JP2008201774A5 - - Google Patents
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- Publication number
- JP2008201774A5 JP2008201774A5 JP2008006447A JP2008006447A JP2008201774A5 JP 2008201774 A5 JP2008201774 A5 JP 2008201774A5 JP 2008006447 A JP2008006447 A JP 2008006447A JP 2008006447 A JP2008006447 A JP 2008006447A JP 2008201774 A5 JP2008201774 A5 JP 2008201774A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- hydrogen
- groups
- radionuclide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 7
- 239000003153 chemical reaction reagent Substances 0.000 claims 6
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 238000003384 imaging method Methods 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 150000003141 primary amines Chemical class 0.000 claims 2
- 150000003335 secondary amines Chemical class 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 150000003512 tertiary amines Chemical class 0.000 claims 2
- -1 HYNIC group Chemical compound 0.000 claims 1
- VSZLQBIIXQRXPT-UHFFFAOYSA-M S1C=CC=C1.[I-] Chemical compound S1C=CC=C1.[I-] VSZLQBIIXQRXPT-UHFFFAOYSA-M 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US786395P | 1995-12-01 | 1995-12-01 | |
| US60/007,863 | 1995-12-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52066997A Division JP4272259B2 (ja) | 1995-12-01 | 1996-11-25 | 診断用イメージングのための脂肪酸アナログの立体異性体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011232673A Division JP2012036215A (ja) | 1995-12-01 | 2011-10-24 | 診断用イメージングのための脂肪酸アナログの立体異性体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008201774A JP2008201774A (ja) | 2008-09-04 |
| JP2008201774A5 true JP2008201774A5 (US20080242721A1-20081002-C00053.png) | 2009-04-09 |
| JP4937144B2 JP4937144B2 (ja) | 2012-05-23 |
Family
ID=21728502
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52066997A Expired - Fee Related JP4272259B2 (ja) | 1995-12-01 | 1996-11-25 | 診断用イメージングのための脂肪酸アナログの立体異性体 |
| JP2008006447A Expired - Fee Related JP4937144B2 (ja) | 1995-12-01 | 2008-01-16 | 診断用イメージングのための脂肪酸アナログの立体異性体 |
| JP2011232673A Withdrawn JP2012036215A (ja) | 1995-12-01 | 2011-10-24 | 診断用イメージングのための脂肪酸アナログの立体異性体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52066997A Expired - Fee Related JP4272259B2 (ja) | 1995-12-01 | 1996-11-25 | 診断用イメージングのための脂肪酸アナログの立体異性体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011232673A Withdrawn JP2012036215A (ja) | 1995-12-01 | 2011-10-24 | 診断用イメージングのための脂肪酸アナログの立体異性体 |
Country Status (9)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69636881T2 (de) * | 1995-12-01 | 2007-09-20 | Molecular Insight Pharmaceuticals, Inc., Cambridge | Stereoisomere von fettsäureanalogen zur diagnostischen bildgebung |
| US20090117032A1 (en) * | 1998-09-08 | 2009-05-07 | The General Hospital Corporation | Imaging Agents for Early Detection and Monitoring of Cardiovascular Plaque |
| EP0992245A1 (en) * | 1998-09-16 | 2000-04-12 | Goldham Bioglan Pharma GmbH | Radio-contrast agents |
| EP1040825A1 (en) * | 1999-03-11 | 2000-10-04 | K.U. Leuven Research & Development | Means for diagnosing bladder carcinoma |
| US6437103B1 (en) | 1999-04-14 | 2002-08-20 | Biostream Inc. | Fatty acid analogs for diagnosis of coronary artery disease |
| JP4951798B2 (ja) | 2002-04-01 | 2012-06-13 | モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド | 側基脂肪酸撮像剤 |
| AU2004232297B2 (en) * | 2003-04-17 | 2010-11-04 | The General Hospital Corporation | Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid |
| US20120100073A1 (en) * | 2009-05-04 | 2012-04-26 | Washington University | Pet radiotracers for imaging fatty acid metabolism and storage |
| DE102010010666A1 (de) * | 2010-03-01 | 2011-09-01 | Sven Reske | Diagnose und Therapie von Krebserkrankungen mittels Fettsäuren |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6802651A (US20080242721A1-20081002-C00053.png) * | 1968-02-23 | 1969-08-26 | ||
| DE2828623C2 (de) * | 1978-06-29 | 1983-11-17 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Mit radioaktivem Flour markierte C↓1↓↓6↓-bis C↓1↓↓8↓- Fettsäuren, ein Verfahren zu ihrer Herstellung sowie deren Verwendung |
| DE2947500C2 (de) * | 1979-11-24 | 1984-05-10 | Dutschka, Klaus, 4300 Essen | Radiojodierte ω -Phenylfettsäuren, ihre Herstellung und deren Verwendung zur szintigraphischen Untersuchung des Herzmuskels und der Leber |
| FR2508902B1 (fr) * | 1981-07-02 | 1985-09-06 | Commissariat Energie Atomique | Procede de preparation extemporanee d'un acide gras injectable, marque a l'iode radioactif et preparation de derives iodes utilisables pour la mise en oeuvre de ce procede |
| US4524059A (en) * | 1983-01-28 | 1985-06-18 | The General Hospital Corporation | Fatty acid analogs |
| US4942231A (en) * | 1984-05-24 | 1990-07-17 | Mallinckrodt, Inc. | Method of preparing a chlorinated, brominated, radio-brominated, iodinated and/or radioiodinated aromatic or heteroaromatic compound |
| EP0194843B1 (en) * | 1985-03-11 | 1993-01-13 | AMERSHAM INTERNATIONAL plc | Complexes of technetium-99m with propylene amine oximes |
| US4746505A (en) * | 1985-04-26 | 1988-05-24 | President And Fellows Of Harvard College | Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands |
| US4764358A (en) * | 1985-04-30 | 1988-08-16 | The United States Of America As Represented By The United States Department Of Energy | Radiolabeled dimethyl branched long chain fatty acid for heart imaging |
| US4877599A (en) | 1986-11-10 | 1989-10-31 | New England Deaconess Hospital Corporation | Detection of vascular disease with labelled antibodies |
| DE3880974T2 (de) * | 1987-11-19 | 1993-08-26 | Univ Vanderbilt | Radiojodhaltige benzamide und verfahren zu ihrer verwendung als radiobildende agenzien. |
| US5242681A (en) * | 1990-03-12 | 1993-09-07 | Research Corporation Technologies, Inc. | Lipophilic contrast agents for diagnostic image analysis |
| US7238340B1 (en) * | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
| DE69636881T2 (de) * | 1995-12-01 | 2007-09-20 | Molecular Insight Pharmaceuticals, Inc., Cambridge | Stereoisomere von fettsäureanalogen zur diagnostischen bildgebung |
| US7060251B1 (en) * | 1997-09-08 | 2006-06-13 | The General Hospital Corporation | Imaging agents for early detection and monitoring of cardiovascular plaque |
| WO1999012579A1 (en) * | 1997-09-08 | 1999-03-18 | The General Hospital Corporation | Imaging agents for early detection and monitoring of cardiovascular plaque |
| US6437103B1 (en) * | 1999-04-14 | 2002-08-20 | Biostream Inc. | Fatty acid analogs for diagnosis of coronary artery disease |
| AU2001245862A1 (en) * | 2000-03-21 | 2001-10-03 | The Procter & Gamble Company | Difluorobutyric acid metalloprotease inhibitors |
| AU2004232297B2 (en) * | 2003-04-17 | 2010-11-04 | The General Hospital Corporation | Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid |
-
1996
- 1996-11-25 DE DE69636881T patent/DE69636881T2/de not_active Expired - Lifetime
- 1996-11-25 AT AT96941503T patent/ATE353019T1/de not_active IP Right Cessation
- 1996-11-25 ES ES96941503T patent/ES2281906T3/es not_active Expired - Lifetime
- 1996-11-25 AT AT06025944T patent/ATE526995T1/de not_active IP Right Cessation
- 1996-11-25 EP EP96941503A patent/EP0869821B1/en not_active Expired - Lifetime
- 1996-11-25 JP JP52066997A patent/JP4272259B2/ja not_active Expired - Fee Related
- 1996-11-25 CA CA002238860A patent/CA2238860C/en not_active Expired - Fee Related
- 1996-11-25 EP EP06025944A patent/EP1767224B1/en not_active Expired - Lifetime
- 1996-11-25 WO PCT/US1996/019024 patent/WO1997019705A1/en active IP Right Grant
- 1996-11-25 ES ES06025944T patent/ES2374743T3/es not_active Expired - Lifetime
-
1999
- 1999-04-14 HK HK99101613A patent/HK1016494A1/xx not_active IP Right Cessation
-
2003
- 2003-05-05 US US10/429,416 patent/US7005119B2/en not_active Expired - Fee Related
-
2005
- 2005-11-16 US US11/274,505 patent/US7314609B2/en not_active Expired - Fee Related
-
2007
- 2007-01-09 US US11/621,241 patent/US20070128110A1/en not_active Abandoned
- 2007-09-21 HK HK07110322.1A patent/HK1102262A1/xx not_active IP Right Cessation
-
2008
- 2008-01-16 JP JP2008006447A patent/JP4937144B2/ja not_active Expired - Fee Related
- 2008-04-02 US US12/061,528 patent/US20080247948A1/en not_active Abandoned
-
2011
- 2011-10-24 JP JP2011232673A patent/JP2012036215A/ja not_active Withdrawn
