JP2008051765A - Autoanalyzer and automatic analysis method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To prevent automatic analysis from being carried out, based on a calibration curve which has not been calibrated, and to improve the reliability of analysis data which is to be acquired. <P>SOLUTION: A control computer 30 includes an analytical parameter setting section 310 for setting the analytical parameters for analysis items; a calibration necessity determining section 311 for determining whether calibrating of the calibration curve is necessary, based on the analysis parameter; and a teaching message display section 312 for displaying a teaching message prompting calibrating operation, when calibration operation of the calibration curve is determined as being necessary. Furthermore, the control computer 30 stores a calibration invalid flag in a calibration invalid flag memory section 360, which is set, when the calibration operation of the calibration curve is determined as being necessary, and which is reset, when the calibration operation is carried out; and then the control computer 30 will not perform analysis about analysis items where the calibration invalid flag is set and appends a data error to the analysis data of the analysis items, regarding the analysis items which have not been performed. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to an automatic analyzer and an automatic analysis method for automatically performing qualitative and quantitative analysis of biological samples such as blood and urine.

  In automatic analyzers such as biochemical automatic analyzers and immune automatic analyzers, various parameters as analysis conditions can be registered on the display device screen so that various analysis items can be arbitrarily selected and measured. Has been. There are various parameters such as analysis method selection, measurement wavelength, sample volume, and reagent volume. Among them, the type of standard solution and its concentration are important for creating a calibration curve. It is a parameter.

  Since the calibration curve is data used as a reference for automatic analysis, it must be calibrated whenever a lot of the standard solution is changed. Furthermore, calibration curves are often calibrated periodically, such as once a day or once a week. In calibration of these calibration curves, if there is an error in data input such as parameters, an erroneous calibration curve is created, and as a result, incorrect analysis data is output from the automatic analyzer.

Patent Document 1 discloses an example of an automatic analyzer that can prevent data input errors such as parameters in calibration of a calibration curve. According to Patent Document 1, parameters such as the type of standard solution and its concentration are acquired from a reagent manufacturer's computer or the like via a communication line, stored in an external storage device of an automatic analyzer, and the like. It is assumed that necessary parameters are read from the external storage device and used.
JP-A-5-288756

  However, the automatic analyzer disclosed in Patent Document 1 does not indicate a solution to the problem of forgetting to calibrate as described below.

  Forgetting to calibrate is attributed to an increase in the opportunities for workers who are unfamiliar with analysis techniques to perform analysis work because the usability of automatic analyzers has improved. Such operators often forget to calibrate because they are not fully aware of when to calibrate the calibration curve. In addition, even when parameters are changed, it may be unclear whether calibration is necessary or not. In any case, if calibration of the calibration curve to be performed is not performed, the reliability of analysis data obtained thereafter is impaired.

  In the conventional automatic analyzer including the automatic analyzer disclosed in Patent Document 1, the calibration curve to be performed is not calibrated after the operator changes the lot of the standard solution, and so on. Even if a predetermined analysis is performed using the calibration curve, the fact cannot be detected. As a result, when the calibration curve is forgotten to be calibrated, unreliable analysis data is acquired without being identified as unreliable.

  In view of the above-described problems of the prior art, the present invention is an automatic analyzer capable of preventing automatic analysis based on a calibration curve that has not been calibrated and improving the reliability of acquired analysis data. And to provide an automated analysis method.

  In order to solve the above-described problems of the prior art, the automatic analyzer of the present invention is an automatic analyzer controlled by a computer including an arithmetic processing device, a storage device, an input device, and a display device. The computer reads an analysis parameter for an analysis item input from an input device, stores the read analysis parameter in a storage device, and the analysis parameter is set by the analysis parameter setting unit. A calibration necessity determination unit that determines whether calibration of the calibration curve of the analysis item is necessary based on the set analysis parameter, and calibration of the analysis item by the calibration necessity determination unit. If it is determined that calibration of the line is necessary, a teaching method that prompts the calibration of the calibration curve for the analysis item is performed. A teaching message display means for displaying a message on the display device, characterized by comprising a.

  That is, according to the present invention, when the computer that controls the analyzer reads the analysis parameter input from the input device and sets the analysis parameter in the storage device (analysis parameter setting means), the set analysis is performed. It is determined whether or not calibration of the calibration curve is necessary based on the parameters (calibration necessity determination means). When it is determined that calibration of the calibration curve is necessary, a teaching message that prompts execution of calibration is displayed on the display device (teaching message display means). Therefore, even if an operator who is not familiar with the analysis technique uses the automatic analyzer of the present invention, it is possible to prevent the calibration curve from being forgotten.

  According to the present invention, it is possible to provide an automatic analyzer and an automatic analysis method capable of preventing automatic analysis based on a calibration curve that has not been calibrated and improving the reliability of acquired analysis data. Can do.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings as appropriate.

  FIG. 1 is a diagram showing an example of the configuration of an automatic analyzer according to an embodiment of the present invention. As shown in FIG. 1, the automatic analyzer 100 includes an analyzer 20 and a control computer 30.

  The analyzer 20 includes a sample disk 2 on which a plurality of sample cups 1 are placed, a sampling mechanism 4 having a sample probe 3 that collects a predetermined amount of sample (sample) from the sample cup 1, and a reagent probe 19 that performs reagent dispensing. A plurality of reagent pipetting mechanisms 5, a plurality of reagent disks 6 holding a plurality of reagent containers, a reaction disk 8 holding a plurality of reaction containers 7 for direct photometry, a stirring mechanism 9, a reaction container washing mechanism 10, etc. And a measurement unit including a light source lamp 13, a photometer 11, and the like.

  The reaction disk 8 holds a plurality of reaction containers 7 divided on the periphery of the disk, and the operation of “rotating once and rotating for one reaction container and temporarily stopping” is performed as a unit operation of one cycle during the analysis operation. repeat. That is, each time the reaction vessel 7 of the reaction disk 8 stops in one cycle of operation, the reaction vessel 7 reacts one reaction in the counterclockwise direction (which may be clockwise, but here is counterclockwise). Stop in the form of progressing by container. When the reaction disk 8 is in a stopped state, the sample is dispensed into the reaction container 7 at a predetermined position (sample discharge position), and the reagent is put into the reaction container 7 at another predetermined position (reagent discharge position). It is dispensed.

  Further, the reaction container cleaning mechanism 10 is installed between the position of the light beam 14 emitted from the lamp 13 and the sample discharge position, and appropriately cleans the reaction container 7 when the reaction disk 8 is in a stopped state. The stirring mechanism 9 is installed at a counterclockwise rear position of the reagent discharge position, and when the reaction disk 8 is in a stopped state, the sample and the reagent dispensed to the reaction container 7 positioned there are appropriately collected. Stir.

  The photometer 11 is a multi-wavelength photometer having a plurality of light detectors, and the light beam 14 emitted from the lamp 13 is opposed to the light source lamp 13 across the reaction container 7. It is installed at a position that crosses. Therefore, when the reaction disk 8 is in the rotating state, the column of the reaction containers 7 passes across the light beam 14, so that the intensity of the light beam 14 at that time is measured by the photometer 11 and accommodated in the reaction container 7. The absorbance of the prepared sample can be acquired.

  In addition to the lamp 13 and the photometer 11, the measurement unit included in the analyzer 20 includes a multiplexer 16 that selects a wavelength in the photometer 11, a logarithmic conversion amplifier 17 that amplifies the output signal of the photometer 11, and the like. An electronic circuit such as an A / D (Analog to Digital) converter 18 that converts the amplified analog signal into a digital signal is included.

  On the other hand, the control computer 30 includes an arithmetic processing unit 31 including a microcomputer, a storage device 32 including a RAM (Random Access Memory), a ROM (Read Only Memory), a flash memory, and a hard disk device, and a keyboard and a mouse. An input device 34, a display device 35 such as a liquid crystal display or a printer, and an analyzer interface 33 that controls a mechanism unit and a measurement unit of the analyzer 20.

  Here, the analyzer interface 33 is a drive circuit (not shown) attached to each analysis mechanism such as the sample disk 2, the reagent disk 6, the reaction disk 8, the sampling mechanism 4, the reagent pipetting mechanism 5, and the reaction container cleaning mechanism 10. And an electronic circuit of a measuring unit such as the A / D converter 18.

  The storage device 32 stores an analysis control program for automatically analyzing the sample by operating the analysis mechanism unit of the analysis device 20, and the arithmetic processing unit 31 executes the analysis control program. Then, a predetermined signal or information is appropriately transmitted from the analyzer interface 33 to the drive circuit of the connected analysis mechanism unit or the electronic circuit of the measurement unit, and the analysis mechanism unit performs a predetermined operation based on the signal or information. In addition, the measurement unit acquires predetermined analysis data.

  That is, the arithmetic processing unit 31 executes the analysis control program to control the entire analysis device 20 including integrated control of the analysis mechanism unit related to automatic analysis, and is necessary for predetermined analysis data measurement. Data processing such as management of various analysis parameters, calibration coefficient used for calculation, concentration or enzyme activity value calculation.

  FIG. 2 is a diagram showing an example of a functional block configuration in the control computer according to the embodiment of the present invention. As shown in FIG. 2, the control computer 30 includes an analysis parameter setting unit 310, a calibration execution control unit 320, an analysis execution control unit 330, and the like as main functional blocks. The control computer 30 includes a calibration necessity determination unit 311, a teaching message display unit 312, a calibration invalid flag setting unit 313, and the like as functional blocks attached to the analysis parameter setting unit 310, and is attached to the calibration execution control unit 320. The functional block includes a calibration execution item selection unit 321 and the like, and the functional block attached to the analysis execution control unit 330 includes an alarm display unit 331 and an analysis result display unit 332.

  Here, the functions of these functional blocks are realized when the arithmetic processing unit 31 of the control computer 30 executes a predetermined program stored in the storage device 32. Hereinafter, functions of these functional blocks will be described with reference to FIGS.

  The storage device 32 includes an analysis parameter storage unit 350, a calibration invalid flag storage unit 360, a calibration data storage unit 370, an analysis data storage unit 380, and the like as storage areas for storing data used by these functional blocks. It has been.

  FIG. 3 is a diagram illustrating an example of the configuration of the analysis parameter storage unit according to the embodiment of the present invention, and (b) an example of the configuration of the calibration invalid flag storage unit.

  As shown in FIG. 3A, the analysis parameter storage unit 350 includes a plurality of analysis parameter records for each of the plurality of analysis items. The analysis parameter record includes fields of parameter name, newly set parameter value, already set parameter value, and calibration necessity flag.

  Here, the field of the newly set parameter value is a field for temporarily storing the parameter value input from the input device 34 when the analysis parameter is set by the analysis parameter setting unit 310. The preset parameter value field is a field for storing an analysis parameter used when the analysis execution control unit 330 analyzes the analysis item. Therefore, when the setting of the analysis parameter for a certain analysis item is completed, the data of the newly set parameter value field is transferred to the already set parameter value field. In other words, the analysis parameter used in the previous analysis at the time of setting the analysis parameter is stored in the field of the preset parameter value.

  The calibration necessity flag is a flag indicating that calibration is required when there is a change in the analysis parameter to which the flag is attached. This flag is set in advance by an engineer familiar with the analysis technique. Here, the value of the calibration necessity flag is “1” when calibration is necessary, and is “0” when calibration is not necessary.

  Further, as shown in FIG. 3B, the calibration invalid flag storage unit 360 stores a calibration invalid flag indicating that calibration of the calibration curve used for each analysis item is invalid for each analysis item. Here, “1” is set when calibration of the calibration curve corresponding to the analysis item is invalid, and “0” is set when it is valid.

  FIG. 4 is a diagram illustrating an example of a flow of processing relating to analysis parameter setting in the embodiment of the present invention, FIG. 5 is a diagram illustrating an example of a parameter setting screen displayed in processing relating to the analysis parameter setting, FIG. 6 is a diagram showing an example of a teaching message display screen displayed in the process related to the analysis parameter setting.

  When setting an analysis parameter for a certain analysis item, the arithmetic processing unit 31 of the control computer 30 selects the analysis item on a display screen (not shown) or the like, and according to the analysis item, an analysis parameter as shown in FIG. A setting screen 51 is displayed. Then, analysis parameters are set based on the data input according to the analysis parameter setting screen 51 (FIG. 4, step S10).

  In other words, when the arithmetic processing unit 31 displays the analysis parameter setting screen 51 on the display device 35, the analysis operator appropriately inputs the value of the analysis parameter via the input device 34 in accordance with the analysis parameter setting screen 51. Therefore, the arithmetic processing unit 31 reads the input analysis parameter value and stores it in the newly set parameter value field of the analysis parameter storage unit 350.

  When the analysis operator finishes inputting these analysis parameters and clicks the registration button 52 on the analysis parameter setting screen 51, the input processing is completed. However, even if the analysis operator sets the analysis parameter on the analysis parameter setting screen 51, if the cancel button 53 is clicked, the analysis parameter input so far is deleted, that is, the newly set parameter value in the analysis parameter storage unit 350 The value of the analysis parameter stored in the field is cleared.

  As specific examples of the analysis parameters, as shown in FIG. 5, the analysis method, reaction time, measurement wavelength, photometric point, sample amount (sample dispensed amount), reagent amount (reagent dispensed amount), There are blank concentration and standard solution concentration. Among these, when there is a change input of analysis parameters mainly related to concentration calculation such as measurement wavelength, sample amount, reagent amount and standard solution concentration, it is necessary to calibrate the calibration curve of the analysis item.

  Therefore, as shown in FIG. 4, the arithmetic processing unit 31 determines whether or not the analysis parameter used so far has been changed by the setting following the setting of the analysis parameter (step S11). This determination can be performed in the analysis parameter storage unit 350 by comparing the newly set parameter value and the already set parameter value for the analysis parameter.

  If the analysis parameter has been changed in the determination (Yes in step S11), the arithmetic processing unit 31 further determines whether or not calibration of the calibration curve is necessary (step S12). The calibration curve calibration necessity determination can be performed by determining in the analysis parameter storage unit 350 whether or not the calibration parameter calibration necessity flag is “1”.

  In the determination, when the calibration necessity flag is “1”, that is, when it is determined that calibration of the calibration curve is necessary (Yes in step S12), the arithmetic processing unit 31 performs the processing shown in FIG. As shown, the display device 35 displays a teaching message 54 urging execution of calibration of the calibration curve of the analysis item (step S13). The teaching message 54 can be deleted when the analysis operator clicks the OK button 55.

  Subsequently, the arithmetic processing unit 31 sets a value “1” to the calibration invalid flag of the analysis item in the calibration invalid flag storage unit 360 (step S14), and ends the processing relating to the analysis parameter setting. In step S11, when the analysis parameter has not been changed (No in step S11), or in step S12, the calibration necessity flag is “0”, so it is determined that calibration of the calibration curve is not necessary. (No in step S12), the process relating to the analysis parameter setting is terminated as it is.

  As described above, the process related to the analysis parameter setting described with reference to FIG. 4 is a process for realizing the function of the analysis parameter setting unit 310 in FIG. 2, and includes the calibration necessity determination unit 311, Processing for realizing the functions of the teaching message display unit 312 and the calibration invalid flag setting unit 313 is included.

  As described above, in the present embodiment, when the calibration curve is required because the analysis parameter is set, the teaching message 54 that prompts the calibration is displayed on the display device 35. Therefore, even if the analysis worker is not familiar with the analysis technology, it becomes possible to know whether or not the calibration curve needs to be calibrated. For this reason, forgetting to calibrate the calibration curve. Can be prevented.

  FIG. 7 is a diagram showing an example of the flow of processing related to calibration execution control in the embodiment of the present invention, and FIG. 8 is a diagram showing an example of a calibration execution request screen displayed in the processing related to calibration execution control. It is.

  When the calibration processing unit 31 of the control computer 30 calibrates a calibration curve for a certain analysis item, a calibration execution request screen 61 as shown in FIG. 8 is displayed on the display device 35 in order to specify the analysis item to be calibrated. (FIG. 7, step S21).

  In the calibration execution request screen 61 of FIG. 8, AST, ALT, TP, ALB, CHO,..., BUN described in the left vertical axis represent analysis item names, and 1 point and 2 points described in the upper horizontal axis direction. ,..., All points represent the number of acquisition points of calibration data. The number of acquisition points is usually predetermined according to the analysis item.

  In the calibration execution request screen 61, a white circle (o) designates an analysis item to be calibrated by the analysis operator by clicking on the column. A black circle (●) is attached to an analysis item in which the processing unit 31 refers to the calibration invalid flag storage unit 360 and the calibration invalid flag is set (flag value is “1”). That is, in the process related to the analysis parameter setting in FIG. 4, the calibration curve is required to be calibrated, and a black circle mark is displayed for the analysis item for which the calibration invalid flag is set.

  Next, the arithmetic processing unit 31 selects an analysis item to be calibrated using the calibration execution request screen 61 and the like, and appropriately controls the analysis device 20 to obtain a calibration curve for the selected analysis item. Calibration is executed (step S22). The calibration curve data obtained by the calibration is stored in the calibration data storage unit 370.

  Further, the arithmetic processing unit 31 resets the calibration invalid flag of the analysis item that has been calibrated in the calibration invalid flag storage unit 360 (step S23). That is, the calibration invalid flag that was set after setting the analysis parameter in step S14 in FIG. 4 (its value is “1”) is reset by executing calibration (its value is “0”).

  The processing related to the calibration execution control described with reference to FIG. 7 is processing for realizing the function of the calibration execution control unit 320 in FIG. 2, and includes the calibration execution item selection unit 321 and Processing for realizing the function of the calibration invalid flag setting unit 313 is included.

  In addition, as described above, in the present embodiment, when performing calibration, the display device 35 displays black circles on the analysis items that require calibration when the analysis parameters are set. Even if the analysis operator is not familiar with the analysis technique, it is possible to prevent forgetting to calibrate the calibration curve.

  FIG. 9 is a diagram showing an example of the flow of processing related to analysis execution control in the embodiment of the present invention, FIG. 10 is a diagram showing an example of an analysis status screen displayed in the processing related to analysis execution control, FIG. 11 is a diagram showing an example of an analysis result screen displayed in the process related to the analysis execution control.

  The arithmetic processing unit 31 of the control computer 30 specifies (generally a plurality of) analysis items on a display screen (not shown) or the like when the analysis is performed by controlling the analysis device 20. As shown in FIG. 9, the arithmetic processing unit 31 determines whether there is an analysis item for which the calibration invalid flag is set for the designated analysis item (step S31). This determination can be made by referring to the calibration invalid flag in the calibration invalid flag storage unit 360.

  As a result of the determination, when there is an analysis item for which the calibration invalid flag is set (its value is “1”) (Yes in step S31), the arithmetic processing unit 31 has the calibration invalid flag set. For the analysis item, an alarm as shown in the alarm list 72 of the analysis status screen 71 of FIG. 10 is displayed on the display device 35 (step S32). Then, the analysis is subsequently executed for the designated analysis item (step S33).

  The alarm list 72 is displayed on the analysis status screen 71 as an alarm whose alarm name has not been calibrated, for example, like other general alarms during analysis execution control. The alarm list 72 displays the alarm name, alarm level, code, time of occurrence, and the like. The analysis status screen 71 displays information related to the analysis to be performed, such as the apparatus status, sample number, analysis item, reaction tank temperature, and the like.

  When the analysis is executed in step S33, the arithmetic processing unit 31 controls the analysis device 20 so that the analysis item for which the alarm list 72 is displayed in step S32 is not analyzed. Therefore, in this case, analysis data of the analysis item is not acquired.

  On the other hand, in the determination in step S31, when there is no analysis item for which the calibration invalid flag is set (its value is “1”) (No in step S31), the arithmetic processing unit 31 performs the analysis device 20 as usual. Is controlled to perform analysis (step S33).

  When the execution of the analysis is completed, the arithmetic processing unit 31 stores the analysis data acquired by the analysis in the analysis data storage unit 380, and further displays the analysis data on the display device 35 (step S34). At this time, since the calibration invalid flag is set, the analysis item for which the analysis data has not been acquired indicates that the analysis item has not been calibrated in the analysis result screen 81 as shown in FIG. Display data errors.

  In the analysis result screen 81 of FIG. 11, sample information such as sample number, sample container, and measurement time is displayed in the left column. When one of the sample information is selected by a click operation or the like (here, sample number 0006 is selected), the measurement result of the sample is displayed in the right column. In this example, there are AST, ALT, GGT, and TP as analysis items of the measurement results. Among them, a data alarm is displayed for GGT, and the analysis data is not acquired.

  As described above, in this embodiment, even if the analysis operator forgets to carry out the analysis item to be calibrated or does not intentionally carry out the calibration, the analysis item Analytical data is not acquired for, and a data alarm is displayed in the measurement result. Therefore, since it is possible to prevent data from being acquired based on an inappropriate calibration curve, it is possible to guarantee that the acquired analysis data is based on a calibrated calibration curve. Become. Therefore, the reliability of the acquired analysis data can be improved.

  In the embodiment described above, the control computer 30 controls the analysis device 20 so as not to acquire analysis data for the analysis item for which the calibration invalid flag is set. In this regard, the embodiment may be modified such that the control computer 30 controls the analysis apparatus 20 so as to acquire the analysis data of the analysis item for which the calibration invalid flag is set.

  In the modification of this embodiment, the control computer 30 acquires the analysis data even for the analysis item for which the calibration invalid flag is set, but the acquired analysis data is not appropriate. At this time, the control computer 30 displays a display screen (not shown) similar to the analysis result screen 81 of FIG. 11 after acquiring the analysis data. The obtained inappropriate analysis data (for example, a numerical value such as 45) is displayed as it is in the portion of the analysis result screen 81 where the measurement value “-” of the item “GGT” is displayed. The control computer 30 also displays in the data alarm column a data error display indicating that the calibration curve is not calibrated based on the value of the calibration invalid flag of the analysis item.

  That is, the analysis operator knows whether the analysis data displayed in the measurement value column is appropriate or inappropriate by displaying the data alarm column on the display screen similar to the analysis result screen 81. it can. Therefore, the analysis worker can ignore or discard the inappropriate analysis data. Therefore, also in the modified example of this embodiment, the reliability of analysis data comparable to that of the original embodiment can be ensured.

It is the figure which showed the example of the structure of the automatic analyzer which concerns on embodiment of this invention. It is the figure which showed the example of the structure of the functional block in the control computer which concerns on embodiment of this invention. It is the figure which showed the example of the structure of (a) the analysis parameter memory | storage part which concerns on embodiment of this invention, (b) the calibration invalid flag memory | storage part. It is the figure which showed the example of the flow of the process which concerns on the analysis parameter setting in embodiment of this invention. FIG. 5 is a diagram showing an example of a parameter setting screen displayed in the processing related to analysis parameter setting in FIG. 4. It is the figure which showed the example of the teaching message display screen displayed in the process which concerns on the analysis parameter setting of FIG. It is a figure showing an example of a flow of processing concerning calibration execution control in an embodiment of the present invention. It is the figure which showed the example of the calibration execution request screen displayed in the process which concerns on the calibration execution control of FIG. It is a figure showing an example of a flow of processing concerning analysis execution control in an embodiment of the present invention. It is the figure which showed the example of the analysis status screen displayed in the process which concerns on the analysis execution control of FIG. It is the figure which showed the example of the analysis result screen displayed in the process which concerns on the analysis execution control of FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Sample cup 2 Sample disk 3 Sample probe 4 Sampling mechanism 5 Reagent pipetting mechanism 6 Reagent disk 7 Reaction container 8 Reaction disk 9 Stirring mechanism 10 Reaction container washing mechanism 11 Photometer 13 Lamp 14 Light beam 16 Multiplexer 17 Amplifier 18 A / D conversion Instrument 19 Reagent probe 20 Analyzing device 30 Control computer 31 Arithmetic processing device 32 Storage device 33 Analyzing device interface 34 Input device 35 Display device 51 Analysis parameter setting screen 54 Teaching message 61 Calibration execution request screen 71 Analysis status screen 72 Alarm list 81 Analysis result Screen 100 Automatic analyzer 310 Analysis parameter setting unit 311 Calibration necessity determination unit 312 Teaching message display unit 313 Calibration invalid flag setting unit 320 Calibration execution control unit 3 1 calibration execution item selection unit 330 analyzes the execution control unit 331 alarm display unit 332 the analysis result display unit 350 analyzes the parameter storage unit 360 calibration invalid flag storage unit 370 calibration data storage unit 380 analyzes the data storage unit

Claims (10)

A sample container for storing a sample, a reagent container for storing a reagent, a dispensing probe for dispensing the sample and the reagent from each of the sample container and the reagent container, the sample dispensed by the dispensing probe, and the An analysis apparatus configured to include a reaction container that contains a reagent, and a measurement mechanism that measures a reaction state of the reagent and the sample in the reaction container;
A computer including an arithmetic processing device, a storage device, an input device, and a display device;
In an automatic analyzer consisting of
An arithmetic processing unit of the computer,
Analysis execution control means for controlling the analyzer to acquire analysis data for a predetermined analysis item;
Calibration execution control means for controlling the analyzer and calibrating a predetermined calibration curve;
An analysis parameter setting means for reading an analysis parameter for the analysis item input from the input device, and storing the read analysis parameter in the storage device;
When the analysis parameter is set by the analysis parameter setting means, based on the set analysis parameter, a calibration necessity determination means that determines whether calibration of the calibration curve of the analysis item is necessary,
A teaching message for displaying on the display device a teaching message prompting to calibrate the calibration curve for the analysis item when it is determined by the calibration necessity determining means that calibration of the calibration curve for the analysis item is necessary Display means;
An automatic analyzer characterized by comprising: A sample container for storing a sample, a reagent container for storing a reagent, a dispensing probe for dispensing the sample and the reagent from each of the sample container and the reagent container, the sample dispensed by the dispensing probe, and the An analysis apparatus configured to include a reaction container that contains a reagent, and a measurement mechanism that measures a reaction state of the reagent and the sample in the reaction container;
A computer including an arithmetic processing device, a storage device, an input device, and a display device;
In an automatic analyzer consisting of
An arithmetic processing unit of the computer,
Analysis execution control means for controlling the analyzer to acquire analysis data for a predetermined analysis item;
Calibration execution control means for controlling the analyzer and calibrating a predetermined calibration curve;
An analysis parameter setting means for reading an analysis parameter for the analysis item input from the input device, and storing the read analysis parameter in the storage device;
When the analysis parameter is set by the analysis parameter setting means, based on the set analysis parameter, a calibration necessity determination means that determines whether calibration of the calibration curve of the analysis item is necessary,
When the calibration necessity determining means determines that calibration of the calibration curve of the analysis item is necessary, a calibration invalid flag provided in the storage device is set in association with the analysis item, and the calibration is executed. A calibration invalid flag setting means for resetting the calibration invalid flag corresponding to the analysis item when the calibration curve of the analysis item is calibrated by the control means;
When calibration curve calibration is performed by the calibration execution control means, the calibration analysis item display means for displaying the identification information of the analysis item for which the calibration invalid flag is set is displayed on the display device;
An automatic analyzer characterized by comprising: A sample container for storing a sample, a reagent container for storing a reagent, a dispensing probe for dispensing the sample and the reagent from each of the sample container and the reagent container, the sample dispensed by the dispensing probe, and the An analysis apparatus configured to include a reaction container that contains a reagent, and a measurement mechanism that measures a reaction state of the reagent and the sample in the reaction container;
A computer including an arithmetic processing device, a storage device, an input device, and a display device;
In an automatic analyzer consisting of
An arithmetic processing unit of the computer,
Analysis execution control means for controlling the analyzer to acquire analysis data for a predetermined analysis item;
Calibration execution control means for controlling the analyzer and calibrating a predetermined calibration curve;
An analysis parameter setting means for reading an analysis parameter for the analysis item input from the input device, and storing the read analysis parameter in the storage device;
When the analysis parameter is set by the analysis parameter setting means, based on the set analysis parameter, a calibration necessity determination means that determines whether calibration of the calibration curve of the analysis item is necessary,
When the calibration necessity determining means determines that calibration of the calibration curve of the analysis item is necessary, a calibration invalid flag provided in the storage device is set in association with the analysis item, and the calibration is executed. A calibration invalid flag setting means for resetting the calibration invalid flag corresponding to the analysis item when the calibration curve of the analysis item is calibrated by the control means;
For the analysis item for which the calibration invalid flag has been set, “acquisition of appropriate analysis data because calibration is not performed” is performed before, after, or both of acquiring the analysis data. Data error display means for performing an error display on the display device indicating that "does not do or did not"
An automatic analyzer characterized by comprising: The analysis execution control means includes
4. The automatic analyzer according to claim 2, wherein the analyzer is controlled not to analyze the analysis item for which the calibration invalid flag is set. 5. The calibration necessity determining means includes
The analysis parameter setting means changes at least one analysis parameter related to the concentration calculation of the analysis target liquid including the standard solution concentration, the sample dispensing amount, the reagent dispensing amount, and the measurement wavelength from a preset value. The automatic analyzer according to any one of claims 1 to 4, wherein, when set, it is determined that calibration of the calibration curve is necessary. A computer including an arithmetic processing device, a storage device, an input device, and a display device includes a sample container for storing a sample, a reagent container for storing a reagent, the sample container, and the sample container from each of the reagent container and the sample container. A dispensing probe for dispensing each of the reagents, the sample dispensed by the dispensing probe, a reaction container containing the reagent, and a reaction state of the reagent and the sample in the reaction container are measured. In an automatic analysis method for analyzing a reaction state of the reagent and the sample by controlling an analyzer configured to include a measurement mechanism,
The computer processing unit comprises:
An analysis execution control step of controlling the analyzer to acquire analysis data for a predetermined analysis item;
A calibration execution control step for controlling the analyzer to calibrate a predetermined calibration curve;
An analysis parameter setting step of reading an analysis parameter for the analysis item input from the input device, and storing the read analysis parameter in the storage device;
When the analysis parameter is set in the analysis parameter setting step, based on the set analysis parameter, a calibration necessity determination step for determining whether calibration of the calibration curve of the analysis item is necessary,
A teaching message for displaying on the display device a teaching message prompting to calibrate the calibration curve for the analysis item when it is determined by the calibration necessity determining means that calibration of the calibration curve for the analysis item is necessary A display step;
The automatic analysis method characterized by performing. A computer including an arithmetic processing device, a storage device, an input device, and a display device includes a sample container for storing a sample, a reagent container for storing a reagent, the sample container, and the sample container from each of the reagent container and the sample container. A dispensing probe for dispensing each of the reagents, the sample dispensed by the dispensing probe, a reaction container containing the reagent, and a reaction state of the reagent and the sample in the reaction container are measured. In an automatic analysis method for analyzing a reaction state of the reagent and the sample by controlling an analyzer configured to include a measurement mechanism,
The computer processing unit comprises:
An analysis execution control step of controlling the analyzer to acquire analysis data for a predetermined analysis item;
A calibration execution control step for controlling the analyzer to calibrate a predetermined calibration curve;
An analysis parameter setting step of reading an analysis parameter for the analysis item input from the input device, and storing the read analysis parameter in the storage device;
When the analysis parameter is set in the analysis parameter setting step, a calibration necessity determination step for determining whether or not calibration of the calibration curve of the analysis item is necessary based on the set analysis parameter;
When it is determined in the calibration necessity determination step that calibration of the calibration curve of the analysis item is necessary, a calibration invalid flag provided in the storage device is set in association with the analysis item, and the calibration is executed. A calibration invalid flag setting step for resetting the calibration invalid flag corresponding to the analysis item when the calibration curve of the analysis item is calibrated in the control step;
When the calibration curve is calibrated by the calibration execution control step, the calibration analysis item display step for displaying the identification information of the analysis item for which the calibration invalid flag is set is displayed on the display device;
The automatic analysis method characterized by performing. A computer including an arithmetic processing device, a storage device, an input device, and a display device includes a sample container for storing a sample, a reagent container for storing a reagent, the sample container, and the sample container from each of the reagent container and the sample container. A dispensing probe for dispensing each of the reagents, the sample dispensed by the dispensing probe, a reaction container containing the reagent, and a reaction state of the reagent and the sample in the reaction container are measured. In an automatic analysis method for analyzing a reaction state of the reagent and the sample by controlling an analyzer configured to include a measurement mechanism,
The computer processing unit comprises:
An analysis execution control step of controlling the analyzer to acquire analysis data for a predetermined analysis item;
A calibration execution control step for controlling the analyzer to calibrate a predetermined calibration curve;
An analysis parameter setting step of reading an analysis parameter for the analysis item input from the input device, and storing the read analysis parameter in the storage device;
When the analysis parameter is set in the analysis parameter setting step, a calibration necessity determination step for determining whether or not calibration of the calibration curve of the analysis item is necessary based on the set analysis parameter;
When it is determined in the calibration necessity determination step that calibration of the calibration curve of the analysis item is necessary, a calibration invalid flag provided in the storage device is set in association with the analysis item, and the calibration is executed. A calibration invalid flag setting step for resetting the calibration invalid flag corresponding to the analysis item when the calibration curve of the analysis item is calibrated in the control step;
For the analysis item for which the calibration invalid flag has been set, “acquisition of appropriate analysis data because calibration is not performed” is performed before, after, or both of acquiring the analysis data. A data error display step for performing an error display on the display device indicating that "does not or has not been done",
The automatic analysis method characterized by performing. The arithmetic processing unit of the computer, in the analysis execution control step,
9. The automatic analysis method according to claim 7, wherein the analysis apparatus is controlled not to perform analysis on the analysis item for which the calibration invalid flag is set. In the computer processing unit, in the calibration necessity determining step,
In the analysis parameter setting step, set at least one analysis parameter related to the concentration calculation of the target solution including standard solution concentration, sample dispensing volume, reagent dispensing volume, and measurement wavelength to be changed from the preset value. The automatic analysis method according to any one of claims 6 to 9, wherein when it is determined, calibration of the calibration curve is necessary.

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