JP2015210114A - Automatic analyzer - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an automatic analyzer comprising plural reaction means for making a sample dispensed in a reaction vessel react periodically for every reaction vessel, supply means for supplying the reaction vessel to the plural reaction means periodically by distributing the reaction vessel, and detection means for periodically detecting a measurement signal from a content in the reaction vessel on which reaction is performed by any one of the plural reaction means for every reaction vessel, capable of minimizing frequency of interruption of sample analysis because an analytical curve is invalidated, and reducing load applied to an operator related to validity management of the analytical curve.SOLUTION: An automatic analyzer comprises: an analytical curve management part for storing information of an analytical curve generated by the reaction means and information of validity of the analytical curve; and control means for selecting the reaction means having the valid analytical curve, based on the information of the analytical curve and the information of the validity of the analytical curve, read out from the analytical curve management part, and instructing the supply means to supply the reaction vessel to the selected reaction means.

Description

  The present invention relates to an automatic analyzer having a plurality of reaction means.

  When analyzing a component in a sample with an automatic analyzer, it is necessary to convert a measurement signal (such as a light amount) derived from the component into a concentration value. Therefore, before analyzing the sample, a standard solution with a known component concentration is measured multiple times under the same conditions using an automatic analyzer, and a calibration curve representing the relationship between the measurement signal and the component concentration in the standard solution is created. To do. A sample whose component concentration is unknown is measured by an automatic analyzer, and the obtained measurement signal is applied to the calibration curve to calculate the component concentration in the sample.

  As an automatic analyzer with high throughput, a plurality of reaction means for periodically reacting the sample dispensed in the reaction container for each reaction container, and the reaction containers are periodically distributed and supplied to the plurality of reaction means There is known an automatic analyzer comprising supply means for detecting, and detection means for periodically detecting, for each reaction container, a measurement signal from the contents of the reaction container reacted by any of the plurality of reaction means (Patent Document 1).

  When analyzing a component in a sample using the automatic analyzer disclosed in Patent Document 1, a reaction means can be selected for each component to be analyzed. For example, component X always uses the first reaction means, component Y always uses the second reaction means, and component Z uses the reaction vessel from the reaction means capable of transporting, after which the first reaction means and Create a test file (file consisting of a collection of measurement condition parameters for each component to be analyzed) that is specified to be used alternately with the second reaction means, and store it in the automatic analysis device. You can make a selection.

  When analyzing components in a sample using the automatic analyzer disclosed in Patent Document 1, it is preferable to create a calibration curve for each reaction means because there are mechanical differences and operating histories between reaction means. . Therefore, when analyzing using a plurality of reaction means like the component Z in the example described above, it is necessary to prepare an effective calibration curve for each reaction means. In this case, there is a possibility that the calibration curve of a specific reaction means becomes invalid due to expiration of the expiration date.

  As a countermeasure against such a situation, the operator side automatically confirms the validity of the calibration curve on the operation screen or the control unit side equipped with the device before sample analysis, and if an invalid calibration curve exists. There is a method of setting to start the analysis after recalibrating the calibration curve. There is also a method of measuring regardless of the validity of the calibration curve and adding a flag indicating that the calibration curve is invalid when reporting the results. However, the former method is not preferable when the interruption of measurement is not allowed, such as when a large number of samples are automatically transported based on an analysis request from the host computer. The latter method also requires the calibration curve to be retaken after the sample measurement, thus reducing the burden on the operator and the overall efficiency.

JP2013-156046A

  An object of the present invention is to provide a plurality of reaction means for periodically reacting a sample dispensed in a reaction container for each reaction container, a supply means for periodically distributing and supplying the reaction containers to the plurality of reaction means, In the automatic analyzer having the detection means for periodically detecting the measurement signal from the contents of the reaction vessel reacted in any of the plurality of reaction means for each reaction vessel, the calibration curve becomes invalid. The purpose of this is to minimize the frequency of interruption of sample analysis and to reduce the burden on the operator related to the effectiveness management of the calibration curve.

  In order to solve the above-mentioned problems, the present inventors have intensively studied to arrive at the present invention.

That is, the first aspect of the present invention is:
A plurality of reaction means for periodically reacting the sample dispensed in the reaction container for each reaction container; a supply means for periodically distributing and supplying the reaction containers to the plurality of reaction means; and a plurality of reaction means In an automatic analyzer equipped with a detection means for periodically detecting the measurement signal from the contents of the reaction vessel reacted in any one reaction vessel,
A calibration curve management unit for storing information on the calibration curve created by the reaction means and its effectiveness; and
A control means for selecting a reaction means having an effective calibration curve based on the calibration curve read from the calibration curve management section and information relating to its effectiveness, and instructing the supply means to supply a reaction vessel to the selected reaction means; ,
The automatic analyzer further comprising:

The second aspect of the present invention is as follows.
An analysis request information storage unit that stores information for specifying a sample and analysis request information including an analysis item for the sample, and an analysis condition storage unit that stores information related to selection of a reaction means used for each analysis item Prepared,
Analysis request information read from the analysis request information storage unit by the control means, information related to selection of reaction means used for each analysis item read from the analysis condition storage unit, and a calibration curve read from the calibration curve management unit and its validity A means for selecting a reaction means having an effective calibration curve based on information on the sex and instructing the supply means to supply a reaction vessel to the selected reaction means;
The automatic analyzer according to the first aspect.

Furthermore, the third aspect of the present invention is
Two reaction means for periodically reacting the sample dispensed in the reaction container for each reaction container, a supply means for periodically distributing and supplying the reaction container to the two reaction means, and the two reaction means In an automatic analyzer equipped with a detection means for periodically detecting the measurement signal from the contents of the reaction vessel reacted in any one reaction vessel,
An analysis request information storage unit for storing information for specifying a sample and analysis request information including an analysis item in the sample;
A calibration curve management unit for storing information on the calibration curve created by the two reaction means and its effectiveness; and
Based on the analysis request information read from the analysis request information storage unit, the calibration curve read from the calibration curve management unit, and information related to its effectiveness, a reaction means having an effective calibration curve is selected, and the selected reaction means is reacted. Control means for instructing the supply means to supply the container;
Is an automatic analyzer. In this aspect, in the second aspect, the plurality of reaction means are two reaction means, and information relating to selection of reaction means used in each analysis item stored in the analysis condition storage unit and read by the control means is provided. This corresponds to an embodiment using either one of the two reaction means.

  Further, the fourth aspect of the present invention permits or prohibits selection of a reaction means having an effective calibration curve based on a calibration curve read from the calibration curve management unit and information related to its effectiveness by the control means. The automatic analyzer according to any one of the first to third aspects, which can be selected.

  A fifth aspect of the present invention is the automatic analyzer according to any one of the first to fourth aspects, further comprising display means for displaying information relating to the selected reaction means.

  In addition, in the reaction means in the present invention, in addition to the reaction part for reacting the sample dispensed in the reaction container, the transport part for conveying the reaction container to the reaction part, and the dispensing part for dispensing the reagent to the reaction container Alternatively, a stirring unit for stirring the reaction vessel and a washing unit for washing the reaction vessel may be further provided.

  The present invention includes a plurality of reaction means for periodically reacting a sample dispensed in a reaction container for each reaction container, a supply means for periodically distributing and supplying the reaction containers to the plurality of reaction means, and the plurality of reactions. A calibration curve prepared by the reaction means and its effectiveness in an automatic analyzer comprising a detection means for periodically detecting a measurement signal from the contents of the reaction vessel reacted by any of the means for each reaction container A calibration curve management unit for storing information relating to the calibration curve, and a reaction means having an effective calibration curve based on the calibration curve read from the calibration curve management part and information relating to the effectiveness thereof, and a reaction vessel as the selected reaction means And a control means for instructing the supply means to supply. Even if there is a reaction means having an invalid calibration curve, the automatic analyzer according to the present invention switches the supply of the reaction vessel to the reaction means having an effective calibration curve, so that the measurement is not interrupted. The results can be reported promptly.

  Note that the automatic analyzer of the present invention stores an analysis request information storage unit for storing analysis request information including information for specifying a sample and analysis items for the sample, and information related to selection of a reaction means to be used for each analysis item. An analysis condition storage unit, and the control unit reads analysis request information read from the analysis request information storage unit, information related to selection of reaction means used for each analysis item read from the analysis condition storage unit, and calibration curve management When selecting a reaction means having an effective calibration curve based on the calibration curve read from the section and information on its effectiveness, and a means for instructing the supply means to supply the reaction vessel to the selected reaction means, Without interrupting the measurement, it is possible to reduce the burden on the operator for managing the effectiveness of the calibration curve.

  Further, the control means provided in the automatic analyzer of the present invention selects a reaction means having an effective calibration curve based on the calibration curve read from the calibration curve management unit and information related to its effectiveness. It may be possible to arbitrarily select whether or not to permit the selection through an operation screen or the like. By doing so, it is possible to freely select on the operator side whether to adopt the initial set value relating to the selection of the reaction means as it is or to use the reaction means having an effective calibration curve preferentially. That is, it is possible to provide an automatic analyzer that can flexibly respond to the operator's request.

  Furthermore, when the automatic analyzer of the present invention is provided with a display screen for displaying information on the selected reaction means, the operator can recognize the information on the actually selected reaction means.

It is a figure which shows the one aspect | mode of the automatic analyzer of this invention. It is a figure which shows an example of the screen which displayed the analysis request information memorize | stored in the analysis request information storage part. It is a figure which shows an example of the screen which displayed the information which concerns on selection of the reaction means used by each analysis item memorize | stored in the analysis condition memory | storage part. It is a figure which shows an example of the screen which displayed the information regarding the calibration curve memorize | stored in the calibration curve management part, and its effectiveness. It is an example of the flowchart which concerns on selection of the reaction means in the automatic analyzer of this invention.

  Hereinafter, the present invention will be described in detail with reference to the drawings.

  One embodiment of the automatic analyzer of the present invention is shown in FIG. The analysis unit 10 provided in the automatic analyzer shown in FIG. 1 includes two reaction means 12a and 12b for periodically reacting the sample dispensed in the reaction container for each reaction container, and the reaction container to the reaction means 12a and 12b. Supply means 11 for alternately distributing and supplying, and detection means 13 for periodically detecting a measurement signal from the contents of the reaction vessel reacted by any of the reaction means 12a and 12b for each reaction vessel ing. The reaction means 12a and 12b have the same configuration and function. The automatic analyzer shown in FIG. 1 also includes an analysis request information storage unit 20 for storing analysis request information including information for specifying a sample and analysis items for the sample, and selection of reaction means 12 used for each analysis item. The analysis condition storage unit 30 for storing information related to the above, the calibration curve management unit 40 for storing the calibration curve created by the reaction means 12 and information related to its effectiveness, and the analysis request information read from the analysis request information storage unit 20 Based on the information related to the selection of the reaction means used for each analysis item read from the analysis condition storage unit 30 and the calibration curve read from the calibration curve management unit 40 and the information related to the effectiveness thereof, an effective calibration curve is provided. And a control means 50 that selects the reaction means 12 and instructs the supply means 11 to supply a reaction vessel to the selected reaction means 12. The analysis request information storage unit 20, the analysis condition storage unit 30, the calibration curve management unit 40, and the control unit 50 can normally use a central processing unit or storage unit of a computer. Further, the automatic analyzer shown in FIG. 1 includes analysis request information, information relating to selection of reaction means used in each analysis item, information relating to a calibration curve and its effectiveness, information relating to the selected reaction means 11, and the like. A display means 60 for displaying as appropriate is also provided, usually in the form of a display connected to the computer. The display means 60 is also used as a screen for operating whether or not to permit selection of the reaction means 11 according to the validity of the calibration curve.

  FIG. 2 is an example of a screen on which the analysis request information stored in the analysis request information storage unit is displayed by the display means. For example, the sample with the sample ID 100020334 measures the analysis item IRI (insulin) / CPEP (C peptide) / HbA1c (glycated hemoglobin A1c) once, and the sample with the sample ID 100020335 has the analysis item FT4 (free). Thyroxine) is measured twice, and FT3 (free triiodothyronine) / TSH (thyroid stimulating hormone) / TsAb (TSH stimulating receptor antibody) is measured once each.

  FIG. 3 shows an example of a screen on which information related to selection of reaction means used for each analysis item stored in the analysis condition storage unit is displayed on the display means. In the example of FIG. 3, a list of analysis conditions (measurement parameters) of the analysis item 15-3 (cancer antigen 15-3) is displayed, and the reaction means to be used is selected in the “measurement unit designation” field on the screen. be able to. Specifically, only one of the two reaction means is used ("A" or "B" on the screen), or the reaction vessel is used from the reaction means that can be transported, and then the two reaction means Can be selected alternately ("device dependent" on the screen).

  FIG. 4 is an example of a screen on which the calibration curve stored in the calibration curve management unit and information related to its effectiveness are displayed on the display means. For example, in the reagent lot 001 of the analysis item 15-3, a standard sample is measured by the analysis unit (reaction means) A at 9:00 on March 11, 2014, and the created calibration curve is valid (“Finalize” on the screen). ") On the other hand, the calibration curve created by the analysis unit (reaction means) B is the same reagent lot, but the standard sample was measured at 9:10 on April 1, 2013, so it has expired and is invalid. ("Expired" on the screen).

  FIG. 5 shows an example of a flowchart relating to selection of reaction means in the automatic analyzer of the present invention shown in FIG. First, analysis request information (for example, information shown in FIG. 2) is read from the analysis request information storage unit (S1), and the item to be analyzed by the sample is recognized. Next, it is selected whether to permit or prohibit the selection of the reaction means to be used according to the effectiveness of the calibration curve in each reaction means (S2). When the selection of the reaction means according to the validity of the calibration curve is permitted, the process proceeds to Yes in step S2, and information relating to the selection of the reaction means used in one item among the items analyzed with the sample (for example, FIG. 3). Information) is read (S3). Thereafter, the calibration curve created by the reaction means used in the one item and the information relating to the effectiveness (for example, information shown in FIG. 4) are read from the calibration curve management unit (S5). If it is determined from the information read in steps S3 and S5 that all the reaction means have valid calibration curves, the process proceeds to No in step S6, and the analysis item for which no reaction means is selected is selected. If there is one (Yes in step S8), the process returns to step S3 and the same processing is performed. On the other hand, if there is a reaction means having an invalid calibration curve in step S6, the process proceeds to Yes. If there is a reaction means having an effective calibration curve, it is changed to use only the reaction means (S7), and the process proceeds to step S8. When selection of the reaction means is completed for all items analyzed with the sample, the process proceeds to No in step S8, and the supply means is instructed to supply the reaction vessel to the selected reaction means (S9). The change of the reaction means can be confirmed by the display means. On the other hand, if the selection of the reaction means according to the effectiveness of the calibration curve is prohibited in step S2, the process proceeds to No, and information relating to the selection of the reaction means to be used (for example, in FIG. Information) is read from the analysis condition storage unit (S4), and the supply means is instructed to supply the reaction vessel based on the information (S9).

10: analysis unit 11: supply unit 12: reaction unit 13: detection unit 20: analysis request information storage unit 30: analysis condition storage unit 40: calibration curve management unit 50: control unit 60: display unit

Claims (5)

A plurality of reaction means for periodically reacting the sample dispensed in the reaction container for each reaction container; a supply means for periodically distributing and supplying the reaction containers to the plurality of reaction means; and a plurality of reaction means In an automatic analyzer equipped with a detection means for periodically detecting the measurement signal from the contents of the reaction vessel reacted in any one reaction vessel,
A calibration curve management unit for storing information on the calibration curve created by the reaction means and its effectiveness; and
A control means for selecting a reaction means having an effective calibration curve based on the calibration curve read from the calibration curve management section and information relating to its effectiveness, and instructing the supply means to supply a reaction vessel to the selected reaction means; ,
The automatic analyzer further comprising: An analysis request information storage unit that stores information for specifying a sample and analysis request information including an analysis item for the sample, and an analysis condition storage unit that stores information related to selection of a reaction means used for each analysis item Prepared,
Analysis request information read from the analysis request information storage unit by the control means, information related to selection of reaction means used for each analysis item read from the analysis condition storage unit, and a calibration curve read from the calibration curve management unit and its validity A means for selecting a reaction means having an effective calibration curve based on information on the sex and instructing the supply means to supply a reaction vessel to the selected reaction means;
The automatic analyzer according to claim 1. Two reaction means for periodically reacting the sample dispensed in the reaction container for each reaction container, a supply means for periodically distributing and supplying the reaction container to the two reaction means, and the two reaction means In an automatic analyzer equipped with a detection means for periodically detecting the measurement signal from the contents of the reaction vessel reacted in any one reaction vessel,
An analysis request information storage unit for storing information for specifying a sample and analysis request information including an analysis item in the sample;
A calibration curve management unit for storing information on the calibration curve created by the two reaction means and its effectiveness; and
Based on the analysis request information read from the analysis request information storage unit, the calibration curve read from the calibration curve management unit, and information related to its effectiveness, a reaction means having an effective calibration curve is selected, and the selected reaction means is reacted. Control means for instructing the supply means to supply the container;
Further equipped with an automatic analyzer. The control means can select whether to permit or prohibit the selection of the reaction means having an effective calibration curve based on the calibration curve read from the calibration curve management unit and information relating to the validity thereof. The automatic analyzer according to any one of the above. The automatic analyzer according to any one of claims 1 to 4, further comprising display means for displaying information relating to the selected reaction means.

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