JP2008208072A - 光力学的治療法に使用するための光増感剤組成物 - Google Patents
光力学的治療法に使用するための光増感剤組成物 Download PDFInfo
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- JP2008208072A JP2008208072A JP2007046640A JP2007046640A JP2008208072A JP 2008208072 A JP2008208072 A JP 2008208072A JP 2007046640 A JP2007046640 A JP 2007046640A JP 2007046640 A JP2007046640 A JP 2007046640A JP 2008208072 A JP2008208072 A JP 2008208072A
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- photosensitizer composition
- ala
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- photodynamic
- titanium oxide
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Abstract
【解決手段】経口投与に適した液体担体中(特に、生理食塩水)に、平均一次粒子径50nm以下の酸化チタン微粒子に担持させた5−アミノレブリン酸を溶解してなる癌の光力学的治療法に使用するための光増感剤組成物。励起波長としては、635nm、405nmが好ましい。
【選択図】なし
Description
10mM 5−ALA水溶液100μLと、TiO2として0.2%の中性チタニアゾル(TKS−203)希釈液10μLとを合し、適量の生理食塩水を加えて全量を1mLとした。
雄性C3H/Heマウス(7週令、体重約20g)の後背部を剃毛し、ヒト扁平上皮癌(SCC)細胞浮遊液0.1mL(細胞数106−107個)を皮下に注入し、SCCを移植した。
Claims (6)
- 経口投与に適した液体担体中に、平均一次粒子径50nm以下の酸化チタン微粒子に担持させた5−アミノレブリン酸を溶解してなる癌の光力学的治療法に使用するための光増感剤組成物。
- 平均一次粒子径50nm以下の酸化チタン微粒子は、リン酸チタン化合物で被覆した解膠酸化チタンである請求項1の光増感剤組成物。
- 経口投与に適した液体担体は生理食塩水である請求項1または2の光増感剤組成物。
- 液体担体中の5−アミノブリン酸の濃度は少なくとも1mMであり、酸化チタンの濃度は少なくとも0.002wt%である請求項1ないし3のいずれかの光増感剤組成物。
- 励起波長が635nmである請求項1ないし4のいずれかの光増感剤組成物。
- 励起波長が405nmである請求項1ないし4のいずれかの光増感剤組成物。
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JP2007046640A JP4982208B2 (ja) | 2007-02-27 | 2007-02-27 | 光力学的治療法に使用するための光増感剤組成物 |
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JP2007046640A JP4982208B2 (ja) | 2007-02-27 | 2007-02-27 | 光力学的治療法に使用するための光増感剤組成物 |
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JP2008208072A true JP2008208072A (ja) | 2008-09-11 |
JP4982208B2 JP4982208B2 (ja) | 2012-07-25 |
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JP2007046640A Expired - Fee Related JP4982208B2 (ja) | 2007-02-27 | 2007-02-27 | 光力学的治療法に使用するための光増感剤組成物 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012026194A1 (ja) * | 2010-08-25 | 2012-03-01 | 国立大学法人 徳島大学 | 金属酸化物ナノ粒子構造体およびその製造方法 |
EP2429498A2 (en) * | 2009-04-28 | 2012-03-21 | CeramOptec GmbH | New oral formulations for tetrapyrrole derivatives |
WO2013005379A1 (ja) | 2011-07-01 | 2013-01-10 | Sbiファーマ株式会社 | 光増感剤又は5-アミノレブリン酸類を用いる光線力学的治療 |
WO2013150745A1 (ja) * | 2012-04-05 | 2013-10-10 | Sbiファーマ株式会社 | センチネルリンパ節がん転移識別装置 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000290015A (ja) * | 1999-04-09 | 2000-10-17 | Tayca Corp | 中性チタニアゾル |
JP2006034375A (ja) * | 2004-07-22 | 2006-02-09 | Toin Gakuen | 光線力学的治療剤 |
-
2007
- 2007-02-27 JP JP2007046640A patent/JP4982208B2/ja not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000290015A (ja) * | 1999-04-09 | 2000-10-17 | Tayca Corp | 中性チタニアゾル |
JP2006034375A (ja) * | 2004-07-22 | 2006-02-09 | Toin Gakuen | 光線力学的治療剤 |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2429498A2 (en) * | 2009-04-28 | 2012-03-21 | CeramOptec GmbH | New oral formulations for tetrapyrrole derivatives |
EP2429498A4 (en) * | 2009-04-28 | 2013-02-06 | Ceramoptec Gmbh | NEW ORAL FORMULATIONS OF TETRAPYRROLE DERIVATIVES |
WO2012026194A1 (ja) * | 2010-08-25 | 2012-03-01 | 国立大学法人 徳島大学 | 金属酸化物ナノ粒子構造体およびその製造方法 |
WO2013005379A1 (ja) | 2011-07-01 | 2013-01-10 | Sbiファーマ株式会社 | 光増感剤又は5-アミノレブリン酸類を用いる光線力学的治療 |
JPWO2013005379A1 (ja) * | 2011-07-01 | 2015-02-23 | Sbiファーマ株式会社 | 光増感剤又は5−アミノレブリン酸類を用いる光線力学的治療 |
US9345904B2 (en) | 2011-07-01 | 2016-05-24 | Sbi Pharmaceuticals Co., Ltd. | Photodynamic therapy using photosensitizing agent or 5-aminolevulinic acid |
WO2013150745A1 (ja) * | 2012-04-05 | 2013-10-10 | Sbiファーマ株式会社 | センチネルリンパ節がん転移識別装置 |
JPWO2013150745A1 (ja) * | 2012-04-05 | 2015-12-17 | Sbiファーマ株式会社 | センチネルリンパ節がん転移識別装置 |
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JP4982208B2 (ja) | 2012-07-25 |
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