes Chemical class 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
- 0 CC(c(cc1)ncc1-c1c(*)cc(*)cc1*)=O Chemical compound CC(c(cc1)ncc1-c1c(*)cc(*)cc1*)=O 0.000 description 8
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0411593A GB0411593D0 (en) | 2004-05-25 | 2004-05-25 | Chemical compounds |
| GB0500054A GB0500054D0 (en) | 2005-01-05 | 2005-01-05 | Chemical compounds |
| PCT/GB2005/002051 WO2005116022A1 (en) | 2004-05-25 | 2005-05-24 | 3- `4- {6-substituted alkanoyl) pyridin-3-yl} -3-phenyl! -5- (1h-1, 2, 3-triazol-1-ylmethyl) -1, 3-oxazolidin-2-ones as antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008500317A JP2008500317A (ja) | 2008-01-10 |
| JP2008500317A5 true JP2008500317A5 (enExample) | 2008-06-26 |
Family
ID=34968778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007514087A Pending JP2008500317A (ja) | 2004-05-25 | 2005-05-24 | 抗菌剤としての３−’４−｛６−置換アルカノイル）ピリジン−３−イル｝−３−フェニル−５−（１ｈ−１，２，３−トリアゾール−１−イルメチル）−１，３−オキサゾリジン−２−オン |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20080021012A1 (enExample) |
| EP (1) | EP1753754A1 (enExample) |
| JP (1) | JP2008500317A (enExample) |
| AU (1) | AU2005247668A1 (enExample) |
| BR (1) | BRPI0511526A (enExample) |
| CA (1) | CA2566963A1 (enExample) |
| IL (1) | IL179349A0 (enExample) |
| MX (1) | MXPA06013537A (enExample) |
| NO (1) | NO20065889L (enExample) |
| WO (1) | WO2005116022A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
| EP2346858B1 (en) * | 2008-10-10 | 2019-08-07 | Merck Sharp & Dohme Corp. | Methods for preparing oxazolidinones and compositions containing them |
| UA114068C2 (xx) | 2009-02-03 | 2017-04-25 | Кристалічні частинки (r)-3-(4-(2-(2-метилтетразол-5-іл)піридин-5-іл)-3-фторфеніл)-5-гідроксиметилоксазолідин-2-ондиводеньфосфату | |
| US8580767B2 (en) * | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
| KR101561964B1 (ko) | 2013-11-15 | 2015-10-20 | 한국과학기술연구원 | 옥사졸리디논 화합물 및 이를 포함하는 c형 간염 예방 또는 치료용 약학 조성물 |
| JP6864379B2 (ja) | 2016-03-31 | 2021-04-28 | オンターナル セラピューティック インコーポレイテッドＯｎｃｔｅｒｎａｌ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | インドール類似体及びその使用 |
| US11555033B2 (en) | 2020-06-18 | 2023-01-17 | Akagera Medicines, Inc. | Oxazolidinone compounds, liposome compositions comprising oxazolidinone compounds and method of use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| US6689779B2 (en) * | 2000-06-05 | 2004-02-10 | Dong A Pharm. Co., Ltd. | Oxazolidinone derivatives and a process for the preparation thereof |
| US7473699B2 (en) * | 2002-02-28 | 2009-01-06 | Astrazeneca Ab | 3-cyclyl-5-(nitrogen-containing 5-membered ring)methyl-oxazolidinone derivatives and their use as antibacterial agents |
-
2005
- 2005-05-24 BR BRPI0511526-4A patent/BRPI0511526A/pt not_active Application Discontinuation
- 2005-05-24 JP JP2007514087A patent/JP2008500317A/ja active Pending
- 2005-05-24 US US11/569,408 patent/US20080021012A1/en not_active Abandoned
- 2005-05-24 CA CA002566963A patent/CA2566963A1/en not_active Abandoned
- 2005-05-24 MX MXPA06013537A patent/MXPA06013537A/es not_active Application Discontinuation
- 2005-05-24 EP EP05746537A patent/EP1753754A1/en not_active Withdrawn
- 2005-05-24 AU AU2005247668A patent/AU2005247668A1/en not_active Abandoned
- 2005-05-24 WO PCT/GB2005/002051 patent/WO2005116022A1/en not_active Ceased
-
2006
- 2006-11-16 IL IL179349A patent/IL179349A0/en unknown
- 2006-12-19 NO NO20065889A patent/NO20065889L/no not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5629214B2 (ja) | ２−メチル−２′−フェニルプロピオン酸誘導体の製造方法およびこれに使用される新規な中間体化合物 | |
| EP2424862B1 (en) | Process for preparing substituted isoxazoline compounds and their precursors | |
| JPH08507085A (ja) | アゼチジノンの合成方法 | |
| JP2012515142A5 (enExample) | ||
| EP2595968B1 (en) | Novel process for preparation of linezolid and its novel intermediates | |
| KR20150020214A (ko) | 하이드록실화 사이클로펜틸피리미딘 화합물 제조 방법 | |
| CN110997645A (zh) | 奥扎尼莫德的制备方法 | |
| JP2008500317A5 (enExample) | ||
| TW201028374A (en) | Method of preparing ezetimibe and intermediates used therein | |
| WO2008125592A1 (en) | Improved process for preparing o-chloromethylphenylglyoxylic esters, improved process for preparing (e)-2-(2-chloromethylphenyl)-2-alkoximinoacetic esters, and novel intermediates for their preparation | |
| JP2017508775A (ja) | ナトリウム（２ｓ，５ｒ）−６−（ベンジルオキシ）−７−オキソ−１，６−ジアザビシクロ［３．２．１］オクタン−２−カルボキシレートを調製する方法 | |
| US9040688B2 (en) | Intermediates in the preparation of 1,4-diphenyl azetidinone | |
| WO2003042180A9 (en) | Process for producing optically active oxoheptenoic acid ester | |
| CN102219803A (zh) | 一种伊替米贝中间体的制备方法 | |
| CA2811466A1 (en) | Process for preparation of aminocyclohexyl ethers and intermediate products used in the process | |
| JP2001294590A (ja) | ３−ビニル−セフェム化合物の製造方法 | |
| US20150011757A1 (en) | Method for preparing linezolid intermediate | |
| Yoon et al. | Diastereoselective synthesis of anti-1, 2-aminoalcohol by palladium (ll) catalyzed aza-claisen rearrangement | |
| WO2016079757A2 (en) | Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives | |
| JP2006516588A5 (enExample) | ||
| WO2015051903A1 (en) | A novel process for the preparation of chiral cyclopentanone intermediates | |
| JP3748933B2 (ja) | １−置換アゼチジノン誘導体の製造法 | |
| KR101032761B1 (ko) | 도세탁셀의 제조방법 및 도세탁셀의 제조를 위한 신규한중간체 | |
| JP6205530B2 (ja) | パクリタキセル及びドセタキセルの側鎖前駆体の製造方法 | |
| WO2012076030A1 (en) | Process for the preparation of intermediate compounds useful in the preparation of ezetimibe |