JPH08262028A - Autoanalyzer - Google Patents

Abstract

PURPOSE: To obtain an autoanalyzer by which the labor of an operation is omitted and which prevents the loss of a standard solution and a reagent from being generated by a method wherein the creation and the correction of a working curve are instructed in a batch according to information on the time remaining until the execution of the creation and the correction of the working curve. CONSTITUTION: A sample disk 2 on which a sample container 1 has been installed is controlled by a computer 3 so as to dispense 7 a sample into a reaction container 6. The container 6 is moved to a first reagent addition position through a reaction tank 9, a reagent in a reagent container 12 is added 11, the container is moved to a stirring mechanism 13, and a first stirring operation is performed. The operation is performed to a first reagent to a fourth reagent. When the container 6 which has stirred its contents is passed through a luminous flux, their absorbance is detected 15, and it is converted 3 into a sample concentration so as to be displayed 21. An operation part stores the time required until the creation of a next working curve as information on every item according to the effective time of the working curve of every reagent. Then, when a calibration execution range is input and set, the input and set time and the information on the remaining time of every item are judged, and an analytical part is instructed in a batch about the execution of the calibration of a relevant item.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an automatic analyzer for analyzing components in a biological sample, and particularly to the effective time of a calibration curve of each analysis item and the execution or correction of the calibration curve in the automatic analyzer. By storing the elapsed time, the automatic analysis with the function to judge the elapsed time and the input setting time of the operator, and to instruct the creation of the calibration curve or the execution of the correction of the relevant analysis item in a batch according to the judgment result Regarding the device.

[0002]

2. Description of the Related Art An automatic analyzer used for clinical tests automatically mixes (reacts) an analyte (eg, serum, urine) and a reagent corresponding to each analysis item, and measures the absorbance of this solution. This is a device for measuring or determining the electrode potential by means of an electrode, and for determining the concentration of the analyte from the calibration curve previously determined by the reagent and the standard substance (standard solution).

The reagent corresponding to each analysis item is generally controlled at about 2 to 8 ° C. on the device, but the deterioration of the reagent cannot be avoided. Therefore, it is necessary to create or correct the calibration curve using the standard substance (standard solution) at the time interval according to each reagent, and to create or correct the calibration curve for each item according to the set interval (effective time). The function of automatically instructing the operating unit of the automatic analyzer to the analyzing unit was used. Note that, regarding this, there is one described in US Pat. No. 4,678,755.

However, this function merely prevents the decrease in the reliability of the measurement result due to the expiration of the effective time of the calibration curve.

In the function, the required interval for preparing or correcting the calibration curve according to the effective time differs depending on the reagent (analysis item), and the standard substance (standard solution) used for preparing or correcting the calibration curve also differs. Also, each standard substance (standard solution) has its own effective time, and since the standard substance (standard solution) is generally easily denatured, each standard substance (standard solution) should be adjusted according to the calibration curve creation or correction execution time of each reagent. The reality was that the operator had to set the liquid) on the device.

[0006]

SUMMARY OF THE INVENTION With the above conventional functions,
Since the emphasis is on preventing the decrease in the reliability of the measurement results due to the expiration of the calibration curve effective time, the effective time of the standard substance (standard solution) used when creating or correcting the calibration curve is not considered,
Since the standard substance (standard solution) is generally easily deteriorated and denatured, there is a labor-intensive problem that the operator has to set it in the device immediately before the execution time of the calibration curve or the correction. In particular, when using many items (reagents) and various standard substances (standard solutions), the above work is a burden on the operator.

Further, there is a problem that the standard substance (standard solution) cannot be avoided from being easily deteriorated or denatured even if it is stored in a place having a cold insulation function on the device. Therefore, when the calibration curve is created or corrected only in accordance with the effective time of the calibration curve that is matched to the reagent, the time interval for executing the calibration curve creation or correction differs for each item, and in order to obtain accurate measurement results, It was necessary to prepare the standard solution each time the calibration was performed. There is a problem that a large amount of standard solution is required and the standard substance (standard solution) is wasted.

If a certain item is calibrated while a general sample is being measured, it takes extra time such as an urgent sample, and a step is generated in the data due to the calibration, so that QC must be executed. Labor increased.

An object of the present invention is to prevent extra work from occurring during analysis by pre-calibrating all the items that would occur during general sample analysis. This method reduces the time burden of setting a wide variety of standard substances (standard solutions) according to the effective time of the calibration curve, creates or corrects the minimum necessary calibration curve, and uses the reagents and standard solutions to be used. An object of the present invention is to provide an automatic analyzer that can contribute to reducing the economic burden such as loss of waste.

[0010]

The automatic analyzer is roughly divided into an analyzing section and an operating section.

In order to achieve the above object,
For each item, you can set and store the time until the calibration curve is created or corrected (automatic calibration execution remaining time), and the calibration execution time. These times decrease in real time. When the calibration is executed, it returns to the initial set time. It is possible to input a certain period of time during calibration, and if it is less than this set time, it will be registered in the calibration item selection list.
Input setting time is judged from all items, and according to the judgment,
The operation unit is configured by using a function capable of collectively instructing the analysis unit on the analysis items to be calibrated.

[0012]

The function of the above technical means is as follows.

The operation unit determines the automatic calibration execution remaining time according to the input setting of the operator, and if it is less than this set time, it is registered in the calibration item selection list. When the analysis start is designated, the registered contents are instructed to execute the calibration collectively. After that, the operation unit collectively instructs the analysis unit on the analysis items to be calibrated according to the determination result. For the items for which calibration has been executed, the remaining execution time is reset, and the initial set time is restored.

[0014]

Embodiments of the present invention will now be described in detail with reference to FIGS.

[Embodiment 1] FIG. 1 is a block diagram showing an embodiment of an automatic analyzer having the functions of the present invention, FIG. 2 is an input screen of an operating section for executing the functions of the present invention, and FIG. Is a flow chart showing the processing in the operation unit for executing the functions of the present invention, and FIGS. 4 and 5 are flow charts showing the details of the processing shown in FIG.

An automatic analyzer according to an embodiment of the present invention will be described.

In FIG. 1, 1 is a sample container, 2 is a sample disk, 3 is a computer, 4 is an interface, 5 is a sample dispensing mechanism, 6 is a reaction container, 7 is a sample pump, 8 is a constant temperature bath, and 9 is Reaction tank, 10 is a reagent dispensing probe, 11 is a reagent pump, 12 is a reagent bottle, 13 is a stirring mechanism, 14 is a light source, 15 is a multi-wavelength photometer, 16 is an A / D converter,
Reference numeral 17 is a printer, 18 is a CRT screen of the operation unit, 19 is a cleaning mechanism, 20 is a reaction container cleaning pump, and 21 is a keyboard.

A plurality of sample containers 1 each containing a sample are set on a sample disk 2. The sample disk 2 is controlled by the computer 3 via the interface 4. Further, the sample disk 2 is rotated and moved to the bottom of the sample dispensing probe 5 in the order of the samples to be analyzed, and the sample in the predetermined sample container 1 is reacted by the sample pump 7 connected to the sample dispensing mechanism 5. A predetermined amount is dispensed into the container 6.

The reaction container 6 into which the sample has been dispensed is a reaction tank 9
To the first reagent addition position. A predetermined amount of the reagent aspirated from the reagent container 12 is added to the moved reaction container 6 by the reagent pump 11 connected to the reagent dispensing probe 8.

After the addition of the first reagent, the reaction vessel 6 moves to the position of the stirring mechanism 13 and the first stirring is performed.

Addition and stirring of such reagents are performed for the first to fourth reagents.

The reaction vessel 6 in which the contents are stirred passes through the light flux emitted from the light source, and the absorbance at this time is detected by the multi-wavelength photometer 15. The detected absorbance signal is A / D
It enters the computer 3 via the interface 4 via the converter 16 and is converted into the concentration of the sample.

The density-converted data is printed out from the printer 23 via the interface 4, and the screen 21
Is displayed in.

The reaction vessel 6 whose photometry has been completed is cleaned by the cleaning mechanism 1.
After moving to the position 9 and discharging the inside by the container washing pump 20, the vessel is washed with water and used for the next analysis.

From the CRT screen 18 or the keyboard 22, it is possible to request analysis items for each sample, input analysis conditions, and input the effective time of the calibration curve for each item. C
According to the valid time of the calibration curve of each reagent input from the RT screen 18 or the keyboard 22, the time until the next calibration curve is created and corrected is counted, and the remaining time information for each item is stored in the operation unit, and the remaining time is stored. The automatic calibration execution determination based on the information is performed, and the analysis unit is instructed to execute the automatic calibration. Also, when requesting the execution of calibration, if the input setting of the calibration execution range is made, the operation unit will judge the time of the input setting and the remaining time information of each item and execute the calibration of the corresponding item. It is possible to instruct the analysis unit at once.

FIG. 2 shows an embodiment of a screen displayed on the CRT screen 18 of FIG.

A time display 31 until execution of automatic calibration of each analysis item and an input setting area 32 of calibration execution range time are provided.

The time display 31 until execution of automatic calibration is (time until execution of automatic calibration)
/ (Valid time of calibration curve).

Next, FIG. 3 shows a flow chart showing the process of measurement in the automatic analyzer of FIG. When the device starts the measurement, it executes the initialization operation, and the CRT shown in FIG.
There is a time input in the calibration execution range time input setting area 32 of the screen shown in FIG. 2 displayed on the screen.
(CAL.TIME ≠ 0), when execution of calibration is designated, determination of remaining time information (TC) of each item and collective registration instruction of calibration execution are performed, and the analysis unit creates a calibration curve according to the above instruction or Make a correction.
The remaining time information (TC) of the item for which the calibration curve has been created or corrected is returned to the valid time (initial value) of the calibration curve of each item, counted again, and the normal analysis is performed.

Next, a flow chart of the judgment process shown in FIG. 3 is shown in FIG. First, it is determined whether the remaining time information (TC) of each item is smaller than CAL.TIME, and if smaller, an instruction to execute calibration is issued.

Next, FIG. 5 shows the processing when CAL.TIME = 0 is input in FIG. CAL.TIME = 0
In the case of, the above function is canceled and only the calibration of the item with TC = 0 is executed.

In the automatic analyzer to which the present invention is applied, it is possible to collectively execute the calibrations that are expected to be performed within the input time, so that the operator can set the remaining time information of each item. Therefore, it is possible to save the trouble of setting the standard solution in and to reduce the loss of the standard solution and the loss of the reagent by collectively using the standard solution common to the items.

[0033]

According to the present invention, since the calibration curve creation and the correction can be collectively executed according to the remaining time information until the calibration curve creation and the correction are executed, the labor of the operation can be saved and the deterioration can be prevented. Alternatively, it is possible to provide an automatic analyzer having a function of eliminating the loss of the standard solution and the reagent due to the failure to create and correct the calibration curve using the denatured standard solution.

[Brief description of drawings]

FIG. 1 is a block diagram showing an automatic analyzer according to an embodiment of the present invention.

FIG. 2 is an explanatory diagram of a CRT screen with a touch screen of an operation unit for executing the present invention.

FIG. 3 is a flowchart showing a process for executing the present invention.

FIG. 4 is a flowchart showing details of processing in FIG.

FIG. 5 is a flowchart showing details of processing in FIG.

[Explanation of symbols]

1 ... Sample container, 2 ... Sample container array part, 3 ... Computer, 4 ... Interface, 5 ... Sample dispensing probe.

Claims (3)

[Claims] 1. An array part of a sample container, a reaction line to which a reaction container row is intermittently transferred, and a sample probe from the sample container of the array part of the sample container to a reaction container on the reaction line by a sample probe. A sample dispensing section for dispensing, an analyzing section including a reagent dispensing section for dispensing a reagent solution into the reaction container on the reaction line, a mechanism control of the analyzing section, and measurement data obtained from the analyzing section It is composed of an operation unit for processing, and the effective time of the calibration curve corresponding to each arbitrary number of analysis items can be input and set.The operation unit stores these input settings and the calibration curve for each stored analysis item is set. Of the effective time of the calibration curve and the elapsed time from the execution of the calibration curve or the correction, and a display means for displaying the information that the calibration curve is newly created or corrected, and the calibration curve is automatically created according to this information. correction In an automatic analyzer that has a function for the operating unit to instruct the analyzing unit to perform the calibration curve creation or correction, the operating unit counts the remaining time for automatic calibration and displays this information. When the display means and the operator instruct the execution of the calibration curve or the correction, the automatic calibration execution remaining time is automatically instructed collectively for the calibration execution of the items below the input setting time of the calibration execution range. An automatic analyzer characterized by having the function of 2. The automatic analyzer according to claim 1, which has a function of displaying the remaining time of automatic calibration before automatically creating or correcting the calibration curve for each method of creating or correcting the calibration curve. 3. The calibration curve validity determination unit according to claim 1, wherein the unit of validity determination is managed by the number of measurement tests, and the device determines the number of tests subtracted from the number of measurement tests and the preset number of validity determination tests. In an automatic analyzer that performs automatic calibration, the operating unit stores the number of tests subtracted from the number of measurement tests and the number of valid judgment tests, and judges the input value of the number of valid judgment tests and the above-mentioned number of subtraction tests. Calibration is performed automatically, and when the operator inputs the number of tests when instructing to create or calibrate the calibration curve, the number of input tests and the number of subtraction tests are judged, and the calibration curve is created or corrected automatically according to the judgment. An automatic analyzer with the function of instructing and executing the analysis section.